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  1. Book ; Online: Reversal of the Kuznets curve

    Tuominen, Elina

    study on the inequality-development relation using top income shares data

    (Working paper / World Institute for Development Economics Research ; 2015/036)

    2015  

    Abstract: This paper uses recently published top 1% income share series in studying the inequality-development association. The top income shares data are of high quality and cover about a century for some countries and thus provide an interesting opportunity to ... ...

    Author's details Elina Tuominen
    Series title Working paper / World Institute for Development Economics Research ; 2015/036
    Abstract This paper uses recently published top 1% income share series in studying the inequality-development association. The top income shares data are of high quality and cover about a century for some countries and thus provide an interesting opportunity to study slow development processes. The empirical inequality-development studies have started to call into question the use of parametric (quadratic) specifications. To address the issue of functional form, this study exploits penalized spline methods. The association between top 1% share and development is found to experience a reversal at later stages of development and, thus, a positive link is observed in many advanced economies. Although this study is not taking a strong stand on causality, additional analysis in this paper advocates that more than sectoral shifts are needed to explain distributional changes.
    Keywords inequality ; top incomes ; development ; nonlinearity ; longitudinal data
    Language English
    Size Online-Ressource (27 S.), graph. Darst.
    Publisher WIDER
    Publishing place Helsinki
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    ISBN 9789292309213 ; 9292309218
    Database ECONomics Information System

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  2. Book ; Article ; Online: Huippuruokaa kotona ja kaupassa – esittelyssä ravintolaruuan uudet jakelukanavat

    Tuominen, Eetu / Puhakainen, Eeva

    28889

    2020  

    Abstract: Koronaepidemian myötä monen ravintolayrittäjän liiketoiminta käytännössä pysähtyi. Aiemmin kotiinkuljetuspalveluita olivat tarjonneet lähinnä pikaruokaravintolat. Nyt asiakkaita palvellaan monipuolisemmin koko ravintola-alalla fine diningista ... ...

    Abstract Koronaepidemian myötä monen ravintolayrittäjän liiketoiminta käytännössä pysähtyi. Aiemmin kotiinkuljetuspalveluita olivat tarjonneet lähinnä pikaruokaravintolat. Nyt asiakkaita palvellaan monipuolisemmin koko ravintola-alalla fine diningista lounaskahviloihin. Syöminen siirtyi ainakin hetkeksi ravintolasta koteihin.
    Keywords ravintolat ; ruoka ; jakelu ; ravintola-ala ; vähittäiskauppa ; liiketoimintamallit ; COVID-19 ; covid19
    Language Finnish
    Publisher Mediatalo Keskisuomalainen
    Publishing country fi
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book: Elämänmuutos ja muutoksen hallinta

    Tuominen, Eila

    tutkimus leskeksi jäämisen taloudellisista, terveydellisistä ja sosiaalisisista vaikutuksista sekä leskeyteen sopeutumisesta

    (Tutkimuksia / Eläketurvakeskus ; 1994,1)

    1994  

    Author's details Eila Tuominen
    Series title Tutkimuksia / Eläketurvakeskus ; 1994,1
    Language Finnish
    Size 532 S
    Publisher Eläketurvakeskus
    Publishing place Helsinki
    Document type Book
    Note Untersuchung der wirtschaftlichen, gesundheitlichen und sozialen Verhältnisse der als Witwen Hinterbliebenen und ihre Anpassung ans Witwendasein ; Zsfassung in engl. Sprache
    ISBN 952963918X ; 9789529639182
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article ; Online: Tat(48-60) peptide amino acid sequence is not unique in its cell penetrating properties and cell-surface glycosaminoglycans inhibit its cellular uptake.

    Subrizi, Astrid / Tuominen, Eva / Bunker, Alex / Róg, Tomasz / Antopolsky, Maxim / Urtti, Arto

    Journal of controlled release : official journal of the Controlled Release Society

    2012  Volume 158, Issue 2, Page(s) 277–285

    Abstract: Biomolecules and drug delivery agents, such as liposomes, are often delivered intracellularly with help of cell penetrating peptides (CPPs) and, in particular, Tat peptide. Tat peptide acts as a membrane shuttle; the structural determinants of transport ... ...

