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  1. Article ; Online: The Neurotransmission Basis of Post-Traumatic Stress Disorders by the Fear Conditioning Paradigm.

    Traina, Giovanna / Tuszynski, Jack A

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: Fear conditioning constitutes the best and most reproducible paradigm to study the neurobiological mechanisms underlying emotions. On the other hand, studies on the synaptic plasticity phenomena underlying fear conditioning present neural circuits ... ...

    Abstract Fear conditioning constitutes the best and most reproducible paradigm to study the neurobiological mechanisms underlying emotions. On the other hand, studies on the synaptic plasticity phenomena underlying fear conditioning present neural circuits enforcing this learning pattern related to post-traumatic stress disorder (PTSD). Notably, in both humans and the rodent model, fear conditioning and context rely on dependent neurocircuitry in the amygdala and prefrontal cortex, cingulate gyrus, and hippocampus. In this review, an overview of the role that classical neurotransmitters play in the contextual conditioning model of fear, and therefore in PTSD, was reported.
    MeSH term(s) Humans ; Stress Disorders, Post-Traumatic/psychology ; Fear/psychology ; Learning ; Amygdala ; Prefrontal Cortex ; Hippocampus ; Synaptic Transmission
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216327
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  2. Article: From quantum chemistry to quantum biology: a path toward consciousness.

    Tuszynski, Jack A

    Journal of integrative neuroscience

    2020  Volume 19, Issue 4, Page(s) 687–700

    Abstract: This paper presents a historical overview of quantum physics methodology's development and application to various science fields beyond physics, especially biology and consciousness. Following a successful interpretation of several early 20t⁢h century ... ...

    Abstract This paper presents a historical overview of quantum physics methodology's development and application to various science fields beyond physics, especially biology and consciousness. Following a successful interpretation of several early 20t⁢h century experiments, quantum physics gradually provided a conceptual framework for molecular bonds via quantum chemistry. In recent years individual biological phenomena such as photosynthesis and bird navigation have been experimentally and theoretically analyzed using quantum methods, building conceptual foundations for quantum physics' entry into biology. Quantum concepts have also been recently employed to explain physiology's allometric scaling laws by introducing quantum metabolism theory. In the second part of this work, we discuss how quantum physics may also be pivotal to our understanding of consciousness, which has been touted by some researchers as the last frontier of modern science. Others believe that consciousness does not belong within the realm of science at all. Several hypotheses, especially the Orch OR theory, have been suggested over the past two decades to introduce a scientific basis to consciousness theory. We discuss the merits and potential extensions of these approaches.
    MeSH term(s) Biology ; Brain/metabolism ; Brain/physiology ; Consciousness/physiology ; Humans ; Models, Theoretical ; Quantum Theory
    Language English
    Publishing date 2020-12-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin.2020.04.393
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6117: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action.

    Tuszynski, Jack A / Costa, Frederico

    Frontiers in medical technology

    2022  Volume 4, Page(s) 869155

    Abstract: Exposure to Low-Energy Amplitude-Modulated Radiofrequency Electromagnetic Fields (LEAMRFEMF) represents a new treatment option for patients with advanced hepatocellular carcinoma (AHCC). We focus on two medical devices that modulate the amplitude of a 27. ...

    Abstract Exposure to Low-Energy Amplitude-Modulated Radiofrequency Electromagnetic Fields (LEAMRFEMF) represents a new treatment option for patients with advanced hepatocellular carcinoma (AHCC). We focus on two medical devices that modulate the amplitude of a 27.12 MHz carrier wave to generate envelope waves in the low Hz to kHz range. Each provides systemic exposure to LEAMRFEMF
    Language English
    Publishing date 2022-09-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3129
    ISSN (online) 2673-3129
    DOI 10.3389/fmedt.2022.869155
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  4. Article ; Online: Holographic Brain Theory: Super-Radiance, Memory Capacity and Control Theory.

