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  1. Book ; Thesis: Freie kappa-Leichtketten im Liquor

    Süße, Marie / Lucht, Michael / Tumani, Hayrettin / Otto, Markus

    ein Biomarker für entzündliche Erkrankungen des zentralen Nervensystems$d

    2022  

    Institution Universität Greifswald
    Author's details vorgelegt von Marie Süße ; 1. Gutachter: Prof. Dr. Michael Lucht, 2. Gutachter: Prof. Dr. Hayrettin Tumani, 3. Gutachter: Prof. Dr. Markus Otto
    Keywords Zentralnervensystem ; Entzündung ; Liquor cerebrospinalis ; Kappa-Kette ; Leichte Kette
    Subject L-Kette ; Cerebrospinalflüssigkeit ; Gehirnflüssigkeit ; Hirn-Rückenmarks-Flüssigkeit ; Rückenmarksflüssigkeit ; Cerebrospinal fluid ; CSF ; Zerebrospinalflüssigkeit ; Gehirn-Rückenmarks-Flüssigkeit ; Nervenwasser ; Hirnwasser ; Gehirnwasser ; Inflammatio ; Entzündungsreaktion ; Zentrales Nervensystem ; ZNS ; Systema nervosum centrale ; Central nervous system ; CNS
    Language German ; English
    Size 1 Band (verschiedene Seitenzählungen), Diagramme
    Publishing place Greifswald
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Universitätsmedizin der Universität Greifswald, 2023
    Note Text deutsch, Publikationen englisch ; Literaturverzeichnis: Blatt 27-30. - Literaturangaben
    HBZ-ID HT030366542
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1374 order for loan Magazin

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  2. Book ; Online ; E-Book: Cerebrospinal fluid in neurologic disorders

    Deisenhammer, Florian / Teunissen, Charlotte E. / Tumani, Hayrettin

    (Handbook of clinical neurology ; volume 146)

    2018  

    Author's details volume editors Florian Deisenhammer, Charlotte E. Teunissen and Hayrettin Tumani
    Series title Handbook of clinical neurology ; volume 146
    Collection
    Keywords Nervous System Diseases / cerebrospinal fluid ; Nervous system/Diseases/Diagnosis ; Cerebrospinal fluid/Examination
    Subject code 616.8047582
    Language English
    Size 1 Online-Ressource (xiv, 306 Seiten), Diagramme
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019667555
    ISBN 978-0-12-804324-0 ; 9780128042793 ; 0-12-804324-5 ; 0128042796
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Progranulin als Inflammationsmarker bei Infektionserkrankungen am Beispiel Neuroborreliose

    Lux, Joachim / Vielhaber, Stefan / Tumani, Hayrettin

    2020  

    Institution Otto-von-Guericke-Universität Magdeburg
    Author's details von Joachim Lux ; Gutachter: Prof. Dr. Stefan Vielhaber ; Prof. Dr. Hayrettin Tumani
    Keywords Meningoencephalitis ; Borreliose ; Entzündung
    Subject Inflammatio ; Entzündungsreaktion ; Meningoenzephalitis
    Language German
    Size VI, 54 Blätter, Diagramme
    Publisher Otto-von-Guericke-Universität Magdeburg
    Publishing place Magdeburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Magdeburg, 2021
    HBZ-ID HT021771580
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 593 order for loan Magazin

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  4. Book: Aktuelle klinische Anwendungen des natürlichen Interferon-beta

    Tumani, Hayrettin

    18 Tabellen

    (Aktuelle Immunologie ; 14)

    2005  

    Author's details hrsg. von H. Tumani
    Series title Aktuelle Immunologie ; 14
    Collection
    Keywords Interferon
    Subject HuIFN-beta ; IFN b ; Fibrinoblasten-Interferon ; CAS 74899-71-1Interferonum beta ; Interferon beta human
    Language German
    Size V, 56 S. : graph. Darst., 235 mm x 165 mm, 188 gr.
    Publisher Zuckschwerdt
    Publishing place München u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014554281
    ISBN 3-88603-853-X ; 978-3-88603-853-4
    Database Catalogue ZB MED Medicine, Health

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    2005 A 5043 order for loan Magazin

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  5. Book ; Thesis: ZNS-Proteine im Liquor

    Tumani, Hayrettin

    welche Faktoren beeinflussen ihre Konzentration und was ist ihre klinische Relevanz?

    2000  

    Author's details vorgelegt von Hayrettin Tumani
    Language German
    Size 137 S. in getr. Zählung, Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Habil.-Schr., 2000
    Note Enth. Sonderdr. aus verschiedenen Zeitschr.
    HBZ-ID HT013334841
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 E 1430 order to use in reading room Magazin

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  6. Article: Lumbalpunktion – Schritt für Schritt

    Tumani, Hayrettin / Lewerenz, Jan / Jesse, Sarah

    Intensivmedizin up2date

    2023  Volume 19, Issue 01, Page(s) 10–16

    Language German
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2180698-6
    ISSN 1614-6697 ; 1614-4856
    ISSN (online) 1614-6697
    ISSN 1614-4856
    DOI 10.1055/a-1984-4050
    Database Thieme publisher's database

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    Zs.A 6476: Show issues Location:
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  7. Article ; Online: Diagnostic biomarkers in tear fluid: from sampling to preanalytical processing.

