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  1. Book ; Online ; E-Book: Antibiotic pharmacokinetic/pharmacodynamic considerations in the critically ill

    Udy, Andrew / Roberts, Jason / Lipman, Jeffrey

    2018  

    Author's details Andrew A. Udy, Jason Roberts, Jeffrey Lipman editors
    Keywords Infectious diseases ; Dosing ; Therapeutic drug monitoring ; TDM ; Antibiotic stewardship ; Bacterial susceptibility ; Physiological manifestations ; Hypoalbuminaemia ; Renal disease ; Obese patients ; Extracorporeal membrane oxygenation ; Critical care
    Subject code 610
    Language English
    Size 1 Online-Ressource (x, 275 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019472939
    ISBN 978-981-10-5336-8 ; 9789811053351 ; 981-10-5336-7 ; 9811053359
    DOI 10.1007/978-981-10-5336-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Venous thromboembolism chemoprophylaxis in traumatic brain injury: is a conservative approach justified?

    Udy, Andrew A

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 23, Issue 4, Page(s) 359–360

    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2021.4.E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Qua pote quisque, in ea conterat arte diem

    Udy, Andrew

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2020  Volume 22, Issue 2, Page(s) 103–104

    MeSH term(s) Australia/epidemiology ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Critical Care ; Humans ; Intensive Care Units ; New Zealand/epidemiology ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Should critically ill patients with COVID-19 be managed in high-volume ICUs?

    Ramanan, Mahesh / Burrell, Aidan / Udy, Andrew

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 22, Issue 4, Page(s) 394–396

    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2020.4.l1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Early Net Ultrafiltration during Continuous Renal Replacement Therapy: Impact of Admission Diagnosis and Association with Mortality.

    Sansom, Benjamin / Udy, Andrew / Presneill, Jeffrey / Bellomo, Rinaldo

    Blood purification

    2023  Volume 53, Issue 3, Page(s) 170–180

    Abstract: Introduction: Continuous renal replacement therapy (CRRT) is common in the intensive care unit (ICU) but a high net ultrafiltration rate (UFNET) calculated with daily data may increase mortality. We aimed to study early UFNET practice using minute-by- ... ...

    Abstract Introduction: Continuous renal replacement therapy (CRRT) is common in the intensive care unit (ICU) but a high net ultrafiltration rate (UFNET) calculated with daily data may increase mortality. We aimed to study early UFNET practice using minute-by-minute CRRT machine recordings and to assess its association with admission diagnosis and mortality.
    Methods: We studied CRRT treatments in three adult ICUs over 7 years. We calculated early UFNET rates minute-by-minute and categorized UFNET into tertiles of mean UFNET in the first 72 h and admission diagnosis. We applied Cox-proportional hazards modelling with censoring of patients who died within 72 h.
    Results: We studied 1,218 patients, 154,712 h, and 9,282,729 min of CRRT (5,702 circuits). Mean early UFNET was 1.52 (1.46-1.57) mL/kg/h. Early UFNET tertiles were similar to, but somewhat higher than, previously reported values at 0.00-1.20 mL/kg/h, 1.21-1.93 mL/kg/h, and >1.93 mL/kg/h. UFNET values were similar whether evaluated at 24 or 72 h or for the entire duration of CRRT. There was, however, significant variation in UFNET practice by admission diagnosis: higher in respiratory diseases (pneumonia p = 0.01, other p < 0.0001) and cardiovascular disease (p = 0.005) but lower in cardiothoracic surgery (p = 0.04), renal (p = 0.0003) and toxicology-associated diagnoses (p = 0.01). Higher UFNET was associated with an increased hazard of death, HR 1.24 (1.13-1.37), independent of admission diagnosis, weight, age, sex, presence of end-stage kidney disease, and severity of illness.
    Conclusion: Early UFNET practice varies significantly by admission diagnosis. Higher early UFNET is independently associated with mortality. Impacts of UFNET on mortality may vary by admission diagnosis. Further work is required to elucidate the nature and mechanisms responsible for this association.
    MeSH term(s) Adult ; Humans ; Continuous Renal Replacement Therapy ; Renal Replacement Therapy ; Ultrafiltration ; Intensive Care Units ; Kidney Failure, Chronic ; Retrospective Studies ; Acute Kidney Injury/therapy ; Critical Illness
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000535315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vitamin C for the prevention of post-partum pulmonary oedema in patients with severe preeclampsia: Should we follow the Yellow Brick Road?

