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Article ; Online: m

Yoneda, Ryoma / Ueda, Naomi / Kurokawa, Riki

International journal of molecular sciences

2021 Volume 22, Issue 20

Abstract: Translocated in LipoSarcoma/Fused in Sarcoma (TLS/FUS) is a nuclear RNA binding protein whose mutations cause amyotrophic lateral sclerosis. TLS/FUS undergoes LLPS and forms membraneless particles with other proteins and nucleic acids. Interaction with ... ...

Abstract	Translocated in LipoSarcoma/Fused in Sarcoma (TLS/FUS) is a nuclear RNA binding protein whose mutations cause amyotrophic lateral sclerosis. TLS/FUS undergoes LLPS and forms membraneless particles with other proteins and nucleic acids. Interaction with RNA alters conformation of TLS/FUS, which affects binding with proteins, but the effect of m
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/chemistry ; Cell Line ; Cell Survival/drug effects ; Cytoplasm/metabolism ; Genetic Loci ; Humans ; Liquid-Liquid Extraction ; Mutagenesis, Site-Directed ; Protein Aggregates/drug effects ; Protein Binding ; RNA/chemistry ; RNA/metabolism ; RNA/pharmacology ; RNA, Long Noncoding/chemistry ; RNA-Binding Protein FUS/chemistry ; RNA-Binding Protein FUS/genetics ; RNA-Binding Protein FUS/metabolism ; Sorbitol/pharmacology
Chemical Substances	Protein Aggregates ; RNA, Long Noncoding ; RNA-Binding Protein FUS ; Sorbitol (506T60A25R) ; RNA (63231-63-0) ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2021-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222011014
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Article ; Online: Long noncoding RNA

Yoneda, Ryoma / Ueda, Naomi / Uranishi, Kousuke / Hirasaki, Masataka / Kurokawa, Riki

The Journal of biological chemistry

2020 Volume 295, Issue 17, Page(s) 5626–5639

Abstract: ... pncRNA- ... ...

Abstract	pncRNA-D
MeSH term(s)	Cell Cycle Checkpoints ; Cyclin D1/genetics ; Down-Regulation ; Epigenesis, Genetic ; Genes, bcl-1 ; HeLa Cells ; Humans ; Methylation ; Promoter Regions, Genetic ; RNA, Long Noncoding/genetics
Chemical Substances	CCND1 protein, human ; RNA, Long Noncoding ; Cyclin D1 (136601-57-5)
Language	English
Publishing date	2020-03-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA119.011556
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Article ; Online: Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.

Cui, Wei / Yoneda, Ryoma / Ueda, Naomi / Kurokawa, Riki

The Journal of biological chemistry

2018 Volume 293, Issue 28, Page(s) 10937–10948

Abstract: Translocated in liposarcoma (TLS) is an RNA-binding protein and a transcription-regulatory sensor of DNA damage. TLS binds promoter-associated noncoding RNA (pncRNA) and inhibits histone acetyltransferase (HAT) activity of CREB-binding protein (CBP)/E1A- ... ...

Abstract	Translocated in liposarcoma (TLS) is an RNA-binding protein and a transcription-regulatory sensor of DNA damage. TLS binds promoter-associated noncoding RNA (pncRNA) and inhibits histone acetyltransferase (HAT) activity of CREB-binding protein (CBP)/E1A-binding protein P300 (p300) on the cyclin D1 (
MeSH term(s)	Arginine/chemistry ; Cyclin D1/genetics ; Cyclin D1/metabolism ; E1A-Associated p300 Protein/genetics ; E1A-Associated p300 Protein/metabolism ; Gene Expression Regulation ; Humans ; Methylation ; Promoter Regions, Genetic ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA-Binding Protein FUS/genetics ; RNA-Binding Protein FUS/metabolism ; Transcription, Genetic
Chemical Substances	CCND1 protein, human ; RNA, Long Noncoding ; RNA-Binding Protein FUS ; Cyclin D1 (136601-57-5) ; Arginine (94ZLA3W45F) ; Protein-Arginine N-Methyltransferases (EC 2.1.1.319) ; E1A-Associated p300 Protein (EC 2.3.1.48) ; EP300 protein, human (EC 2.3.1.48)
Language	English
Publishing date	2018-05-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA117.000598
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Article ; Online: A novel challenge of nondestructive analysis on OGATA Koan's sealed medicine by muonic X-ray analysis.

