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  1. Article ; Online: Trials and tribulations of young residents fighting COVID-19.

    Beyens, Michiel Marcel Jozef / Verelst, Faro R / Moorkens, Greta / Twickler, Marcel ThB

    European journal of clinical investigation

    2020  Volume 50, Issue 7, Page(s) e13336

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Infection Control ; Internal Medicine/education ; Internship and Residency ; Medical Staff, Hospital ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Terminal Care ; Visitors to Patients
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Editorial
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13336
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    Zs.A 677: Show issues Location:
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  2. Article ; Online: Is prolactin involved in the evolution of atherothrombotic disease?

    Reuwer, Anne Q / Hoekstra, Menno / Touraine, Philippe / Twickler, Marcel ThB / Goffin, Vincent

    Expert review of endocrinology & metabolism

    2019  Volume 7, Issue 3, Page(s) 345–361

    Abstract: Cardiovascular diseases (CVDs) account for approximately 30% of all deaths globally. The most important cause of CVD is atherothrombosis, in other words, narrowing of the arteries as a result of the deposition of cholesterol and other lipoid substances ... ...

    Abstract Cardiovascular diseases (CVDs) account for approximately 30% of all deaths globally. The most important cause of CVD is atherothrombosis, in other words, narrowing of the arteries as a result of the deposition of cholesterol and other lipoid substances within the arterial wall. Several endocrine disorders have been linked to this pathological state. Recent clinical and experimental studies have suggested that prolactin, a pleiotropic pituitary hormone, may potentially contribute to CVD, either through direct modulation of local cellular processes within atherosclerotic plaques/thrombi and/or through influencing conventional cardiovascular metabolic risk factors. However, the precise role of prolactin in the pathology of CVD remains largely unknown. Here, the authors speculate whether prolactin-lowering treatment may become a future therapeutic approach in patients with elevated prolactin levels and concomitantly presenting with coexisting vascular disease or a significantly elevated risk for premature atherothrombotic vascular disease. Awareness of these new developments may also change our clinical opinions about therapeutic strategies in patients with prolactinomas.
    Language English
    Publishing date 2019-02-19
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/eem.12.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Trials and tribulations of young residents fighting COVID‐19

    Beyens, Michiel Marcel Jozef / Verelst, Faro R. / Moorkens, Greta / Twickler, Marcel ThB

    European Journal of Clinical Investigation

    2020  Volume 50, Issue 7

    Keywords Clinical Biochemistry ; Biochemistry ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13336
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Cardiovascular Endocrinology

    Twickler, Marcel Th.B

    Seminars in Vascular Medicine

    (Cardiovascular Endocrinology)

    2004  Volume 4, Issue 02, Page(s) 105–106

    Series title Cardiovascular Endocrinology
    Language English
    Publishing date 2004-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2055723-1
    ISSN 1529-3505 ; 1528-9648
    ISSN (online) 1529-3505
    ISSN 1528-9648
    DOI 10.1055/s-2004-835366
    Database Thieme publisher's database

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  6. Article: High-Density Lipoprotein as a Key Component in the Prevention of Premature Atherosclerotic Disease in the Insulin Resistance Syndrome

    Hansel, Boris / Kontush, Anatol / Twickler, Marcel Th.B

    Seminars in Vascular Medicine

    2004  Volume 4, Issue 02, Page(s) 215–223

    Keywords Metabolic syndrome ; insulin resistance ; HDL ; prevention ; atherosclerotic disease
    Language English
    Publishing date 2004-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2055723-1
    ISSN 1529-3505 ; 1528-9648
    ISSN (online) 1529-3505
    ISSN 1528-9648
    DOI 10.1055/s-2004-835381
    Database Thieme publisher's database

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  7. Article: Mechanistic Insights and Clinical Relevance of the Interaction between Acute Coronary Syndromes and Lipid Metabolism

    Correia, Luis C.L / Twickler, Marcel Th.B / Sposito, Andrei C

    Seminars in Vascular Medicine

    2004  Volume 4, Issue 02, Page(s) 197–202

    Keywords Acute coronary syndromes ; lipoproteins ; cholesterol ; triglycerides
    Language English
    Publishing date 2004-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2055723-1
    ISSN 1529-3505 ; 1528-9648
    ISSN (online) 1529-3505
    ISSN 1528-9648
    DOI 10.1055/s-2004-835378
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Prolactin levels and the risk of future coronary artery disease in apparently healthy men and women.

    Reuwer, Anne Q / Twickler, Marcel ThB / Hutten, Barbara A / Molema, Frederique W / Wareham, Nicholas J / Dallinga-Thie, Geesje M / Bogorad, Roman L / Goffin, Vincent / Smink-Bol, Mijke / Kastelein, John J P / Boekholdt, S Matthijs / Khaw, Kay-Tee

    Circulation. Cardiovascular genetics

    2009  Volume 2, Issue 4, Page(s) 389–395

    Abstract: Background: Prolactin is increasingly recognized to play a stimulatory role in the inflammatory response. Because inflammation is considered of crucial importance in the development of atherosclerosis, we aimed to evaluate whether prolactin levels are ... ...

    Abstract Background: Prolactin is increasingly recognized to play a stimulatory role in the inflammatory response. Because inflammation is considered of crucial importance in the development of atherosclerosis, we aimed to evaluate whether prolactin levels are associated with the occurrence of coronary artery disease (CAD).
    Methods and results: We performed a nested case-control study in the prospective EPIC-Norfolk cohort. Cases were apparently healthy men and women, aged 45 to 79 years, who developed fatal or nonfatal CAD (n=882). Controls remained free of CAD (n=1490). Overall, systemic prolactin levels did not differ between cases and controls, and people in the highest prolactin tertile did not have a significantly increased risk of developing future CAD (in men, odds ratio, 1.21; 95% CI, 0.92 to 1.61; in women, odds ratio, 1.12; 95% CI, 0.76 to 1.64). However, in a separate immunohistochemical study, the presence of prolactin receptors could be demonstrated in postmortem human coronary artery plaques (preliminary data).
    Conclusions: Elevated systemic prolactin levels do not predict CAD in the general population. However, prolactin receptors were found in human coronary artery plaques. This observation may indicate a role of prolactin within atherosclerotic plaques. More studies are needed to define the possible role of prolactin in atherosclerotic plaque development.
    MeSH term(s) Aged ; Atherosclerosis/pathology ; Case-Control Studies ; Cohort Studies ; Coronary Artery Disease/epidemiology ; Coronary Vessels/pathology ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Prolactin/blood ; Receptors, Prolactin/metabolism ; Risk Factors
    Chemical Substances Receptors, Prolactin ; Prolactin (9002-62-4)
    Language English
    Publishing date 2009-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2477394-3
    ISSN 1942-3268 ; 1942-325X
    ISSN (online) 1942-3268
    ISSN 1942-325X
    DOI 10.1161/CIRCGENETICS.109.853572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6731: Show issues Location:
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