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  1. Book: Einfluß des Lebensalters, der Umgebungstemperatur, der relativen Luftfeuchtigkeit und der Luftgeschwindigkeit auf den Wärmehaushalt von Legehybriden / <2>

    Tzschentke, Barbara

    1986  

    Author's details vorgelegt von Tzschentke, Barbara geb. Oeser
    Collection Einfluß des Lebensalters, der Umgebungstemperatur, der relativen Luftfeuchtigkeit und der Luftgeschwindigkeit auf den Wärmehaushalt von Legehybriden
    Size [188] Bl. : graph. Darst.
    Publishing country XA-DDDE
    Document type Book
    HBZ-ID HT005032956
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  2. Book: Einfluß des Lebensalters, der Umgebungstemperatur, der relativen Luftfeuchtigkeit und der Luftgeschwindigkeit auf den Wärmehaushalt von Legehybriden / <1>

    Tzschentke, Barbara

    1986  

    Author's details vorgelegt von Tzschentke, Barbara geb. Oeser
    Collection Einfluß des Lebensalters, der Umgebungstemperatur, der relativen Luftfeuchtigkeit und der Luftgeschwindigkeit auf den Wärmehaushalt von Legehybriden
    Size 143, 6 Bl. : graph. Darst.
    Publishing country XA-DDDE
    Document type Book
    HBZ-ID HT005032929
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Impact of environmental thermal stimulation on activation of hypothalamic neuronal nitric oxide synthase during the prenatal ontogenesis in Muscovy ducks.

    Dunai, Valery / Tzschentke, Barbara

    TheScientificWorldJournal

    2012  Volume 2012, Page(s) 416936

    Abstract: The aim of the study is to investigate the influence of prenatal temperature stimulation on neuronal NO synthase (nNOS) expression in the anterior hypothalamus of Muscovy duck embryos. Experiments were performed on embryonic day (E) E20, E23, E28, and ... ...

    Abstract The aim of the study is to investigate the influence of prenatal temperature stimulation on neuronal NO synthase (nNOS) expression in the anterior hypothalamus of Muscovy duck embryos. Experiments were performed on embryonic day (E) E20, E23, E28, and E33 using histochemistry for identification of the nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) as marker of NOS-containing neurons. Until the experiments, all duck embryos were incubated under standard temperature conditions (37.5°C). During 3 hours before the start of the experiments, one group was incubated at 37.5°C (control group), the second was warm-experienced at 39°C, and the third was cold-experienced at 34°C. In normal and warm-incubated duck embryos, nNOS activity could be first detected on E23. Particularly, after cold stimulation, a significant increase in nNOS activity was found in all embryos investigated even on day 20. Warm stimulation obviously induces the opposite effect, but at later embryonic age (E33). It can be concluded that probably in late-term bird embryos NO acts as a mediator of the neuronal cold pathway in the anterior hypothalamus, which might be improved by prenatal cold stimulation.
    MeSH term(s) Age Factors ; Animals ; Biomarkers/metabolism ; Ducks/embryology ; Ducks/metabolism ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/embryology ; Embryo, Nonmammalian/enzymology ; Embryonic Development ; Enzyme Activation ; Hypothalamus, Anterior/cytology ; Hypothalamus, Anterior/embryology ; Hypothalamus, Anterior/enzymology ; NADPH Dehydrogenase/metabolism ; Neurons/cytology ; Neurons/enzymology ; Nitric Oxide Synthase Type I/metabolism ; Temperature
    Chemical Substances Biomarkers ; Nitric Oxide Synthase Type I (EC 1.14.13.39) ; NADPH Dehydrogenase (EC 1.6.99.1)
    Language English
    Publishing date 2012-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075968-X
    ISSN 1537-744X ; 1537-744X
    ISSN (online) 1537-744X
    ISSN 1537-744X
    DOI 10.1100/2012/416936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: DNA methylation and expression of proopiomelanocortin (POMC) gene in the hypothalamus of three‐week‐old chickens show sex‐specific differences

    Rancourt, Rebecca C. / Schellong, Karen / Tzschentke, Barbara / Henrich, Wolfgang / Plagemann, Andreas

    FEBS Open Bio. 2018 June, v. 8, no. 6

    2018  

    Abstract: Increased availability and improved sequence annotation of the chicken (Gallus gallus f. domestica) genome have sparked interest in the bird as a model system to investigate translational embryonic development and health/disease outcomes. However, the ... ...

