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  1. AU="Tzung-Chi Huang"
  2. AU="Nisa, Maherun"
  3. AU="Resnick, Adam C"
  4. AU="Thomas, Brodie"
  5. AU="Yaming Wang"
  6. AU="Lee, Chun‐Tsu"
  7. AU="Albert Gargallo‐Garriga"
  8. AU="Serwin, Natalia Maria"
  9. AU="La Rosa, Stefano"
  10. AU="Yin-Yin Xie"
  11. AU=White David P
  12. AU="Maria Teresa Viadero"
  13. AU="Wingeter, Márcia A"
  14. AU="Stein, Joshua D"
  15. AU="De Vecchis, Liana"
  16. AU="Chapman, Janet"
  17. AU="Umlai, Umm-Kulthum Ismail"
  18. AU="Reddi, Jyoti M"
  19. AU=Zeissig Sebastian
  20. AU="Valentini, Mariaconsuelo"

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  1. Artikel ; Online: Planning Lung Radiotherapy Incorporating Motion Freeze PET/CT Imaging

    Shih-Neng Yang / Wan-Chi Chiang / Kuei-Ting Chou / Geoffrey Zhang / Tzung-Chi Huang

    Applied Sciences, Vol 8, Iss 9, p

    2018  Band 1583

    Abstract: Motion Freeze (MF), which integrates 100% of the signal of each respiratory phase in four-dimensional positron emission tomography (4D-PET) images and creates the MF-PET, is capable of eliminate the influences induced by respiratory motion and dispersing ...

    Abstract Motion Freeze (MF), which integrates 100% of the signal of each respiratory phase in four-dimensional positron emission tomography (4D-PET) images and creates the MF-PET, is capable of eliminate the influences induced by respiratory motion and dispersing from three-dimensional PET (3D-PET) and 4D-PET images. In this study, the effectiveness of respiratory gated radiotherapy applying MF-PET (MF-Plan) in lung cancer patient was investigated and compared with three-dimensional intensity modulated radiotherapy (3D-Plan) and routine respiratory gated radiotherapy (4D-Plan) on the impact of target volume and dosimetry. Thirteen lung cancer patients were enrolled. The internal target volumes were generated with 40% of maximum standardized uptake value. The 3D-Plan, 4D-Plan, and MF-Plan were created for each patient to study the radiation to the targets and organs at risk. MF-Plans were associated with significant reductions in lung, heart, and spinal cord doses. The median reductions in lung V20, lung mean, heart mean doses, and spinal cord maximum dose compared with 3D-Plans were improved. When compared with 4D-Plans, the median reductions in lung V20, lung mean dose, heart mean dose, and spinal cord maximum dose were improved. Our results indicate that the MF-Plan may improve critical organ sparing in the lung, heart, and spinal cord, while maintaining high target coverage.
    Schlagwörter lung cancer ; 4D PET/CT ; respiratory gated radiotherapy ; motion freeze ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Deformation effect on SUVmax changes in thoracic tumors using 4-D PET/CT scan.

    Tzung-Chi Huang / Yao-Ching Wang

    PLoS ONE, Vol 8, Iss 3, p e

    2013  Band 58886

    Abstract: Respiratory motion blurs the standardized uptake value (SUV) and leads to a further signal reduction and changes in the SUV maxima. 4D PET can provide accurate tumor localization as a function of the respiratory phase in PET/CT imaging. We investigated ... ...

