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Article: [A Long-Term Survival Case of Gastric Cancer with Pyloric Stenosis and Peritoneum Dissemination That Received Intravenous and Intraperitoneal Paclitaxel Combined with S-1 Therapy after Bypass Surgery].

Matono, Satoru / Matsuo, Toshihiro / Uchida, Shinji / Nagano, Takeshi / Sueyoshi, Susumu / Shimomura, Susumu / Hino, Haruhiro / Hashimoto, Kousuke / Horiuchi, Hiroyuki / Akagi, Yoshito

Gan to kagaku ryoho. Cancer & chemotherapy

2023 Volume 50, Issue 11, Page(s) 1195–1197

Abstract: Although a 74-year-old man with gastric cancer with pyloric stenosis(cT4aN[+]M0, Stage Ⅲ)had undergone surgery, he was diagnosed with peritoneum dissemination. He received bypass surgery, and an intraperitoneal access port was implanted in his ... ...

Abstract	Although a 74-year-old man with gastric cancer with pyloric stenosis(cT4aN[+]M0, Stage Ⅲ)had undergone surgery, he was diagnosed with peritoneum dissemination. He received bypass surgery, and an intraperitoneal access port was implanted in his subcutaneous space. Postoperatively, he received 4 courses of SOX therapy. In treatment effect, the primary tumor showed no change, and ascites developed. Therefore, we changed the chemotherapy regimen in intravenous and intraperitoneal paclitaxel combined with S-1 therapy. After starting this regimen, the primary tumor decreased in size, and the pyloric stenosis improved. Currently, the patient is alive without recurrence for 5 years and 8 months after intravenous and intraperitoneal paclitaxel combined with S-1 therapy and receiving this treatment regularly.
MeSH term(s)	Male ; Humans ; Aged ; Paclitaxel ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Peritoneum/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/surgery ; Pyloric Stenosis/etiology ; Pyloric Stenosis/surgery
Chemical Substances	Paclitaxel (P88XT4IS4D)
Language	Japanese
Publishing date	2023-12-06
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Randomized phase II study of 5-fluorouracil hepatic arterial infusion with or without antineoplastons as an adjuvant therapy after hepatectomy for liver metastases from colorectal cancer.

Ogata, Yutaka / Matono, Keiko / Tsuda, Hideaki / Ushijima, Masataka / Uchida, Shinji / Akagi, Yoshito / Shirouzu, Kazuo

PloS one

2015 Volume 10, Issue 3, Page(s) e0120064

Abstract: Background: Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. Antineoplaston A10 and AS2-1 reportedly control neoplastic growth and do not significantly inhibit normal cell growth. ... ...

