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Article: Legionella

Jingu, Daisuke / Takahashi, Hiroshi / Ubukata, Satoshi / Watanabe, Hiroshi / Horii, Akira

2022 Volume 10, Issue 7, Page(s) e6090

Abstract: We experienced a patient ... ...

Abstract	We experienced a patient with
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.6090
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Article: Atezolizumab-related sclerosing cholangitis with multiple liver abscesses in a patient with lung squamous cell carcinoma: A case report.

Jingu, Daisuke / Horii, Akira / Yajima, Takehiro / Ohira, Ryuta / Ubukata, Satoshi / Satou, Kosuke / Takahashi, Hiroshi / Watanabe, Hiroshi / Funayama, Hiroyuki

Respirology case reports

2024 Volume 12, Issue 3, Page(s) e01324

Abstract: A 76-year-old man underwent an operation for lung squamous cell carcinoma in the right lower lobe, followed by initial adjuvant therapy with atezolizumab, an antibody against anti-programmed death-ligand 1 (PD-L1). On day 4 after atezolizumab treatment, ... ...

Abstract	A 76-year-old man underwent an operation for lung squamous cell carcinoma in the right lower lobe, followed by initial adjuvant therapy with atezolizumab, an antibody against anti-programmed death-ligand 1 (PD-L1). On day 4 after atezolizumab treatment, the patient developed general malaise and fatigue. He was diagnosed with atezolizumab-induced sclerosing cholangitis. Steroid treatment was started, and patient's condition, including symptoms, laboratory data and imaging findings, improved. Antibiotic treatments were ended on day 40, and the steroid dose was gradually reduced. Multiple liver abscesses were observed on day 106, and another treatment with antibiotics became necessary. The patient eventually recovered from liver abscesses. Sclerosing cholangitis induced by immune checkpoint inhibitor is rare, and the long-term clinical data about this adverse effect is limited. Hence, we think it is important to raise an alarm over sclerosing cholangitis coupled with liver abscesses after immunosuppressive therapy.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1324
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Article ; Online: Comparison of sputum specimens and nasopharyngeal swab specimens for diagnosis of acute human metapneumovirus-related lower respiratory tract infections in adults.

Yajima, Takehiro / Takahashi, Hiroshi / Kimura, Nozomu / Sato, Kosuke / Jingu, Daisuke / Ubukata, Satoshi / Shoji, Makoto / Watanabe, Hiroshi / Kodama, Prof Eiichi N / Nishimura, Hidekazu

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2022 Volume 154, Page(s) 105238

Abstract: Background: To detect human metapneumovirus, tests besides reverse transcription-polymerase chain reaction (RT-PCR) on nasopharyngeal swab specimens are less accessible. Immunochromatography assays are rapid and simple without the need of any special ... ...

Abstract	Background: To detect human metapneumovirus, tests besides reverse transcription-polymerase chain reaction (RT-PCR) on nasopharyngeal swab specimens are less accessible. Immunochromatography assays are rapid and simple without the need of any special equipment but sometimes are insufficiently sensitive. This study describes the usefulness of immunochromatography assays to detect human metapneumovirus in adult patients with human metapneumovirus-related acute lower respiratory tract infection using sputum specimens. Methods: This prospective single-center study enrolled adults and adolescents aged ≥16 years with signs and symptoms of an acute respiratory illness who were diagnosed with acute lower respiratory tract infection. The presence of human metapneumovirus infection was confirmed by seroconversion. Immunochromatography assays and real-time RT-PCR were performed to compare the efficacy of nasopharyngeal swab specimens and sputum specimens. Comparative results were obtained via McNemar's test. Results: Overall, 337 patients were recruited in this study; 63 (18.7%) patients were seroconverted. Sputum specimens showed significantly higher positivity rates than nasopharyngeal swab specimens with both immunochromatography assays (p = 0.0008) and real-time RT-PCR (p = 0.014). Among 29 patients with pneumonia who had concordant positive real-time RT-PCR results for both nasopharyngeal swab specimens and sputum specimens, 21 (72.4%) had a higher viral load in the sputum specimens. Conclusions: Sputum specimens are more useful in detecting human metapneumovirus than nasopharyngeal swab specimens in adult patients with acute lower respiratory tract infection.
MeSH term(s)	Adolescent ; Adult ; Humans ; Metapneumovirus/genetics ; Nasopharynx ; Paramyxoviridae Infections/diagnosis ; Prospective Studies ; Respiratory Tract Infections/diagnosis ; Reverse Transcriptase Polymerase Chain Reaction ; Sensitivity and Specificity ; Sputum
Language	English
Publishing date	2022-07-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2022.105238
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Article: A useful and safe method for retrieving a round metallic object from an airway.

