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  1. Article: Circulating Tumour DNA and Its Prognostic Role in Management of Muscle Invasive Bladder Cancer: A Narrative Review of the Literature.

    Kapriniotis, Konstantinos / Tzelves, Lazaros / Lazarou, Lazaros / Mitsogianni, Maria / Mitsogiannis, Iraklis

    Biomedicines

    2024  Volume 12, Issue 4

    Abstract: Current management of non-metastatic muscle invasive bladder cancer (MIBC) includes radical cystectomy and cisplatin-based neoadjuvant chemotherapy (NAC), offers a 5-year survival rate of approximately 50% and is associated with significant toxicities. A ...

    Abstract Current management of non-metastatic muscle invasive bladder cancer (MIBC) includes radical cystectomy and cisplatin-based neoadjuvant chemotherapy (NAC), offers a 5-year survival rate of approximately 50% and is associated with significant toxicities. A growing body of evidence supports the role of liquid biopsies including circulating tumour DNA (ctDNA) as a prognostic and predictive marker that could stratify patients according to individualised risk of progression/recurrence. Detectable ctDNA levels prior to radical cystectomy have been shown to be correlated with higher risk of recurrence and worse overall prognosis after cystectomy. In addition, ctDNA status after NAC/neoadjuvant immunotherapy is predictive of the pathological response to these treatments, with persistently detectable ctDNA being associated with residual bladder tumour at cystectomy. Finally, detectable ctDNA levels post-cystectomy have been associated with disease relapse and worse disease-free (DFS) and overall survival (OS) and might identify a population with survival benefit from adjuvant immunotherapy.
    Language English
    Publishing date 2024-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12040921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cystine Stones: Developments in Minimally Invasive Surgery and Their Impact on Morbidity and Stone Clearance.

    Hughes, Thomas / Tzelves, Lazaros / Somani, Bhaskar K

    Research and reports in urology

    2023  Volume 15, Page(s) 175–185

    Abstract: Cystinuria is a rare genetic condition that is responsible for cystine stones. Besides stone recurrence, patients with cystine stones have reduced health-related quality of life, increased rates of chronic kidney disease and hypertension. Although ... ...

    Abstract Cystinuria is a rare genetic condition that is responsible for cystine stones. Besides stone recurrence, patients with cystine stones have reduced health-related quality of life, increased rates of chronic kidney disease and hypertension. Although lifestyle measures, medical therapy and close follow up are essential to reduce and monitor cystine stone recurrences, surgical intervention is frequently needed for most cystinuria patients. Shock wave lithotripsy, ureteroscopy, percutaneous nephrolithotomy and active surveillance all have a role, and technological advances in endourology are vital in achieving a stone-free status and to prevent recurrences. The complexity of managing cystine stones necessitates a multidisciplinary team discussion, patient involvement and an individualised approach in a specialist centre for optimum management. Thulium fibre laser and virtual reality may have an increasing role in the future of cystine stone management.
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2649530-2
    ISSN 2253-2447
    ISSN 2253-2447
    DOI 10.2147/RRU.S381190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Patient experiences and perceptions of kidney stone surgery: what lessons can be learned from TikTok?

    Juliebø-Jones, Patrick / Tzelves, Lazaros / Beisland, Christian / Roth, Ingunn / Somani, Bhaskar K

    Frontiers in surgery

    2024  Volume 11, Page(s) 1374851

    Abstract: Introduction: The aim of this study was to perform an evaluation of patient experiences and perceptions regarding kidney stone surgery on the social media platform TikTok. An increasing number of the public use social media (SoMe) as a platform to share ...

    Abstract Introduction: The aim of this study was to perform an evaluation of patient experiences and perceptions regarding kidney stone surgery on the social media platform TikTok. An increasing number of the public use social media (SoMe) as a platform to share their views regarding their experiences related to surgical treatment.
    Methods: Using the hashtag #kidneystonesurgery, the 100 most recent video posts as of 01.01.2024 on TikTok were included. As well as demographic data such as gender and location, thematic content was also collected. To achieve this, a previously published framework was used and adapted for application in the setting of kidney stone surgery. This was piloted on 20 sample videos to assess its feasibility before revision and establishment of the final framework. This included the following key areas: Pain, Complications, Anxiety, Recovery, Return to work, Finances, Treatment delays, Diet and Prevention and stent complaints.
    Results: The majority of posts (95%) were from North America, 80% by females and the mean number of video views was 92,826 (range: 261-2,000,000). 76% of the videos discussed ureteroscopy (URS). 49% were filmed at the hospital, which was named in 9% of the videos. Top three topics discussed were: Recovery (65%), pain (62%) and stents (55%). This was followed by anxiety (39%) and complications (24%). 12% of these videos uploaded by lay people included basic medical information that was wholly incorrect. More than half of the posts (51%) were negative in tone. Treatment delays (5%) and a lack of sufficient preoperative information (4%) were also raised, that appeared to contribute to the negative reports. However, the main cause for negative tone owed to the 80% of the patients (
    Conclusion: There is a high level of usership and engagement on TikTok on the subject of kidney stone surgery. The proportion of negative videos is high and much of this is related to the bothersome stent symptoms and complications. This could easily lead to misperceptions among potential patients about the true burden of such adverse events.
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2024.1374851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Lymphoepithelioma-Like Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature.

