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  1. Article: Assessment of Gastrointestinal Adverse Effects during the First Six Months of "Biktarvy" Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period.

    Suba, Madalina-Ianca / Abu-Awwad, Simona-Alina / Rosca, Ovidiu / Turaiche, Mirela-Mădălina / Hogea, Bogdan / Abu-Awwad, Ahmed / Nitu, Razvan / Lazureanu, Voichita Elena

    Diseases (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: Background: The battle against HIV has led to the development of antiretroviral therapy (ART), including BIKTARVY: Materials and methods: This retrospective cohort study, conducted over four years in Romania, examined 222 patients initiated on ... ...

    Abstract Background: The battle against HIV has led to the development of antiretroviral therapy (ART), including BIKTARVY
    Materials and methods: This retrospective cohort study, conducted over four years in Romania, examined 222 patients initiated on BIKTARVY
    Results: This study revealed significant differences in the prevalence of gastrointestinal symptoms between age groups, with older patients experiencing more symptoms. Notably, diarrhea did not exhibit a statistically significant age-related difference. Furthermore, weight loss exceeding 5 kg was more common in older patients. Of the patients who continued BIKTARVY
    Conclusion: Understanding age-related patterns and gastrointestinal side effects of BIKTARVY
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases12010003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Direct-Acting Antiviral Use for Genotype 1b Hepatitis C Patients with Associated Hematological Disorders from Romania.

    Marincu, Iosif / Bratosin, Felix / Curescu, Manuela / Suciu, Oana / Turaiche, Mirela / Cerbu, Bianca / Vidican, Iulia

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 9

    Abstract: Background and ... ...

    Abstract Background and objectives
    MeSH term(s) Antiviral Agents/therapeutic use ; Drug Therapy, Combination ; Genotype ; Hepatitis C ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Romania ; Treatment Outcome
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57090986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Listeria Monocytogenes Meningitis in an Immunocompetent Patient.

    Magiar, Oana / Vulpie, Silvana / Musuroi, Corina / Marincu, Iosif / Murariu, Alina / Turaiche, Mirela / Musuroi, Silvia Ioana / Muntean, Delia / Licker, Monica

    Infection and drug resistance

    2022  Volume 15, Page(s) 989–994

    Abstract: ... Listeria ... ...

    Abstract Listeria monocytogenes
    Language English
    Publishing date 2022-03-10
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S351132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Predictive Factors for the First Recurrence of

    Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

    Medicina (Kaunas, Lithuania)

    2020  Volume 56, Issue 9

    Abstract: Background and objectives: ...

    Abstract Background and objectives:
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Clostridium Infections/complications ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy ; Cross Infection/complications ; Cross Infection/diagnosis ; Cross Infection/drug therapy ; Cross Infection/microbiology ; Enterocolitis/complications ; Enterocolitis/diagnosis ; Enterocolitis/drug therapy ; Enterocolitis/microbiology ; Female ; Fever/microbiology ; Gastrointestinal Diseases/complications ; Humans ; Immunocompromised Host ; Male ; Reinfection ; Retrospective Studies ; Risk Factors ; Romania
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina56090439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Predictive Value of Comorbid Conditions for COVID-19 Mortality.

    Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Bostanaru, Andra-Cristina / Frent, Stefan / Cerbu, Bianca / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

    Journal of clinical medicine

    2021  Volume 10, Issue 12

    Abstract: In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 ... ...

    Abstract In this paper, we aim at understanding the broad spectrum of factors influencing the survival of infected patients and the correlations between these factors to create a predictive probabilistic score for surviving the COVID-19 disease. Initially, 510 hospital admissions were counted in the study, out of which 310 patients did not survive. A prediction model was developed based on this data by using a Bayesian approach. Following the data collection process for the development study, the second cohort of patients totaling 541 was built to validate the risk matrix previously created. The final model has an area under the curve of 0.773 and predicts the mortality risk of SARS-CoV-2 infection based on nine disease groups while considering the gender and age of the patient as distinct risk groups. To ease medical workers' assessment of patients, we created a visual risk matrix based on a probabilistic model, ranging from a score of 1 (very low mortality risk) to 5 (very high mortality risk). Each score comprises a correlation between existing comorbid conditions, the number of comorbid conditions, gender, and age group category. This clinical model can be generalized in a hospital context and can be used to identify patients at high risk for whom immediate intervention might be required.
    Language English
    Publishing date 2021-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10122652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Foodborne Botulism in Western Romania: Ten Years' Experience at a Tertiary Infectious Disease Hospital.

    Marincu, Iosif / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Suciu, Oana / Turaiche, Mirela / Tirnea, Livius / Timircan, Madalina

    Healthcare (Basel, Switzerland)

    2021  Volume 9, Issue 9

    Abstract: Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium : Methods: Medical records were retrospectively analyzed from ...

