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  1. Article: Unveiling the modulation of

    Barone, Simona / Mateu, Baptiste / Turco, Luigia / Pelliccia, Sveva / Lembo, Francesca / Summa, Vincenzo / Buommino, Elisabetta / Brindisi, Margherita

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1340585

    Abstract: Bacterial infections represent a key public health issue due to the occurrence of multidrug-resistant bacteria. Recently, the amount of data supporting the dynamic control of epigenetic pathways by environmental cues has triggered research efforts toward ...

    Abstract Bacterial infections represent a key public health issue due to the occurrence of multidrug-resistant bacteria. Recently, the amount of data supporting the dynamic control of epigenetic pathways by environmental cues has triggered research efforts toward the clarification of their role in microbial infections. Among protein post-translational modifications, reversible acetylation is the most implicated in the feedback to environmental stimuli and in cellular homeostasis. Accordingly, the latest studies identified the histone deacetylase 6 (HDAC6) enzyme as a crucial player in the complex molecular machinery underlying bacterial clearance or killing. A very important milestone for the elucidation of the consequence of HDAC6 activity in bacterial infections is herein described, unveiling for the first time the role of a potent HDAC6 inhibitor in interfering with biofilm formation and modulating virulence factors of
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1340585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5

    Pelliccia, Sveva / Alfano, Antonella Ilenia / Gomes Da Assunção, Beatriz Ramos / Turco, Luigia / Lembo, Francesca / Summa, Vincenzo / Buommino, Elisabetta / Brindisi, Margherita

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1126427

    Abstract: The [1,2,3]-triazolo [1,5-a] quinoxalin-4( ... ...

    Abstract The [1,2,3]-triazolo [1,5-a] quinoxalin-4(5
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1126427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Zooming into Gut Dysbiosis in Parkinson's Disease: New Insights from Functional Mapping.

    Turco, Luigia / Opallo, Nicola / Buommino, Elisabetta / De Caro, Carmen / Pirozzi, Claudio / Mattace Raso, Giuseppina / Lembo, Francesca / Coretti, Lorena

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Gut dysbiosis has been involved in the pathogenesis and progression of Parkinson's disease (PD), but the mechanisms through which gut microbiota (GM) exerts its influences deserve further study. Recently, we proposed a two-hit mouse model of PD in which ... ...

    Abstract Gut dysbiosis has been involved in the pathogenesis and progression of Parkinson's disease (PD), but the mechanisms through which gut microbiota (GM) exerts its influences deserve further study. Recently, we proposed a two-hit mouse model of PD in which ceftriaxone (CFX)-induced dysbiosis amplifies the neurodegenerative phenotype generated by striatal 6-hydroxydopamine (6-OHDA) injection in mice. Low GM diversity and the depletion of key gut colonizers and butyrate producers were the main signatures of GM alteration in this model. Here, we used the phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt2) to unravel candidate pathways of cell-to-cell communication associated with dual-hit mice and potentially involved in PD progression. We focused our analysis on short-chain fatty acids (SCFAs) metabolism and quorum sensing (QS) signaling. Based on linear discriminant analysis, combined with the effect size results, we found increased functions linked to pyruvate utilization and a depletion of acetate and butyrate production in 6-OHDA+CFX mice. The specific arrangement of QS signaling as a possible result of the disrupted GM structure was also observed. With this exploratory study, we suggested a scenario in which SCFAs metabolism and QS signaling might represent the effectors of gut dysbiosis potentially involved in the designation of the functional outcomes that contribute to the exacerbation of the neurodegenerative phenotype in the dual-hit animal model of PD.
    MeSH term(s) Mice ; Animals ; Parkinson Disease/metabolism ; Dysbiosis/metabolism ; Phylogeny ; Oxidopamine ; Butyrates
    Chemical Substances Oxidopamine (8HW4YBZ748) ; Butyrates
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolism.

    Pirozzi, Claudio / Coretti, Lorena / Opallo, Nicola / Bove, Maria / Annunziata, Chiara / Comella, Federica / Turco, Luigia / Lama, Adriano / Trabace, Luigia / Meli, Rosaria / Lembo, Francesca / Mattace Raso, Giuseppina

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1143004

    Abstract: Obesity is associated with gastrointestinal (GI) tract and central nervous system (CNS) disorders. High-fat diet (HFD) feeding-induced obesity in mice induces dysbiosis, causing a shift toward bacteria-derived metabolites with detrimental effects on ... ...

    Abstract Obesity is associated with gastrointestinal (GI) tract and central nervous system (CNS) disorders. High-fat diet (HFD) feeding-induced obesity in mice induces dysbiosis, causing a shift toward bacteria-derived metabolites with detrimental effects on metabolism and inflammation: events often contributing to the onset and progression of both GI and CNS disorders. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with beneficial effects in mouse models of GI and CNS disorders. However, the mechanisms underlining its enteroprotective and neuroprotective effects still need to be fully understood. Here, we aimed to study the effects of PEA on intestinal inflammation and microbiota alterations resulting from lipid overnutrition. Ultramicronized PEA (30 mg/kg/die
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1143004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Synthesis and antimicrobial properties of guanidine-functionalized labdane type diterpenoids.