    Mitsogiannis, Iraklis / Tzelves, Lazaros / Mitsogianni, Maria / Vgenopoulou, Stephanie

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21281

    Abstract: Lymphoepithelioma-like carcinoma of the urinary bladder is a rare variant of infiltrating urothelial carcinoma. Diagnostic and therapeutic manipulations are not yet standardised, due to the rarity of the tumour, with surgery and chemotherapy being ... ...

    Abstract Lymphoepithelioma-like carcinoma of the urinary bladder is a rare variant of infiltrating urothelial carcinoma. Diagnostic and therapeutic manipulations are not yet standardised, due to the rarity of the tumour, with surgery and chemotherapy being reported as potential therapeutic options. We report on a case of lymphoepithelioma-like carcinoma of the bladder in a 93-year-old female patient and discuss the pathological features and therapeutic options of the neoplasm. Due to her increased age and associated comorbidities such as hypertension, diabetes mellitus and ischemic heart disease, the patient was treated with transurethral resection of the tumour and subsequent cisplatin-based chemotherapy but unfortunately died of chemotherapy-related complications.
    Language English
    Publishing date 2022-01-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Denonvilliers' Fascia: The Prostate Border to the Outside World.

    Tzelves, Lazaros / Protogerou, Vassilis / Varkarakis, Ioannis

    Cancers

    2022  Volume 14, Issue 3

    Abstract: The fascial structure around the prostate has been a controversial issue for several decades, but its role in radical prostatectomy is crucial to achieving successful nerve-sparing surgery. One of the fasciae surrounding the prostate is Denonvilliers' ... ...

    Abstract The fascial structure around the prostate has been a controversial issue for several decades, but its role in radical prostatectomy is crucial to achieving successful nerve-sparing surgery. One of the fasciae surrounding the prostate is Denonvilliers' fascia, forming its posterior border with the rectum and enclosing along its layers several fibers of the neurovascular bundle. This review focuses on embryological and anatomical points of Denonvilliers' fascia, aiming to provide a summary for the operating general surgeons and urologists of this area.
    Language English
    Publishing date 2022-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14030688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Suction Use During Endourological Procedures.

    Tzelves, Lazaros / Skolarikos, Andreas

    Current urology reports

    2020  Volume 21, Issue 11, Page(s) 46

    Abstract: Purpose of review: Equipment used in endourology is constantly evolving due to increasing incidence of urolithiasis. Suctioning has been used mainly in PCNL in conjunction with ultrasonic and ballistic devices for stone removal. Recently technological ... ...

    Abstract Purpose of review: Equipment used in endourology is constantly evolving due to increasing incidence of urolithiasis. Suctioning has been used mainly in PCNL in conjunction with ultrasonic and ballistic devices for stone removal. Recently technological advances permitted the use of suctioning in more endourological techniques. This review aims to summarize the literature regarding these advancements and analyze the upcoming results.
    Recent findings: Several centers have conducted experimental and clinical studies on suctioning use during PCNL, mPCNL, and ureteroscopy and concluded that it is an effective and safe adjustment that improves stone-free rates and limits complication rates after these procedures. Suctioning use during common endourological procedures led to improved safety and efficacy among several indications. Due to the observational nature and small sample size of many studies, larger RCTs are needed to make safe conclusions.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Nephrolithotomy, Percutaneous/adverse effects ; Nephrolithotomy, Percutaneous/instrumentation ; Nephrolithotomy, Percutaneous/methods ; Suction/adverse effects ; Suction/instrumentation ; Suction/methods ; Treatment Outcome ; Ureteroscopy/instrumentation ; Ureteroscopy/methods ; Urolithiasis/therapy
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057354-6
    ISSN 1534-6285 ; 1527-2737
    ISSN (online) 1534-6285
    ISSN 1527-2737
    DOI 10.1007/s11934-020-00998-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Innovations in Kidney Stone Removal.

    Tzelves, Lazaros / Geraghty, Robert Michael / Hughes, Thomas / Juliebø-Jones, Patrick / Somani, Bhaskar K

    Research and reports in urology

    2023  Volume 15, Page(s) 131–139

    Abstract: Urolithiasis is a common clinical condition, and surgical treatment is performed with different minimally invasive procedures, such as ureteroscopy, shockwave lithotripsy and percutaneous nephrolithotomy. Although the transition from open surgery to ... ...