    Fujii, Tomoko / Udy, Andrew A

    Anaesthesia, critical care & pain medicine

    2021  Volume 40, Issue 1, Page(s) 100806

    MeSH term(s) Ascorbic Acid/therapeutic use ; Double-Blind Method ; Female ; Humans ; Postpartum Period ; Pre-Eclampsia ; Pregnancy ; Pulmonary Edema/etiology ; Pulmonary Edema/prevention & control
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2021-01-22
    Publishing country France
    Document type Editorial ; Comment
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2021.100806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Therapeutic Hypothermia for Refractory Hypoxemia on Venovenous Extracorporeal Membrane Oxygenation: An In Silico Study.

    Joyce, Christopher J / Udy, Andrew / Burrell, Aidan / Brown, Alastair

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2023  Volume 69, Issue 11, Page(s) 1031–1038

    Abstract: Patients with respiratory failure may remain hypoxemic despite treatment with venovenous extracorporeal membrane oxygenation (VV-ECMO). Therapeutic hypothermia is a potential treatment for such hypoxia as it reduces cardiac output ( ) and oxygen ... ...

    Abstract Patients with respiratory failure may remain hypoxemic despite treatment with venovenous extracorporeal membrane oxygenation (VV-ECMO). Therapeutic hypothermia is a potential treatment for such hypoxia as it reduces cardiac output ( ) and oxygen consumption. We modified a previously published mathematical model of gas exchange to investigate the effects of hypothermia during VV-ECMO. Partial pressures were expressed as measured at 37°C (α-stat). The effect of hypothermia on gas exchange was examined in four clinical scenarios of hypoxemia on VV-ECMO, each with different physiological derangements. All scenarios had arterial partial pressure of oxygen (PaO 2 ) ≤ 46 mm Hg and arterial oxygen saturation of hemoglobin (SaO 2 ) ≤ 81%. Three had high with low extracorporeal blood flow to ratio ( ). The problem in the fourth scenario was recirculation, with normal . Cooling to 33°C increased SaO 2 to > 89% and PaO 2 to > 50 mm Hg in all scenarios. Mixed venous oxygen saturation of hemoglobin as % ( ) increased to > 70% and mixed venous partial pressure of oxygen in mm Hg ( ) increased to > 34 mm Hg in scenarios with low . In the scenario with high recirculation, and increased, but to < 50% and < 27 mm Hg, respectively. This in silico study predicted cooling to 33°C will improve oxygenation in refractory hypoxemia on VV-ECMO, but the improvement will be less when the problem is recirculation.
    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation/adverse effects ; Hypothermia/therapy ; Hypoxia/etiology ; Hypoxia/therapy ; Oxygen ; Hypothermia, Induced ; Hemoglobins
    Chemical Substances Oxygen (S88TT14065) ; Hemoglobins
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000002020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.199: Show issues Location:
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  9. Article: Using central venous pressure waveform to confirm the placement of an internal jugular central venous catheter in the intensive care unit.

    Chua, Charlene Kit Zhen / Le Guen, Maurice / Lim, Richard / Udy, Andrew

    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

    2023  

    Abstract: Background: A mobile chest X-ray is traditionally performed to confirm the position of an internal jugular central venous catheter (CVC) after placement in the intensive care unit (ICU). Using chest radiography to confirm CVC position often results in ... ...