Abstract	Background: Antineoplastons are naturally occurring peptides and amino acid derivatives found in human blood and urine. Antineoplaston A10 and AS2-1 reportedly control neoplastic growth and do not significantly inhibit normal cell growth. Antineoplastons contain 3-phenylacetylamino-2, 6-piperidinedione (A10), phenylacetylglutamine plus phenylacetylisoglutamine (A10-I), and phenylacetylglutamine plus phenylacetate (AS2-1). This open label, non- blinded randomized phase II study compared the efficacy of hepatic arterial infusion (HAI) with 5-fluorouracil,with or without antineoplastons as a postoperative therapy for colorectal metastasis to the liver. Methods: Sixty-five patients with histologically confirmed metastatic colon adenocarcinoma in liver, who had undergone hepatectomy, and/or thermal ablation for liver metastases were enrolled between 1998- 2004 in Kurume University Hospital. Patients were randomly assigned to receive systemic antineoplastons (A10-I infusion followed by per-oral AS2-1) plus HAI (AN arm) or HAI alone (control arm) based on the number of metastases and presence/ absence of extra-hepatic metastasis at the time of surgery. Primary endpoint was cancer-specific survival (CSS); secondary endpoints were relapse-free survival (RFS), status and extent of recurrence, salvage surgery (rate) and toxicity. Findings: Overall survival was not statistically improved (p=0.105) in the AN arm (n=32). RFS was not significant (p=0.343). Nevertheless, the CSS rate was significantly higher in the AN arm versus the control arm (n=33) with a median survival time 67 months (95%CI 43-not calculated) versus 39 months (95%CI 28-47) (p=0.037) and 5 year CSS rate 60% versus 32% respectively. Cancer recurred more often in a single organ than in multiple organs in the AN arm versus the control arm. The limited extent of recurrent tumours in the AN arm meant more patients remained eligible for salvage surgery. Major adverse effects of antineoplastons were fullness of the stomach and phlebitis. No serious toxicity, including bone marrow suppression, liver or renal dysfunction, were found in the AN arm. Interpretation: Antineoplastons (A10 Injection and AS2-1) might be useful as adjunctive therapy in addition to HAI after hepatectomy in colorectal metastases to the liver. Trial registration information: ClinicalTrials.gov UMIN000012099.
MeSH term(s)	Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzeneacetamides/administration & dosage ; Benzeneacetamides/therapeutic use ; Chemotherapy, Adjuvant/methods ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/surgery ; Drug Combinations ; Fluorouracil/administration & dosage ; Fluorouracil/therapeutic use ; Glutamine/administration & dosage ; Glutamine/analogs & derivatives ; Glutamine/therapeutic use ; Hepatectomy ; Humans ; Infusions, Intra-Arterial ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Middle Aged ; Phenylacetates/administration & dosage ; Phenylacetates/therapeutic use ; Piperidones/administration & dosage ; Piperidones/therapeutic use ; Survival Analysis ; Treatment Outcome
Chemical Substances	Antimetabolites, Antineoplastic ; Benzeneacetamides ; Drug Combinations ; Phenylacetates ; Piperidones ; Glutamine (0RH81L854J) ; antineoplaston AS 2-1 (104624-98-8) ; antineoplaston A10 (16VY3TM7ZO) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2015-03-19
Publishing country	United States
Document type	Clinical Trial, Phase II ; Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0120064
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Organo- and Cytoprotective Effects of Heat-shock Protein in Response to Injury Due to Radiofrequency Ablation in Rat Liver.

Kawashima, Yusuke / Hisaka, Toru / Horiuchi, Hiroyuki / Ishikawa, Hiroto / Uchida, Shinji / Kinugasa, Tetsushi / Etou, Daimei / Okuda, Kouji / Akagi, Yoshito

Anticancer research

2016 Volume 36, Issue 7, Page(s) 3591–3597

Abstract: Aim: In treating liver tumors, preserving hepatic reserve and reducing surgical invasiveness are important for minimizing postoperative complications. Geranylgeranylacetone (GGA) is reported to selectively induce heat-shock protein 70 (HSP70), which ... ...

