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  1. Article ; Online: CKD screening for better kidney health: Why? Who? How? When?

    Tuttle, Katherine R

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2024  

    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfae055
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  2. Article ; Online: Digging deep into cells to find mechanisms of kidney protection by SGLT2 inhibitors.

    Tuttle, Katherine R

    The Journal of clinical investigation

    2023  Volume 133, Issue 5

    Abstract: The sodium-glucose cotransporter-2 (SGLT2) is expressed on the luminal side of proximal tubule epithelial cells in the kidney. While pharmacological inhibition of SGLT2 provides kidney protection in diabetic kidney disease (DKD), the molecular mechanisms ...

    Abstract The sodium-glucose cotransporter-2 (SGLT2) is expressed on the luminal side of proximal tubule epithelial cells in the kidney. While pharmacological inhibition of SGLT2 provides kidney protection in diabetic kidney disease (DKD), the molecular mechanisms remain unclear. In this issue of the JCI, Schaub et al. report on the changes in single-cell transcriptional profiles of young participants with type 2 diabetes who received SGLT2 inhibitors. Treatment with SGLT2 inhibitors restored metabolic perturbations in proximal tubular cells and reduced expression of the inflammatory signaling molecule mTORC1. Notably, changes in transcripts and mTORC1 were also found in the kidney of a diabetes mouse model treated with an SGLT2 inhibitor, supporting use of this model for further studies. These findings reveal cellular mechanisms of SGLT2 inhibitors and are important for advancing therapeutic targets in the treatment of DKD.
    MeSH term(s) Animals ; Mice ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2/genetics ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Kidney ; Mechanistic Target of Rapamycin Complex 1/genetics
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Sodium-Glucose Transporter 2 ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI167700
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  3. Article ; Online: Learnings from Throwing Paint at the Wall for COVID-19 with an SGLT2 Inhibitor.

    Tuttle, Katherine R

    Clinical journal of the American Society of Nephrology : CJASN

    2022  Volume 17, Issue 5, Page(s) 628–630

    MeSH term(s) Benzhydryl Compounds ; COVID-19 ; Glucosides ; Humans ; Kidney/drug effects ; Paint ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects
    Chemical Substances Benzhydryl Compounds ; Glucosides ; Sodium-Glucose Transporter 2 Inhibitors ; dapagliflozin (1ULL0QJ8UC)
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.03250322
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  4. Article ; Online: Forecasting therapeutic responses by albuminuria and eGFR slope during the DAPA-CKD trial.

    Tuttle, Katherine R

    The lancet. Diabetes & endocrinology

    2021  Volume 9, Issue 11, Page(s) 727–728

    MeSH term(s) Albuminuria ; Glomerular Filtration Rate ; Humans ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2021-10-04
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(21)00265-5
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  5. Article ; Online: Breaking New Ground with Incretin Therapy in Diabetes.

    Tuttle, Katherine R

    The New England journal of medicine

    2021  Volume 385, Issue 6, Page(s) 560–561

    MeSH term(s) Diabetes Mellitus ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Incretins/therapeutic use
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents ; Incretins
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2109957
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  6. Article ; Online: Accelerated Risk-Based Implementation of Guideline-Directed Medical Therapy for Type 2 Diabetes and Chronic Kidney Disease.

    Neuen, Brendon L / Tuttle, Katherine R / Vaduganathan, Muthiah

    Circulation

    2024  Volume 149, Issue 16, Page(s) 1238–1240

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/epidemiology
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.068524
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  7. Article ; Online: The authors reply.

    Fung, Winston W S / Luyckx, Valerie A / Tuttle, Katherine R

    Kidney international

    2024  

    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.03.013
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  8. Article ; Online: The authors reply.

    Fung, Winston W S / Luyckx, Valerie A / Tuttle, Katherine R

    Kidney international

    2024  

    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.03.015
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  9. Article ; Online: SGLT2 inhibition and chronic kidney disease outcomes: in diabetes and beyond.

    Tuttle, Katherine R

    The lancet. Diabetes & endocrinology

    2020  Volume 9, Issue 1, Page(s) 3–5

    MeSH term(s) Benzhydryl Compounds ; Cardiovascular Diseases ; Diabetes Mellitus ; Glucosides ; Humans ; Kidney ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Sodium-Glucose Transporter 2
    Chemical Substances Benzhydryl Compounds ; Glucosides ; Sodium-Glucose Transporter 2 ; dapagliflozin (1ULL0QJ8UC)
    Language English
    Publishing date 2020-12-29
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(20)30374-0
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  10. Article ; Online: Impact of the COVID-19 pandemic on clinical research.

    Tuttle, Katherine R

    Nature reviews. Nephrology

    2020  Volume 16, Issue 10, Page(s) 562–564

    MeSH term(s) Betacoronavirus ; Biomedical Research/trends ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-00336-9
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