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Article ; Online: A patient with autonomic imbalance: Treating symptomatic neurogenic orthostatic hypotension.

Turner, Debra

2018 Volume 43, Issue 6, Page(s) 18–22

MeSH term(s)	Aged ; Autonomic Nervous System Diseases/complications ; Autonomic Nervous System Diseases/diagnosis ; Humans ; Hypotension, Orthostatic/etiology ; Hypotension, Orthostatic/nursing ; Male
Language	English
Publishing date	2018-05-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	604085-8
ISSN	1538-8662 ; 0361-1817
ISSN (online)	1538-8662
ISSN	0361-1817
DOI	10.1097/01.NPR.0000531925.09173.62
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Article: Skin microbiota of quaker parrots (Myiopsitta monachus) with normal feathering or feather loss via next-generation sequencing technology

Krumbeck, Janina A. / Turner, Debra D. / Diesel, Ali / Hoffman, Aline Rodrigues / Heatley, J. Jill

Journal of exotic pet medicine. 2022 Apr. 03,

2022

Abstract: Feather damaging behavior (feather picking) is a common malady of captive parrots. Diagnosis is challenging as a primary disadvantage to clinicians faced with diagnosis of parrot skin disease remains the lack of normative data for the healthy parrot ... ...

Abstract	Feather damaging behavior (feather picking) is a common malady of captive parrots. Diagnosis is challenging as a primary disadvantage to clinicians faced with diagnosis of parrot skin disease remains the lack of normative data for the healthy parrot epidermal microbiology. The objective of this pilot study was to establish bacterial and fungal cutaneous microbiota baselines for quaker parrots with and without feather loss. Healthy quaker parrots (Myiopsitta monachus n = 12) with intact feathers were compared to 12 quaker parrots with evidence of feather loss via next-generation DNA sequencing of bacteria and fungus swabbed from skin. Of 351 bacterial and 97 fungal species identified, no statistical differences occurred in bacteria or fungal alpha-diversity or beta-diversity based on age, sex, or feather loss. However, enclosure affected bacterial beta-diversity. The most abundant bacterial species for fully feathered quaker parrots were Exiguobacterium indicum, Sphingomonas yabuuchiae, and Corynebacterium spp., and Fragaria/Populus euphratica, S. yabuuchiae, and E. indicum for quaker parrots with feather loss. Lactobacillales, Acinetobacter, Kocuria sp., and Streptococcus epidermidis were significantly enriched in fully feathered quaker parrots, while Streptococcaceae, Methylobacterium, Clostridiales, Nocardioidaceae, Nesterenkonia, and Actinomycetospora were significantly enriched in quaker parrots with feather loss. Both groups had Cladosporium halotolerans/sphaerospermum as the predominant fungus, while Capnodiales was significantly enriched in quaker parrots with feather loss. Use of next generation microbial sequencing as a preliminary diagnostic tool of bacterial and fungal communities of captive birds allows veterinarians to confirm cytologic diagnoses and circumvent the limitations of culture testing. Diagnostic implications include the potential transmission of pathogenic bacteria and/or fungi and pathogen resistance between cohoused birds.
Keywords	Acinetobacter ; Clostridiales ; Corynebacterium ; DNA ; Exiguobacterium ; Fragaria ; Kocuria ; Methylobacterium ; Myiopsitta monachus ; Nesterenkonia ; Nocardioidaceae ; Populus euphratica ; Sphingomonas ; Streptococcus ; diagnostic techniques ; fungi ; medicine ; parrots ; pathogens ; skin diseases ; species diversity
Language	English
Dates of publication	2022-0403
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	2228614-7
ISSN	1557-5063
ISSN	1557-5063
DOI	10.1053/j.jepm.2022.04.004
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Article: Role of nurses and nurse practitioners in the recognition, diagnosis, and management of neurogenic orthostatic hypotension: a narrative review.

Biswas, Debashis / Karabin, Beverly / Turner, Debra

International journal of general medicine

2019 Volume 12, Page(s) 173–184

Abstract: Neurogenic orthostatic hypotension (nOH) is a sustained reduction in blood pressure (BP) upon standing that is caused by autonomic dysfunction and is common among patients with a variety of neurodegenerative disorders (eg, Parkinson's disease, multiple ... ...