Abstract	Aim: In treating liver tumors, preserving hepatic reserve and reducing surgical invasiveness are important for minimizing postoperative complications. Geranylgeranylacetone (GGA) is reported to selectively induce heat-shock protein 70 (HSP70), which initiates a powerful cytoprotective effect. We investigated the function of HSP70 under conditions of radiofrequency ablation (RFA) of the liver. Materials and methods: Male Wistar rats were divided into three groups: a control group, a group administered GGA, and a group administered GGA plus quercetin, an HSP70 synthesis inhibitor. Expression of HSP70 and heat-shock factor-1 (HSF1) in the liver was measured at the protein level, and severity of liver damage was investigated using serum and hepatic tissue. Results: The GGA-treated group had higher expression of HSP70 and HSF1 than the other groups. Peak liver damage in all groups occurred 6 h after RFA. The GGA-treated group also had significantly less liver damage and lower serum level of the inflammatory cytokine tumor necrosis factor-α, and a lower rate of apoptosis in tissue around post-ablation necrosis. Expression of HSP70 and HSF1 was suppressed in the group treated with GGA and quercetin, and this group had severe liver damage. Conclusion: Induction of HSP in the liver by GGA may be applicable in future treatments for hepatocellular carcinoma or liver metastasis. The present findings suggest that if preoperative administration of GGA can offer protective effects in the liver, treatment options could be increased and liver failure and other complications might be avoided.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; DNA-Binding Proteins/metabolism ; Diterpenes/pharmacology ; HSP70 Heat-Shock Proteins/metabolism ; Heat Shock Transcription Factors ; Liver/metabolism ; Liver/pathology ; Liver/radiation effects ; Male ; Protective Factors ; Quercetin/pharmacology ; Radiation Injuries, Experimental/metabolism ; Radiosurgery/adverse effects ; Rats, Wistar ; Transcription Factors/metabolism
Chemical Substances	Antioxidants ; DNA-Binding Proteins ; Diterpenes ; HSP70 Heat-Shock Proteins ; Heat Shock Transcription Factors ; Hsf1 protein, rat ; Transcription Factors ; Quercetin (9IKM0I5T1E) ; geranylgeranylacetone (S8S8451A4O)
Language	English
Publishing date	2016-07
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
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Article ; Online: Preventive effects of amino-acid-rich elemental diet Elental® on chemotherapy-induced oral mucositis in patients with colorectal cancer: a prospective pilot study.

Ogata, Yutaka / Ishibashi, Nobuya / Yamaguchi, Keizou / Uchida, Shinji / Kamei, Hideki / Nakayama, Goichi / Hirakawa, Hiroaki / Tanigawa, Masahiko / Akagi, Yoshito

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2016 Volume 24, Issue 2, Page(s) 783–789

Abstract: Purpose: The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), Elental(®), on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are ... ...

Abstract	Purpose: The prospective pilot study was designed to evaluate the preventive effects of amino-acid-rich elemental diet (ED), Elental(®), on chemotherapy-induced oral mucositis in patients with colorectal cancer. The factors influencing its efficacy are also investigated. Methods: A total of 22 eligible patients with colorectal cancer experiencing grade 1-3 oral mucositis during treatment with fluorouracil-based chemotherapy entered the current study. Their average age was 67 years. There were 10 male and 12 female. The PS was 0 in the majority of patients. Patients received two courses of the same chemotherapy regimen and Elental(®) concurrently after recovery to grade 0 or 1 oral mucositis. Results: FOLFOX6 + bevacizumab in 8 patients, FOLFIRI + bevacizumab in 8 patients, FOLFIRI + panitumumab in 1 patient, FOLFIRI in 1 patient, XELOX + bevacizumab in 2 patients, and S-1 + cetuximab in 2 patients were used as first-line (16 cases) or as second-line (6 cases) chemotherapy. Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. The maximum grade of oral mucositis decreased in 18 of the 22 patients during the first treatment course with Elental(®) (p = 0.0002) and in 20 of the 22 patients in the second course (p < 0.0001). Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. Conclusion: The amino-acid-rich elemental diet Elental(®) may be useful as a countermeasure for 5-FU-based chemotherapy-induced oral mucositis in patients with colorectal cancer.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Colorectal Neoplasms/drug therapy ; Female ; Food, Formulated ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Stomatitis/chemically induced ; Stomatitis/diet therapy ; Stomatitis/prevention & control ; Treatment Outcome
Language	English
Publishing date	2016-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-015-2844-0
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Article: [A long-term survivor of advanced gallbladder carcinoma treated with curative operation and hepatic arterial infusion].

Nogita, Hidefumi / Uchida, Shinji / Ishikawa, Hiroto / Hisaka, Toru / Horiuchi, Hiroyuki / Kinoshita, Hisafumi / Shirouzu, Kazuo

Gan to kagaku ryoho. Cancer & chemotherapy

2013 Volume 40, Issue 8, Page(s) 1081–1083

Abstract: 60-year-old woman was referred to us for epigastralagia under the diagnosis of chronic cholecystitis. Cholecystectomy was performed, and gallbladder carcinoma was pinpointed by postoperative pathological diagnosis. Because liver invasion should have been ...

