LIVIVO - Search results -

Search results

Result 1 - 10 of total 20

Search options

Article: Multiomics Picture of Obesity in Young Adults.

Kiseleva, Olga I / Pyatnitskiy, Mikhail A / Arzumanian, Viktoriia A / Kurbatov, Ilya Y / Ilinsky, Valery V / Ilgisonis, Ekaterina V / Plotnikova, Oksana A / Sharafetdinov, Khaider K / Tutelyan, Victor A / Nikityuk, Dmitry B / Ponomarenko, Elena A / Poverennaya, Ekaterina V

Biology

2024 Volume 13, Issue 4

Abstract: Obesity is a socially significant disease that is characterized by a disproportionate accumulation of fat. It is also associated with chronic inflammation, cancer, diabetes, and other comorbidities. Investigating biomarkers and pathological processes ... ...

Abstract	Obesity is a socially significant disease that is characterized by a disproportionate accumulation of fat. It is also associated with chronic inflammation, cancer, diabetes, and other comorbidities. Investigating biomarkers and pathological processes linked to obesity is especially vital for young individuals, given their increased potential for lifestyle modifications. By comparing the genetic, proteomic, and metabolomic profiles of individuals categorized as underweight, normal, overweight, and obese, we aimed to determine which omics layer most accurately reflects the phenotypic changes in an organism that result from obesity. We profiled blood plasma samples by employing three omics methodologies. The untargeted GC×GC-MS metabolomics approach identified 313 metabolites. To augment the metabolomic dataset, we integrated a label-free HPLC-MS/MS proteomics method, leading to the identification of 708 proteins. The genomic layer encompassed the genotyping of 647,250 SNPs. Utilizing omics data, we trained sparse Partial Least Squares models to predict body mass index. Molecular features exhibiting frequently non-zero coefficients were selected as potential biomarkers, and we further explored enriched biological pathways. Proteomics was the most effective in single-omics analyses, with a median absolute error (MAE) of 5.44 ± 0.31 kg/m
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology13040272
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Clinical Blood Metabogram: Application to Overweight and Obese Patients.

Lokhov, Petr G / Balashova, Elena E / Trifonova, Oxana P / Maslov, Dmitry L / Plotnikova, Oksana A / Sharafetdinov, Khaider K / Nikityuk, Dmitry B / Tutelyan, Victor A / Ponomarenko, Elena A / Archakov, Alexander I

Metabolites

2023 Volume 13, Issue 7

Abstract: Recently, the concept of a mass spectrometric blood metabogram was introduced, which allows the analysis of the blood metabolome in terms of the time, cost, and reproducibility of clinical laboratory tests. It was demonstrated that the components of the ... ...

Abstract	Recently, the concept of a mass spectrometric blood metabogram was introduced, which allows the analysis of the blood metabolome in terms of the time, cost, and reproducibility of clinical laboratory tests. It was demonstrated that the components of the metabogram are related groups of the blood metabolites associated with humoral regulation; the metabolism of lipids, carbohydrates, and amines; lipid intake into the organism; and liver function, thereby providing clinically relevant information. The purpose of this work was to evaluate the relevance of using the metabogram in a disease. To do this, the metabogram was used to analyze patients with various degrees of metabolic alterations associated with obesity. The study involved 20 healthy individuals, 20 overweight individuals, and 60 individuals with class 1, 2, or 3 obesity. The results showed that the metabogram revealed obesity-associated metabolic alterations, including changes in the blood levels of steroids, amino acids, fatty acids, and phospholipids, which are consistent with the available scientific data to date. Therefore, the metabogram allows testing of metabolically unhealthy overweight or obese patients, providing both a general overview of their metabolic alterations and detailing their individual characteristics. It was concluded that the metabogram is an accurate and clinically applicable test for assessing an individual's metabolic status in disease.
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13070798
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet.