Abstract	Neurogenic orthostatic hypotension (nOH) is a sustained reduction in blood pressure (BP) upon standing that is caused by autonomic dysfunction and is common among patients with a variety of neurodegenerative disorders (eg, Parkinson's disease, multiple system atrophy, pure autonomic failure). A systolic BP drop of ≥20 mmHg (or ≥10 mmHg diastolic) upon standing with little or no compensatory increase in heart rate is consistent with nOH. Symptoms of nOH include light-headedness, dizziness, presyncope, and syncope; these symptoms can severely impact patients' activities of daily living and increase the likelihood of potentially dangerous falls. Because of their patient contact, nurses and nurse practitioners can play a key role in identifying and evaluating patients at risk for nOH. It is advisable to screen for nOH in patients presenting with one or more of the following characteristics: those who have disorders associated with autonomic failure, those with episodes of falls or syncope, those with symptoms upon standing, those who are elderly or frail, or those taking multiple medications. Initial evaluations should include questions about postural symptoms and measurement of orthostatic BP and heart rate. A review of medications for potential agents that can have hypotensive effects should be performed before initiating treatment. Treatment for nOH may include non-pharmacologic measures and pharmacologic therapy. Droxidopa and midodrine are approved by the US Food and Drug Administration for the treatment of symptomatic nOH and symptomatic OH, respectively. nOH is associated with the coexistence of supine hypertension, and the two disorders must be carefully managed. In conclusion, timely screening and diagnosis of patients with nOH can streamline the path to disease management and treatment, potentially improving patient outcomes.
Language	English
Publishing date	2019-05-01
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S170655
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Article ; Online: An Improved Inactivated Influenza Vaccine with Enhanced Cross Protection.

Ni, Yawei / Guo, Jianhua / Turner, Debra / Tizard, Ian

Frontiers in immunology

2018 Volume 9, Page(s) 1815

Abstract: Current inactivated influenza vaccines are strain-specific and poorly effective against variant or mismatched viruses. They are standardized based on their hemagglutinin (HA) or ability to induce strain-specific hemagglutination inhibition (HAI) ... ...

Abstract	Current inactivated influenza vaccines are strain-specific and poorly effective against variant or mismatched viruses. They are standardized based on their hemagglutinin (HA) or ability to induce strain-specific hemagglutination inhibition (HAI) antibodies. The HA is known to undergo major conformational changes when exposed to the low pH environment of endosomes (pH 5.0 and 37°C), which are required for membrane fusion during virus cell entry. In an effort to improve these vaccines, influenza antigens treated under various low pH conditions were evaluated for increased cross-reactive antibody response and cross protection. It was found that a full range of structural and antigenic changes in HA could be induced by varying low pH treatment conditions from the mild (low pH at ≤25°C) to the strong (low pH at ≥37°C) as determined by analysis of potency, HA morphology, protease sensitivity, and reactivity with an anti-HA2 domain (CD) antibody. Inactivated antigens of both H1N1 and H3N2 strains treated at mild low pH conditions (0-25°C) exhibited only moderate HA structural and antigenic changes and markedly increased antibody response against HA2, the highly conserved part of HA, and cross protection against heterologous challenge in mice by up to 30% in survival. By contrast, antigen treated with low pH at 37°C showed more extensive structural and antigenic changes, and induced much less of an increase in antibody response against HA2, but a greater increase with response against HA1, and did not provide any increased cross protection. These results suggest that the increased response against HA2 obtained with the mild low pH treatment is associated with the increased cross protection. These antigens treated at the mild low pH conditions remained capable of inducing a high level of strain-specific HAI antibodies. Thus, they could readily be formulated as an inactivated influenza vaccine which not only provides the same strain-specific protection but also an increased cross protection against heterologous viruses. Such a vaccine could be particularly beneficial in cases of vaccine mismatch.
MeSH term(s)	Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Cross Protection/immunology ; Cross Reactions ; Enzyme-Linked Immunosorbent Assay ; Hemagglutination Inhibition Tests ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Humans ; Hydrogen-Ion Concentration ; Immunization ; Immunogenicity, Vaccine ; Influenza A virus/classification ; Influenza A virus/immunology ; Influenza A virus/ultrastructure ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Mice ; Neutralization Tests ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/prevention & control ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza Vaccines ; Vaccines, Inactivated
Language	English
Publishing date	2018-08-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.01815
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Article: Ammonia emissions from irrigated pastures on Solonetz in Victoria, Australia

