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Article ; Online: Faecal immunochemical test: challenges and opportunities for cancer diagnosis in primary care.

Craig, Mary / Turner, Jeff / Torkington, Jared / Crosby, Tom

The British journal of general practice : the journal of the Royal College of General Practitioners

2022 Volume 72, Issue 721, Page(s) 366–367

MeSH term(s)	Colonoscopy ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer ; Feces/chemistry ; Hemoglobins/analysis ; Humans ; Immunochemistry ; Mass Screening ; Neoplasms/diagnosis ; Occult Blood ; Primary Health Care
Chemical Substances	Hemoglobins
Language	English
Publishing date	2022-07-28
Publishing country	England
Document type	Editorial
ZDB-ID	1043148-2
ISSN	1478-5242 ; 0035-8797 ; 0960-1643
ISSN (online)	1478-5242
ISSN	0035-8797 ; 0960-1643
DOI	10.3399/bjgp22X720209
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Zs.B 576: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 100: Show issues

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Article: Late gastrointestinal effects of pelvic radiation: a nurse-led service.

Ludlow, Helen / Green, John / Turner, Jeff

British journal of nursing (Mark Allen Publishing)

2017 Volume 26, Issue 4, Page(s) S15–S22

Abstract: There are currently at least 2 million people in the UK living with and following a cancer diagnosis. Typically four out of every ten people with cancer will receive radiotherapy, but a large proportion of people who have pelvic radiotherapy may go on to ...

Abstract	There are currently at least 2 million people in the UK living with and following a cancer diagnosis. Typically four out of every ten people with cancer will receive radiotherapy, but a large proportion of people who have pelvic radiotherapy may go on to develop gastrointestinal (GI) symptoms. This includes rectal bleeding and faecal incontinence, which can have a huge impact on quality of life. These problems often go under-reported by patients and are also under-recognised or under-treated by health professionals. Cancer survivorship is a growing topic that is likely to have a major impact on the NHS, with increasing numbers of patients presenting. A late GI effects of pelvic radiotherapy clinic was set up to address these growing needs of patients with GI symptoms following radiotherapy. This article also shares insights from a doctoral study that is underway looking at people's experiences of living with symptoms following their treatment, in order to improve awareness of the major impact that this can have.
MeSH term(s)	Attitude to Health ; Bile Acids and Salts/metabolism ; Blind Loop Syndrome/etiology ; Blind Loop Syndrome/nursing ; Dietary Carbohydrates/metabolism ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/nursing ; Humans ; Malabsorption Syndromes/etiology ; Malabsorption Syndromes/metabolism ; Malabsorption Syndromes/nursing ; Patient Satisfaction ; Pelvic Neoplasms/radiotherapy ; Pelvis ; Practice Patterns, Nurses' ; Radiotherapy/adverse effects ; Rectal Diseases/etiology ; Rectal Diseases/nursing ; Survivors
Chemical Substances	Bile Acids and Salts ; Dietary Carbohydrates
Language	English
Publishing date	2017-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1119191-0
ISSN	0966-0461
ISSN	0966-0461
DOI	10.12968/bjon.2017.26.4.S15
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Zs.A 3449: Show issues

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Article: Impact of a simulation-based induction programme in gastroscopy on trainee outcomes and learning curves.

Siau, Keith / Hodson, James / Neville, Peter / Turner, Jeff / Beale, Amanda / Green, Susi / Murugananthan, Aravinth / Dunckley, Paul / Hawkes, Neil D

World journal of gastrointestinal endoscopy

2020 Volume 12, Issue 3, Page(s) 98–110

Abstract: Background: Pre-clinical simulation-based training (SBT) in endoscopy has been shown to augment trainee performance in the short-term, but longer-term data are lacking.: Aim: To assess the impact of a two-day gastroscopy induction course combining ... ...

Abstract	Background: Pre-clinical simulation-based training (SBT) in endoscopy has been shown to augment trainee performance in the short-term, but longer-term data are lacking. Aim: To assess the impact of a two-day gastroscopy induction course combining theory and SBT (Structured PRogramme of INduction and Training - SPRINT) on trainee outcomes over a 16-mo period. Methods: This prospective case-control study compared outcomes between novice SPRINT attendees and controls matched from a United Kingdom training database. Study outcomes comprised: (1) Unassisted D2 intubation rates; (2) Procedural discomfort scores; (3) Sedation practice; (4) Time to 200 procedures; and (5) Time to certification. Results: Total 15 cases and 24 controls were included, with mean procedure counts of 10 and 3 ( Conclusion: In this pilot study, attendees of the SPRINT cohort tended to perform more procedures and achieved gastroscopy certification earlier than controls. These data support the role for wider evaluation of pre-clinical induction involving SBT.
Language	English
Publishing date	2020-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573698-X
ISSN	1948-5190
ISSN	1948-5190
DOI	10.4253/wjge.v12.i3.98
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Article ; Online: Effect of Loop Diuretics on the Fractional Excretion of Urea in Decompensated Heart Failure.