Kravchenko, Lidia V / Aksenov, Ilya V / Nikitin, Nikolay S / Guseva, Galina V / Avrenyeva, Ludmila I / Trusov, Nikita V / Balakina, Anastasia S / Tutelyan, Victor A

Nutrients

2021 Volume 13, Issue 6

Abstract: Non-alcoholic fatty liver disease (NAFLD) is currently estimated as the most prevalent chronic liver disease in all age groups. An increasing body of evidence obtained in experimental and clinical data indicates that oxidative stress is the most ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is currently estimated as the most prevalent chronic liver disease in all age groups. An increasing body of evidence obtained in experimental and clinical data indicates that oxidative stress is the most important pathogenic factor in the development of NAFLD. The study aimed to investigate the impact of α-lipoic acid (LA), widely used as an antioxidant, on the effects of a hypercaloric choline-deficient diet. Male Wistar rats were divided into three groups: control diet (C); hypercaloric choline-deficient diet (HCCD), and hypercaloric choline-deficient diet with α-lipoic acid (HCCD+LA). Supplementation of HCCD with LA for eight weeks led to a decrease in visceral adipose tissue/body weight ratio, the activity of liver glutathione peroxidase and paraoxonase-1, plasma, and liver total antioxidant activity, as well as an increase in liver/body weight ratio, liver total lipid and triglyceride content, and liver transaminase activities compared to the HCCD group without LA. In conclusion, our study shows that α-lipoic acid detains obesity development but exacerbates the severity of diet-induced oxidative stress and lipid accumulation in the liver of male Wistar rats fed a hypercaloric choline-deficient diet.
MeSH term(s)	Animals ; Biomarkers/metabolism ; Body Weight/drug effects ; Choline ; Diet ; Feeding Behavior ; Lipid Metabolism/drug effects ; Liver/drug effects ; Liver/pathology ; Male ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Rats, Wistar ; Thioctic Acid/adverse effects ; Rats
Chemical Substances	Biomarkers ; Thioctic Acid (73Y7P0K73Y) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2021-06-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13061999
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

Kravchenko, Lidia V. / Aksenov, Ilya V. / Nikitin, Nikolay S. / Guseva, Galina V. / Avrenyeva, Ludmila I. / Trusov, Nikita V. / Balakina, Anastasia S. / Tutelyan, Victor A.

Nutrients. 2021 June 10, v. 13, no. 6

2021

Abstract	Non-alcoholic fatty liver disease (NAFLD) is currently estimated as the most prevalent chronic liver disease in all age groups. An increasing body of evidence obtained in experimental and clinical data indicates that oxidative stress is the most important pathogenic factor in the development of NAFLD. The study aimed to investigate the impact of α-lipoic acid (LA), widely used as an antioxidant, on the effects of a hypercaloric choline-deficient diet. Male Wistar rats were divided into three groups: control diet (C); hypercaloric choline-deficient diet (HCCD), and hypercaloric choline-deficient diet with α-lipoic acid (HCCD+LA). Supplementation of HCCD with LA for eight weeks led to a decrease in visceral adipose tissue/body weight ratio, the activity of liver glutathione peroxidase and paraoxonase-1, plasma, and liver total antioxidant activity, as well as an increase in liver/body weight ratio, liver total lipid and triglyceride content, and liver transaminase activities compared to the HCCD group without LA. In conclusion, our study shows that α-lipoic acid detains obesity development but exacerbates the severity of diet-induced oxidative stress and lipid accumulation in the liver of male Wistar rats fed a hypercaloric choline-deficient diet.
Keywords	adipose tissue ; antioxidant activity ; antioxidants ; diet ; fatty liver ; glutathione peroxidase ; lipoic acid ; liver ; males ; obesity ; oxidative stress ; triacylglycerols
Language	English
Dates of publication	2021-0610
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13061999
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Linking Clinical Blood Metabogram and Gut Microbiota.

Lokhov, Petr G / Balashova, Elena E / Maslov, Dmitry L / Trifonova, Oxana P / Lisitsa, Andrey V / Markova, Yulia M / Stetsenko, Valentina V / Polyanina, Anna S / Sheveleva, Svetlana A / Sharafetdinov, Khaider K / Nikityuk, Dmitry B / Tutelyan, Victor A / Archakov, Alexander I

Metabolites

2023 Volume 13, Issue 10

Abstract: Recently, a clinical blood metabogram was developed as a fast, low-cost and reproducible test that allows the implementation of metabolomics in clinical practice. The components of the metabogram are functionally related groups of blood metabolites ... ...