Denmead, Owen Thomas / Bai, Mei / Chen, Deli / Edis, Robert / Li, Yong / Turner, Debra

Geoderma regional. 2020 Mar., v. 20

2020

Abstract: This paper reports ammonia (NH3) emissions from irrigated, fertilized pastures grazed intensively by dairy cattle in Victoria, Australia. Irrigation bays (65 × 365 m) were grazed in rotation by 315 dairy cattle and daily emissions were measured in summer ...

Abstract	This paper reports ammonia (NH3) emissions from irrigated, fertilized pastures grazed intensively by dairy cattle in Victoria, Australia. Irrigation bays (65 × 365 m) were grazed in rotation by 315 dairy cattle and daily emissions were measured in summer and autumn. After grazing for a few days, the bays were fertilized with urea at 50 kg N ha−1 and irrigated with 50 mm of water. Passive NH3 samplers were used to measure horizontal fluxes of NH3 from different sectors of the bays directly and the corresponding surface emissions were calculated from the sampler data using a backward Lagrangian stochastic (bLs) model of atmospheric dispersion. Ammonia emissions from the whole herd during the grazing phases were 14.8 kg NH3−N in summer, but only 2.0 kg NH3−N in autumn, corresponding to emission factors of 12% and 1% for an assumed annual input of nitrogen (N) in excreta of 150 kg N head−1 yr−1. Only 1% of the urea-N was lost through NH3 volatilization when irrigation followed fertilization immediately, but 6% was lost when irrigation was delayed for 3 days. The bLs model appears to be a useful tool for assessing gas emissions from dairy farm operations.
Keywords	ammonia ; autumn ; dairy cattle ; dairy farming ; emissions factor ; excreta ; gas emissions ; grazing ; herds ; irrigated pastures ; irrigation ; models ; nitrogen ; samplers ; Solonetz ; summer ; urea ; urea nitrogen ; volatilization ; Victoria (Australia)
Language	English
Dates of publication	2020-03
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2352-0094
DOI	10.1016/j.geodrs.2020.e00254
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Article ; Online: Development of a novel dual-domain nanoparticle antigen construct for universal influenza vaccine.

Ni, Yawei / Guo, Jianhua / Turner, Debra / Tizard, Ian

Vaccine

2017 Volume 35, Issue 50, Page(s) 7026–7032

Abstract: A highly effective antigen construct for presenting conserved antigen domains is essential to the development of a universal influenza vaccine. We have developed a novel dual-domain nanoparticle fusion protein (DDNFP) which allows independent ... ...

Abstract	A highly effective antigen construct for presenting conserved antigen domains is essential to the development of a universal influenza vaccine. We have developed a novel dual-domain nanoparticle fusion protein (DDNFP) which allows independent presentation of two conserved domains. The conserved domains used were from two separate viral surface proteins, M2e of M2 and fusion peptide (FP) or long alpha helix (CD) of HA2. The carrier is a novel nanoparticle protein - the dodecameric DNA binding protein from starved cells (Dps) of bacteria or archaea. Dps was found to be uniquely capable of simultaneous fusion and surface presentation at both N- and C-termini while retaining the ability to form nanoparticles. Thus, DDNFPs with M2e and FP or CD fused at N- and C-termini of Dps from E. coli (EcDps) or other bacteria were first constructed based on the H1 subtype sequences along with corresponding single-domain nanoparticle fusion proteins (SDNFPs). They were expressed at high levels in bacteria and found to form nanoparticles of the expected size (∼9 nm). They were stable against treatment at high temperatures. The DDNFPs (M2e-EcDps-FP and M2e-EcDps-CD) induced strong antibody responses against individual antigen domains and provided full protection against lethal challenge with PR8 virus (H1N1). Importantly, the protection by DDNFPs was synergistically enhanced as compared to SDNFPs. The M2e-EcDps-CD provided an even stronger protection than M2e-EcDps-FP and therefore appeared to be the superior construct. Together, with novel domain combination, enhanced protection and ease of production, this M2e/CD DDNFP could potentially be a highly effective antigen construct for the universal influenza vaccine.
MeSH term(s)	Animals ; Antibodies, Viral/blood ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Bacterial Proteins/administration & dosage ; Bacterial Proteins/genetics ; DNA-Binding Proteins/administration & dosage ; DNA-Binding Proteins/genetics ; Drug Carriers/administration & dosage ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/genetics ; Influenza Vaccines/immunology ; Mice, Inbred BALB C ; Nanoparticles/administration & dosage ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology ; Viral Matrix Proteins/genetics ; Viral Matrix Proteins/immunology
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; Bacterial Proteins ; DNA-Binding Proteins ; DPS protein, Bacteria ; Drug Carriers ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza Vaccines ; M2 protein, Influenza A virus ; Recombinant Fusion Proteins ; Vaccines, Synthetic ; Viral Matrix Proteins
Language	English
Publishing date	2017-11-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2017.10.051
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Article: Development of a novel dual-domain nanoparticle antigen construct for universal influenza vaccine