    Abstract Increased availability and improved sequence annotation of the chicken (Gallus gallus f. domestica) genome have sparked interest in the bird as a model system to investigate translational embryonic development and health/disease outcomes. However, the epigenetics of this bird genome remain unclear. The aim of this study was to determine the levels of gene expression and DNA methylation at the proopiomelanocortin (POMC) gene in the hypothalamus of 3‐week‐old chickens. POMC is a key player in the control of the stress response, food intake, and metabolism. DNA methylation of the promoter, CpG island, and gene body regions of POMC were measured. Our data illustrate the pattern, variability, and functionality of DNA methylation for POMC expression in the chicken. Our findings show correlation of methylation pattern and gene expression along with sex‐specific differences in POMC. Overall, these novel data highlight the promising potential of the chicken as a model and also the need for breeders and researchers to consider sex ratios in their studies.
    Keywords DNA methylation ; Gallus gallus ; chickens ; embryogenesis ; epigenetics ; food intake ; gene expression ; genes ; genomic islands ; hypothalamus ; metabolism ; models ; pro-opiomelanocortin ; stress response
    Language English
    Dates of publication 2018-06
    Size p. 932-939.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2651702-4
    ISSN 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.12427
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Embryonic development of endothermy.

    Tzschentke, Barbara / Rumpf, Marion

    Respiratory physiology & neurobiology

    2011  Volume 178, Issue 1, Page(s) 97–107

    Abstract: During embryonic development of homeothermic animals like birds and mammals transition from ectothermy to endothermy occurs especially in precocial species of both taxa. Based on some evolutionary aspects of the development of endothermy the review ... ...

    Abstract During embryonic development of homeothermic animals like birds and mammals transition from ectothermy to endothermy occurs especially in precocial species of both taxa. Based on some evolutionary aspects of the development of endothermy the review focuses on the prenatal development of endothermy and of the thermoregulatory system using the precocial bird as a model. During final incubation precocial bird embryos have all the prerequisites to respond to environmental (temperature) influences in a nearly appropriate way. Autonomic, neuronal and molecular mechanisms underlying the development of endothermy are established and the transition of the thermoregulatory system from a control system without feedback into a system with feedback mechanisms occurs. Precocial bird embryos are endothermic, but not homeothermic if incubation temperature decreases below the normal level, which seems to be associated with summit metabolism. At increased incubation temperatures the embryos are able to stabilize their body temperature. Therefore, above normal temperatures, homoeothermy can occur over a limited temperature range.
    MeSH term(s) Animals ; Birds/embryology ; Body Temperature Regulation/physiology ; Embryo, Mammalian/physiology ; Embryo, Nonmammalian/physiology ; Humans
    Language English
    Publishing date 2011-08-31
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2011.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: DNA methylation and expression of proopiomelanocortin (

    Rancourt, Rebecca C / Schellong, Karen / Tzschentke, Barbara / Henrich, Wolfgang / Plagemann, Andreas

    FEBS open bio

    2018  Volume 8, Issue 6, Page(s) 932–939

    Abstract: Increased availability and improved sequence annotation of the chicken ( ...

    Abstract Increased availability and improved sequence annotation of the chicken (
    Language English
    Publishing date 2018-06
    Publishing country England
    Document type Journal Article
    ISSN 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.12427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Detection of long-term influence of prenatal temperature stimulation on hypothalamic type-II iodothyronine deiodinase in juvenile female broiler chickens using a novel immunohistochemical amplification protocol.

    Nassar, Maaly / Halle, Ingrid / Plagemann, Andreas / Tzschentke, Barbara

    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

    2014  Volume 179, Page(s) 120–124

    Abstract: It has been clearly shown that early environmental stimulation may have long-lasting influence on body functions. Because of the strong relationship between thermoregulation and other homeostatic linked physiological parameters, perinatal thermal ... ...