Abstract	Recently, a clinical blood metabogram was developed as a fast, low-cost and reproducible test that allows the implementation of metabolomics in clinical practice. The components of the metabogram are functionally related groups of blood metabolites associated with humoral regulation, the metabolism of lipids, carbohydrates and amines, lipid intake into the organism, and liver function, thereby providing clinically relevant information. It is known that the gut microbiota affects the blood metabolome, and the components of the blood metabolome may affect the composition of the gut microbiota. Therefore, before using the metabogram in the clinic, the link between the metabogram components and the level of gut microorganisms should be established. For this purpose, the metabogram and microbiota data were obtained in this work for the same individuals. Metabograms of blood plasma were obtained by direct mass spectrometry of blood plasma, and the gut microbiome was determined by a culture-based method and real-time polymerase chain reaction (PCR). This study involved healthy volunteers and individuals with varying degrees of deviation in body weight (
Language	English
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13101095
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Deoxynivalenol in cereals in Russia.

Tutelyan, Victor A

Toxicology letters

2004 Volume 153, Issue 1, Page(s) 173–179

Abstract: A survey of the occurrence of deoxynivalenol (DON) and zearalenone (ZEN) in wheat, rye, barley and maize harvested in 1989-2001 in several regions of Russia has been conducted. A total of 5652 samples of cereals were analysed for DON and ZEN by using TLC ...

Abstract	A survey of the occurrence of deoxynivalenol (DON) and zearalenone (ZEN) in wheat, rye, barley and maize harvested in 1989-2001 in several regions of Russia has been conducted. A total of 5652 samples of cereals were analysed for DON and ZEN by using TLC and normal-phase HPLC with UV-detector. DON was detected in 69% of 2166 samples from Krasnodar region which is considered to be the major Fusarium endemic region of Russia. The contamination levels ranged from 0.1 till 8.6 ppm, MTEL was exceeded in 37% of these samples. The positive correlation between DON concentration and a percentage of Fusaria-damaged wheat kernels has been shown. DON occurrence and contamination levels were much lower that for wheat. Based on the results of monitoring and the data of average actual consumption of wheat products in Russia, the estimated daily intake of DON per 1 kg of body weight (EDI)was calculated. EDI varied from 0.07 ug in 1990-1991 till 1.40 ug in 1992. Although average EDI were lower than adopted tolerable daily intake (TDI, 3 ug/kg body weight) EDIs for the North-Caucasian region in some cases exceeded TDI.
MeSH term(s)	Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Edible Grain/chemistry ; Food Contamination/analysis ; Humans ; Russia ; Trichothecenes/analysis ; Zearalenone/analysis
Chemical Substances	Trichothecenes ; Zearalenone (5W827M159J) ; deoxynivalenol (JT37HYP23V)
Language	English
Publishing date	2004-10-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2004.04.042
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1367: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Does Proteomic Mirror Reflect Clinical Characteristics of Obesity?

Kiseleva, Olga I / Arzumanian, Viktoriia A / Poverennaya, Ekaterina V / Pyatnitskiy, Mikhail A / Ilgisonis, Ekaterina V / Zgoda, Victor G / Plotnikova, Oksana A / Sharafetdinov, Khaider K / Lisitsa, Andrey V / Tutelyan, Victor A / Nikityuk, Dmitry B / Archakov, Alexander I / Ponomarenko, Elena A

Journal of personalized medicine

2021 Volume 11, Issue 2

Abstract: Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive ...