    Grinco, Marina / Morarescu, Olga / Lembo, Francesca / Ungur, Nicon / Turco, Luigia / Coretti, Lorena / Carbone, Marianna / Celentano, Carmela / Ciavatta, Maria Letizia / Mollo, Ernesto / Kulcitki, Veaceslav / Buommino, Elisabetta

    European journal of medicinal chemistry

    2023  Volume 264, Page(s) 115981

    Abstract: The occurrence of increased antibiotic resistance has reduced the availability of drugs effective in the control of infectious diseases, especially those caused by various combinations of bacteria and/or fungi that are often associated with poorer ... ...

    Abstract The occurrence of increased antibiotic resistance has reduced the availability of drugs effective in the control of infectious diseases, especially those caused by various combinations of bacteria and/or fungi that are often associated with poorer patient outcomes. In the hunt for novel antibiotics of interest to treat polymicrobial diseases, molecules bearing guanidine moieties have recently come to the fore in designing and optimizing antimicrobial agents. Due to their remarkable antibacterial and antifungal activities, labdane diterpenes are also attracting increasing interest in antimicrobial drug discovery. In this study, six different guanidines prenylated with labdanic fragments were synthesized and evaluated for their antimicrobial properties. Assays were carried out against both non-resistant and antibiotic-resistant bacteria strains, while their possible antifungal activities have been tested on the yeast Candida albicans. Two of the synthesized compounds, namely labdan-8,13(R)-epoxy-15-oyl guanidine and labdan-8,13(S)-epoxy-15-oyl guanidine, were finally selected as the best candidates for further developments in drug discovery, due to their antimicrobial effects on both Gram-negative and Gram-positive bacterial strains, their fungicide action, and their moderate toxicity in vivo on zebrafish embryos. The study also provides insights into the structure-activity relationships of the guanidine-functionalized labdane-type diterpenoids.
    MeSH term(s) Animals ; Humans ; Antifungal Agents/pharmacology ; Guanidine/pharmacology ; Zebrafish ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Bacteria ; Diterpenes/pharmacology ; Candida albicans ; Guanidines/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Guanidine (JU58VJ6Y3B) ; Anti-Infective Agents ; Anti-Bacterial Agents ; Diterpenes ; Guanidines
    Language English
    Publishing date 2023-12-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dual-Hit Model of Parkinson's Disease: Impact of Dysbiosis on 6-Hydroxydopamine-Insulted Mice-Neuroprotective and Anti-Inflammatory Effects of Butyrate.

    Avagliano, Carmen / Coretti, Lorena / Lama, Adriano / Pirozzi, Claudio / De Caro, Carmen / De Biase, Davide / Turco, Luigia / Mollica, Maria Pina / Paciello, Orlando / Calignano, Antonio / Meli, Rosaria / Lembo, Francesca / Mattace Raso, Giuseppina

    International journal of molecular sciences

    2022  Volume 23, Issue 12

    Abstract: Recent evidence highlights Parkinson's disease (PD) initiation in the gut as the prodromal phase of neurodegeneration. Gut impairment due to microbial dysbiosis could affect PD pathogenesis and progression. Here, we propose a two-hit model of PD through ... ...

    Abstract Recent evidence highlights Parkinson's disease (PD) initiation in the gut as the prodromal phase of neurodegeneration. Gut impairment due to microbial dysbiosis could affect PD pathogenesis and progression. Here, we propose a two-hit model of PD through ceftriaxone (CFX)-induced dysbiosis and gut inflammation before the 6-hydroxydopamine (6-OHDA) intrastriatal injection to mimic dysfunctional gut-associated mechanisms preceding PD onset. Therefore, we showed that dysbiosis and gut damage amplified PD progression, worsening motor deficits induced by 6-OHDA up to 14 days post intrastriatal injection. This effect was accompanied by a significant increase in neuronal dopaminergic loss (reduced tyrosine hydroxylase expression and increased Bcl-2/Bax ratio). Notably, CFX pretreatment also enhanced systemic and colon inflammation of dual-hit subjected mice. The exacerbated inflammatory response ran in tandem with a worsening of colonic architecture and gut microbiota perturbation. Finally, we demonstrated the beneficial effect of post-biotic sodium butyrate in limiting at once motor deficits, neuroinflammation, and colon damage and re-shaping microbiota composition in this novel dual-hit model of PD. Taken together, the bidirectional communication of the microbiota-gut-brain axis and the recapitulation of PD prodromal/pathogenic features make this new paradigm a useful tool for testing or repurposing new multi-target compounds in the treatment of PD.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Butyrates/pharmacology ; Butyrates/therapeutic use ; Dysbiosis/pathology ; Inflammation/pathology ; Mice ; Oxidopamine ; Parkinson Disease/metabolism
    Chemical Substances Anti-Inflammatory Agents ; Butyrates ; Oxidopamine (8HW4YBZ748)
    Language English
    Publishing date 2022-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23126367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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