Ni, Yawei / Guo, Jianhua / Turner, Debra / Tizard, Ian

Vaccine. 2017 Dec. 15, v. 35, no. 50

2017

Abstract	A highly effective antigen construct for presenting conserved antigen domains is essential to the development of a universal influenza vaccine. We have developed a novel dual-domain nanoparticle fusion protein (DDNFP) which allows independent presentation of two conserved domains. The conserved domains used were from two separate viral surface proteins, M2e of M2 and fusion peptide (FP) or long alpha helix (CD) of HA2. The carrier is a novel nanoparticle protein – the dodecameric DNA binding protein from starved cells (Dps) of bacteria or archaea. Dps was found to be uniquely capable of simultaneous fusion and surface presentation at both N- and C-termini while retaining the ability to form nanoparticles. Thus, DDNFPs with M2e and FP or CD fused at N- and C-termini of Dps from E. coli (EcDps) or other bacteria were first constructed based on the H1 subtype sequences along with corresponding single-domain nanoparticle fusion proteins (SDNFPs). They were expressed at high levels in bacteria and found to form nanoparticles of the expected size (∼9 nm). They were stable against treatment at high temperatures. The DDNFPs (M2e-EcDps-FP and M2e-EcDps-CD) induced strong antibody responses against individual antigen domains and provided full protection against lethal challenge with PR8 virus (H1N1). Importantly, the protection by DDNFPs was synergistically enhanced as compared to SDNFPs. The M2e-EcDps-CD provided an even stronger protection than M2e-EcDps-FP and therefore appeared to be the superior construct. Together, with novel domain combination, enhanced protection and ease of production, this M2e/CD DDNFP could potentially be a highly effective antigen construct for the universal influenza vaccine.
Keywords	Archaea ; DNA-binding proteins ; Escherichia coli ; Influenza A virus ; antibodies ; antigens ; bacteria ; influenza vaccines ; nanoparticles ; surface proteins ; temperature ; viruses
Language	English
Dates of publication	2017-1215
Size	p. 7026-7032.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2017.10.051
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Campylobacter

Bulbow, Holden / Wu, Jing / Turner, Debra / McEntire, Michael / Tizard, Ian

Veterinary medicine (Auckland, N.Z.)

2017 Volume 8, Page(s) 37–40

Abstract: Psittacine proventricular dilatation disease (PDD) is a neurological disease caused by parrot bornaviruses. A competing theory suggests that intestinal colonization ... ...

Abstract	Psittacine proventricular dilatation disease (PDD) is a neurological disease caused by parrot bornaviruses. A competing theory suggests that intestinal colonization by
Language	English
Publishing date	2017-08-03
Publishing country	New Zealand
Document type	Journal Article
ISSN	2230-2034
ISSN (online)	2230-2034
DOI	10.2147/VMRR.S137213
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Book ; Online: Performance of open-path lasers and Fourier transform infrared spectroscopic systems in agriculture emissions research

Bai, Mei / Loh, Zoe / Griffith, David W. T. / Turner, Debra / Eckard, Richard / Edis, Robert / Denmead, Owen T. / Bryant, Glenn W. / Paton-Walsh, Clare / Tonini, Matthew / McGinn, Sean M. / Chen, Deli

eISSN: 1867-8548

2022

Abstract: The accumulation of gases into our atmosphere is a growing global concern that requires considerable quantification of the emission rates to mitigate the accumulation of gases in the atmosphere, especially the greenhouse gases (GHGs). In agriculture ... ...