Abstract	Obesity is a frightening chronic disease, which has tripled since 1975. It is not expected to slow down staying one of the leading cases of preventable death and resulting in an increased clinical and economic burden. Poor lifestyle choices and excessive intake of "cheap calories" are major contributors to obesity, triggering type 2 diabetes, cardiovascular diseases, and other comorbidities. Understanding the molecular mechanisms responsible for development of obesity is essential as it might result in the introducing of anti-obesity targets and early-stage obesity biomarkers, allowing the distinction between metabolic syndromes. The complex nature of this disease, coupled with the phenomenon of metabolically healthy obesity, inspired us to perform data-centric, hypothesis-generating pilot research, aimed to find correlations between parameters of classic clinical blood tests and proteomic profiles of 104 lean and obese subjects. As the result, we assembled patterns of proteins, which presence or absence allows predicting the weight of the patient fairly well. We believe that such proteomic patterns with high prediction power should facilitate the translation of potential candidates into biomarkers of clinical use for early-stage stratification of obesity therapy.
Language	English
Publishing date	2021-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11020064
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Effects of Multivitamin, Multimineral and Phytonutrient Supplementation on Nutrient Status and Biomarkers of Heart Health Risk in a Russian Population: A Randomized, Double Blind, Placebo Controlled Study

Isakov, Vasily A / Bogdanova, Alexandra A / Bessonov, Vladimir V / Sentsova, Tatiana B / Tutelyan, Victor A / Lin, Yumei / Kazlova, Valentina / Hong, Jina / Velliquette, Rodney A

Nutrients. 2018 Jan. 25, v. 10, no. 2

2018

Abstract: The primary objective of this clinical study was to evaluate the effect of a dietary multivitamin, multimineral and phytonutrient (VMP) supplement on blood nutrient status and biomarkers of heart health risk in a Russian population. One hundred twenty ... ...

Abstract	The primary objective of this clinical study was to evaluate the effect of a dietary multivitamin, multimineral and phytonutrient (VMP) supplement on blood nutrient status and biomarkers of heart health risk in a Russian population. One hundred twenty healthy adults (40–70 years) were recruited for a 56-day (eight-week) randomized, double blind, placebo controlled study with parallel design. Subjects were divided into two groups and received either a VMP or a placebo (PLA) supplement. Blood nutrient levels of β-carotene, α-tocopherol, vitamin C, B6, B12, red blood cell (RBC) folate, Zinc and Selenium were measured at baseline and on Days 28 and 56, and quercetin was measured at baseline and on Day 56. Blood biomarkers of heart health, i.e. homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), oxidized LDL (ox-LDL), gamma-glutamyl transferase (GGT), uric acid and blood lipid profile, were measured at baseline and Day 56. Dietary VMP supplementation for 56 days significantly increased circulating levels of quercetin, vitamin C, RBC folate and partially prevented the decline in vitamin B6 and B12 status. Both serum Hcy and GGT were significantly reduced (−3.97 ± 10.09 μmol/L; −1.68 ± 14.53 U/L, respectively) after VMP supplementation compared to baseline. Dietary VMP supplementation improved the nutrient status and reduced biomarkers of heart health risk in a Russian population.
Keywords	C-reactive protein ; adults ; alpha-tocopherol ; ascorbic acid ; beta-carotene ; biomarkers ; blood lipids ; blood serum ; erythrocytes ; folic acid ; gamma-glutamyltransferase ; heart health ; homocysteine ; lipid composition ; low density lipoprotein ; nutrient content ; oxidation ; phytonutrients ; placebos ; pyridoxine ; quercetin ; risk ; selenium ; uric acid ; zinc
Language	English
Dates of publication	2018-0125
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu10020120
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes - A real-life risk simulation approach.

Tsatsakis, Aristidis / Tyshko, Nadezhda V / Docea, Anca Oana / Shestakova, Svetlana I / Sidorova, Yuliia S / Petrov, Nikita A / Zlatian, Ovidiu / Mach, Mojmir / Hartung, Thomas / Tutelyan, Victor A

Toxicology letters

2019 Volume 315, Page(s) 96–106

Abstract: We investigate the long-term effect of very-low dose exposure to a mixture of six pesticides associated with hydrophilic vitamin deficiency on the neurobehavioral outcomes of rats. Two hundred Wistar rats were divided into four groups, two control groups, ...