Cox, Zachary L / Sury, Krishna / Rao, Veena S / Ivey-Miranda, Juan B / Griffin, Matthew / Mahoney, Devin / Gomez, Nicole / Fleming, James H / Inker, Lesley A / Coca, Steven G / Turner, Jeff / Wilson, F Perry / Testani, Jeffrey M

Journal of cardiac failure

2020 Volume 26, Issue 5, Page(s) 402–409

Abstract: Background: Fractional excretion of urea (FEUrea) is often used to understand the etiology of acute kidney injury (AKI) in patients receiving diuretics. Although FEUrea demonstrates diagnostic superiority over fractional excretion of sodium (FENa), ... ...

Abstract	Background: Fractional excretion of urea (FEUrea) is often used to understand the etiology of acute kidney injury (AKI) in patients receiving diuretics. Although FEUrea demonstrates diagnostic superiority over fractional excretion of sodium (FENa), clinicians often assume FEUrea is not affected by diuretics. Objective: To assess the intravenous loop diuretic effect on FEUrea. Methods: We analyzed a prospective cohort (n=297) hospitalized with hypervolemic heart failure at Yale New Haven Hospital System. FENa and FEUrea were calculated at baseline and serially after diuretics. The change in FEUrea at peak diuresis was compared with the pre-diuretic baseline. Results: Mean baseline FEUrea was 35.2% ± 10.5% and increased by a mean 5.6% ± 10.5% following 80 mg (40-160 mg) of furosemide equivalents (P < .001). The magnitude of change in FEUrea was clinically important as the distribution of change in FEUrea was similar to the overall distribution of baseline FEUrea. Change in FEUrea was related to the diuretic response (r = 0.61, P < .001), with a larger FEUrea increase in diuretic responders (8.8%, interquartile range [IQR]: 1.8-16.9) than non-responders (1.2%, IQR: -3.2 to 5.5; P < .001). Diuretic administration reclassified 27% of patients between low and high FEUrea groups across a 35% threshold. Neither change in FEUrea nor percentage reclassified out of a low FEUrea category differed between patients with and without AKI (P > .63 for both). Conclusions: FEUrea is meaningfully affected by loop diuretics. The degree of change in FEUrea is highly variable between patients and commonly of a magnitude that could reclassify across categories of FEUrea.
MeSH term(s)	Diuretics/therapeutic use ; Furosemide ; Heart Failure/drug therapy ; Humans ; Prospective Studies ; Sodium ; Sodium Potassium Chloride Symporter Inhibitors ; Urea
Chemical Substances	Diuretics ; Sodium Potassium Chloride Symporter Inhibitors ; Furosemide (7LXU5N7ZO5) ; Urea (8W8T17847W) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2020.01.019
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Zs.A 4340: Show issues

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Book: "Cockney Reject: Fußball, Oi! und Krawalle"

Turner, Jeff / Bushell, Garry

2010

Author's details	von Jeff Turner. Mit Garry Bushell. [Übersetzt von Andreas Schiffmann]
Keywords	1964- ; Autobiografie ; Turner, Jeff
Size	248 Seiten: Illustrationen
Edition	1. Aufl.
Publisher	I.P.-Verl. Jeske/Mader; Berlin
Document type	Book
HBZ-ID	HT016400244
ISBN	978-3-931624-55-2 ; 3-931624-55-2
Database	Central Library of Sport Science of the German Sport University Cologne

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Article ; Online: Use of gelofusine for endoscopic mucosal resection.

Turner, Jeff / Green, John / Dolwani, Sunil

Gut

2010 Volume 59, Issue 10, Page(s) 1446–7; author reply 1447

MeSH term(s)	Colonic Polyps/surgery ; Colonoscopy/methods ; Coloring Agents ; Humans ; Indigo Carmine ; Intraoperative Care/methods ; Polygeline/administration & dosage
Chemical Substances	Coloring Agents ; Polygeline (9015-56-9) ; Indigo Carmine (D3741U8K7L)
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gut.2009.198648
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Article ; Online: A prospective study of the accuracy and concordance between in-situ and postfixation measurements of colorectal polyp size and their potential impact upon surveillance.

