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  1. Article: Editorial: Pelvic floor disorders: a multidisciplinary issue.

    Tutino, Roberta / Pata, Francesco

    Frontiers in surgery

    2024  Volume 11, Page(s) 1400636

    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2024.1400636
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  2. Article: Editorial: Colorectal surgery and proctology: past, present, and future.

    Pata, Francesco / Tutino, Roberta / Picciariello, Arcangelo / Cantarella, Francesco

    Frontiers in surgery

    2024  Volume 11, Page(s) 1373867

    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2024.1373867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Locally advanced mid/low rectal cancer with synchronous resectable liver metastases: systematic review of the available strategies and outcome.

    Tutino, R / Bonomi, A / Zingaretti, C C / Risi, L / Ragaini, E M / Viganò, L / Paterno, M / Pezzoli, I

    Updates in surgery

    2024  Volume 76, Issue 2, Page(s) 345–361

    Abstract: The management of patients with locally advanced mid/low rectal cancer with resectable liver metastases is complex because of the need to combine the optimal treatment of both tumors. This study aims to review the available treatment strategies and ... ...

    Abstract The management of patients with locally advanced mid/low rectal cancer with resectable liver metastases is complex because of the need to combine the optimal treatment of both tumors. This study aims to review the available treatment strategies and compare their outcome, focusing on radiotherapy (RT) and liver-first approach (LFA). A systematic review was performed in PubMed, Embase, and web sources including articles published between 2000 and 02/2023 and reporting mid-/long-term outcomes. Overall, twenty studies were included (n = 1837 patients). Three- and 5-year overall survival (OS) rates were 51-88% and 36-59%. Although several strategies were reported, most patients received RT (1448/1837, 79%; > 85% neoadjuvant). RT reduced the pelvic recurrence risk (5.8 vs. 13.5%, P = 0.005) but did not impact OS. Six studies analyzed LFA (n = 307 patients). LFA had a completion rate similar to the rectum-first approach (RFA, 81% vs. 79%) but the interval strategy-an LFA variant with liver surgery in the interval between radiotherapy and rectal surgery-had a better completion rate than standard LFA (liver surgery/radiotherapy/rectal surgery, 92% vs. 75%, P = 0.011) and RFA (79%, P = 0.048). Across all series, LFA achieved the best survival rates, and in one paper it led to a survival advantage in patients with multiple metastases. In conclusion, different strategies can be adopted, but RT should be included to decrease the pelvic recurrence risk. LFA should be considered, especially in patients with high hepatic tumor burden, and RT before liver surgery (interval strategy) could maximize its completion rate.
    MeSH term(s) Humans ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Rectum/surgery ; Liver Neoplasms/surgery ; Liver Neoplasms/secondary ; Neoadjuvant Therapy
    Language English
    Publishing date 2024-01-05
    Publishing country Italy
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01735-w
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    Zs.B 101: Show issues Location:
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  4. Article ; Online: The kids are all right.

    Tutino, Rebecca / Martinez, Caroline / Pressman, Aliza W / Chung, Jaeah / Shemesh, Eyal

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2024  Volume 132, Issue 5, Page(s) 549–550

    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2024.01.021
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  5. Article ; Online: Alexithymia, intolerance to uncertainty and mental health difficulties in adolescents with Type 1 diabetes mellitus.

    Merlo, Emanuele Maria / Tutino, Rita / Myles, Liam Alexander MacKenzie / Lia, Maria Carmela / Minasi, Domenico

    Italian journal of pediatrics

    2024  Volume 50, Issue 1, Page(s) 99

    Abstract: Background: Type 1 Diabetes Mellitus (T1DM) represents a serious chronic condition affecting a wide number of people. Discussion of the physical issues associated with T1DM pervades the literature, however, there is less discussion of the psychological ... ...

