LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article: Fatigue and Sleep Disturbance among Breast Cancer Patients during Treatment in Saudi Arabia.

    Alsharif, Fatmah / Shibily, Faygah / Almutairi, Wedad / Alsaedi, Ahlam / Alsubaie, Tahani / Alshuaibi, Bashayer / Turkistani, Arwa

    Nursing research and practice

    2022  Volume 2022, Page(s) 1832346

    Abstract: Background: Fatigue and sleep disturbances are highly prevalent side effects encountered during treatment by patients with breast cancer, and they affect women's quality of life. Most studies investigating sleep and exhaustion in cancer patients provide ...

    Abstract Background: Fatigue and sleep disturbances are highly prevalent side effects encountered during treatment by patients with breast cancer, and they affect women's quality of life. Most studies investigating sleep and exhaustion in cancer patients provide evidence that supports a strong connection between different sleep parameters and fatigue associated with cancer.
    Objective: This study was to assess the level of fatigue and sleep disturbance in breast cancer patients during treatment in Saudi Arabia.
    Method: A descriptive cross-sectional study design was conducted on breast cancer patients undergoing treatment in Saudi Arabia. The data were collected through convenience sampling of patients. The study involved self-administered questionnaires comprising three categories: demographic data, perceived Pittsburgh Sleep Quality Index (PSQI), and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F). A total of 101 participants took part in this study. The significant statistical test was determined at a 95% confidence interval and at
    Results: Half of the study participants were aged between 30 and 50 years. Significant differences were found in fatigue and sleep disturbance among BC patients during treatment in Saudi Arabia. A high prevalence of fatigue was found at 21.8%, and 5% of participants experienced sleep disturbance.
    Conclusions: Breast cancer patients in Saudi Arabia have a low overall global quality of life. The patients experience poor sleep quality and fatigue, which suggests that during treatment, patients need to be assessed routinely for these symptoms to prevent or reduce fatigue and sleep disturbance. Sleep disturbance might be correlated with fatigue.
    Language English
    Publishing date 2022-09-05
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2621482-9
    ISSN 2090-1437 ; 2090-1429
    ISSN (online) 2090-1437
    ISSN 2090-1429
    DOI 10.1155/2022/1832346
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Apocynin attenuates methotrexate-induced mucositis by regulating NF-κB, PPAR-γ and Bax/Bcl-2/Puma signals.

    Ms Mansoury, Manal / Almukadi, Haifa / M Turkistani, Arwa / Ah Khattab, Hala / S Ali, Soad / Hm Hassanein, Emad / A Alahmadi, Bassam / Al-Jaouni, Soad / A El-Shitany, Nagla

    Pakistan journal of pharmaceutical sciences

    2023  Volume 36, Issue 2, Page(s) 457–466

    Abstract: Oxidative stress, inflammation and apoptosis are the primary inducers of Methotrexate (MTX)-induced mucositis. This research aimed to determine whether apocynin (APO) could protect against MTX-induced mucositis. The antioxidants, anti-inflammatory and ... ...

    Abstract Oxidative stress, inflammation and apoptosis are the primary inducers of Methotrexate (MTX)-induced mucositis. This research aimed to determine whether apocynin (APO) could protect against MTX-induced mucositis. The antioxidants, anti-inflammatory and anti-apoptotic actions of APO in this model will be evaluated. The experiment was performed on 32 rats. A single dose (20 mg/kg) of MTX was injected i.p. to induce intestinal mucositis. APO was given orally once per day at a dose of 100mg/kg (five days prior to and five days following an MTX injection). APO safeguarded the histological structure of the duodenal mucosa, as observed by the conserved histology of goblet cells (villi and crypts). APO mitigated oxidative stress by reducing intestin MDA and raising GSH, SOD and GST, also suppressing NF-κB mRNA expression. Intestinal content of proinflammatory cytokines was reduced in APO-treated MTX rats, with downregulation of proinflammatory iNOS and upregulation of anti-inflammatory PPAR-γ proteins. The intestinal mucosa of rats treated with APO and MTX displayed weekly positive immune staining for cleaved caspase-3. APO upregulate the anti-apoptotic Bcl2 mRNA and down regulate the proapoptotic Bax and Puma mRNA in the duodenal mucosa. The results indicate the possibility of using APO as a novel therapeutic agent to prevent MTX-induced mucositis.
    MeSH term(s) Rats ; Animals ; Methotrexate/therapeutic use ; Mucositis/chemically induced ; Mucositis/drug therapy ; Mucositis/prevention & control ; NF-kappa B/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; PPAR gamma/metabolism ; Apoptosis Regulatory Proteins/metabolism ; Oxidative Stress ; RNA, Messenger/metabolism
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; NF-kappa B ; bcl-2-Associated X Protein ; acetovanillone (B6J7B9UDTR) ; PPAR gamma ; Apoptosis Regulatory Proteins ; RNA, Messenger
    Language English
    Publishing date 2023-08-02
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top