    Abstract Background: A mobile chest X-ray is traditionally performed to confirm the position of an internal jugular central venous catheter (CVC) after placement in the intensive care unit (ICU). Using chest radiography to confirm CVC position often results in delays in authorising the use of the CVC, requires the deployment of additional human resources, and is costly.
    Objective: This study aimed to determine the feasibility and accuracy of using the central venous pressure (CVP) waveform to confirm the placement of internal jugular CVCs.
    Methods: This retrospective study was conducted in a single quaternary ICU over a 6-month period. We included adult patients who had internal jugular CVC inserted and CVP transduced as part of their routine care in the ICU. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of CVP waveform analysis in confirming the position of internal jugular CVC relative to chest radiography were calculated.
    Results: A total of 241 internal jugular CVCs were inserted (in 219 patients, 35.6% female), and the CVP waveform was assessed. In 231 cases, this suggested adequate placement in a central vein, which corresponded with a correct position on subsequent chest X-ray. On six occasions, the CVP waveforms were interpreted as suboptimal; however, on chest X-rays, the CVCs were noted to be in a suitable position (sensitivity: 97.5%). Four suboptimal CVP waveforms were obtained, and they correctly identified CVC malposition on subsequent chest X-ray (specificity: 100%). The average time from CVC insertion to radiological completion was 118 minutes.
    Conclusion: CVP waveform analysis provides a feasible and reliable method for confirming adequate internal jugular CVC position. The use of chest radiography can be limited to cases where suboptimal CVP waveforms are obtained.
    Language English
    Publishing date 2023-12-07
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1159493-7
    ISSN 1878-1721 ; 1036-7314
    ISSN (online) 1878-1721
    ISSN 1036-7314
    DOI 10.1016/j.aucc.2023.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3762: Show issues Location:
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  10. Article ; Online: Inter-hospital transfer and clinical outcomes for people with COVID-19 admitted to intensive care units in Australia: an observational cohort study.

    Cini, Courtney / Neto, Ary S / Burrell, Aidan / Udy, Andrew

    The Medical journal of Australia

    2023  Volume 218, Issue 10, Page(s) 474–481

    Abstract: Objectives: To examine the association between inter-hospital transfer and in-hospital mortality among people with coronavirus disease 2019 (COVID-19) admitted to intensive care units (ICUs) in Australia.: Design: Retrospective cohort study; analysis ...

    Abstract Objectives: To examine the association between inter-hospital transfer and in-hospital mortality among people with coronavirus disease 2019 (COVID-19) admitted to intensive care units (ICUs) in Australia.
    Design: Retrospective cohort study; analysis of data collected for the Short Period Incidence Study of Severe Acute Respiratory Illness (SPRINT-SARI) Australia study.
    Setting, participants: People with COVID-19 admitted to 63 ICUs, 1 January 2020 - 1 April 2022.
    Main outcome measures: Primary outcome: in-hospital mortality; secondary outcomes: ICU and hospital lengths of stay and frequency of selected complications.
    Results: Of 5207 people with records in the SPRINT-SARI Australia database at 1 April 2022, 328 (6.3%) had been transferred between hospitals, 305 (93%) during the third pandemic wave. Compared with patients not transferred, their median age was lower (53 years; interquartile range [IQR], 45-61 years v 60 years; IQR, 46-70 years), their median body mass index higher (32.5 [IQR, 27.2-39.0] kg/m
    Conclusions: Among people with COVID-19 admitted to ICUs, patients transferred from another hospital required more intense interventions and remained in hospital longer, but were not at greater risk of dying in hospital than the patients who were not transferred.
    MeSH term(s) Humans ; Middle Aged ; COVID-19/epidemiology ; COVID-19/therapy ; Retrospective Studies ; COVID-19 Vaccines ; Cohort Studies ; Intensive Care Units ; Hospitals ; Hospital Mortality ; Critical Illness
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-10
    Publishing country Australia
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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