    Abstract Objectives: The purpose of this study was to analyze epidemiological data concerning foodborne botulism in Western Romania over the last decade. Botulism, the toxin formed by the bacterium
    Methods: Medical records were retrospectively analyzed from 2010 to 2020 for all food botulism cases. A seroneutralization test was performed with type A, B and E anti-botulinum sera to establish the kind of toxin involved.
    Results: Overall, 18 cases of foodborne botulism were admitted to the hospital during this period and confirmed by laboratory analysis. Most of the participants in our study were men (61.1%), and 77.8% of the total lived in rural areas. All the participants showed classic symptoms of botulism, and dysphagia was present in all cases. The trivalent ABE antitoxin was administered by the hospital, and toxin type B was isolated in all patients. The main sources of the toxin were pork, ham and canned pork meat.
    Conclusions: Stronger efforts are needed to foster community awareness of foodborne botulism, particularly in home-preserved food.
    Language English
    Publishing date 2021-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare9091149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Liver Impairment and Hematological Changes in Patients with Chronic Hepatitis C and COVID-19: A Retrospective Study after One Year of Pandemic.

    Cerbu, Bianca / Pantea, Stelian / Bratosin, Felix / Vidican, Iulia / Turaiche, Mirela / Frent, Stefan / Borsi, Ema / Marincu, Iosif

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 6

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) COVID-19 ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57060597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Efficacy of Convalescent Plasma Use in Critically Ill COVID-19 Patients.

    Tirnea, Livius / Bratosin, Felix / Vidican, Iulia / Cerbu, Bianca / Turaiche, Mirela / Timircan, Madalina / Margan, Madalin-Marius / Marincu, Iosif

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 3

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Anticoagulants/therapeutic use ; Antiviral Agents/therapeutic use ; C-Reactive Protein/metabolism ; COVID-19/blood ; COVID-19/physiopathology ; COVID-19/therapy ; Critical Illness ; Glucocorticoids/therapeutic use ; Humans ; Immunization, Passive/methods ; Interleukin-6/blood ; Leukocyte Count ; Male ; Middle Aged ; Pilot Projects ; Romania ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Anticoagulants ; Antiviral Agents ; Glucocorticoids ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2021-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57030257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coping Strategies and Health-Related Quality of Life in Pregnant Women with SARS-CoV-2 Infection.

    Timircan, Madalina / Bratosin, Felix / Vidican, Iulia / Suciu, Oana / Turaiche, Mirela / Bota, Adrian Vasile / Mitrescu, Sorina / Marincu, Iosif

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 10

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Adaptation, Psychological ; Anxiety/epidemiology ; COVID-19 ; Cross-Sectional Studies ; Depression/epidemiology ; Female ; Humans ; Pregnancy ; Pregnant Women ; Quality of Life ; SARS-CoV-2 ; Stress, Psychological/epidemiology
    Language English
    Publishing date 2021-10-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57101113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania

    Turaiche, Mirela / Feciche, Bogdan / Gluhovschi, Adrian / Bratosin, Felix / Bogdan, Iulia / Bota, Adrian Vasile / Grigoras, Mirela Loredana / Gurban, Camelia Vidita / Cerbu, Bianca / Toma, Ana-Olivia / Gurumurthy, Srivathsava / Wulandari, Prima Hapsari / Marincu, Iosif

    Pathogens. 2022 Sept. 07, v. 11, no. 9

    2022  

    Abstract: Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive ... ...

    Abstract Measles is a highly infectious and sometimes deadly illness that is preventable with vaccination. The present research aims to analyze the most recent measles epidemic from Romania that occurred in a population with a falling desire to receive immunizations, by detailing the clinical picture and biological profile of hospitalized patients. A secondary goal of the present research is to identify characteristics that increase the likelihood of a longer hospitalization and the development of measles-related pneumonia. A retrospective cohort study was conducted to follow the course and effects of measles virus infection in adult hospitalized patients who were divided into two groups based on whether they had been in the hospital for more than 6 days or fewer than 6 days. A total of 114 adult patients with measles were eligible to participate in the trial if they had a positive measles-specific IgM antibody test resulting from the study. The average age in the short hospital stay group was 28.1 years, while the average age in the long hospital stay group was 31.9 years. There was a statistically significant difference in the number of Roma persons in the research groups, with 17.4 percent of them having a lengthy hospital stay compared to 5.9 percent in the group with a short hospital stay, according to the findings. It was observed that many patients had a long hospitalization associated with chronic lung disease (OR = 1.07), liver damage (OR = 1.66), Roma ethnicity (OR = 1.79), a long duration elapsed from the last MMR dose (OR = 2.02), elevated c-reactive protein (OR = 2.17), the presence of bilateral pulmonary condensations on X-ray (OR = 3.13), and elevated procalcitonin (OR = 3.49). The same significant independent risk factors were also associated with the development of pneumonia. It is of imperative need to address these risk factors in a patient with measles, moreover in association with an unknown status of vaccination. Vaccination awareness against measles must be pushed in Romania to determine a higher than 95% coverage. Significant efforts are still needed to ensure improved protection against measles epidemics within a specific region or population and, more importantly, in patients with significant risk factors for complications, as described in this study.
    Keywords C-reactive protein ; Measles morbillivirus ; X-radiation ; adults ; antibodies ; cohort studies ; hospitals ; liver ; measles ; nationalities and ethnic groups ; patients ; pneumonia ; risk ; vaccination ; Romania
    Language English
    Dates of publication 2022-0907
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11091018
    Database NAL-Catalogue (AGRICOLA)

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