    Abstract Background: Type 1 Diabetes Mellitus (T1DM) represents a serious chronic condition affecting a wide number of people. Discussion of the physical issues associated with T1DM pervades the literature, however, there is less discussion of the psychological consequences. Mental health difficulties, alexithymia and uncertainty are present in this population, and known to be harmful for the onset, maintenance and worsening of T1DM. This study aimed to evaluate the presence of these phenomena in people with T1DM.
    Methods: 105 participants aged between 11 and 17 years old (M: 13.88; SD: 2.16) affected by T1DM were included in the sample. To assess the presence of mental health difficulties, SAFA scales (Depression, Anxiety and Somatic symptoms) were included in the protocol together with TAS-20 and IUS-12, which evaluate the presence and role of alexithymia and intolerance to uncertainty in the sample, respectively.
    Results: A concerning presence of anxiety, depression and somatic symptoms was found in the sample. Mental health difficulties appeared to be consistently present in the sample, often overcoming pathological thesholds. Alexithymia and uncertainty were also common, highlighting their role in T1DM.
    Conclusions: Active mental health difficulties together with high rates of alexithymia and intolerance to uncertainty were prevalent in the sample of adolescents with diabetes.
    MeSH term(s) Humans ; Adolescent ; Diabetes Mellitus, Type 1/psychology ; Diabetes Mellitus, Type 1/complications ; Male ; Female ; Affective Symptoms/epidemiology ; Child ; Uncertainty ; Anxiety/epidemiology ; Depression/epidemiology ; Mental Health ; Prevalence
    Language English
    Publishing date 2024-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-024-01647-4
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  6. Article ; Online: Massive late postoperative bleeding after abdominal surgery in a haematologic patient with postoperative CoV-2 infection.

    Tutino, Roberta / Bonariol, Luca / Caratozzolo, Ezio / Massani, Marco

    BMJ case reports

    2021  Volume 14, Issue 8

    Abstract: The role of viral infection in extrapulmonary postoperative complications in CoV-2 patients is still debated. Perioperative bleeding is rare compared with thrombotic events, but can be related to a haemorrhagic CoV-2-associated disseminated intravascular ...

    Abstract The role of viral infection in extrapulmonary postoperative complications in CoV-2 patients is still debated. Perioperative bleeding is rare compared with thrombotic events, but can be related to a haemorrhagic CoV-2-associated disseminated intravascular coagulopathy-like syndrome.
    MeSH term(s) Humans ; Postoperative Complications ; Postoperative Hemorrhage/etiology ; Postoperative Period ; Thrombosis
    Language English
    Publishing date 2021-08-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-243744
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  7. Article ; Online: Anal canal mixed adenoneuroendocrine carcinoma in a young patient misdiagnosed as anal abscess.

    Tutino, Roberta / Battistella, Enrico / Bonariol, Luca / Massani, Marco

    BMJ case reports

    2021  Volume 14, Issue 9

    Abstract: Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) are rare tumours of gastrointestinal tract, extremely rare in anal canal. We report a case of misdiagnosed MiNEN in a 38-year-old woman initially conservatively treated for a supposed anal ... ...

    Abstract Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) are rare tumours of gastrointestinal tract, extremely rare in anal canal. We report a case of misdiagnosed MiNEN in a 38-year-old woman initially conservatively treated for a supposed anal fistula. In a second proctological evaluation, biopsy of the anal neoformation was performed and the histological specimen diagnosed a MiNEN. The complete staging showed a disseminate disease and the patient started a chemotherapy schedule. After 6 months, stable disease was revealed at the last imaging performed and radical surgery was offered to the patient that is actually on oncological follow-up without recurrence at 1 year.
    MeSH term(s) Abscess/diagnostic imaging ; Adult ; Anal Canal ; Carcinoma, Neuroendocrine/diagnostic imaging ; Carcinoma, Neuroendocrine/surgery ; Diagnostic Errors ; Female ; Humans ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2021-09-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-244737
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  8. Article ; Online: A survey of statistical methods utilized for analysis of randomized controlled trials of behavioral interventions.

    Tutino, Rebecca / Schofield, Elizabeth / Saracino, Rebecca M / Walsh, Leah / Straus, Emma / Nelson, Christian J

    Palliative & supportive care

    2023  Volume 22, Issue 2, Page(s) 221–225

    Abstract: Objectives: Given the many statistical analysis options used for randomized controlled trials (RCTs) of behavioral interventions and the lack of clear guidance for analysis selection, the present study aimed to characterize the predominate statistical ... ...

