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Article ; Online: Prolyl Isomerase, Pin1, Controls Meiotic Progression in Mouse Oocytes.

Hoshino, Yumi / Uchida, Takafumi

2022 Volume 11, Issue 23

Abstract: During meiotic maturation, accurate progression of meiosis is ensured by multiple protein kinases and by signal transduction pathways they are involved in. However, the mechanisms regulating the functions of phosphorylated proteins are unclear. Herein, ... ...

Abstract	During meiotic maturation, accurate progression of meiosis is ensured by multiple protein kinases and by signal transduction pathways they are involved in. However, the mechanisms regulating the functions of phosphorylated proteins are unclear. Herein, we investigated the role of Pin1, a peptidyl-prolyl cis-trans isomerase family member that regulates protein functions by altering the structure of the peptide bond of proline in phosphorylated proteins in meiosis. First, we analyzed changes in the expression of Pin1 during meiotic maturation and found that although its levels were constant, its localization was dynamic in different stages of meiosis. Furthermore, we confirmed that the spindle rotates near the cortex when Pin1 is inhibited by juglone during meiotic maturation, resulting in an error in the extrusion of the first polar body. In Pin1
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11233772
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: iPhone charger-induced chemical burn from overnight contact with sweat: Two cases.

Nakagawa, Yuki / Uchida, Takafumi / Morizane, Shin

The Journal of dermatology

2020 Volume 47, Issue 10, Page(s) 1187–1190

Abstract: Smartphones have become essential devices in modern society. The coverage rate of smartphones in 2017 in Japan was 75% according to the Ministry of Internal Affairs and Communications. The iPhone is one of the most well-known smartphone brands. According ...

Abstract	Smartphones have become essential devices in modern society. The coverage rate of smartphones in 2017 in Japan was 75% according to the Ministry of Internal Affairs and Communications. The iPhone is one of the most well-known smartphone brands. According to the manufacturer of iPhones (Apple), more than 200 million iPhones had been sold worldwide by 2017. These devices are often charged at night-time, especially while being used in bed. There are only three reports of smartphone charger-induced skin damage. We present two new cases of skin ulcers induced by an iPhone charger. The iPhone's "lightning cable" has electrodes outside, and we found that this can present a higher risk of causing a skin injury compared with other types of phone chargers. We also investigated the mechanism of the skin ulcers caused by the iPhone charger. The results indicated that these ulcers were chemical burns rather than an electrical injury or heat-induced burn.
MeSH term(s)	Burns, Chemical/etiology ; Humans ; Japan ; Smartphone ; Sweat
Language	English
Publishing date	2020-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.15475
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Article ; Online: Growth arrest specific protein 7 inhibits tau fibrillogenesis.

Shimizu, Taiki / Hirose, Keiko / Uchida, Chiyoko / Uchida, Takafumi

Biochemical and biophysical research communications

2020 Volume 526, Issue 2, Page(s) 281–286

Abstract: Here we show that Gas7 inhibits phosphorylated tau fibrillogenesis by binding to phosphorylated tau at its non-WW domain, presumably F-BAR domain. We revealed that Gas7 binds to the third repeat domain of tau, the core element of tau oligomerization and ... ...

Abstract	Here we show that Gas7 inhibits phosphorylated tau fibrillogenesis by binding to phosphorylated tau at its non-WW domain, presumably F-BAR domain. We revealed that Gas7 binds to the third repeat domain of tau, the core element of tau oligomerization and the C-terminal domain of tau and alters the conformation not to form fibrils. These results suggest that Gas7 may serve to protect against Alzheimer's disease and other tauopathies by preventing tau fibrillogenesis.
MeSH term(s)	HEK293 Cells ; Humans ; Nerve Tissue Proteins/metabolism ; Neurofibrillary Tangles/metabolism ; Phosphorylation ; Protein Aggregates ; Protein Aggregation, Pathological/metabolism ; Protein Binding ; Protein Conformation ; Protein Domains ; Tauopathies/metabolism ; WW Domains ; tau Proteins/chemistry ; tau Proteins/metabolism
Chemical Substances	GAS7 protein, human ; Nerve Tissue Proteins ; Protein Aggregates ; tau Proteins
Language	English
Publishing date	2020-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.03.041
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Article: Growth arrest specific protein 7 inhibits tau fibrillogenesis

Shimizu, Taiki / Hirose, Keiko / Uchida, Chiyoko / Uchida, Takafumi

Biochemical and biophysical research communications. 2020 May 28, v. 526, no. 2

2020

Abstract	Here we show that Gas7 inhibits phosphorylated tau fibrillogenesis by binding to phosphorylated tau at its non-WW domain, presumably F-BAR domain. We revealed that Gas7 binds to the third repeat domain of tau, the core element of tau oligomerization and the C-terminal domain of tau and alters the conformation not to form fibrils. These results suggest that Gas7 may serve to protect against Alzheimer’s disease and other tauopathies by preventing tau fibrillogenesis.
Keywords	amino acid sequences ; oligomerization ; research
Language	English
Dates of publication	2020-0528
Size	p. 281-286.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.03.041
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Article ; Online: New device for sperm preparation involving migration-gravity sedimentation without centrifugation compared with density-gradient centrifugation for normozoospermic intrauterine insemination.