    Abstract Biomolecules and drug delivery agents, such as liposomes, are often delivered intracellularly with help of cell penetrating peptides (CPPs) and, in particular, Tat peptide. Tat peptide acts as a membrane shuttle; the structural determinants of transport and the manner by which the peptide crosses the lipid bilayer are, however, still unknown. The roles of direct membrane translocation, endocytosis and cell surface proteoglycans, in particular, remain elusive. Our study aimed to explore the relationship between structure and activity of Tat peptide and its uptake mechanism. For this purpose we introduced several modifications (e.g. lipophilic, aromatic, neutral and non-natural amino acids) into the original Tat sequence. We studied the interaction of the peptides with a model lipid membrane and with three cell lines, a phagocytic cell line (human retinal pigment epithelium cell line, ARPE-19), a non-phagocytic cell line (Chinese hamster ovary cells, CHO wt) and a mutant form of the latter cell line deficient in glycosaminoglycans chondroitin sulfate and heparan sulfate (CHO-pgsB 618). The amino acid residues introduced into the original sequence of Tat peptide failed to influence cellular uptake, indicating that the cationic charge alone may be responsible for translocation. Clear discrepancy between permeation activity of the peptides into cells and their interaction with lipid bilayers of liposomes indicated the limited value of the model membrane in predicting cellular peptide delivery. Cell uptake of Tat peptide was unspecific, took place either by phagocytosis or pinocytosis, and was inhibited by cell-surface glycosaminoglycans. The internalized peptides were localized in vesicles and unable to reach the cell nuclei. In conclusion, we show that Tat-related peptides enter cells on the basis of their cationic charge following different endocytosis pathways and that glycosaminoglycans on the cell surface negatively affect their uptake. This lack of specificity should be taken into account when exploiting Tat peptide as vehicle for intracellular delivery of biomacromolecules.
    MeSH term(s) Amino Acid Sequence ; Animals ; CHO Cells ; Cell Line ; Cell Membrane/metabolism ; Cell Membrane Permeability ; Cell Survival ; Cricetinae ; Cricetulus ; Endocytosis ; Glycosaminoglycans/metabolism ; Humans ; Molecular Sequence Data ; Peptide Fragments/metabolism ; tat Gene Products, Human Immunodeficiency Virus/metabolism
    Chemical Substances Glycosaminoglycans ; Peptide Fragments ; tat Gene Products, Human Immunodeficiency Virus ; tat peptide (48-60), Human immunodeficiency virus 1
    Language English
    Publishing date 2012-03-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2011.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment of non-traumatic rotator cuff tears: A randomised controlled trial with one-year clinical results.

    Kukkonen, J / Joukainen, A / Lehtinen, J / Mattila, K T / Tuominen, E K J / Kauko, T / Aärimaa, V

    The bone & joint journal

    2014  Volume 96-B, Issue 1, Page(s) 75–81

    Abstract: We have compared three different methods of treating symptomatic non-traumatic tears of the supraspinatus tendon in patients above 55 years of age. A total of 180 shoulders (173 patients) with supraspinatus tendon tears were randomly allocated into one ... ...

