Article ; Online: E-cigarette Use and Disease Outcomes in Inflammatory Bowel Diseases: A Case-Control Study.
Digestive diseases and sciences
2022 Volume 68, Issue 1, Page(s) 208–213
Abstract: Introduction: Traditional cigarette use adversely impacts disease outcomes in Crohn's disease (CD). There has been a worldwide increase in the use of e-cigarettes over the past decade. The impact of use of nicotine containing e-cigarettes on disease ... ...
| Abstract | Introduction: Traditional cigarette use adversely impacts disease outcomes in Crohn's disease (CD). There has been a worldwide increase in the use of e-cigarettes over the past decade. The impact of use of nicotine containing e-cigarettes on disease outcomes in CD or ulcerative colitis (UC) has not been well defined. Methods: This was a retrospective case-control study of patients with CD or UC who were current users of nicotine containing e-cigarettes (cases). Each case was matched to two non-vaping controls. Our primary study outcome was a composite of new biologic initiation, switch of existing biologic therapy, or IBD-related hospitalization or surgery over 2 years. Multivariable models adjusting for relevant covariates were construction. Results: The study consisted of 127 patients with IBD who were current e-cigarette users compared to 251 controls. Current e-cigarette users were younger than non-users and were more likely to have had an IBD-related surgery previously. On multivariable analysis among those with CD, current e-cigarette use was not associated with higher risk of study outcome (OR 0.82, 95% CI 0.36-1.87). No difference was observed separately among those who were current or former smokers. Similarly, in those with UC, current e-cigarette use was not associated with the primary outcome (OR 1.05, 95% CI 0.33-3.39). Conclusion: Current e-cigarette use was not associated with worse outcomes among patients with IBD. However, larger studies particularly of patients de novo initiating vaping are needed to draw robust conclusions. Patients should be discouraged from initiating vaping recognizing overall adverse health effects. |
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| MeSH term(s) | Humans ; Electronic Nicotine Delivery Systems ; Case-Control Studies ; Nicotine ; Retrospective Studies ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/therapy ; Crohn Disease/diagnosis ; Crohn Disease/epidemiology |
| Chemical Substances | Nicotine (6M3C89ZY6R) |
| Language | English |
| Publishing date | 2022-05-17 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
| ZDB-ID | 304250-9 |
| ISSN | 1573-2568 ; 0163-2116 |
| ISSN (online) | 1573-2568 |
| ISSN | 0163-2116 |
| DOI | 10.1007/s10620-022-07539-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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