Article ; Online: Correlation of Preoperative Anemia Subtypes with Tumor Characteristics, Systemic Inflammation and Immediate Postoperative Outcomes in Gastrointestinal Cancer Patients - A Prospective Observational Study.
Journal of gastrointestinal cancer
2023 Volume 54, Issue 4, Page(s) 1220–1230
Abstract: Purpose: Patients with gastrointestinal (GI) malignancies more frequently present with anemia. A large proportion of them exhibit a systemic inflammatory response causing anemia of chronic disease. Although tumor factors play an essential role in ... ...
| Abstract | Purpose: Patients with gastrointestinal (GI) malignancies more frequently present with anemia. A large proportion of them exhibit a systemic inflammatory response causing anemia of chronic disease. Although tumor factors play an essential role in determining the prognosis, studies have also reported the role of host factors in the outcome. This study was done to determine the association between systemic inflammation, tumor characteristics, and immediate postoperative outcome among various anemia subgroups. Methods: This was a single-center, prospective observational study of patients undergoing treatment for GI cancers. The modified Glasgow Prognostic Score (mGPS) was calculated, and patients were followed up until discharge regarding postoperative complications, length of the hospital, ICU stay, and mortality. The patient demographics, tumor characteristics, systemic inflammation, and postoperative complications were studied among different subtypes of anemia. Results: A total of 209 patients were analyzed, and a higher prevalence of normocytic anemia (52.63%) and systemic inflammatory response (62.21%) was observed among the study population. Systemic inflammation was significantly associated with a higher nodal stage (p = 0.02) and margin positivity (p = 0.006). Patients with higher mGPS had significantly higher requirements for blood transfusion (p = 0.003), superficial SSI (p = 0.03), and sepsis (p = 0.02); however, other postoperative complications were comparable among patients without an inflammatory response. Conclusion: Higher prevalence of normocytic anemia is observed among patients with gastrointestinal cancer. Normocytic anemia is significantly associated with systemic inflammation with no significant difference in tumor characters and immediate postoperative outcomes. |
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| MeSH term(s) | Humans ; Anemia/epidemiology ; Prognosis ; Inflammation/complications ; Gastrointestinal Neoplasms/complications ; Gastrointestinal Neoplasms/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/etiology ; Retrospective Studies | |||||
| Language | English | |||||
| Publishing date | 2023-01-12 | |||||
| Publishing country | United States | |||||
| Document type | Observational Study ; Journal Article | |||||
| ZDB-ID | 2452514-5 | |||||
| ISSN | 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649 | |||||
| ISSN (online) | 1941-6636 ; 1559-0739 | |||||
| ISSN | 1941-6628 ; 1537-3649 | |||||
| DOI | 10.1007/s12029-022-00902-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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