    Abstract It has been clearly shown that early environmental stimulation may have long-lasting influence on body functions. Because of the strong relationship between thermoregulation and other homeostatic linked physiological parameters, perinatal thermal manipulation will also have an impact on other body functions like reproduction. As a maturation stimulant for later reproductive performance, hypothalamic type-2 iodothyronine deiodinase (Dio2) expression was investigated in 35day old immature female broilers with and without embryonic temperature stimulation. For the first time, human-specific Dio2 primary antibodies combined with additional amplification enabled the immunohistochemical detection of hypothalamic Dio2 protein in birds. The novel protocol includes an additional amplification step involving swine-anti-rabbit/mouse/goat antibodies against both goat anti-Dio2 primary and rabbit anti-goat biotinylated secondary commercial antibodies in the standard diaminobenzidine protocol. However, significant Dio2 expression was exclusively found in perinatally short-term temperature stimulated hens. Caudal but not rostral hypothalamic slices revealed that elevating incubation temperature by 1°C for 2h daily, from day 18 of embryonic development until hatching, induced a statistical significant expression of Dio2 within the subcommisural organ and the median eminence. This ample expression of Dio2 protein within caudal but not rostral hypothalamic slices of embryonic temperature stimulated chickens, leads to the assumption of a novel physiological prospective for embryonic thermal manipulation involving the suppression of thyroid hormone and the boosting of hypothalamic Dio2-induced FSH secretion to considerably advance the age of photoinduced egg production. It could be also of practicable relevance for broiler breeder females, and needs further investigations.
    MeSH term(s) Animals ; Chick Embryo ; Chickens/metabolism ; Female ; Hypothalamus/embryology ; Hypothalamus/enzymology ; Immunohistochemistry/methods ; Iodide Peroxidase/metabolism ; Median Eminence/enzymology ; Temperature ; Time Factors ; Iodothyronine Deiodinase Type II
    Chemical Substances Iodide Peroxidase (EC 1.11.1.8)
    Language English
    Publishing date 2014-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2014.09.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 44/A: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Acquired alterations of hypothalamic gene expression of insulin and leptin receptors and glucose transporters in prenatally high-glucose exposed three-week old chickens do not coincide with aberrant promoter DNA methylation.

    Rancourt, Rebecca C / Schellong, Karen / Ott, Raffael / Bogatyrev, Semen / Tzschentke, Barbara / Plagemann, Andreas

    PloS one

    2015  Volume 10, Issue 3, Page(s) e0119213

    Abstract: Background: Prenatal exposures may have a distinct impact for long-term health, one example being exposure to maternal 'diabesity' during pregnancy increasing offspring 'diabesity' risk. Malprogramming of the central nervous regulation of body weight, ... ...

    Abstract Background: Prenatal exposures may have a distinct impact for long-term health, one example being exposure to maternal 'diabesity' during pregnancy increasing offspring 'diabesity' risk. Malprogramming of the central nervous regulation of body weight, food intake and metabolism has been identified as a critical mechanism. While concrete disrupting factors still remain unclear, growing focus on acquired epigenomic alterations have been proposed. Due to the independent development from the mother, the chicken embryo provides a valuable model to distinctively establish causal factors and mechanisms.
    Aim: The aim of this study was to determine the effects of prenatal hyperglycemia on postnatal hypothalamic gene expression and promoter DNA methylation in the chicken.
    Methods and findings: To temporarily induce high-glucose exposure in chicken embryos, 0.5 ml glucose solution (30 mmol/l) were administered daily via catheter into a vessel of the chorioallantoic egg membrane from days 14 to 17 of incubation. At three weeks of postnatal age, body weight, total body fat, blood glucose, mRNA expression (INSR, LEPR, GLUT1, GLUT3) as well as corresponding promoter DNA methylation were determined in mediobasal hypothalamic brain slices (Nucleus infundibuli hypothalami). Although no significant changes in morphometric and metabolic parameters were detected, strongly decreased mRNA expression occurred in all candidate genes. Surprisingly, however, no relevant alterations were observed in respective promoter methylation.
    Conclusion: Prenatal hyperglycemia induces strong changes in later hypothalamic expression of INSR, LEPR, GLUT1, and GLUT3 mRNA. While the chicken provides an interesting approach for developmental malprogramming, the classical expression regulation via promoter methylation was not observed here. This may be due to alternative/interacting brain mechanisms or the thus far under-explored bird epigenome.
    MeSH term(s) Animals ; Blood Glucose ; Body Weight ; Chick Embryo ; Chickens ; DNA Methylation ; Female ; Gene Expression ; Gene Expression Profiling ; Glucose/metabolism ; Glucose Transport Proteins, Facilitative/genetics ; Hypothalamus/metabolism ; Male ; Promoter Regions, Genetic ; Receptor, Insulin/genetics ; Receptors, Leptin/genetics ; Sex Factors
    Chemical Substances Blood Glucose ; Glucose Transport Proteins, Facilitative ; Receptors, Leptin ; Receptor, Insulin (EC 2.7.10.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0119213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Temporary prenatal hyperglycemia leads to postnatal neuronal 'glucose-resistance' in the chicken hypothalamus.