Tatsumi, Kenichi / Tatsumi, Takayuki / Uchida, Takafumi / Saito, Kazuki / Saito, Hidekazu

F&S reports

2020 Volume 1, Issue 2, Page(s) 106–112

Abstract: Objective: To investigate the efficacy of a new device for sperm preparation involving migration-gravity sedimentation without centrifugation (MIGLIS), compared with density-gradient centrifugation (DGC) for normozoospermic intrauterine insemination ( ... ...

Abstract	Objective: To investigate the efficacy of a new device for sperm preparation involving migration-gravity sedimentation without centrifugation (MIGLIS), compared with density-gradient centrifugation (DGC) for normozoospermic intrauterine insemination (IUI). Design: Retrospective cohort study. Setting: Not applicable. Patients: A total of 10,318 cases of IUI (3,015 MIGLIS and 7,303 DGC) between October 2013 and September 2019. Interventions: None. Main outcome measures: Sperm analysis, subsequent pregnancy outcomes, and complications. Results: MIGLIS was associated with a lower sperm recovery rate and fewer injected sperm compared with DGC. However, the overall pregnancy rates following MIGLIS and DGC were similar (MIGLIS 8.8%, DGC 9.3%). In a subanalysis according to age, the pregnancy rate was higher for MIGLIS among women 40-41 years of age (8.6% vs. 5.9%). Peritonitis was the only recorded complication, with similar frequencies in the MIGLIS and DGC groups (MIGLIS two cases, DGC four cases). No cases became severe, and all improved after antibiotic treatment. There were no cases of uterine cramping or pain symptoms. Conclusions: MIGLIS is a new sperm preparation method that does not require centrifugation. Its use was associated with pregnancy rates similar to those with DGC and a higher pregnancy rate in older women. MIGLIS is a novel sperm preparation method for selecting spermatozoa with high motility and good fertilization ability in patients undergoing IUI, in vitro fertilization, and intracytoplasmic sperm injection.
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Journal Article
ISSN	2666-3341
ISSN (online)	2666-3341
DOI	10.1016/j.xfre.2020.06.003
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Article: Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains.

Shimizu, Taiki / Kanai, Kenta / Sugawara, Yui / Uchida, Chiyoko / Uchida, Takafumi

Frontiers in pharmacology

2018 Volume 9, Page(s) 1351

Abstract: Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the ... ...

Abstract	Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1
Language	English
Publishing date	2018-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.01351
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Article ; Online: Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau.

Shimizu, Taiki / Uchida, Chiyoko / Shimizu, Ritsuko / Motohashi, Hozumi / Uchida, Takafumi

Biochemical and biophysical research communications

2017 Volume 493, Issue 2, Page(s) 946–951

Abstract: Here we show that Pin1, a peptidyl-prolyl cis/trans isomerase which catalyzes the isomerization of phosphorylated Ser/Thr-Pro, is a regulatory molecule of thrombopoiesis. We found that mice lacking the Pin1 gene ( ... ...

Abstract	Here we show that Pin1, a peptidyl-prolyl cis/trans isomerase which catalyzes the isomerization of phosphorylated Ser/Thr-Pro, is a regulatory molecule of thrombopoiesis. We found that mice lacking the Pin1 gene (Pin1
MeSH term(s)	Animals ; Cells, Cultured ; Gene Deletion ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Megakaryocytes/cytology ; Megakaryocytes/metabolism ; Mice ; Microtubules/metabolism ; NIMA-Interacting Peptidylprolyl Isomerase/genetics ; NIMA-Interacting Peptidylprolyl Isomerase/metabolism ; Phosphorylation ; RNA Interference ; Thrombopoiesis ; tau Proteins/genetics ; tau Proteins/metabolism
Chemical Substances	NIMA-Interacting Peptidylprolyl Isomerase ; tau Proteins ; Pin1 protein, mouse (EC 5.2.1.8)
Language	English
Publishing date	2017-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2017.09.115
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Article ; Online: Fluorescent resonance energy transfer -based biosensor for detecting conformational changes of Pin1.

Hidaka, Masafumi / Okabe, Emiko / Hatakeyama, Kodai / Zook, Heather / Uchida, Chiyoko / Uchida, Takafumi

Biochemical and biophysical research communications

2018 Volume 505, Issue 2, Page(s) 399–404

Abstract: Pin1, a peptidyl prolyl cis/trans isomerase (PPIase), regulates the activity and stability of various phosphorylated proteins. Pin1 consists of a PPIase domain and WW domain, both of which are required for the function of Pin1. However, how the behavior ... ...