Jingu, Daisuke / Horii, Akira / Matsuzono, Yu / Ubukata, Satoshi / Sato, Kosuke / Shoji, Makoto / Kondo, Noriko / Takahashi, Hiroshi / Watanabe, Hiroshi

Clinical case reports

2020 Volume 9, Issue 2, Page(s) 1033–1034

Abstract: The endoscopic net forceps with the support of a laryngeal mask airway are a dependable choice for retrieving a round metallic object from an airway. ...

Abstract	The endoscopic net forceps with the support of a laryngeal mask airway are a dependable choice for retrieving a round metallic object from an airway.
Language	English
Publishing date	2020-12-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.3634
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Article: [Clinical Characteristics of Adult Onset RSV Infection During Two Consecutive Winter Seasons].

Takahashi, Hiroshi / Jinguu, Daisuke / Yajima, Takehiro / Ubukata, Satoshi / Shoji, Makoto / Watanabe, Akira

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases

2018 Volume 90, Issue 5, Page(s) 645–651

Abstract: We performed a retrospective study examining adult patients with RSV infection who were diagnosed at our hospital during two consecutive winter seasons, 2011-2012 and 2012-2013; these patients were compared with, adult patients who had been diagnosed as ... ...

Abstract	We performed a retrospective study examining adult patients with RSV infection who were diagnosed at our hospital during two consecutive winter seasons, 2011-2012 and 2012-2013; these patients were compared with, adult patients who had been diagnosed as having influenza during the same periods. RSV infection was confirmed by a 4-fold increase in the CF antibody titer, while influenza was diagnosed based on a rapid antigen test. Forty-three patients with RSV infection and pneumonia patients (39 inpatients and 4 outpatients) and 25 patients with influenza and pneumonia (23 inpatients and 2 outpatients) were detected. Overall, 54 patients with RSV infection and 42 patients with influenza, were hospitalized during the two seasons. A history of the influenza vaccination was verified for 48% of the influenza patients with pneumonia and 35% of the non-pneumonia influenza patients who were hospitalized, and neuraminidase inhibitors were used for the treatment of all the influenza patients and 88% of the non-pneumonia influenza patients who were hospitalized. Overall, 5.3% of the adult cases with pneumonia (43/817) during the two seasons were diagnosed as having RSV related illness, and within the peak period, in particular, 14.6% were judged as having RSV pneumonia. Furthermore, 63% of the patients with RSV infection and pneumonia had mixed infections with other common respiratory pathogen, such as Streptococcus pneumoniae, and within the peak period, almost 15% of the patients with pneumonococcal pneumonia were confirmed to have mixed infections that included RSV. In both groups, one-fourth of the patients had been living in nursing homes or had been receibing home medical care. Up to 20% of the RSV pneumonia patients were initially diagnosed as having aspiration pneumonia. We suspect that some of these elderly patients might have developed pneumonia as a result of preceding viral infection or following vomiting or aspiration. The overall clinical picture, such as the mean age, maximum body temperature, hypoxemia, CRP, and WBC, did not differ significantly between the two groups. The 30-day mortality and overall hospital mortality rates were similar in both groups, but the lengths of the hospital stay were significantly longer, and several patients survived but continued to have a reduced activities of daily living score at the time of their discharge in the RSV pneumonia group.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Coinfection ; Humans ; Middle Aged ; Respiratory Syncytial Virus Infections/complications ; Respiratory Syncytial Virus Infections/diagnosis ; Retrospective Studies ; Seasons ; Young Adult
Language	Japanese
Publishing date	2018-08-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	605664-7
ISSN	0387-5911
ISSN	0387-5911
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Article: [[TUBERCULOSIS DIAGNOSIS FOLLOWING A VISIT TO THE EMERGENCY ROOM].]

Yajima, Takehiro / Jingu, Daisuke / Ubukata, Satoshi / Shoji, Makoto / Takahashi, Hiroshi

Kekkaku : [Tuberculosis

2016 Volume 91, Issue 5, Page(s) 503–507

Abstract: We aimed to evaluate the clinical char- acteristics of patients admitted to the emergency room (ER) and diagnosed with tuberculosis. [Method] We conducted a retrospective study of patients aged ... 16 years admitted to the hospital between April 1980 and ... ...