    Nishiyama, Akihiro / Tanaka, Shigenori / Tuszynski, Jack A / Tsenkova, Roumiana

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: We investigate Quantum Electrodynamics corresponding to the holographic brain theory introduced by Pribram to describe memory in the human brain. First, we derive a super-radiance solution in Quantum Electrodynamics with non-relativistic charged bosons ( ... ...

    Abstract We investigate Quantum Electrodynamics corresponding to the holographic brain theory introduced by Pribram to describe memory in the human brain. First, we derive a super-radiance solution in Quantum Electrodynamics with non-relativistic charged bosons (a model of molecular conformational states of water) for coherent light sources of holograms. Next, we estimate memory capacity of a brain neocortex, and adopt binary holograms to manipulate optical information. Finally, we introduce a control theory to manipulate holograms involving biological water's molecular conformational states. We show how a desired waveform in holography is achieved in a hierarchical model using numerical simulations.
    MeSH term(s) Humans ; Holography ; Brain ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042399
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  5. Article: Editorial: The isotypes of

    Moore, Jeffrey / Luduena, Richard / Tuszynski, Jack A

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1176739

    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1176739
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  6. Article: Toward a holographic brain paradigm: a lipid-centric model of brain functioning.

    Cavaglià, Marco / Deriu, Marco A / Tuszynski, Jack A

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1302519

    Abstract: Due to the stimulation of neuronal membrane dipoles by action potentials, under suitable conditions coherent dipole oscillations can be formed. We argue that these dipole oscillations satisfy the weak Bose-Einstein condensate criteria of the Froehlich ... ...

    Abstract Due to the stimulation of neuronal membrane dipoles by action potentials, under suitable conditions coherent dipole oscillations can be formed. We argue that these dipole oscillations satisfy the weak Bose-Einstein condensate criteria of the Froehlich model of biological coherence. They can subsequently generate electromagnetic fields (EMFs) propagating in the inter-neuronal space. When neighboring neurons fire synchronously, EMFs can create interference patterns and hence form holographic images containing analog information about the sensory inputs that trigger neuronal activity. The mirror pattern projected by EMFs inside the neuron can encode information in the neuronal cytoskeleton. We outline an experimental verification of our hypothesis and its consequences for anesthesia, neurodegenerative diseases, and psychiatric states.
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1302519
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  7. Article ; Online: Cancer Metabolism as a Therapeutic Target and Review of Interventions.

    Halma, Matthew T J / Tuszynski, Jack A / Marik, Paul E

    Nutrients

    2023  Volume 15, Issue 19

    Abstract: Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism ... ...

    Abstract Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention and better treatment outcomes. These interventions and their evidentiary basis are covered in the latter half of this review to guide future cancer treatment.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Glycolysis ; Energy Metabolism ; Treatment Outcome
    Language English
    Publishing date 2023-10-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15194245
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  8. Article ; Online: Development of Novel siRNA Therapeutics: A Review with a Focus on Inclisiran for the Treatment of Hypercholesterolemia.

    Ebenezer, Oluwakemi / Comoglio, Pietro / Wong, Gane Ka-Shu / Tuszynski, Jack A

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Over the past two decades, it was discovered that introducing synthetic small interfering RNAs (siRNAs) into the cytoplasm facilitates effective gene-targeted silencing. This compromises gene expression and regulation by repressing transcription or ... ...