Abstract	Pin1, a peptidyl prolyl cis/trans isomerase (PPIase), regulates the activity and stability of various phosphorylated proteins. Pin1 consists of a PPIase domain and WW domain, both of which are required for the function of Pin1. However, how the behavior of these domains changes upon binding to phosphorylated proteins has not been analyzed. We created a Fluorescent Resonance Energy Transfer (FRET)-based biosensor "CPinY", which is composed of Pin1 flanked by CFP and YFP, and analyzed the interaction between Pin1 and c-Myc. Our results indicated that the dual phosphorylation of c-Myc at Thr58 and Ser62 is essential for tight interaction with Pin1. Additionally, this interaction caused a significant conformational change in Pin1. Our CPinY biosensor also detected a novel type of inhibitor of Pin1 function. We believe that his biosensor will be a novel drug screening technology targeting Pin1.
MeSH term(s)	Binding Sites ; Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; Fluorescence Resonance Energy Transfer ; Humans ; NIMA-Interacting Peptidylprolyl Isomerase/chemistry ; Peptidylprolyl Isomerase ; Phosphorylation ; Protein Binding ; Protein Conformation
Chemical Substances	NIMA-Interacting Peptidylprolyl Isomerase ; PIN1 protein, human (EC 5.2.1.8) ; Peptidylprolyl Isomerase (EC 5.2.1.8)
Language	English
Publishing date	2018-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2018.09.123
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Article ; Online: Prolyl isomerase Pin1 is required sperm production by promoting mitosis progression of spermatogonial stem cells.

Kurita-Suzuki, Atsuko / Kamo, Yuki / Uchida, Chiyoko / Tanemura, Kentaro / Hara, Kenshiro / Uchida, Takafumi

Biochemical and biophysical research communications

2018 Volume 497, Issue 1, Page(s) 388–393

Abstract: A prolyl isomerase Pin1 deficient ( ... ...

Abstract	A prolyl isomerase Pin1 deficient (Pin1
MeSH term(s)	Animals ; Cell Differentiation/physiology ; Cells, Cultured ; Male ; Mice ; Mice, Knockout ; Mitosis/physiology ; NIMA-Interacting Peptidylprolyl Isomerase/metabolism ; Spermatogenesis/physiology ; Spermatogonia/cytology ; Spermatogonia/physiology ; Stem Cells/cytology ; Stem Cells/physiology
Chemical Substances	NIMA-Interacting Peptidylprolyl Isomerase ; Pin1 protein, mouse (EC 5.2.1.8)
Language	English
Publishing date	2018--26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2018.02.090
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Article ; Online: Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes.

Suzuki, Atsuko / Saeki, Toshiyuki / Ikuji, Hiroko / Uchida, Chiyoko / Uchida, Takafumi

PloS one

2016 Volume 11, Issue 12, Page(s) e0168830

Abstract: Background: While screening for an inhibitor of the peptidyl prolyl cis/trans isomerase, Pin1, we came across a brown algae polyphenol that blocks the differentiation of fibroblasts into adipocytes. However, its effectiveness on the accumulation of fat ... ...

Abstract	Background: While screening for an inhibitor of the peptidyl prolyl cis/trans isomerase, Pin1, we came across a brown algae polyphenol that blocks the differentiation of fibroblasts into adipocytes. However, its effectiveness on the accumulation of fat in the body has never been studied. Methodology/principal findings: Oral administration of brown algae polyphenol to mice fed with a high fat diet, suppressed the increase in fat volume to a level observed in mice fed with a normal diet. We speculate that Pin1 might be required for the differentiation of stem cell to adipocytes. We established wild type (WT) and Pin1-/- (Pin1-KO) adipose-derived mesenchymal stem cell (ASC) lines and found that WT ASCs differentiate to adipocytes but Pin1-KO ASCs do not. Conclusion and significance: Oral administration of brown algae polyphenol, a Pin1 inhibitor, reduced fat buildup in mice. We showed that Pin1 is required for the differentiation of stem cells into adipocytes. We propose that oral intake of brown algae polyphenol is useful for the treatment of obesity.
MeSH term(s)	Adipocytes/drug effects ; Adiposity/drug effects ; Animals ; Cell Differentiation/drug effects ; Diet, High-Fat/adverse effects ; Fibroblasts/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; NIMA-Interacting Peptidylprolyl Isomerase/antagonists & inhibitors ; Obesity/drug therapy ; Peptidylprolyl Isomerase/antagonists & inhibitors ; Phaeophyceae/chemistry ; Polyphenols/pharmacology ; Stem Cells/drug effects
Chemical Substances	NIMA-Interacting Peptidylprolyl Isomerase ; Polyphenols ; Peptidylprolyl Isomerase (EC 5.2.1.8) ; Pin1 protein, mouse (EC 5.2.1.8)
Language	English
Publishing date	2016-12-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0168830
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