Abstract	We aimed to evaluate the clinical char- acteristics of patients admitted to the emergency room (ER) and diagnosed with tuberculosis. [Method] We conducted a retrospective study of patients aged 16 years admitted to the hospital between April 1980 and March 2015 and diagnosed with tuberculosis. We com- pared patient clinical characteristics and type of tuberculosis between ER and non-ER patients. We also compared the incidence of delayed diagnosis of tuberculosis between ER patients with and without respiratory symptoms. We compared the tuberculosis encounter rate and the time to diagnosis of tuberculosis in ER and non-ER patients. [Results] A total of 255 patients, including 54 ER and 201 non-ER patients were enrolled in this study. The average age J was higher in ER patients than in non-ER patients (71.7? 16.3 vs. 63.3 ?20.3 years, p=0.006). The reasons for visiting the ER included acute conditions such as fracture of the lumbar spine, acute myocardial infarction, hemorrhagic gastric ulcer, brain infarction, and carbon monoxide intoxication, requiring immediate treatment. The time to diagnosis of tuberculosis in ER patients without respiratory symptoms (n=21) was approximately three times longer than that in patients with respiratory symptoms (n=33) as urgent treatment is priori- tized. The tuberculosis encounter rate was 1/1,800 for pa- tients transported by ambulance and 1/22,000 for emergency outpatients. The time to diagnosis of tuberculosis for patients transported by ambulance was approximately 4-6 days lon- ger than that for emergency outpatients or non-ER patients. [Conclusion] Physicians should seek to rule out the possi- bility of tuberculosis in all patients admitted to the ER, even where more urgent clinical conditions are prioritized.
MeSH term(s)	Aged ; Emergency Service, Hospital ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Tuberculosis/diagnosis
Language	Japanese
Publishing date	2016-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	131032-x
ISSN	1884-2410 ; 0022-9776
ISSN (online)	1884-2410
ISSN	0022-9776
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Article: [Occurrence and clinical characteristics of tuberculosis among home medical care patients].

Ubukata, Satoshi / Jingu, Daisuke / Yajima, Takehiro / Shoji, Makoto / Takahashi, Hiroshi

Kekkaku : [Tuberculosis

2014 Volume 89, Issue 7, Page(s) 649–654

Abstract: Objective: To clarify the occurrence and clinical characteristics of tuberculosis among home medical care patients, we conducted a retrospective study of patients who received home medical care from our hospital.: Subjects and methods: We ... ...

Abstract	Objective: To clarify the occurrence and clinical characteristics of tuberculosis among home medical care patients, we conducted a retrospective study of patients who received home medical care from our hospital. Subjects and methods: We investigated 502 patients (mean age, 79.5 years) who received home medical care from our hospital between January 2003 and December 2012. The newly notified tuberculosis cases aged > or = 70 years in the general population in Miyagi were defined as the control group. Among the patients receiving home medical care, we evaluated the clinical characteristics of the patients with tuberculosis. Results: Four of the 502 patients (0.8%) developed tuberculosis. Using the person-years method, the case rate of tuberculosis was calculated as 298.3 per 100,000 among home medical care patients. Compared with the control group, home medical care patients had a greater incidence of tuberculosis (298.3 vs. 36.06; rate ratio, 8.27; 95% confidence interval, 3.06-22.3; p < 0.001). When home medical care patients visited the hospital or were transported there by ambulance, they were initially often diagnosed with aspiration pneumonia. Moreover, the time interval to the onset of disease from the introduction of home medical care varied among cases (3-192 months). Conclusion: Patients receiving home medical care are at high risk of contracting tuberculosis. Therefore, for the medical staff involved in treating home medical care patients, the onset of tuberculosis should be carefully considered in daily medical practice.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Home Care Services ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Tuberculosis, Pulmonary/epidemiology
Language	Japanese
Publishing date	2014-07
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	131032-x
ISSN	1884-2410 ; 0022-9776
ISSN (online)	1884-2410
ISSN	0022-9776
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Article: [A case of septic pulmonary embolism due to Peptostreptococcus micros with multiple infection of the head and neck].

Ubukata, Satoshi / Jingu, Daisuke / Yajima, Takehiro / Shoji, Makoto / Takahashi, Hiroshi

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases

2013 Volume 87, Issue 6, Page(s) 761–766

Abstract: A 46-year-old man with no underlying diseases visited our hospital with otorrhea, ocular motility disorder of the left eye, dizziness and loss of appetite which had lasted for two months. Chest radiography and computed tomography (CT) showed bilateral ... ...

