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  1. Article ; Online: Correction to Insights to the Binding of a Selective Adenosine A

    Lagarias, Panagiotis / Barkan, Kerry / Tzortzini, Eva / Stampelou, Margarita / Vrontaki, Eleni / Ladds, Graham / Kolocouris, Antonios

    Journal of chemical information and modeling

    2020  Volume 60, Issue 4, Page(s) 2405–2406

    Language English
    Publishing date 2020-03-25
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.0c00240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1230: Show issues Location:
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  2. Article ; Online: Insights to the Binding of a Selective Adenosine A

    Lagarias, Panagiotis / Barkan, Kerry / Tzortzini, Eva / Stampelou, Margarita / Vrontaki, Eleni / Ladds, Graham / Kolocouris, Antonios

    Journal of chemical information and modeling

    2019  Volume 59, Issue 12, Page(s) 5183–5197

    Abstract: Adenosine ... ...

    Abstract Adenosine A
    MeSH term(s) Adenosine A3 Receptor Antagonists/chemistry ; Adenosine A3 Receptor Antagonists/metabolism ; Adenosine A3 Receptor Antagonists/pharmacology ; Amides/chemistry ; Amides/metabolism ; Amides/pharmacology ; Melphalan/metabolism ; Melphalan/pharmacology ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutagenesis ; Poisson Distribution ; Protein Binding ; Protein Conformation ; Receptor, Adenosine A3/chemistry ; Receptor, Adenosine A3/genetics ; Receptor, Adenosine A3/metabolism ; Substrate Specificity ; Thermodynamics ; gamma-Globulins/metabolism ; gamma-Globulins/pharmacology
    Chemical Substances Adenosine A3 Receptor Antagonists ; Amides ; K-18 conjugate ; Receptor, Adenosine A3 ; gamma-Globulins ; Melphalan (Q41OR9510P)
    Language English
    Publishing date 2019-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.9b00751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Author Correction: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro.

    Toft-Bertelsen, Trine Lisberg / Jeppesen, Mads Gravers / Tzortzini, Eva / Xue, Kai / Giller, Karin / Becker, Stefan / Mujezinovic, Amer / Bentzen, Bo Hjorth / Andreas, Loren B / Kolocouris, Antonios / Kledal, Thomas Nitschke / Rosenkilde, Mette Marie

    Communications biology

    2021  Volume 4, Issue 1, Page(s) 1402

    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Published Erratum
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-021-02940-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2.

    Toft-Bertelsen, Trine Lisberg / Jeppesen, Mads Gravers / Tzortzini, Eva / Xue, Kai / Giller, Karin / Becker, Stefan / Mujezinovic, Amer / Bentzen, Bo Hjorth / B Andreas, Loren / Kolocouris, Antonios / Kledal, Thomas Nitschke / Rosenkilde, Mette Marie

    Communications biology

    2021  Volume 4, Issue 1, Page(s) 1347

    Abstract: The dire need for COVID-19 treatments has inspired strategies of repurposing approved drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical studies have indicated beneficial effects of this drug. We demonstrate that ... ...

    Abstract The dire need for COVID-19 treatments has inspired strategies of repurposing approved drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical studies have indicated beneficial effects of this drug. We demonstrate that amantadine and hexamethylene-amiloride (HMA), but not rimantadine, block the ion channel activity of Protein E from SARS-CoV-2, a conserved viroporin among coronaviruses. These findings agree with their binding to Protein E as evaluated by solution NMR and molecular dynamics simulations. Moreover, we identify two novel viroporins of SARS-CoV-2; ORF7b and ORF10, by showing ion channel activity in a X. laevis oocyte expression system. Notably, amantadine also blocks the ion channel activity of ORF10, thereby providing two ion channel targets in SARS-CoV-2 for amantadine treatment in COVID-19 patients. A screen of known viroporin inhibitors on Protein E, ORF7b, ORF10 and Protein 3a from SARS-CoV-2 revealed inhibition of Protein E and ORF7b by emodin and xanthene, the latter also blocking Protein 3a. This illustrates a general potential of well-known ion channel blockers against SARS-CoV-2 and specifically a dual molecular basis for the promising effects of amantadine in COVID-19 treatment. We therefore propose amantadine as a novel, cheap, readily available and effective way to treat COVID-19.
    MeSH term(s) Amantadine/pharmacology ; Amiloride/analogs & derivatives ; Amiloride/pharmacology ; Antiviral Agents/pharmacology ; Ion Channels/physiology ; Rimantadine/pharmacology ; SARS-CoV-2/drug effects ; Viral Proteins/physiology
    Chemical Substances Antiviral Agents ; Ion Channels ; Viral Proteins ; Rimantadine (0T2EF4JQTU) ; 5-(N,N-hexamethylene)amiloride (1428-95-1) ; Amiloride (7DZO8EB0Z3) ; Amantadine (BF4C9Z1J53)
    Language English
    Publishing date 2021-12-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-021-02866-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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