    Abstract Objectives: Given the many statistical analysis options used for randomized controlled trials (RCTs) of behavioral interventions and the lack of clear guidance for analysis selection, the present study aimed to characterize the predominate statistical analyses utilized in RCTs in palliative care and behavioral research and to highlight the relative strengths and weaknesses of each of these methods as guidance for future researchers and reform.
    Methods: All RCTs published between 2015 and 2021 were systematically extracted from 4 behavioral medicine journals and analyzed based on prespecified inclusion criteria. Two independent raters classified each of the manuscripts into 1 of 5 RCT analysis strategies.
    Results: There was wide variation in the methods used. The 2 most prevalent analyses for RCTs were longitudinal modeling and analysis of covariance. Application of method varied significantly by sample size.
    Significance of results: Each statistical analysis presents its own unique strengths and weaknesses. The information resulting from this research may prove helpful for researchers in palliative care and behavioral medicine in navigating the variety of statistical methods available. Future discussion around best practices in RCT analyses is warranted to compare the relative impact of interventions in a more standardized way.
    MeSH term(s) Humans ; Randomized Controlled Trials as Topic ; Surveys and Questionnaires
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2454009-2
    ISSN 1478-9523 ; 1478-9515
    ISSN (online) 1478-9523
    ISSN 1478-9515
    DOI 10.1017/S1478951523000512
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    Zs.A 6697: Show issues Location:
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  9. Article: Type 1 Diabetes Mellitus, Psychopathology, Uncertainty and Alexithymia: A Clinical and Differential Exploratory Study.

    Merlo, Emanuele Maria / Tutino, Rita / Myles, Liam Alexander MacKenzie / Alibrandi, Angela / Lia, Maria Carmela / Minasi, Domenico

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 2

    Abstract: Type 1 diabetes mellitus (T1DM) represents a complex pathology affecting a large number of people. Research suggests that psychological factors influence coping with T1DM. This study aimed to investigate the presence and role of psychopathology, ... ...

    Abstract Type 1 diabetes mellitus (T1DM) represents a complex pathology affecting a large number of people. Research suggests that psychological factors influence coping with T1DM. This study aimed to investigate the presence and role of psychopathology, alexithymia and uncertainty in people affected by T1DM. The sample consisted of 137 patients (88 females, 49 males) affected by T1DM aged from 11 to 19 years old (Mean: 13.87; SD: 2.40). The diagnostic protocol consisted of a sociodemographic questionnaire, Self-administration Psychiatric Scales for Children and Adolescents (SAFA), Toronto Alexithymia Scale-20 (TAS-20) and Intolerance to Uncertainty Scale-12 (IUS-12). Descriptive, differential, correlational and regression analyses were performed in order to examine the relationships between these variables. The results suggested the sample had high levels of psychopathological indexes, alexithymia and intolerance of uncertainty. Also, there were significant differences between TAS-20 and IUS-12 distributions with respect to psychopathology. Correlations and multivariate linear regressions indicated age, gender and education significantly predicted alexithymia and intolerance of uncertainty. This data suggest the presence of elevated psychopathology, alexithymia and uncertainty in people with diabetes.
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12020257
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  10. Article: Bowel perforation in Crohn's Disease: correlation between CDAI and Clavien-Dindo scores.

    Fontana, T / Falco, N / Torchia, M / Tutino, R / Gulotta, G

    Il Giornale di chirurgia

    2018  Volume 38, Issue 6, Page(s) 303–312

    Abstract: Background: Many studies have elaborated different kind of activity indices for Crohn's Disesase (CD) with the endpoint of univocally measure and evaluate the gravity of its lesions and symptoms.: Aim: Purpose of this work is to study and define the ... ...

    Abstract Background: Many studies have elaborated different kind of activity indices for Crohn's Disesase (CD) with the endpoint of univocally measure and evaluate the gravity of its lesions and symptoms.
    Aim: Purpose of this work is to study and define the correlation that runs between the preoperative score obtained at the Crohn's Disease Activity Index, the occurrence of postoperative complications that will require re-intervention and the severity of the postoperative lesions evaluated using the Clavien-Dindo score.
    Patients and methods: We have collected and analyzed data from 23 patients (12 males, 11 females) that in a period that spans from 2010 to 2016 had been recovered in our Operative Unit and then undergone surgical treatment for the perforative complications of the CD.
    Results: The CDAI scores obtained for each patient and the data concerning their postoperative period have been analyzed using the ANOVA system. Results demonstrate the existence of a statistically signifying correlation (p = 0.0016) between the mean category's CDAI score and the Clavien-Dindo classification.
    Conclusions: Despite the small number of patients that had been recruited and analyzed in our study, it clearly shows a statistically signifying correlation between CDAI scores higher than 150 points and the risk of occurrence of severe postoperative complications in patients that had been subjected to surgical procedures for perforative or abscessual complications in Crohn's Disease.
    MeSH term(s) Adult ; Crohn Disease/complications ; Female ; Humans ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Male ; Postoperative Complications/epidemiology ; Severity of Illness Index
    Language English
    Publishing date 2018-02-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605974-0
    ISSN 1971-145X ; 0391-9005
    ISSN (online) 1971-145X
    ISSN 0391-9005
    DOI 10.11138/gchir/2017.38.6.303
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