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  1. Article ; Online: COVID-19 and public health efforts in Mongolia

    Tumenbayar Bayasgalan / Erdembileg Anuurad / Enkhmaa Byambaa

    Journal of Clinical and Translational Science, Vol

    A lesson maybe learned?

    2021  Volume 5

    Keywords Coronavirus ; novel virus ; new infection ; spread control measurements ; Asia ; Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Prevalence of Type 2 Diabetes in Mongolia: Results from Population-Based Survey Compared with 1999 Study.

    Dayan, Angarmurun / Erkhembayar, Ryenchindorj / Luvsandavaajav, Oyunbileg / Mukhtar, Yerkyebulan / Enkhtuvshin, Bolormaa / Tumenbayar, Bayasgalan

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2023  Volume 16, Page(s) 1833–1846

    Abstract: Purpose: The burden of diabetes in Mongolia has risen tremendously over the last three decades, and an individually tracked, national registry of diabetes is lacking. Therefore, we aim to investigate diabetes prevalence in Mongolia and analyze some ... ...

    Abstract Purpose: The burden of diabetes in Mongolia has risen tremendously over the last three decades, and an individually tracked, national registry of diabetes is lacking. Therefore, we aim to investigate diabetes prevalence in Mongolia and analyze some associated factors.
    Materials and methods: A cross-sectional, nationally representative, population-based survey was carried out in Mongolia. We recruited participants from randomly selected six different clusters for the required 3113 ± 311 sample size. We collected detailed demographics, diabetes condition and medications, anthropometric measurements, body composition, and glucose profiles. Oral glucose tolerance tests were used to diagnose diabetes using the International Diabetes Federation algorithm. Chi-square and multinomial logistic regression tests were used to determine associated factors. Age-standardized prevalence rates were estimated.
    Results: We recruited 3272 participants in the study between June and October 2019. Crude prevalence rates for prediabetes and diabetes were 10.8% (95% CI; 9.8-11.9) and 11.2% (95% CI; 10.1-12.3), respectively. Sixty-one adults were newly diagnosed with diabetes. Age-standardized prediabetes and diabetes prevalence rates were 9.8% (95% CI; 8.5-11.1) and 10.0% (95% CI; 8.7-11.3) among adults 30 or older. Higher BMI, central obesity, diabetes inheritance, sedentary habitus, and hypertension are significantly associated with diabetes in adjusted analysis for sex and age group.
    Conclusion: The prevalence of diabetes has increased at least threefold since 1999 in Mongolia. In addition, numerous modifiable risk factors were associated with diabetes. Therefore, future investigations and programs should focus on combating obesity and sedentary lifestyles and propose dietary recommendations in the context of expanding diabetes in Mongolia.
    Language English
    Publishing date 2023-06-21
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S413320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages.

    Sakai, Kent / Nagashima, Shuichi / Wakabayashi, Tetsuji / Tumenbayar, Bayasgalan / Hayakawa, Hiroko / Hayakawa, Morisada / Karasawa, Tadayoshi / Ohashi, Ken / Yamazaki, Hisataka / Takei, Akihito / Takei, Shoko / Yamamuro, Daisuke / Takahashi, Manabu / Yagyu, Hiroaki / Osuga, Jun-Ichi / Takahashi, Masafumi / Tominaga, Shin-Ichi / Ishibashi, Shun

    Arteriosclerosis, thrombosis, and vascular biology

    2018  Volume 38, Issue 11, Page(s) 2590–2600

    Abstract: Objective- Inhibition of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is atheroprotective primarily by decreasing plasma LDL (low-density lipoprotein)-cholesterol. However, it is unknown whether inhibition of HMGCR in myeloid cells contributes ...