    Abstract Respiratory motion blurs the standardized uptake value (SUV) and leads to a further signal reduction and changes in the SUV maxima. 4D PET can provide accurate tumor localization as a function of the respiratory phase in PET/CT imaging. We investigated thoracic tumor motion by respiratory 4D CT and assessed its deformation effect on the SUV changes in 4D PET imaging using clinical patient data. Twelve radiation oncology patients with thoracic cancer, including five lung cancer patients and seven esophageal cancer patients, were recruited to the present study. The 4D CT and PET image sets were acquired and reconstructed for 10 respiratory phases across the whole respiratory cycle. The optical flow method was applied to the 4D CT data to calculate the maximum displacements of the tumor motion in respiration. Our results show that increased tumor motion has a significant degree of association with the SUVmax loss for lung cancer. The results also show that the SUVmax loss has a higher correlation with tumors located at lower lobe of lung or at lower regions of esophagus.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Quantitative Motion Analysis of Tai Chi Chuan

    Tsung-Jung Ho / Kuei-Ting Chou / Cheng-Hsuan Li / Bor-Chen Kuo / Tzung-Chi Huang

    BioMed Research International, Vol

    The Upper Extremity Movement

    2018  Band 2018

    Abstract: The quantitative and reproducible analysis of the standard body movement in Tai Chi Chuan (TCC) was performed in this study. We aimed to provide a reference of the upper extremities for standardizing TCC practice. Microsoft Kinect was used to record the ... ...

    Abstract The quantitative and reproducible analysis of the standard body movement in Tai Chi Chuan (TCC) was performed in this study. We aimed to provide a reference of the upper extremities for standardizing TCC practice. Microsoft Kinect was used to record the motion during the practice of TCC. The preparation form and eight essential forms of TCC performed by an instructor and 101 practitioners were analyzed in this study. The instructor completed an entire TCC practice cycle and performed the cycle 12 times. An entire cycle of TCC was performed by practitioners and images were recorded for statistics analysis. The performance of the instructor showed high similarity (Pearson correlation coefficient (r)=0.71~0.84) to the first practice cycle. Among the 9 forms, lay form had the highest similarity (rmean=0.90) and push form had the lowest similarity (rmean=0.52). For the practitioners, ward off form (rmean=0.51) and roll back form (rmean=0.45) had the highest similarity with moderate correlation. We used Microsoft Kinect to record the spatial coordinates of the upper extremity joints during the practice of TCC and the data to perform quantitative and qualitative analysis of the joint positions and elbow joint angle.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Thoracic tumor volume delineation in 4D-PET/CT by low dose interpolated CT for attenuation correction.

    Tzung-Chi Huang / Yao-Ching Wang / Chia-Hung Kao

    PLoS ONE, Vol 8, Iss 9, p e

    2013  Band 75903

    Abstract: PURPOSE: 4D-PET/CT imaging is an excellent solution for reducing the breathing-induced effects in both CT and PET images. In 4D-PET/CT, 4D-CT images are selected to match those of 4D-PET phase by phase and the corresponding phases are used for ... ...

    Abstract PURPOSE: 4D-PET/CT imaging is an excellent solution for reducing the breathing-induced effects in both CT and PET images. In 4D-PET/CT, 4D-CT images are selected to match those of 4D-PET phase by phase and the corresponding phases are used for attenuation correction in 4D-PET. However, the high radiation dose that patients acquire while undergoing 4D-CT imaging for diagnostic purposes remains a concern. This study aims to assess low-dose interpolated CT (ICT) for PET attenuation correction (PETICT) in thoracic tumor volume delineation. METHODS AND MATERIALS: Twelve thoracic cancer patients (10 esophageal and 2 lung cancer cases) were recruited. All patients underwent 4D-PET/CT scans. The optical flow method based on image intensity gradient was applied to calculate the motion displacement in three dimensions for each voxel on two original extreme CT phases in the respiratory cycle, end-inspiration and end-expiration. The interpolated CTs were generated from two phases of the original 4D-CT using motion displacement. RESULTS: Tumor motion due to respiration was estimated in the anterior-posterior dimension, the lateral dimension and the superior-inferior dimension by the optical flow method. The PETICT and ICT (4D-PET ICT/ICT) matched each other spatially in all the phases. The distortion of tumor shape and size resulting from respiratory motion artifacts were not observed in 4D-PETICT. The tumor volume measured by 4D-PET ICT/ICT correlated to the tumor volume measured by 4D-PET/CT (p = 0.98). CONCLUSIONS: 4D-PETICT consistently represented the interpretation of FDG uptake as effectively as 4D-PET. 4D-PET ICT/ICT is a low-dose alternative to 4D-CT and significantly improves the interpretation of PET and CT images, while solving the respiratory motion problem as effectively as 4D-PET/CT.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Respiratory motion reduction in PET/CT using abdominal compression for lung cancer patients.