Abstract	The accumulation of gases into our atmosphere is a growing global concern that requires considerable quantification of the emission rates to mitigate the accumulation of gases in the atmosphere, especially the greenhouse gases (GHGs). In agriculture there are many sources of GHGs that require attention in order to develop practical mitigation strategies. Measuring these GHG sources often relies on highly technical instrumentation originally designed for applications outside of the emissions research in agriculture. Although the open-path laser (OPL) and open-path Fourier transform infrared (OP-FTIR) spectroscopic techniques are used in agricultural research currently, insight into their contributing error to emissions research has not been the focus of these studies. The objective of this study was to assess the applicability and performance (accuracy and precision) of OPL and OP-FTIR spectroscopic techniques for measuring gas mole fractions from agricultural sources. We measured the mole fractions of trace gases methane (CH 4 ), nitrous oxide (N 2 O), and ammonia (NH 3 ), downwind of point and area sources with a known release rate. The mole fractions measured by OP-FTIR and OPL were also input into models of atmospheric dispersion (WindTrax) allowing the calculation of fluxes. Trace gas release recoveries with WindTrax were examined by comparing the ratio of estimated and known fluxes. The OP-FTIR provided the best performance regarding stability of drift in stable conditions. The CH 4 OPL accurately detected the low background (free-air) level of CH 4 however, the NH 3 OPL was unable to detect the background values <10 ppbv. The dispersion modelling using WindTrax coupled with open-path measurements can be a useful tool to calculate trace gas fluxes from the well-defined source area.
Subject code	621
Language	English
Publishing date	2022-06-15
Publishing country	de
Document type	Book ; Online
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Article ; Online: Apparent resolution of parrot bornavirus infection in cockatiels (

Murray, Olivia / Turner, Debra / Streeter, Kristen / Guo, Jianhua / Shivaprasad, H L / Payne, Susan / Tizard, Ian

Veterinary medicine (Auckland, N.Z.)

2017 Volume 8, Page(s) 31–36

Abstract: Parrot bornavirus (PaBV), the etiologic agent of proventricular dilatation disease (PDD), is a major cause of concern in the avian health community. Within an infected flock, some birds will develop PDD and succumb to disease, while others remain healthy. ...

Abstract	Parrot bornavirus (PaBV), the etiologic agent of proventricular dilatation disease (PDD), is a major cause of concern in the avian health community. Within an infected flock, some birds will develop PDD and succumb to disease, while others remain healthy. Until now, there has been no study describing the results of long-term infection in apparently healthy carriers. For the last 5 years, the Schubot Exotic Bird Health Center at Texas A&M University has monitored individual PaBV shedding data in a flock of 66 naturally infected cockatiels. Of these birds, 53 were detected shedding PaBV4 in their droppings by reverse transcriptase polymerase chain reaction on at least one occasion. However, the prevalence of shedding declined over time, with the last positive cloacal swab being in October 2013. To determine whether the decline and eventual lack of shedding was an indication of virus elimination, seven previously shedding birds were euthanized and necropsied in 2016. Neither any gross lesion of PDD was observed nor was there any evidence of PDD or bornaviral encephalitis detected by histopathology. All tissues tested were negative for the presence of PaBV by reverse transcriptase polymerase chain reaction and immunohistochemistry. Thus, there was no evidence of an ongoing, productive infection in these birds. There are two possible explanations for these results. One possibility is that the birds were previously infected and have subsequently eliminated the virus. Alternatively, there may have been as few as three truly infected birds in the flock and the transient detection of PaBV in the droppings of other birds may simply be a "pass-through" phenomenon.
Language	English
Publishing date	2017-07-06
Publishing country	New Zealand
Document type	Journal Article
ISSN	2230-2034
ISSN (online)	2230-2034
DOI	10.2147/VMRR.S134969
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