Turner, Jeff K / Wright, Melissa / Morgan, Meleri / Williams, Geraint T / Dolwani, Sunil

European journal of gastroenterology & hepatology

2013 Volume 25, Issue 5, Page(s) 562–567

Abstract: Objectives: To determine the differences between in-situ, prefixation and postfixation colorectal polyp measurements, their clinical impact upon determining adenoma surveillance intervals, and to compare postfixation measurements using three different ... ...

Abstract	Objectives: To determine the differences between in-situ, prefixation and postfixation colorectal polyp measurements, their clinical impact upon determining adenoma surveillance intervals, and to compare postfixation measurements using three different devices. Patients and methods: A prospective study of 107 colorectal polyps resected from 65 consecutive patients (45 men, 20 women) undergoing colonoscopy as part of the Bowel Cancer Screening Programme was undertaken. The polyps were measured in situ, prefixation (study gold standard) and using three measurement devices (ruler, callipers and magnifying lens) postfixation in formalin. Results: Prefixation ruler measurements were significantly higher than in-situ (P=0.02) and postfixation ruler measurements (P=0.04). No significant difference was observed between in-situ and postfixation ruler measurements (P=0.36), although in-situ measurements were more variable. In-situ measurements also generated more variation in surveillance intervals than postfixation measurements (9.3 vs. 5.6%). No significant difference was seen between measurements obtained by the three different devices postfixation (P=0.89). Conclusion: This study provides evidence supporting the use of postfixation polyp size measurements as advised by recent European pathology colorectal cancer screening recommendations. In the absence of a clinically significant difference between measurement devices, we advise the ruler to be used as a standard for postfixation measurements because of its widespread availability.
MeSH term(s)	Adenomatous Polyps/pathology ; Adenomatous Polyps/surgery ; Aged ; Colonic Polyps/pathology ; Colonic Polyps/surgery ; Colonoscopy ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Early Detection of Cancer/methods ; Female ; Fixatives ; Formaldehyde ; Humans ; Intestinal Polyps/pathology ; Intestinal Polyps/surgery ; Male ; Middle Aged ; Pathology, Surgical/instrumentation ; Pathology, Surgical/methods ; Population Surveillance/methods ; Prospective Studies ; Reproducibility of Results ; Time Factors ; Tissue Fixation/methods
Chemical Substances	Fixatives ; Formaldehyde (1HG84L3525)
Language	English
Publishing date	2013-05
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0b013e32835d1f2d
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Zs.A 2932: Show issues

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Article ; Online: Interobserver agreement in the reporting of colorectal polyp pathology among bowel cancer screening pathologists in Wales.

Turner, Jeff K / Williams, Geraint T / Morgan, Meleri / Wright, Melissa / Dolwani, Sunil

Histopathology

2013 Volume 62, Issue 6, Page(s) 916–924

Abstract: Aims: To assess the interobserver agreement in the reporting of colorectal polyps among histopathologists participating in the Welsh Bowel Cancer Screening (BCS) programme.: Methods and results: Twelve benign polyps representative of BCS cases were ... ...

Abstract	Aims: To assess the interobserver agreement in the reporting of colorectal polyps among histopathologists participating in the Welsh Bowel Cancer Screening (BCS) programme. Methods and results: Twelve benign polyps representative of BCS cases were identified from pathology files and reported by 28 BCS histopathologists using proforma sheets. The level of agreement between the participants and a gold standard was determined using kappa (κ) statistics. A moderate level of agreement was achieved in the reporting of polyp type [κ = 0.45; 95% confidence interval (CI) 0.34-0.59] and adenomatous lesions were distinguished from non-adenomatous lesions in 96% of cases. Substantial agreement was obtained in distinguishing low- and high-grade dysplasias (κ = 0.67; 95% CI 0.50-0.86), but there was only fair agreement in reporting excision margin status (κ = 0.24; 95% CI 0.07-0.43) with frequent use of the 'uncertain' category. Significant issues included categorizing serrated lesions, recognizing focal high-grade dysplasia and epithelial misplacement, and apparent overdiagnosis of villous change in adenomas. Conclusions: Interobserver variability in some aspects of reporting colorectal polyps by BCS pathologists is suboptimal, with a potential impact upon patient management and the efficient running of the screening service. Approaches to addressing this are discussed.
MeSH term(s)	Adenocarcinoma/classification ; Adenocarcinoma/pathology ; Adenoma/classification ; Adenoma/pathology ; Adenomatous Polyps/classification ; Adenomatous Polyps/pathology ; Colonic Polyps/classification ; Colonic Polyps/pathology ; Colorectal Neoplasms/classification ; Colorectal Neoplasms/pathology ; Early Detection of Cancer ; Humans ; Hyperplasia ; Intestinal Polyps/classification ; Intestinal Polyps/pathology ; Observer Variation ; Pathology, Clinical ; Wales
Language	English
Publishing date	2013-05
Publishing country	England
Document type	Journal Article
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.12110
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Article: Stents and stentability: treatment for malignant bowel obstruction.