Abstract	60-year-old woman was referred to us for epigastralagia under the diagnosis of chronic cholecystitis. Cholecystectomy was performed, and gallbladder carcinoma was pinpointed by postoperative pathological diagnosis. Because liver invasion should have been detected by pathological diagnosis, we conducted liver S4a+S5 resection, extrahepatic bile duct resection and D2 lymphadenectomy. The pathological diagnosis was advanced gallbladder carcinoma with liver metastasis. We treated a patient with curative operation and hepatic arterial infusion adjuvant chemotherapy by low-dose FP therapy for advanced gallbladder carcinoma, and she is doing well now without disease recurrence eight years after surgery.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Gallbladder Neoplasms/drug therapy ; Gallbladder Neoplasms/pathology ; Gallbladder Neoplasms/surgery ; Hepatic Artery ; Humans ; Infusions, Intra-Arterial ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Time Factors
Language	Japanese
Publishing date	2013-08
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [Stevens-Johnson syndrome induced by regorafenib in a patient with progressive recurrent rectal carcinoma].

Mihara, Yutaro / Yamaguchi, Keizo / Nakama, Takekuni / Nakayama, Goichi / Kamei, Hideki / Ishibashi, Nobuya / Uchida, Shinji / Akagi, Yoshito / Ogata, Yutaka

Gan to kagaku ryoho. Cancer & chemotherapy

2015 Volume 42, Issue 2, Page(s) 233–236

Abstract: A 55-year-old man with rectal carcinoma underwent lower anterior resection. Eight years after surgery, multiple metastases were detected in the liver, lung, and abdominal lymph nodes. The metastatic cancers were resistant to standard chemotherapy. Thus, ... ...

Abstract	A 55-year-old man with rectal carcinoma underwent lower anterior resection. Eight years after surgery, multiple metastases were detected in the liver, lung, and abdominal lymph nodes. The metastatic cancers were resistant to standard chemotherapy. Thus, regorafenib was administered to the patient. The patient presented symptoms of Stevens-Johnson syndrome (SJS) nine days after regorafenib administration, and hence, treatment was terminated. To treat SJS, he received oral and topical steroid therapies. SJS is an important adverse event that hinders the continuation of regorafenib treatment. Thus, it is necessary to continually check the patient's skin condition carefully, especially at early stages of treatment. To our knowledge, this is the first report of SJS arising during the course of regorafenib treatment.
MeSH term(s)	Disease Progression ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Phenylurea Compounds/adverse effects ; Phenylurea Compounds/therapeutic use ; Pyridines/adverse effects ; Pyridines/therapeutic use ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Recurrence ; Stevens-Johnson Syndrome/etiology
Chemical Substances	Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB)
Language	Japanese
Publishing date	2015-02
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [Treatment and outcome in small bowel cancer].

Ogata, Yutaka / Yamaguchi, Keizo / Sasatomi, Teruo / Uchida, Shinji / Akagi, Yoshito / Shirouzu, Kazuo

Gan to kagaku ryoho. Cancer & chemotherapy

2010 Volume 37, Issue 8, Page(s) 1454–1457

Abstract: In adenocarcinoma of the small intestine, delays in diagnosis are frequent, and the majority of patients present with advanced- stage disease and either lymph node involvement or distant metastatic disease. Surgical resection is a mainstay in treatment ... ...