    Abstract Over the past two decades, it was discovered that introducing synthetic small interfering RNAs (siRNAs) into the cytoplasm facilitates effective gene-targeted silencing. This compromises gene expression and regulation by repressing transcription or stimulating sequence-specific RNA degradation. Substantial investments in developing RNA therapeutics for disease prevention and treatment have been made. We discuss the application to proprotein convertase subtilisin/kexin type 9 (PCSK9), which binds to and degrades the low-density lipoprotein cholesterol (LDL-C) receptor, interrupting the process of LDL-C uptake into hepatocytes. PCSK9 loss-of-function modifications show significant clinical importance by causing dominant hypocholesterolemia and lessening the risk of cardiovascular disease (CVD). Monoclonal antibodies and small interfering RNA (siRNA) drugs targeting PCSK9 are a significant new option for managing lipid disorders and improving CVD outcomes. In general, monoclonal antibodies are restricted to binding with cell surface receptors or circulating proteins. Similarly, overcoming the intracellular and extracellular defenses that prevent exogenous RNA from entering cells must be achieved for the clinical application of siRNAs.
    MeSH term(s) Humans ; Antibodies, Monoclonal/therapeutic use ; Anticholesteremic Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cholesterol, LDL ; Hypercholesterolemia/metabolism ; Hypercholesterolemia/therapy ; Proprotein Convertase 9/genetics ; RNA, Small Interfering/therapeutic use
    Chemical Substances ALN-PCS ; Antibodies, Monoclonal ; Anticholesteremic Agents ; Cholesterol, LDL ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; RNA, Small Interfering
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24044019
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  9. Article ; Online: Gibbs Energy and Gene Expression Combined as a New Technique for Selecting Drug Targets for Inhibiting Specific Protein-Protein Interactions.

    Rietman, Edward A / Siegelmann, Hava T / Klement, Giannoula Lakka / Tuszynski, Jack A

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: One of the most important aspects of successful cancer therapy is the identification of a target protein for inhibition interaction. Conventionally, this consists of screening a panel of genes to assess which is mutated and then developing a small ... ...

    Abstract One of the most important aspects of successful cancer therapy is the identification of a target protein for inhibition interaction. Conventionally, this consists of screening a panel of genes to assess which is mutated and then developing a small molecule to inhibit the interaction of two proteins or to simply inhibit a specific protein from all interactions. In previous work, we have proposed computational methods that analyze protein-protein networks using both topological approaches and thermodynamic quantification provided by Gibbs free energy. In order to make these approaches both easier to implement and free of arbitrary topological filtration criteria, in the present paper, we propose a modification of the topological-thermodynamic analysis, which focuses on the selection of the most thermodynamically stable proteins and their subnetwork interaction partners with the highest expression levels. We illustrate the implementation of the new approach with two specific cases, glioblastoma (glioma brain tumors) and chronic lymphatic leukoma (CLL), based on the publicly available patient-derived datasets. We also discuss how this can be used in clinical practice in connection with the availability of approved and investigational drugs.
    MeSH term(s) Humans ; Brain Neoplasms ; Thermodynamics ; Proteins ; Glioma ; Gene Expression ; Protein Interaction Maps ; Computational Biology/methods
    Chemical Substances Proteins
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914648
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  10. Article: Computational Investigation of the Ordered Water System Around Microtubules: Implications for Protein Interactions.

    Chierici, Francesco / Dogariu, Aristide / Tuszynski, Jack A

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 884043

    Abstract: The existence of an exclusion zone in which particles of a colloidal suspension in water are repelled from hydrophilic surfaces has been experimentally demonstrated in numerous studies, especially in the case of Nafion surfaces. Various explanations have ...

    Abstract The existence of an exclusion zone in which particles of a colloidal suspension in water are repelled from hydrophilic surfaces has been experimentally demonstrated in numerous studies, especially in the case of Nafion surfaces. Various explanations have been proposed for the origin of this phenomenon, which is not completely understood yet. In particular, the existence of a fourth phase of water has been proposed by G. Pollack and if this theory is proven correct, its implications on our understanding of the properties of water, especially in biological systems, would be profound and could give rise to new medical therapies. Here, a simple approach based on the linearized Poisson-Boltzmann equation is developed in order to study the repulsive forces mediated by ordered water and involving the following interacting biomolecules: 1) microtubule and a tubulin dimer, 2) two tubulin dimers and 3) a tubulin sheet and a tubulin dimer. The choice of microtubules in this study is motivated because they could be a good candidate for the generation of an exclusion zone in the cell and these models could be a starting point for detailed experimental investigations of this phenomenon.
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.884043
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