    Bachhuber, Franziska / Huss, André / Senel, Makbule / Tumani, Hayrettin

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 10064

    Abstract: Tear fluid is receiving growing attention as a source for novel diagnostic biomarkers. Multiple techniques are available for its collection and impact the composition of acquired samples. We sought to provide a direct comparison of two collection methods ...

    Abstract Tear fluid is receiving growing attention as a source for novel diagnostic biomarkers. Multiple techniques are available for its collection and impact the composition of acquired samples. We sought to provide a direct comparison of two collection methods with regard to implementation, acceptance, and impact on sample composition. Tear fluid was collected from fifteen healthy volunteers with capillary tubes and Schirmer strips and analyzed for total protein and IgG concentrations. Sampling parameters and perception by test persons were compared. The use of capillary tubes was more convenient for the participants while causing more effort for the collector. Tear flow rates as well as the relative and absolute amount of IgG were higher when Schirmer strips were used. Consecutive collections with Schirmer strips significantly influenced tear flow rates, IgG, and protein concentrations. A moderate correlation was observed between tear flow rates and IgG concentrations for both methods. Samples collected with both methods can be analyzed by isoelectric focusing, a potential diagnostic application in the field of neurology. The specific advantages and limitations of tear fluid sampling with either capillary tubes or Schirmer strips demonstrate the need for a thorough investigation of collection methods with regard to the application of interest.
    MeSH term(s) Adult ; Biomarkers/metabolism ; Eye Proteins/metabolism ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Reagent Strips/standards ; Specimen Handling/methods ; Tears/chemistry
    Chemical Substances Biomarkers ; Eye Proteins ; Reagent Strips
    Language English
    Publishing date 2021-05-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-89514-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Correspondence: Humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies.

    Petereit, Hela-Felicitas / Tumani, Hayrettin / Zettl, Uwe K

    Therapeutic advances in neurological disorders

    2021  Volume 14, Page(s) 17562864211022581

    Language English
    Publishing date 2021-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442245-9
    ISSN 1756-2864 ; 1756-2856
    ISSN (online) 1756-2864
    ISSN 1756-2856
    DOI 10.1177/17562864211022581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Serum neurofilament light chain and glial fibrillary acidic protein for predicting response to apheresis in steroid-refractory multiple sclerosis relapses.

    Vardakas, Ioannis / Dorst, Johannes / Huss, André / Mayer, Benjamin / Fangerau, Tanja / Taranu, Daniela / Tumani, Hayrettin / Senel, Makbule

    European journal of neurology

    2024  , Page(s) e16323

    Abstract: Background and purpose: The predictive value of serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) for apheresis outcome in steroid-refractory multiple sclerosis (MS) relapse has not yet been evaluated.: Methods: ...

    Abstract Background and purpose: The predictive value of serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) for apheresis outcome in steroid-refractory multiple sclerosis (MS) relapse has not yet been evaluated.
    Methods: We used pre- and postapheresis serum samples from 38 participants of the IAPEMS trial (clinicaltrials.gov: NCT02671682), which investigated the use of immunoadsorption versus plasma exchange for the treatment of steroid-refractory MS attacks. Response to apheresis was classified based on improvement on (i) the Expanded Disability Status Scale (EDSS), (ii) the affected functional system scores (FSS) of the EDSS, or (iii) the visual acuity for patients with optic neuritis, 4 weeks postapheresis. sNFL and sGFAP were measured by single molecule arrays.
    Results: Preprocedural sGFAP levels could discriminate between responders and nonresponders, determined by FSS improvement (p = 0.017). In multivariate logistic regression analysis, younger age (odds ratio [OR] = 0.781, 95% confidence interval [CI] = 0.635-0.962, p = 0.020) and lower sGFAP levels (OR = 0.948, 95% CI = 0.903-0.995, p = 0.031) could predict response to apheresis in the overall cohort. We could observe a trend towards a favourable apheresis outcome with higher sNfL levels (OR = 1.413, 95% CI = 0.965-2.069, p = 0.076). Analysis of the sNfL-to-sGFAP ratio showed an OR of 1.924 (95% CI = 1.073-3.451, p = 0.028) for predicting apheresis response. The ratio showed a better predictive value than the individual parameters. Neither biomarker was affected by the number of steroid cycles preapheresis.
    Conclusions: Lower sGFAP levels, a higher sNfL-to-sGFAP ratio, and younger age are associated with a favourable apheresis outcome.
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4738: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 592: Show issues

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  10. Article ; Online: CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study.

    Erhart, Deborah Katharina / Klose, Veronika / Schäper, Tatjana / Tumani, Hayrettin / Senel, Makbule

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: C-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal fluid (CSF) is increasingly used in clinical routines, although its diagnostic specificity and divergent cut-off values have been defined so far mainly for neuroborreliosis. Our aim was to ... ...

    Abstract C-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal fluid (CSF) is increasingly used in clinical routines, although its diagnostic specificity and divergent cut-off values have been defined so far mainly for neuroborreliosis. Our aim was to evaluate the value of CSF-CXCL13 as a diagnostic and treatment response marker and its role as an activity marker in a larger disease spectrum, including neuroborreliosis and other neuroinflammatory and malignant CNS-disorders. Patients who received a diagnostic lumbar puncture (LP) (
    MeSH term(s) Humans ; Cross-Sectional Studies ; Retrospective Studies ; Spinal Puncture ; Multiple Sclerosis ; Neurosyphilis ; Syndrome ; Chemokine CXCL13
    Chemical Substances CXCL13 protein, human ; Chemokine CXCL13
    Language English
    Publishing date 2023-12-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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