Abstract	In adenocarcinoma of the small intestine, delays in diagnosis are frequent, and the majority of patients present with advanced- stage disease and either lymph node involvement or distant metastatic disease. Surgical resection is a mainstay in treatment of this disease, but the role of adjuvant therapy is unclear. Recent retrospective and prospective studies have helped to clarify the optimal chemotherapy approach for advanced small bowel adenocarcinoma. The combination of capecitabine and oxaliplatin is reportedly highly effective. Further clinical studies on this rare type of tumor are needed. This article reviews the focuses on recent advances in management. The 72nd Japanese Society for Cancer of the Colon and Rectum have conducted a retrospective review of Japanese patients with adenocarcinoma of the jejunum or ileum. The data indicated that although not statistically significant, there was a trend in median overall survival favoring the chemotherapy for advanced jejunal or ileal adenocarcinoma (17 months vs. 8 months, p=0.114).
MeSH term(s)	Adenocarcinoma/therapy ; Combined Modality Therapy ; Humans ; Intestinal Neoplasms/therapy ; Intestine, Small ; Prognosis ; Treatment Outcome
Language	Japanese
Publishing date	2010-08
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Expression of HSP27 in Hepatocellular Carcinoma.

Eto, Daimei / Hisaka, Toru / Horiuchi, Hiroyuki / Uchida, Shinji / Ishikawa, Hiroto / Kawashima, Yusuke / Kinugasa, Tetsushi / Nakashima, Osamu / Yano, Hirohisa / Okuda, Koji / Akagi, Yoshito

Anticancer research

2016 Volume 36, Issue 7, Page(s) 3775–3779

Abstract: Background/aim: Heat-shock protein 27 (HSP27), a low molecular weight stress protein, is recognized as a molecular chaperone. The expression of HSP27 has been detected in some human tumors and while HSP27 is phosphorylated as a reresponse to stress, the ...

Abstract	Background/aim: Heat-shock protein 27 (HSP27), a low molecular weight stress protein, is recognized as a molecular chaperone. The expression of HSP27 has been detected in some human tumors and while HSP27 is phosphorylated as a reresponse to stress, the function of phosphorylated HSP27 (p-HSP27) is not known. The aim of this study was to investigate what kind of effect expression of HSP27 and p-HSP27 in HCC has on clinicopathological characteristics and prognosis. Materials and methods: An immunohistochemical study for HSP27 and p-HSP27 was performed on 194 resected HCC cases. We analyzed the correlation of HSP27 expression with various parameters statistically. Results: There was no correlation between expression of HSP27 and the clinicopathological characteristics and prognosis from the analysis of 194 cases. From the analysis of the hepatitis C virus (HCV)-positive group of 142 cases, those that were p-HSP27-positive had a larger tumor diameter and the portal vein invasion rate was high. Conclusion: The expression of total HSP27 may serve as a new, clinically useful marker of HCC. In addition, the present study suggests that the expression of phosphorylated HSP27 is useful in the screening and grading of HCC occurring in the setting of HCV.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/virology ; Female ; HSP27 Heat-Shock Proteins/metabolism ; Hepatitis C/complications ; Hepatitis C/metabolism ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/virology ; Male ; Middle Aged ; Phosphorylation ; Protein Processing, Post-Translational
Chemical Substances	Biomarkers, Tumor ; HSP27 Heat-Shock Proteins ; HSPB1 protein, human
Language	English
Publishing date	2016-07
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
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Article: A new vascular prosthesis coated with polyamino-acid urethane copolymer (PAU) to enhance endothelialization.

Wang, Chunren / Zhang, Qing / Uchida, Shinji / Kodama, Makoto

Journal of biomedical materials research

2002 Volume 62, Issue 3, Page(s) 315–322

Abstract: Clinically available synthetic ePTFE vascular grafts frequently fail when used for small-diameter arterial substitution. The lower long-term patency of ePTFE grafts is due mainly to thrombogenicity and poor healing. We developed a new small-diameter (1.5- ...