Turner, Jeff / Cummin, Tom / Bennett, Adam / Swift, Gillian / Green, John

British journal of hospital medicine (London, England : 2005)

2009 Volume 69, Issue 12, Page(s) 676–680

Abstract: Colonic stents offer a palliative treatment for patients with malignant bowel obstruction otherwise requiring surgery and possible stoma, or as a bridge to surgery for potentially curative malignant disease. This article reviews the indications, risks ... ...

Abstract	Colonic stents offer a palliative treatment for patients with malignant bowel obstruction otherwise requiring surgery and possible stoma, or as a bridge to surgery for potentially curative malignant disease. This article reviews the indications, risks and benefits of stent insertion.
MeSH term(s)	Colorectal Neoplasms/complications ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Contraindications ; Cost-Benefit Analysis ; Female ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/pathology ; Intestinal Obstruction/therapy ; Male ; Palliative Care/economics ; Palliative Care/methods ; Stents/adverse effects ; Stents/economics ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2009-01-29
Publishing country	England
Document type	Journal Article ; Review
ISSN	1750-8460
ISSN	1750-8460
DOI	10.12968/hmed.2008.69.12.676
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Article ; Online: Exchange versus simple transfusion for acute chest syndrome in sickle cell anemia adults.

Turner, Jeff M / Kaplan, Jason B / Cohen, Hillel W / Billett, Henny H

Transfusion

2009 Volume 49, Issue 5, Page(s) 863–868

Abstract: Background: There are scant data regarding the relative efficacy of exchange transfusion (XC) versus simple transfusion (ST) for treatment of sickle cell anemia acute chest syndrome (ACS).: Study design and methods: Twenty patients who received XC ... ...

Abstract	Background: There are scant data regarding the relative efficacy of exchange transfusion (XC) versus simple transfusion (ST) for treatment of sickle cell anemia acute chest syndrome (ACS). Study design and methods: Twenty patients who received XC for ACS were compared with 20 ST patients. Hemoglobin (Hb) levels, platelet and white blood cell counts, lactate dehydrogenase (LDH), indirect bilirubin, and temperature were used to assess disease severity. Primary outcome was postprocedure length of hospital stay; secondary outcome was total length of stay. Results: Cohorts were similar with regard to age; sex; prior ACS episodes; echocardiogram results; and antibiotic, bronchodilator, and hydroxyurea use. Maximum temperature recorded was higher in the XC group (39.1 degrees C vs. 38.4 degrees C, p = 0.02), but LDH, WBCs, and indirect bilirubin were comparable. Admission Hb levels were higher for XC (XC 8.6 g/dL vs. ST 7.4 g/dL, p = 0.02) and XC had higher peak Hb levels during hospitalization (10.4 +/- 1.4 g/dL vs. 9.3 +/- 1.0 g/dL, p < or = 0.01). No differences were demonstrable in postprocedure length of stay (XC 5.6 days vs. ST 5.9 days, p = 0.82) or total length of stay (XC 8.4 days vs. ST 8.0 days, p = 0.76). A total of 10.3 +/- 3.0 units were transfused for XC compared to 2.4 +/- 1.2 units for ST (p < 0.001). Conclusions: Based on postprocedure length of stay or total length of stay, we could not detect a difference in the efficacy of XC compared to ST in populations despite red blood cell product usage fourfold higher in the XC group. We suggest that it is time for an adequately powered, randomized trial to examine the true risk:benefit ratio of XC in ACS.
MeSH term(s)	Adult ; Anemia, Sickle Cell/therapy ; Blood Transfusion/methods ; Chest Pain ; Data Collection ; Exchange Transfusion, Whole Blood/methods ; Female ; Humans ; Length of Stay ; Male ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2009-05
Publishing country	United States
Document type	Comparative Study ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/j.1537-2995.2008.02075.x
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