    Abstract Urolithiasis is a common clinical condition, and surgical treatment is performed with different minimally invasive procedures, such as ureteroscopy, shockwave lithotripsy and percutaneous nephrolithotomy. Although the transition from open surgery to endourological procedures to treat this condition has been a paradigm shift, ongoing technological advancements have permitted further improvement of clinical outcomes with the development of modern equipment. Such innovations in kidney stone removal are new lasers, modern ureteroscopes, development of applications and training systems utilizing three-dimensional models, artificial intelligence and virtual reality, implementation of robotic systems, sheaths connected to vacuum devices and new types of lithotripters. Innovations in kidney stone removal have led to an exciting new era of endourological options for patients and clinicians alike.
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2649530-2
    ISSN 2253-2447
    ISSN 2253-2447
    DOI 10.2147/RRU.S386844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The effect of pelvic floor muscle training on urodynamic parameters in women with stress urinary incontinence.

    Tsikopoulos, Ioannis / Lazarou, Lazaros / Tzelves, Lazaros / Sakalis, Vasileios / Papathanasiou, Christina / Samarinas, Michael

    Central European journal of urology

    2023  Volume 76, Issue 4, Page(s) 315–321

    Abstract: Introduction: Pelvic floor muscle training (PFMT) is suggested for women with stress urinary incontinence (SUI). The aim of our study is to examine the effectiveness of PFMT on urodynamic (UDS) parameters.: Material and methods: This is a prospective ...

    Abstract Introduction: Pelvic floor muscle training (PFMT) is suggested for women with stress urinary incontinence (SUI). The aim of our study is to examine the effectiveness of PFMT on urodynamic (UDS) parameters.
    Material and methods: This is a prospective observational study enrolling women with SUI. Pelvic surgery, prolapse, body mass index >30, and cognitive disability were exclusion criteria. Patients had baseline UDS, then PFMT only (Group A) or PFMT plus biofeedback (BFD) (Group B) for 6 months and UDS 3 months after treatment. The primary investigated parameters were the number of pads used per day and Valsalva leak point pressure (VLPP).
    Results: Forty-six women completed the study, 22 in Group A and 24 in Group B. At baseline, all patients documented SUI with 3 median pads used per day. Urodynamic SUI was documented with a median Valsalva leak point pressure (mVLPP) of 45 cmH
    Conclusions: PFMT improves urodynamic parameters among women with SUI.
    Language English
    Publishing date 2023-11-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2672528-9
    ISSN 2080-4873 ; 2080-4806
    ISSN (online) 2080-4873
    ISSN 2080-4806
    DOI 10.5173/ceju.2023.148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Synchronous Testicular Cancer in Monozygotic Twins.

    Manolitsis, Ioannis / Tzelves, Lazaros / Bellos, Themistoklis / Berdempes, Marinos / Skolarikos, Andreas

    Cureus

    2022  Volume 14, Issue 3, Page(s) e22956

    Abstract: Testicular cancer is the most common neoplasm in men aged 15-45 years old, with several established risk factors such as cryptorchidism, age, and family history. We report a case of a 44-year-old man with a history of cryptorchidism who presented with ... ...

    Abstract Testicular cancer is the most common neoplasm in men aged 15-45 years old, with several established risk factors such as cryptorchidism, age, and family history. We report a case of a 44-year-old man with a history of cryptorchidism who presented with lesions in his right testis, a large retroperitoneal mass, and diffuse nodal lesions in his lungs. He underwent radical orchiectomy that showed testicular cancer and was immediately inducted into systemic therapy based on bleomycin, etoposide, and cisplatin. Two weeks later, his monozygotic twin brother, also reporting cryptorchidism at a young age, presented with a painless mass in his left testis. He underwent radical orchiectomy that revealed testicular cancer and received adjuvant chemotherapy. The first patient, after two cycles of chemotherapy, suffered from an episode of massive hematochezia and died while his brother remains relapse-free.
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Optimal Delivery of Follow-Up Care for the Prevention of Stone Recurrence in Urolithiasis Patients: Improving Outcomes.

    Tzelves, Lazaros / Berdempes, Marinos / Mourmouris, Panagiotis / Mitsogiannis, Iraklis / Skolarikos, Andreas

    Research and reports in urology

    2022  Volume 14, Page(s) 141–148

    Abstract: Urolithiasis is a common clinical condition with frequent recurrences. Advances in knowledge of pathophysiological mechanisms permit the categorization of patients to low and high risk for recurrence, with specific metabolic abnormalities diagnosed in ... ...

    Abstract Urolithiasis is a common clinical condition with frequent recurrences. Advances in knowledge of pathophysiological mechanisms permit the categorization of patients to low and high risk for recurrence, with specific metabolic abnormalities diagnosed in the second category. Follow-up is essential for patients with urolithiasis and consists of both imaging and metabolic follow-up with urine studies. No formal guidelines or solid evidence currently exists regarding frequency and type of follow-up studies to be performed in each category. This review aims to summarize existing evidence regarding follow-up, in order to guide clinicians on how and when to follow-up urolithiasis patients according to existing clinical scenario.
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2649530-2
    ISSN 2253-2447
    ISSN 2253-2447
    DOI 10.2147/RRU.S277498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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