Abstract	Clinically available synthetic ePTFE vascular grafts frequently fail when used for small-diameter arterial substitution. The lower long-term patency of ePTFE grafts is due mainly to thrombogenicity and poor healing. We developed a new small-diameter (1.5-mm) ePTFE vascular prosthesis coated with polyamino-acid urethane copolymer (PAU) to enhance endothelialization. Coating with PAU made the hydrophobic ePTFE vascular graft hydrophilic. Scanning electron microscopy (SEM) observation showed that PAU was homogeneously coated on the ePTFE graft while maintaining the graft's porous structure. Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectra showed PAU was present on graft inner surfaces. Noncoated and PAU-coated ePTFE vascular grafts were implanted into the rat abdominal aorta and evaluated within 1 week and at 8 weeks after implantation. We evaluated the extent of neoendothelialization by SEM, light microscopy, and immunohistochemical staining. Noncoated grafts showed partial endothelialization at proximal and distal areas of grafts but none at midsection. One-percent PAU-coated grafts showed incomplete neoendothelialization, but endothelial cells were observed in the midsection of grafts. Three-percent PAU-coated ePTFE grafts showed complete endothelialization with typical endothelial cell layers under SEM and histologic observation. Immunohistochemical staining also showed that an endothelial cell lining positively reacted with anti-von Willebrand factor (endothelial cell marker) antibody. We conclude that PAU-coated ePTFE vascular grafts enhance endothelialization.
MeSH term(s)	Amino Acids/chemistry ; Animals ; Biocompatible Materials ; Blood Vessel Prosthesis ; Endothelium, Vascular/cytology ; Immunohistochemistry ; Male ; Microscopy, Electron, Scanning ; Rats ; Rats, Wistar ; Urethane/chemistry
Chemical Substances	Amino Acids ; Biocompatible Materials ; Urethane (3IN71E75Z5)
Language	English
Publishing date	2002-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280321-5
ISSN	1097-4636 ; 0021-9304
ISSN (online)	1097-4636
ISSN	0021-9304
DOI	10.1002/jbm.10137
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Article: [Efficacy of Elental on prevention for chemotherapy-induced oral mucositis in colorectal cancer patients].

Ogata, Yutaka / Takeuchi, Masaaki / Ishibashi, Nobuya / Kibe, Shirou / Takahashi, Kenjirou / Uchida, Shinji / Murakami, Naotaka / Yahara, Toshirou / Shirouzu, Kazuo

Gan to kagaku ryoho. Cancer & chemotherapy

2012 Volume 39, Issue 4, Page(s) 583–587

Abstract: Background: The present study was designed to evaluate the preventive effects of elemental diet Elental (ED) on chemotherapy-induced stomatitis in patients with colorectal cancer.: Materials and methods: A total of 23 patients with colorectal cancer ... ...

Abstract	Background: The present study was designed to evaluate the preventive effects of elemental diet Elental (ED) on chemotherapy-induced stomatitis in patients with colorectal cancer. Materials and methods: A total of 23 patients with colorectal cancer experiencing grade 1-3 stomatitis during treatment with chemotherapy (2- or 3-week per cycle) entered the current study. Their average age was 67 years, ranging from 44 to 84 years. Results: A total of 22 patients received the same chemotherapy regimen, but also received more than 80 g of Elental (ED) (including 1, 932 mg of L-glutamine), per day. FOLFOX, FOLFIRI or XELOX-based chemotherapy was used. A dose reduction of 5-FU, capacitabine or S-1 was performed in 5 patients who experienced grade 2 or 3 stomatitis. The maximum grade of stomatitis decreased in 18 of the 22 patients after the first treatment course, and decreased in 20 of 22 patients after the second course with ED.The preventive efficacy of ED on stomatitis was noted in a dose-dependent manner.Similarly, the maximum grade of neutropenia decreased in 10 of 11 patients after their first or second treatment course with ED. Conclusion: We conclude that ED can significantly decrease the severity of chemotherapy-induced stomatitis in colorectal cancer patients in association with the control of neutropenia.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Colorectal Neoplasms/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Nutritional Support ; Prospective Studies ; Stomatitis/chemically induced ; Stomatitis/prevention & control
Chemical Substances	Antineoplastic Agents
Language	Japanese
Publishing date	2012-04
Publishing country	Japan
Document type	Clinical Trial ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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