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  1. Book ; Thesis: Vermehrte Aktivierung der Basalganglien bei repetitiven Armbewegungen bei Patienten mit fokaler Dystonie

    Tumczak, Felicitas

    2009  

    Author's details vorgelegt von Felicitas Tumczak
    Language German
    Size 51 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Duisburg, Essen, Univ., Diss., 2009
    HBZ-ID HT016289655
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 E 1493 order for loan Magazin

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  2. Article: SEVTAR-A multicenter randomized controlled trial to investigate the impact of prophylactic endoluminal placed vacuum sponge for prevention of anastomotic leakage after low rectal resections.

    Schiffmann, Leif / Becker, Matthias / Develing, Leendert / Varga-Szabo, David / Scheidereiter-Krüger, Caroline / Zirngibl, Hubert / Seifert, Michael / Biermann, Lothar / Schlüter, Claudia / Tumczak, Felicitas / Weimann, Arved / Jansen-Winkeln, Boris / Wallstabe, Ingo / Schwandner, Frank / Denecke, Sandra / Schafmayer, Clemens / Kamaleddine, Imad / Stier, Albrecht / Haegele, Katharina /
    Kindler, Michael / Michling, Sabine / Horling, Ernst-Wilhelm / Denzer, Ulrike

    Frontiers in surgery

    2023  Volume 9, Page(s) 1099549

    Abstract: Background: Low anterior resection for rectal cancer is commonly associated with a diverting stoma. In general, the stoma is closed 3 months after the initial operation. The diverting stoma reduces the rate of anastomotic leakage as well as the ... ...

    Abstract Background: Low anterior resection for rectal cancer is commonly associated with a diverting stoma. In general, the stoma is closed 3 months after the initial operation. The diverting stoma reduces the rate of anastomotic leakage as well as the severeness of a potential leakage itself. Nevertheless, anastomotic leakage is still a life-threatening complication and might reduce the quality of life in the short and long term. In case of leakage, the construction can be converted into a Hartmann situation or it could be treated by endoscopic vacuum therapy or by leaving the drains. In recent years, endoscopic vacuum therapy has become the treatment of choice in many institutions. In this study, the hypothesis is to be evaluated, if a prophylactic endoscopic vacuum therapy reduces the rate of anastomotic leakage after rectal resections.
    Methods: A multicenter parallel group randomized controlled trial is planned in as many as possible centers in Europe. The study aims to recruit 362 analyzable patients with a resection of the rectum combined with a diverting ileostoma. The anastomosis has to be between 2 and 8 cm off the anal verge. Half of these patients receive a sponge for 5 days, and the control group is treated as usual in the participating hospitals. There will be a check for anastomotic leakage after 30 days. Primary end point is the rate of anastomotic leakages. The study will have 60% power to detect a difference of 10%, at a one-sided alpha significance level of 5%, assuming an anastomosis leakage rate of 10%-15%.
    Discussion: If the hypothesis proves to be true, anastomosis leakage could be reduced significantly by placing a vacuum sponge over the anastomosis for 5 days.
    Trial registration: The trial is registered at DRKS: DRKS00023436. It has been accredited by Onkocert of the German Society of Cancer: ST-D483. The leading Ethics Committee is the Ethics Committee of Rostock University with the registration ID A 2019-0203.
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.1099549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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