    Tzung-Chi Huang / Yao-Ching Wang / Yu-Rou Chiou / Chia-Hung Kao

    PLoS ONE, Vol 9, Iss 5, p e

    2014  Band 98033

    Abstract: PURPOSE: Respiratory motion causes substantial artifacts in reconstructed PET images when using helical CT as the attenuation map in PET/CT imaging. In this study, we aimed to reduce the respiratory artifacts in PET/CT images of patients with lung tumors ...

    Abstract PURPOSE: Respiratory motion causes substantial artifacts in reconstructed PET images when using helical CT as the attenuation map in PET/CT imaging. In this study, we aimed to reduce the respiratory artifacts in PET/CT images of patients with lung tumors using an abdominal compression device. METHODS: Twelve patients with lung cancer located in the middle or lower lobe of the lung were recruited. The patients were injected with 370 MBq of 18F-FDG. During PET, the patients assumed two bed positions for 1.5 min/bed. After conducting free-breathing imaging, we obtained images of the patients with abdominal compression by applying the same setup used in the free-breathing scan. The differences in the standardized uptake value (SUV)max, SUVmean, tumor volume, and the centroid of the tumors between PET and various CT schemes were measured. RESULTS: The SUVmax and SUVmean derived from PET/CT imaging using an abdominal compression device increased for all the lesions, compared with those obtained using the conventional approach. The percentage increases were 18.1% ±14% and 17% ±16.8% for SUVmax and SUVmean, respectively. PET/CT imaging combined with abdominal compression generally reduced the tumor mismatch between CT and the corresponding attenuation corrected PET images, with an average decrease of 1.9±1.7 mm over all the cases. CONCLUSIONS: PET/CT imaging combined with abdominal compression reduces respiratory artifacts and PET/CT misregistration, and enhances quantitative SUV in tumor. Abdominal compression is easy to set up and is an effective method used in PET/CT imaging for clinical oncology, especially in the thoracic region.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Motion Freeze for Respiration Motion Correction in PET/CT

    Tzung-Chi Huang / Kuei-Ting Chou / Yao-Ching Wang / Geoffrey Zhang

    BioMed Research International, Vol

    A Preliminary Investigation with Lung Cancer Patient Data

    2014  Band 2014

    Abstract: Purpose. Respiratory motion presents significant challenges for accurate PET/CT. It often introduces apparent increase of lesion size, reduction of measured standardized uptake value (SUV), and the mismatch in PET/CT fusion images. In this study, we ... ...

    Abstract Purpose. Respiratory motion presents significant challenges for accurate PET/CT. It often introduces apparent increase of lesion size, reduction of measured standardized uptake value (SUV), and the mismatch in PET/CT fusion images. In this study, we developed the motion freeze method to use 100% of the counts collected by recombining the counts acquired from all phases of gated PET data into a single 3D PET data, with correction of respiration by deformable image registration. Methods. Six patients with diagnosis of lung cancer confirmed by oncologists were recruited. PET/CT scans were performed with Discovery STE system. The 4D PET/CT with the Varian real-time position management for respiratory motion tracking was followed by a clinical 3D PET/CT scan procedure in the static mode. Motion freeze applies the deformation matrices calculated by optical flow method to generate a single 3D effective PET image using the data from all the 4D PET phases. Results. The increase in SUV and decrease in tumor size with motion freeze for all lesions compared to the results from 3D and 4D was observed in the preliminary data of lung cancer patients. In addition, motion freeze substantially reduced tumor mismatch between the CT image and the corresponding PET images. Conclusion. Motion freeze integrating 100% of the PET counts has the potential to eliminate the influences induced by respiratory motion in PET data.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Kinetic Curve Type Assessment for Classification of Breast Lesions Using Dynamic Contrast-Enhanced MR Imaging.