Abstract	We investigate the long-term effect of very-low dose exposure to a mixture of six pesticides associated with hydrophilic vitamin deficiency on the neurobehavioral outcomes of rats. Two hundred Wistar rats were divided into four groups, two control groups, a vitamin sufficient control group and a vitamin deficiency control group and 2 test groups, a vitamin sufficient test group, and a vitamin deficiency group. The test groups were exposed for 9 months to a mixture of diquat, imazamox, imazethapyr, tepraloxydin, bentazone and acifluorfen in doses of 0.01xNOAEL (mg/kg bw/day). After 9 months of exposure, the behavior changes were evaluated by open field test and elevated plus maze test and the memory was assessed by passive avoidance test. Chronic vitamin deficiency decreased locomotor and special orientation activity and increased anxiety-like behavior in rats. Exposure to very low doses of a mixture of 6 pesticides caused central nervous effects, manifested as decreased locomotor activity, and increased anxiety levels. Vitamin deficiency and low dose chronic pesticides mixture exposure thus affected the central nervous system, especially long-term memory.
MeSH term(s)	Animals ; Avitaminosis/complications ; Avitaminosis/physiopathology ; Avoidance Learning/drug effects ; Disease Models, Animal ; Male ; Maze Learning/drug effects ; Nervous System Diseases/chemically induced ; Nervous System Diseases/physiopathology ; Pesticides/toxicity ; Rats ; Rats, Wistar
Chemical Substances	Pesticides
Language	English
Publishing date	2019-08-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2019.07.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1367: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Improved strategies to counter the COVID-19 pandemic: Lockdowns vs. primary and community healthcare

Farsalinos, Konstantinos / Poulas, Konstantinos / Kouretas, Dimitrios / Vantarakis, Apostolos / Leotsinidis, Michalis / Kouvelas, Dimitrios / Docea, Anca Oana / Kostoff, Ronald / Gerotziafas, Grigorios T / Antoniou, Michael N / Polosa, Riccardo / Barbouni, Anastastia / Yiakoumaki, Vassiliki / Giannouchos, Theodoros V / Bagos, Pantelis G / Lazopoulos, George / Izotov, Boris N / Tutelyan, Victor A / Aschner, Michael /

Hartung, Thomas / Wallace, Heather M / Carvalho, Félix / Domingo, Jose L / Tsatsakis, Aristides

Toxicology reports. 2021, v. 8

2021

Abstract: COVID-19 pandemic mitigation strategies are mainly based on social distancing measures and healthcare system reinforcement. However, many countries in Europe and elsewhere implemented strict, horizontal lockdowns because of extensive viral spread in the ... ...

Abstract	COVID-19 pandemic mitigation strategies are mainly based on social distancing measures and healthcare system reinforcement. However, many countries in Europe and elsewhere implemented strict, horizontal lockdowns because of extensive viral spread in the community which challenges the capacity of the healthcare systems. However, strict lockdowns have various untintended adverse social, economic and health effects, which have yet to be fully elucidated, and have not been considered in models examining the effects of various mitigation measures. Unlike commonly suggested, the dilemma is not about health vs wealth because the economic devastation of long-lasting lockdowns will definitely have adverse health effects in the population. Furthermore, they cannot provide a lasting solution in pandemic containment, potentially resulting in a vicious cycle of consecutive lockdowns with in-between breaks. Hospital preparedness has been the main strategy used by governments. However, a major characteristic of the COVID-19 pandemic is the rapid viral transmission in populations with no immunity. Thus, even the best hospital system could not cope with the demand. Primary, community and home care are the only viable strategies that could achieve the goal of pandemic mitigation. We present the case example of Greece, a country which followed a strategy focused on hospital preparedness but failed to reinforce primary and community care. This, along with strategic mistakes in epidemiological surveillance, resulted in Greece implementing a second strict, horizontal lockdown and having one of the highest COVID-19 death rates in Europe during the second wave. We provide recommendations for measures that will reinstate primary and community care at the forefront in managing the current public health crisis by protecting hospitals from unnecessary admissions, providing primary and secondary prevention services in relation to COVID-19 and maintaining population health through treatment of non−COVID-19 conditions. This, together with more selective social distancing measures (instead of horizontal lockdowns), represents the only viable and realistic long-term strategy for COVID-19 pandemic mitigation.
Keywords	COVID-19 infection ; death ; health services ; hospitals ; immunity ; monitoring ; pandemic ; public health ; toxicology ; virus transmission ; Greece
Language	English
Size	p. 1-9.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2805786-7
ISSN	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2020.12.001
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito