Article ; Online: CTX-M-55-type ESBL-producing fluoroquinolone-resistant Escherichia coli sequence type 23 repeatedly caused avian colibacillosis in Kagoshima Prefecture, Japan.
Journal of global antimicrobial resistance
2023 Volume 35, Page(s) 325–331
Abstract: Objectives: The production of expanded-spectrum beta-lactamases (ESBLs) and fluoroquinolone resistance in Enterobacteriaceae has become a global concern. The aim of this study was to investigate the spread of ESBL-producing and fluoroquinolone-resistant ...
| Abstract | Objectives: The production of expanded-spectrum beta-lactamases (ESBLs) and fluoroquinolone resistance in Enterobacteriaceae has become a global concern. The aim of this study was to investigate the spread of ESBL-producing and fluoroquinolone-resistant avian pathogenic Escherichia coli (APEC) in Kagoshima, a prefecture with the largest amount of poultry in Japan. Methods: The antimicrobial susceptibility and genetic characteristics of 228 APEC strains isolated from 57 farms in Kagoshima Prefecture, Japan, between 2005 and 2017 were analysed. Information about the companies with hatcheries connected to the farms was also collected, and the epidemiologic relatedness of APEC strains and the processes of adopting chicks were compared. Results: Seven CTX-M-type ESBL genes, bla Conclusions: APEC is often transferred from hatcheries to farms via healthy chicks, and the prudent use of antimicrobials and careful monitoring of resistant strains on poultry farms and hatcheries are important in preventing the selection and spread of high-risk APEC strains such as CTX-M-55-type ESBL-producing Og78-ST23. |
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| MeSH term(s) | Animals ; Humans ; Fluoroquinolones/pharmacology ; Japan/epidemiology ; Anti-Bacterial Agents/therapeutic use ; Escherichia coli ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/veterinary ; Escherichia coli Infections/drug therapy ; Chickens ; Poultry ; Ciprofloxacin |
| Chemical Substances | Fluoroquinolones ; Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) |
| Language | English |
| Publishing date | 2023-10-31 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2710046-7 |
| ISSN | 2213-7173 ; 2213-7173 |
| ISSN (online) | 2213-7173 |
| ISSN | 2213-7173 |
| DOI | 10.1016/j.jgar.2023.10.015 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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