    Tzschentke, Barbara / Bogatyrev, Semjon / Schellong, Karen / Rancourt, Rebecca C / Plagemann, Andreas

    Brain research

    2015  Volume 1618, Page(s) 231–240

    Abstract: Prenatal exposures may have a distinct impact for long-term health. Exposure to maternal 'diabesity' during pregnancy increases offspring 'diabesity' risk, e.g. by malprogramming the central nervous regulation of body weight, food intake and metabolism. ... ...

    Abstract Prenatal exposures may have a distinct impact for long-term health. Exposure to maternal 'diabesity' during pregnancy increases offspring 'diabesity' risk, e.g. by malprogramming the central nervous regulation of body weight, food intake and metabolism. Critical mechanisms and concrete disrupting factors still remain unclear. Due to the independent development, from the mother, the chicken embryo could provide a valuable model to distinctively establish causal factors. Aim of this study was to determine effects of temporary prenatal hyperglycemia on postnatal hypothalamic neuronal glucose sensitivity in the chicken. To induce hyperglycemia in chicken embryos, 0.5 ml glucose solution (concentration 30 mmol/l) were daily administered via catheter into a vessel of the chorioallantoic egg membrane from days 14 to 17 of incubation. On day 21 of postnatal age, body weight, body fat content, blood glucose, neuroelectrophysiological glucose sensitivity as well as glucose transporter expression were determined in hypothalamic brain slices. No significant changes in morphometric and metabolic parameters were observed. However, strongly decreased neuronal glucose sensitivity and glucose transporter expression occurred, indicating prenatally acquired hypothalamic 'glucose-resistance'. In conclusion, temporary late prenatal hyperglycemia induces lasting changes in central glucose sensing. The prenatally glucose-treated chicken provides a valuable new model for investigating early central nervous origins of 'diabesity' and related disorders.
    MeSH term(s) Age Factors ; Animals ; Animals, Newborn ; Blood Glucose ; Body Composition/physiology ; Body Weight ; Chick Embryo ; Chickens ; Female ; Gene Expression Regulation, Developmental/physiology ; Glucose/adverse effects ; Glucose/metabolism ; Glucose Transporter Type 1/genetics ; Glucose Transporter Type 1/metabolism ; Glucose Transporter Type 3/genetics ; Glucose Transporter Type 3/metabolism ; Hyperglycemia/pathology ; Hypothalamus/growth & development ; Hypothalamus/metabolism ; In Vitro Techniques ; Neurons/drug effects ; Neurons/metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/pathology ; Statistics, Nonparametric
    Chemical Substances Blood Glucose ; Glucose Transporter Type 1 ; Glucose Transporter Type 3 ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2015-08-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2015.05.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book ; Online ; Thesis: Sex-linked molecular markers and their application to endocrine disruption research in amphibians

    Tamschick, Stephanie [Verfasser] / Stöck, Matthias [Gutachter] / Braunbeck, Thomas [Gutachter] / Tzschentke, Barbara [Gutachter]

    2016  

    Author's details Stephanie Tamschick ; Gutachter: Matthias Stöck, Thomas Braunbeck, Barbara Tzschentke
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Lebenswissenschaftliche Fakultät
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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