    Shih-Neng Yang / Fang-Jing Li / Jun-Ming Chen / Geoffrey Zhang / Yen-Hsiu Liao / Tzung-Chi Huang

    PLoS ONE, Vol 11, Iss 4, p e

    2016  Band 0152827

    Abstract: OBJECTIVE:The aim of this study was to employ a kinetic model with dynamic contrast enhancement-magnetic resonance imaging to develop an approach that can efficiently distinguish malignant from benign lesions. MATERIALS AND METHODS:A total of 43 patients ...

    Abstract OBJECTIVE:The aim of this study was to employ a kinetic model with dynamic contrast enhancement-magnetic resonance imaging to develop an approach that can efficiently distinguish malignant from benign lesions. MATERIALS AND METHODS:A total of 43 patients with 46 lesions who underwent breast dynamic contrast enhancement-magnetic resonance imaging were included in this retrospective study. The distribution of malignant to benign lesions was 31/15 based on histological results. This study integrated a single-compartment kinetic model and dynamic contrast enhancement-magnetic resonance imaging to generate a kinetic modeling curve for improving the accuracy of diagnosis of breast lesions. Kinetic modeling curves of all different lesions were analyzed by three experienced radiologists and classified into one of three given types. Receiver operating characteristic and Kappa statistics were used for the qualitative method. The findings of the three radiologists based on the time-signal intensity curve and the kinetic curve were compared. RESULTS:An average sensitivity of 82%, a specificity of 65%, an area under the receiver operating characteristic curve of 0.76, and a positive predictive value of 82% and negative predictive value of 63% was shown with the kinetic model (p = 0.017, 0.052, 0.068), as compared to an average sensitivity of 80%, a specificity of 55%, an area under the receiver operating characteristic of 0.69, and a positive predictive value of 79% and negative predictive value of 57% with the time-signal intensity curve method (p = 0.003, 0.004, 0.008). The diagnostic consistency of the three radiologists was shown by the κ-value, 0.857 (p<0.001) with the method based on the time-signal intensity curve and 0.826 (p<0.001) with the method of the kinetic model. CONCLUSIONS:According to the statistic results based on the 46 lesions, the kinetic modeling curve method showed higher sensitivity, specificity, positive and negative predictive values as compared with the time-signal intensity curve method in ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Reconstructive Effects of Percutaneous Electrical Stimulation Combined with GGT Composite on Large Bone Defect in Rats

    Bo-Yin Yang / Tzung-Chi Huang / Yueh-Sheng Chen / Chun-Hsu Yao

    Evidence-Based Complementary and Alternative Medicine, Vol

    2013  Band 2013

    Abstract: Previous studies have shown the electromagnetic stimulation improves bone remodeling and bone healing. However, the effect of percutaneous electrical stimulation (ES) was not directly explored. The purpose of this study was to evaluate effect of ES on ... ...

    Abstract Previous studies have shown the electromagnetic stimulation improves bone remodeling and bone healing. However, the effect of percutaneous electrical stimulation (ES) was not directly explored. The purpose of this study was to evaluate effect of ES on improvement of bone repair. Twenty-four adult male Sprague-Dawley rats were used for cranial implantation. We used a composite comprising genipin cross-linked gelatin mixed with tricalcium phosphate (GGT). Bone defects of all rats were filled with the GGT composites, and the rats were assigned into six groups after operation. The first three groups underwent 4, 8, and 12 weeks of ES, and the anode was connected to the backward of the defect on the neck; the cathode was connected to the front of the defect on the head. Rats were under inhalation anesthesia during the stimulation. The other three groups only received inhalation anesthesia without ES, as control groups. All the rats were examined afterward at 4, 8, and 12 weeks. Radiographic examinations including X-ray and micro-CT showed the progressive bone regeneration in the both ES and non-ES groups. The amount of the newly formed bone increased with the time between implantation and examination in the ES and non-ES groups and was higher in the ES groups. Besides, the new bone growth trended on bilateral sides in ES groups and accumulated in U-shape in non-ES groups. The results indicated that ES could improve bone repair, and the effect is higher around the cathode.
    Schlagwörter Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Quantification of blood flow in internal cerebral artery by optical flow method on digital subtraction angiography in comparison with time-of-flight magnetic resonance angiography.