    Abstract We have compared three different methods of treating symptomatic non-traumatic tears of the supraspinatus tendon in patients above 55 years of age. A total of 180 shoulders (173 patients) with supraspinatus tendon tears were randomly allocated into one of three groups (each of 60 shoulders); physiotherapy (group 1), acromioplasty and physiotherapy (group 2) and rotator cuff repair, acromioplasty and physiotherapy (group 3). The Constant score was assessed and followed up by an independent observer pre-operatively and at three, six and twelve months after the intervention. Of these, 167 shoulders were available for assessment at one year (follow-up rate of 92.8%). There were 55 shoulders in group 1 (24 in males and 31 in females, mean age 65 years (55 to 79)), 57 in group 2 (29 male and 28 female, mean age 65 years (55 to 79)) and 55 shoulders in group 3 (26 male and 29 female, mean age 65 years (55 to 81)). There were no between-group differences in the Constant score at final follow-up: 74.1 (sd 14.2), 77.2 (sd 13.0) and 77.9 (sd 12.1) in groups 1, 2 and 3, respectively (p = 0.34). The mean change in the Constant score was 17.0, 17.5, and 19.8, respectively (p = 0.34). These results suggest that at one-year follow-up, operative treatment is no better than conservative treatment with regard to non-traumatic supraspinatus tears, and that conservative treatment should be considered as the primary method of treatment for this condition.
    MeSH term(s) Acromion/surgery ; Activities of Daily Living ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Physical Therapy Modalities ; Range of Motion, Articular ; Rotator Cuff/pathology ; Rotator Cuff/surgery ; Rotator Cuff Injuries ; Shoulder Joint/physiopathology ; Shoulder Joint/surgery ; Single-Blind Method ; Treatment Outcome
    Language English
    Publishing date 2014-01
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.96B1.32168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6989: Show issues Location:
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  6. Article ; Online: Ultrasmall integrin-targeted silica nanoparticles modulate signaling events and cellular processes in a concentration-dependent manner.

    Benezra, Miriam / Phillips, Evan / Overholtzer, Michael / Zanzonico, Pat B / Tuominen, Esa / Wiesner, Ulrich / Bradbury, Michelle S

    Small (Weinheim an der Bergstrasse, Germany)

    2014  Volume 11, Issue 14, Page(s) 1721–1732

    Abstract: Cellular and molecular-level interactions of nanoparticles with biological systems are a rapidly evolving field requiring an improved understanding of endocytic trafficking as the principal driver and regulator of signaling events and cellular responses. ...

    Abstract Cellular and molecular-level interactions of nanoparticles with biological systems are a rapidly evolving field requiring an improved understanding of endocytic trafficking as the principal driver and regulator of signaling events and cellular responses. An understanding of these processes is vital to nanomedicine applications. Studies investigating the complex interplay of these processes and their relationship to targeted nanoparticles exploiting endocytic pathways are notably lacking. It is known that integrins traffic through the endosomal pathway and participate in diverse roles controlling signal transduction, cell migration, and proliferation. Here, it is shown that ultrasmall, nontoxic, core-shell silica nanoparticles (C-dots), surface-functionalized with cRGDY peptides, modestly activate integrin-signaling pathways, in turn, promoting the enhancement of cellular functions. First, nanomolar concentrations, two orders of magnitude higher than clinical trial doses, internalize within αvβ3 integrin-expressing melanoma and endothelial cells, predominantly through an integrin receptor-dependent endocytic route. Second, integrin-mediated activation of focal adhesion kinase (FAK) and downstream signaling pathways occurs, in turn, upregulating phosphorylated protein expression levels and promoting concentration-dependent cellular migration and proliferative activity. Inhibiting FAK catalytic activity leads to decreased phosphorylation levels and cellular migration rates. These findings may inform the design of more effectively-targeted nanomedicines and provide insights into endocytic regulation of signal transduction.
    MeSH term(s) Cell Cycle ; Endocytosis ; Human Umbilical Vein Endothelial Cells ; Humans ; Integrins/metabolism ; Nanoparticles ; Signal Transduction ; Silicon Dioxide/chemistry
    Chemical Substances Integrins ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2014-12-03
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.201402331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Säästöpankkikriisi USA:ssa 1980-luvulla

    Tuominen, Esa

    asuntorahoitusjärjestelmän kujanjuoksu ja johtopäätökset Suomen oloihin

    1991  

    Author's details Esa Tuominen
    Keywords Bankenkrise ; Immobilienfinanzierung ; USA ; 13*31*23*32
    Language Finnish
    Size 125 S, Ill., graph. Darst
    Document type Book
    ISBN 9514559304 ; 9789514559303
    Database ECONomics Information System

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  8. Article: Seramidi ja apoptoosi.

    Holopainen, J / Mustonen, P / Söderlund, T / Tuominen, E / Kinnunen, P

    Duodecim; laaketieteellinen aikakauskirja

    1997  Volume 113, Issue 16, Page(s) 1605–1611

    Title translation Ceramide and apoptosis.
    MeSH term(s) Apoptosis/physiology ; Ceramides/physiology ; Humans ; In Vitro Techniques ; Membrane Lipids/biosynthesis ; Membrane Lipids/physiology ; Signal Transduction/physiology
    Chemical Substances Ceramides ; Membrane Lipids
    Language Finnish
    Publishing date 1997
    Publishing country Finland
    Document type Journal Article ; Review
    ZDB-ID 127604-9
    ISSN 0012-7183
    ISSN 0012-7183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 109: Show issues Location:
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  9. Book: Test methodology and characterization of batteries for remote power applications

    Manninen, L. M / Lund, P. D / Tuominen, E

    (Report TKK-F-A ; 771)

    1998  

    Author's details L. M. Manninen, E. Tuominen and P. D. Lund
    Series title Report TKK-F-A ; 771
    Language English
    Size 29, [6] S, graph. Darst
    Publishing place Espoo, Finland
    Document type Book
    ISBN 951223694X ; 9789512236947
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article: Effects of i-propanol on the structural dynamics of Thermomyces lanuginosa lipase revealed by tryptophan fluorescence.

    Zhu, K / Jutila, A / Tuominen, E K / Kinnunen, P K

    Protein science : a publication of the Protein Society

    2001  Volume 10, Issue 2, Page(s) 339–351

    Abstract: Influence of isopropanol (iPrOH) on the structural dynamics of Thermomyces lanuginosa lipase (TLL) was studied by steady-state, time-resolved, and stopped-flow fluorescence spectroscopy, monitoring the intrinsic emission of Trp residues. The fluorescence ...

    Abstract Influence of isopropanol (iPrOH) on the structural dynamics of Thermomyces lanuginosa lipase (TLL) was studied by steady-state, time-resolved, and stopped-flow fluorescence spectroscopy, monitoring the intrinsic emission of Trp residues. The fluorescence of the four Trps of the wild-type enzyme report on the global changes of the whole lipase molecule. To monitor the conformational changes in the so-called "lid," an alpha-helical surface loop, the single Trp mutant W89m (W117F, W221H, W260H) was employed. Circular dichroism (CD) spectra revealed that iPrOH does not cause major alterations in the secondary structures of the wild-type TLL and W89m. With increasing [iPrOH], judged by the ratio of emission intensities at 350 nm and 330 nm, the average microenvironment of the Trps in the wild-type TLL became more hydrophobic, whereas Trp89 of W89m moved into a more hydrophilic microenvironment. Time-resolved fluorescence measurements revealed no major changes to be induced by iPrOH neither in the shorter fluorescence lifetime component (tau(1) = 0.5--1.2 ns) for the wild-type TLL nor in the longer fluorescence lifetime component (tau(2) = 4.8--6.0 ns) in the wild-type TLL and the W89m mutant. Instead, for W89m on increasing iPrOH from 25% to 50% the value for tau(1) increased significantly, from 0.43 to 1.5 ns. The shorter correlation time phi(1) of W89m had a minimum of 0.08 ns in 25% iPrOH. Judged from the residual anisotropy r(infinity) the amplitude of the local motion of Trp89 increased upon increasing [iPrOH] 10%. Stopped-flow fluorescence spectroscopy measurements suggested the lid to open within approximately 2 ms upon transfer of W89m into 25% iPrOH. Steady-state anisotropies and longer correlation times revealed increasing concentrations of iPrOH to result also in the formation of dimers as well as possibly also higher oligomers by TLL.
    MeSH term(s) 2-Propanol/chemistry ; 2-Propanol/pharmacology ; Anisotropy ; Ascomycota/chemistry ; Catalysis ; Circular Dichroism ; Lipase/chemistry ; Lipase/genetics ; Models, Statistical ; Mutagenesis, Site-Directed ; Protein Conformation/drug effects ; Protein Structure, Secondary ; Spectrometry, Fluorescence ; Time Factors ; Tryptophan/chemistry ; Ultraviolet Rays
    Chemical Substances Tryptophan (8DUH1N11BX) ; Lipase (EC 3.1.1.3) ; 2-Propanol (ND2M416302)
    Language English
    Publishing date 2001-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1110/ps.21201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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