Abstract	A 46-year-old man with no underlying diseases visited our hospital with otorrhea, ocular motility disorder of the left eye, dizziness and loss of appetite which had lasted for two months. Chest radiography and computed tomography (CT) showed bilateral multiple pulmonary nodules and cavities. Furthermore, CT of the head and neck revealed bilateral mastoiditis, a left orbital abscess and a deep neck abscess. Peptostreptococcus micros was cultured from blood and otorrhea specimens. In addition, P. micros DNA was detected with the polymerase chain reaction (PCR) method in the specimens from the site of culture-negative lesions (i.e. sputum, bronchoalveolar lavage, neck abscess). Thus, we diagnosed the lung lesions as septic pulmonary embolisms (SPEs). The clinical findings of the head and neck had improved following antibiotics treatment for five weeks, and follow-up chest radiography and CT showed that all lesions almost disappeared. Since some SPE patients demonstrate a slow progression, SPE should be included in the differential diagnosis of multiple pulmonary nodules such as Wegener's glanulomatosis or neoplasm.
MeSH term(s)	Abscess/complications ; Gram-Positive Bacterial Infections/complications ; Gram-Positive Bacterial Infections/diagnosis ; Humans ; Male ; Mastoiditis/complications ; Middle Aged ; Neck ; Orbital Diseases/complications ; Peptostreptococcus ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/etiology
Language	Japanese
Publishing date	2013-09-10
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	605664-7
ISSN	0387-5911
ISSN	0387-5911
DOI	10.11150/kansenshogakuzasshi.87.761
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Article ; Online: Efficacy and Usefulness of New Single-Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis in Active Ulcerative Colitis Patients Without Corticosteroids and Biologics.

Shimazu, Keiji / Fukuchi, Takumi / Kim, Insung / Noguchi, Yuki / Iwata, Megumi / Koyama, Shintaro / Ubukata, Satoshi / Tanaka, Atsuo

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2016 Volume 20, Issue 4, Page(s) 383–389

Abstract: Intensive granulocyte and monocyte adsorptive apheresis (GMA) twice weekly is effective and safe for patients with active ulcerative colitis (UC), but the requirement for maintaining two blood access routes is problematic. Here we compared the efficacy ... ...

Abstract	Intensive granulocyte and monocyte adsorptive apheresis (GMA) twice weekly is effective and safe for patients with active ulcerative colitis (UC), but the requirement for maintaining two blood access routes is problematic. Here we compared the efficacy and safety of one-route blood access intensive GMA using a single-needle (SN) and conventional two-route blood access intensive GMA using a double-needle (DN) in patients with active UC not undergoing corticosteroid therapy. Among 80 active UC patients, 38 patients received SN intensive GMA and 42 patients received DN intensive GMA. The clinical remission ratio and mucosal healing ratio at 6 weeks, and the cumulative non-relapse ratio at 52 weeks did not differ significantly between groups. In addition, no serious or mild adverse effects were observed in SN intensive GMA. SN intensive GMA may be an adequate and novel therapeutic option for active UC as an alternative therapy before using corticosteroids.
MeSH term(s)	Adrenal Cortex Hormones ; Adult ; Biological Products ; Blood Component Removal/instrumentation ; Blood Component Removal/methods ; Colitis, Ulcerative/therapy ; Female ; Granulocytes ; Humans ; Male ; Monocytes ; Remission Induction ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones ; Biological Products
Language	English
Publishing date	2016-08
Publishing country	Australia
Document type	Journal Article ; Observational Study
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.12470
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Article: [Case report; familial occurrence of cat-scratch disease diagnosed by PCR of lymph node aspirate].

Iijima, Hiroyuki / Jingu, Daisuke / Ubukata, Satoshi / Syouji, Makoto / Watanabe, Hiroshi / Takahashi, Hiroshi

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2013 Volume 102, Issue 8, Page(s) 2043–2045

MeSH term(s)	Adolescent ; Animals ; Bartonella henselae/genetics ; Cat-Scratch Disease/diagnosis ; Cat-Scratch Disease/pathology ; Cats ; Female ; Humans ; Lymph Nodes/pathology ; Middle Aged ; Polymerase Chain Reaction/methods ; Tomography, X-Ray Computed
Language	Japanese
Publishing date	2013-09-12
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
DOI	10.2169/naika.102.2043
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