    Tzung-Chi Huang / Chih-Kai Chang / Chun-Han Liao / Yung-Jen Ho

    PLoS ONE, Vol 8, Iss 1, p e

    2013  Band 54678

    Abstract: OBJECTIVE: This study compared data on the blood flow velocity in the internal carotid artery, which was obtained using the optical flow method (OFM) with digital subtraction angiography (DSA) and the time-of-flight (TOF) technique using magnetic ... ...

    Abstract OBJECTIVE: This study compared data on the blood flow velocity in the internal carotid artery, which was obtained using the optical flow method (OFM) with digital subtraction angiography (DSA) and the time-of-flight (TOF) technique using magnetic resonance angiography (MRA). MATERIALS AND METHODS: Images were obtained from 12 cerebrovascular patients who underwent both brain DSA and MRA imaging. The OFM was applied on the DSA images to determine the average blood flow velocity. The calculated results were compared with the values obtained from the TOF-MRA data. A linear fit was performed on the data and Bland-Altman plots were analyzed. RESULTS: The blood flow velocity was closely associated with vascular diseases. Color-coding of the OFM measurements were superimposed on to the DSA images, which quantitatively illustrated the relative flow in the vessels. The average blood flow velocity was calculated using OFM and DSA, which demonstrated a high correlation with the MRA measurements in the anterior-posterior (AP) view (R = 0.71). In contrast, the average blood flow velocity was low in the lateral view (R = 0.28). The consistency between the high and low blood velocity in the AP view was better compared to the lateral view. The blood flow velocity distribution in the AP view was statistically closer to the MRA measurement compared to the lateral view. CONCLUSIONS: This study evaluated the correlation of blood flow measured using DSA and TOF-MRA in a small heterogeneous group of patients with cerebrovascular lesions. OFM with DSA imaging reveals hemodynamic information and TOF-MRA.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Radiomic features analysis in computed tomography images of lung nodule classification.

    Chia-Hung Chen / Chih-Kun Chang / Chih-Yen Tu / Wei-Chih Liao / Bing-Ru Wu / Kuei-Ting Chou / Yu-Rou Chiou / Shih-Neng Yang / Geoffrey Zhang / Tzung-Chi Huang

    PLoS ONE, Vol 13, Iss 2, p e

    2018  Band 0192002

    Abstract: Radiomics, which extract large amount of quantification image features from diagnostic medical images had been widely used for prognostication, treatment response prediction and cancer detection. The treatment options for lung nodules depend on their ... ...

    Abstract Radiomics, which extract large amount of quantification image features from diagnostic medical images had been widely used for prognostication, treatment response prediction and cancer detection. The treatment options for lung nodules depend on their diagnosis, benign or malignant. Conventionally, lung nodule diagnosis is based on invasive biopsy. Recently, radiomics features, a non-invasive method based on clinical images, have shown high potential in lesion classification, treatment outcome prediction.Lung nodule classification using radiomics based on Computed Tomography (CT) image data was investigated and a 4-feature signature was introduced for lung nodule classification. Retrospectively, 72 patients with 75 pulmonary nodules were collected. Radiomics feature extraction was performed on non-enhanced CT images with contours which were delineated by an experienced radiation oncologist.Among the 750 image features in each case, 76 features were found to have significant differences between benign and malignant lesions. A radiomics signature was composed of the best 4 features which included Laws_LSL_min, Laws_SLL_energy, Laws_SSL_skewness and Laws_EEL_uniformity. The accuracy using the signature in benign or malignant classification was 84% with the sensitivity of 92.85% and the specificity of 72.73%.The classification signature based on radiomics features demonstrated very good accuracy and high potential in clinical application.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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