Shimada-Takaura, Kayoko / Ninomiya, Kazuhiko / Sato, Akira / Ueda, Naomi / Tampo, Motonobu / Takeshita, Soshi / Umegaki, Izumi / Miyake, Yasuhiro / Takahashi, Kyoko

Journal of natural medicines

2021 Volume 75, Issue 3, Page(s) 532–539

Abstract: OGATA Koan (1810-63) was a physician and the director of Tekijuku, and he contributed to Western medicine in the late Edo period. Osaka University preserves two of his medicine chests. One of the chests, which was used in his last years (the second chest) ...

Abstract	OGATA Koan (1810-63) was a physician and the director of Tekijuku, and he contributed to Western medicine in the late Edo period. Osaka University preserves two of his medicine chests. One of the chests, which was used in his last years (the second chest) contained 22 glass bottles and 6 wooden cylinders. These bottles and cylinders contained formulated medicines; however, about half cannot be opened because of the long-term storage. It is necessary to comprehend the physical property of both the containers and their contents for investigation of this adequate preservation method; however, destructive analysis is not allowed. To analyze the medicines sealed in the glass bottles, we focused on muonic X-ray analysis, which has high transmittance. First, we certified the analytical methods using a historical medicinal specimen preserved in Osaka University. Thereafter, we applied the method on the bottles stored in the second chest. X-ray fluorescence identified the glass of those bottles to be lead potash glass. Among these bottles, we chose the bottle with the label "," which contains white powdered medication, for muonic X-ray analysis. We identified the contents of the medication in the glass to be Hg
MeSH term(s)	Biological Products/analysis ; Biological Products/history ; History, 19th Century ; Humans ; Japan ; Pharmacognosy ; X-Rays
Chemical Substances	Biological Products
Language	English
Publishing date	2021-03-13
Publishing country	Japan
Document type	Historical Article ; Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-021-01487-0
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Article: A novel challenge of nondestructive analysis on OGATA Koan’s sealed medicine by muonic X-ray analysis

Shimada-Takaura, Kayoko / Ninomiya, Kazuhiko / Sato, Akira / Ueda, Naomi / Tampo, Motonobu / Takeshita, Soshi / Umegaki, Izumi / Miyake, Yasuhiro / Takahashi, Kyoko

Natural medicines. 2021 June, v. 75, no. 3

2021

Abstract: OGATA Koan (1810–63) was a physician and the director of Tekijuku, and he contributed to Western medicine in the late Edo period. Osaka University preserves two of his medicine chests. One of the chests, which was used in his last years (the second chest) ...

Abstract	OGATA Koan (1810–63) was a physician and the director of Tekijuku, and he contributed to Western medicine in the late Edo period. Osaka University preserves two of his medicine chests. One of the chests, which was used in his last years (the second chest) contained 22 glass bottles and 6 wooden cylinders. These bottles and cylinders contained formulated medicines; however, about half cannot be opened because of the long-term storage. It is necessary to comprehend the physical property of both the containers and their contents for investigation of this adequate preservation method; however, destructive analysis is not allowed. To analyze the medicines sealed in the glass bottles, we focused on muonic X-ray analysis, which has high transmittance. First, we certified the analytical methods using a historical medicinal specimen preserved in Osaka University. Thereafter, we applied the method on the bottles stored in the second chest. X-ray fluorescence identified the glass of those bottles to be lead potash glass. Among these bottles, we chose the bottle with the label “甘,” which contains white powdered medication, for muonic X-ray analysis. We identified the contents of the medication in the glass to be Hg₂Cl₂. Through this study, we first applied muonic X-ray analysis on the medical inheritances and succeeded to detect the elements contained both in the container and in the contents of the sealed bottle. This would be a new method for nondestructive analysis of such cultural properties.
Keywords	X-radiation ; chest ; drug therapy ; fluorescence ; glass ; lead ; medicine ; nondestructive methods ; storage time ; transmittance
Language	English
Dates of publication	2021-06
Size	p. 532-539.
Publishing place	Springer Singapore
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1201350-x
ISSN	1340-3443
ISSN	1340-3443
DOI	10.1007/s11418-021-01487-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Internal evaluation of impregnation treatment of waterlogged wood; relation between concentration of internal materials and relaxation time using magnetic resonance imaging.

Kanazawa, Yuki / Yamada, Tetsuya / Kido, Aki / Fujimoto, Koji / Takakura, Kyoko / Hayashi, Hiroaki / Fushimi, Yasutaka / Kozawa, Satoshi / Koizumi, Koji / