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  1. Conference proceedings: Einfluss von Hyperglykämie auf die Entstehung von Monosomie-3 bei uvealem Melanom

    Tura, Aysegül / Grisanti, S.

    2023  , Page(s) 23vnda11

    Event/congress 72. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA); Osnabrück; Vereinigung Norddeutscher Augenärzte; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-06-01
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23vnda11
    Database German Medical Science

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  2. Article ; Online: Impact of Nintedanib and Anti-Angiogenic Agents on Uveal Melanoma Cell Behavior.

    Pawlik, Vera E / Sonntag, Svenja R / Grisanti, Salvatore / Tura, Aysegül / Kakkassery, Vinodh / Ranjbar, Mahdy

    Investigative ophthalmology & visual science

    2024  Volume 65, Issue 2, Page(s) 30

    Abstract: Purpose: The purpose of this study was to investigate the direct impact of the combined angiokinase inhibitor nintedanib as well as the anti-angiogenic agents ranibizumab, bevacizumab, and aflibercept on the primary uveal melanoma (UM) cell line Mel270 ... ...

    Abstract Purpose: The purpose of this study was to investigate the direct impact of the combined angiokinase inhibitor nintedanib as well as the anti-angiogenic agents ranibizumab, bevacizumab, and aflibercept on the primary uveal melanoma (UM) cell line Mel270 and liver metastasis UM cell line OMM2.5.
    Methods: The metabolic activity, viability, and oxidative stress levels were analyzed by the Thiazolyl Blue Tetrazolium Bromide (MTT), LIVE/DEAD, and reactive oxygen species (ROS) assays. Expression of intracellular VEGF-A165 and VEGF receptor-2 was detected by immunofluorescent staining. The secretion of VEGF-A165 into the cell culture supernatants was evaluated by VEGF-A165 ELISA.
    Results: Nintedanib, at a concentration of 1 µg/mL, resulted in a median reduction of metabolic activity (for Mel270 of approximately 38% and for OMM2.5 of 46% compared to the untreated control) without exerting toxicity in either cell line, whereas the other 3 substances did not result in any changes (which also means that none of the 4 substances led to an increased cell death). Moreover, nintedanib (1 µg/mL) induced oxidative stress in the Mel270 by approximately 1.2 to 1.5-fold compared to the untreated control, but not the OMM2.5 cells.
    Conclusions: Nintedanib could suppress the growth of UM cells in a concentration-dependent manner. The metastatic UM cell line OMM2.5 was not sensitive to the pro-oxidant activity of nintedanib. This study was the first to investigate nintedanib in the context of UM. We propose further investigation of this substance to elucidate its effects on this tumor entity with the hope of identifying advantageous therapeutic options for future adjuvant tumor therapies.
    MeSH term(s) Humans ; Vascular Endothelial Growth Factor A ; Uveal Neoplasms/drug therapy ; Angiogenesis Inhibitors/pharmacology ; Indoles ; Melanoma
    Chemical Substances nintedanib (G6HRD2P839) ; Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors ; Indoles
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.65.2.30
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Conference proceedings: Energy metabolism of the choroidal melanocytes and its role in malignant transformation

    Tura, Aysegül / Grisanti, S.

    2022  , Page(s) 04.03

    Event/congress 34. Jahrestagung der Retinologischen Gesellschaft; Lübeck; Retinologische Gesellschaft; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-06-29
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22rg18
    Database German Medical Science

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  4. Article ; Online: Interleukin levels in neovascular age-related macular degeneration: evaluation of morphological and functional progression over 5 years.

    Prasuhn, Michelle / Nassar, Khaled / Tura, Aysegül / Ranjbar, Mahdy

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2022  Volume 260, Issue 10, Page(s) 3397–3399

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Child, Preschool ; Choroidal Neovascularization/diagnosis ; Fluorescein Angiography ; Humans ; Interleukins ; Macular Degeneration ; Tomography, Optical Coherence ; Wet Macular Degeneration/diagnosis
    Chemical Substances Angiogenesis Inhibitors ; Interleukins
    Language English
    Publishing date 2022-04-12
    Publishing country Germany
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-022-05635-4
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  5. Article ; Online: Quercetin Impairs the Growth of Uveal Melanoma Cells by Interfering with Glucose Uptake and Metabolism.

    Tura, Aysegül / Herfs, Viktoria / Maaßen, Tjorge / Zuo, Huaxin / Vardanyan, Siranush / Prasuhn, Michelle / Ranjbar, Mahdy / Kakkassery, Vinodh / Grisanti, Salvatore

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Monosomy 3 in uveal melanoma (UM) increases the risk of lethal metastases, mainly in the liver, which serves as the major site for the storage of excessive glucose and the metabolization of the dietary flavonoid quercetin. Although primary UMs with ... ...

    Abstract Monosomy 3 in uveal melanoma (UM) increases the risk of lethal metastases, mainly in the liver, which serves as the major site for the storage of excessive glucose and the metabolization of the dietary flavonoid quercetin. Although primary UMs with monosomy 3 exhibit a higher potential for basal glucose uptake, it remains unknown as to whether glycolytic capacity is altered in such tumors. Herein, we initially analyzed the expression of
    MeSH term(s) Quercetin/pharmacology ; Melanoma/metabolism ; Melanoma/pathology ; Melanoma/genetics ; Melanoma/drug therapy ; Humans ; Uveal Neoplasms/metabolism ; Uveal Neoplasms/genetics ; Uveal Neoplasms/pathology ; Uveal Neoplasms/drug therapy ; Glucose/metabolism ; Glycolysis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Pentose Phosphate Pathway/drug effects ; Chromosomes, Human, Pair 3/genetics
    Chemical Substances Quercetin (9IKM0I5T1E) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Detection of Circulating Tumor Cells in Patients with Small Choroidal Melanocytic Lesions.

    Grisanti, Salvatore / Schindler, Friederike / Merz, Hartmut / Kakkassery, Vinodh / Sonntag, Svenja Rebecca / Tura, Ayseguel

    Ophthalmology

    2023  Volume 130, Issue 12, Page(s) 1290–1303

    Abstract: Purpose: To determine the presence of circulating tumor cells (CTCs) in patients with indeterminate small choroidal melanocytic lesions (SCMLs).: Design: Retrospective case series.: Participants: Forty-seven patients with choroidal melanocytic ... ...

    Abstract Purpose: To determine the presence of circulating tumor cells (CTCs) in patients with indeterminate small choroidal melanocytic lesions (SCMLs).
    Design: Retrospective case series.
    Participants: Forty-seven patients with choroidal melanocytic lesions 2.5 mm or less in tumor thickness and ≤ 10 mm in largest basal diameter (LBD).
    Methods: Blood samples were analyzed for CTCs and the presence of monosomy-3 (M3) in CTCs. Tissue biopsy was performed in the patients who were CTC-positive (pCTC).
    Main outcome measures: Presence and M3 status of the CTCs with regard to the clinical characteristics and results from tissue biopsy.
    Results: Median thickness of all (n = 47) lesions was 1.1 mm (range: 0.2-2.5 mm), and LBD was 5.6 mm (range: 2.0-10.0 mm). Circulating tumor cells were found in 25 patients (n = 25). This group was classified as pCTC and compared with the CTC-negative (nCTC) group consisting of 22 patients (n = 22). Median tumor dimensions in the pCTC versus the nCTC group were 1.6 mm (range: 0.6-2.5 mm) versus 0.5 mm (range: 0.2-2.5 mm) for thickness and 6.6 mm (range: 4.1-10.0 mm) versus 4.0 mm (range: 2.0-8.0 mm) for LBD, respectively. Both LBD and thickness were positively associated (P < 0.001) with the presence of CTC. Compared with the nCTC group, a higher percentage of the pCTC group exhibited LBD > 5 mm (36% vs. 88%), subretinal fluid (9.1% vs. 56%), orange pigment (4.5% vs. 60%), sonographic hollowness (9.1% vs. 60%), and the presence of multiple risk factors (0% vs. 68% for ≥3 factors) with P < 0.001 for all parameters. No significant difference was detected in the clinical parameters of the patients who had disomy-3 (D3) (n = 7) versus M3 (n = 17) in their CTC. The tissue biopsy confirmed the uveal melanoma (UM) in 22 of the 25 pCTC patients (88%), whereas no conclusive diagnosis could be determined in the remaining 3 cases because of insufficient or invalid material.
    Conclusions: We report compelling evidence for the potential of liquid biopsy as an additional tool to screen SCMLs for malignancy. These findings pave the way toward the implementation of liquid biopsy to detect small UM and monitor melanocytic lesions.
    Financial disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
    MeSH term(s) Humans ; Neoplastic Cells, Circulating ; Retrospective Studies ; Melanoma/diagnosis ; Melanoma/genetics ; Biopsy
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2023.07.025
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    Ul II Zs.83: Show issues Location:
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    Zs.MO 533: Show issues

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  7. Book ; Online ; Thesis: Expression der Glucosetransporter GLUT1-3 in uvealen Melanomzellen mit Monosomie 3

    Maaßen, Tjorge [Verfasser] / Tura, Aysegül [Akademischer Betreuer]

    2022  

    Author's details Tjorge Maaßen ; Akademischer Betreuer: Aysegül Tura
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
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  8. Book ; Online ; Thesis: Einfluss von Bestrahlung auf den DNA-Schaden in uvealen Melanomzellen mit Monosomie 3

    Zhu, Yingda [Verfasser] / Tura, Aysegül [Akademischer Betreuer] / Janssen, Stefan [Akademischer Betreuer]

    2022  

    Author's details Yingda Zhu ; Akademische Betreuer: Aysegül Tura, Stefan Janssen
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
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  9. Book ; Online ; Thesis: Dysregulation des Glykogenstoffwechsels, der Adiponektinexpression und des Glukosetransporterprofils bei den uvealen Melanomen mit Monosomie-3

    Vardanyan, Siranush [Verfasser] / Tura, Aysegül [Akademischer Betreuer] / Iwen, Alexander [Akademischer Betreuer]

    2022  

    Author's details Siranush Vardanyan ; Akademische Betreuer: Aysegül Tura, Alexander Iwen
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
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  10. Article ; Online: In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery.

    Gniesmer, Stefanie / Sonntag, Svenja Rebecca / Gapeeva, Anna / Cojocaru, Ala / Kaps, Sören / Adelung, Rainer / Sewing, Judith / Tura, Aysegül / Grisanti, Salvatore / Grisanti, Swaantje

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4452

    Abstract: To carry out the preclinical and histological evaluation of a novel nanotechnology-based microshunt for drainage glaucoma surgery. Twelve New Zealand White rabbits were implanted with a novel microshunt and followed up for 6 weeks. The new material ... ...

    Abstract To carry out the preclinical and histological evaluation of a novel nanotechnology-based microshunt for drainage glaucoma surgery. Twelve New Zealand White rabbits were implanted with a novel microshunt and followed up for 6 weeks. The new material composite consists of the silicone polydimethylsiloxane (PDMS) and tetrapodal Zinc Oxide (ZnO-T) nano-/microparticles. The microshunts were inserted ab externo to connect the subconjunctival space with the anterior chamber. Animals were euthanized after 2 and 6 weeks for histological evaluation. Ocular health and implant position were assessed at postoperative days 1, 3, 7 and twice a week thereafter by slit lamp biomicroscopy. Intraocular pressure (IOP) was measured using rebound tonometry. A good tolerability was observed in both short- and medium-term follow-up. Intraocular pressure was reduced following surgery but increased to preoperative levels after 2 weeks. No clinical or histological signs of inflammatory or toxic reactions were seen; the fibrotic encapsulation was barely noticeable after two weeks and very mild after six weeks. The new material composite PDMS/ZnO-T is well tolerated and the associated foreign body fibrotic reaction quite mild. The new microshunt reduces the IOP for 2 weeks. Further research will elucidate a tube-like shape to improve and prolong outflow performance and longer follow-up to exclude medium-term adverse effects.
    MeSH term(s) Animals ; Rabbits ; Zinc Oxide ; Glaucoma Drainage Implants/adverse effects ; Glaucoma/surgery ; Glaucoma/etiology ; Intraocular Pressure ; Tonometry, Ocular ; Anterior Chamber/surgery ; Nanotechnology
    Chemical Substances Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54960-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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