    Abstract Objective- Inhibition of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is atheroprotective primarily by decreasing plasma LDL (low-density lipoprotein)-cholesterol. However, it is unknown whether inhibition of HMGCR in myeloid cells contributes to this atheroprotection. We sought to determine the role of myeloid HMGCR in the development of atherosclerosis. Approach and Results- We generated mice with genetically reduced Hmgcr in myeloid cells ( Hmgcr
    MeSH term(s) Adoptive Transfer ; Animals ; Aorta/enzymology ; Aorta/pathology ; Aortic Diseases/enzymology ; Aortic Diseases/genetics ; Aortic Diseases/pathology ; Aortic Diseases/prevention & control ; Atherosclerosis/enzymology ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Atherosclerosis/prevention & control ; Cell Movement ; Cell Proliferation ; Cell Survival ; Cells, Cultured ; Disease Models, Animal ; Female ; Genetic Predisposition to Disease ; Hydroxymethylglutaryl CoA Reductases/genetics ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Lipids/blood ; Macrophages, Peritoneal/enzymology ; Macrophages, Peritoneal/pathology ; Macrophages, Peritoneal/transplantation ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/enzymology ; Monocytes/pathology ; Monomeric GTP-Binding Proteins/metabolism ; Phenotype ; Receptors, LDL/deficiency ; Receptors, LDL/genetics ; Signal Transduction
    Chemical Substances Lipids ; Receptors, LDL ; Hydroxymethylglutaryl CoA Reductases (EC 1.1.1.-) ; Hmgcr protein, mouse (EC 1.1.1.34) ; Monomeric GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2018-10-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.118.311664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes.

    Eto, Kazuhiro / Tumenbayar, Bayasgalan / Nagashima, Shu-ichi / Tazoe, Fumiko / Miyamoto, Michiaki / Takahashi, Manabu / Ando, Akihiko / Okada, Kenta / Yagyu, Hiroaki / Ishibashi, Shun

    Diabetes research and clinical practice

    2010  Volume 89, Issue 1, Page(s) 52–57

    Abstract: Fibroblast growth factor 21 (FGF21) has been identified as a novel metabolic regulator. This cross-sectional study was performed to clarify how serum FGF21 levels were associated with clinical parameters in Japanese subjects with type 2 diabetes (n=139). ...

    Abstract Fibroblast growth factor 21 (FGF21) has been identified as a novel metabolic regulator. This cross-sectional study was performed to clarify how serum FGF21 levels were associated with clinical parameters in Japanese subjects with type 2 diabetes (n=139). Anthropometric and blood biochemical parameters, uses of drugs for diabetes, hypertension and dyslipidemia were examined regarding associations with fasting serum FGF21 concentrations. FGF21 levels were 6-times higher in those subjects taking fibrates. However, a use of thiazolidinediones did not affect serum FGF21 levels while it induced higher serum adiponectin levels. In univariate analyses, FGF21 levels showed associations with a use of fibrates, triglyceride levels, creatinine levels, waist circumference, and BMI. Multiple regression analyses adjusted for age, gender and BMI showed that a use of fibrates, triglyceride levels and creatinine levels were strong contributors to serum FGF21 levels. In contrast, a use of thiazolidinediones, HDL-cholesterol levels and fasting insulin levels were strong contributors to serum adiponectin levels. This study revealed that serum FGF21 levels were biochemical indicators correlating to a set of essential metabolic parameters, which was distinct from that correlating to serum adiponectin levels in subjects with type 2 diabetes.
    MeSH term(s) Adiponectin/blood ; Aged ; Asian Continental Ancestry Group ; Creatinine/blood ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Fasting/metabolism ; Female ; Fibroblast Growth Factors/blood ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/blood ; Insulin/therapeutic use ; Male ; Middle Aged ; Regression (Psychology) ; Risk Factors ; Thiazolidinediones/therapeutic use ; Triglycerides/blood
    Chemical Substances ADIPOQ protein, human ; Adiponectin ; Hypoglycemic Agents ; Insulin ; Thiazolidinediones ; Triglycerides ; fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3) ; 2,4-thiazolidinedione (AA68LXK93C) ; Creatinine (AYI8EX34EU) ; pioglitazone (X4OV71U42S)
    Language English
    Publishing date 2010-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2010.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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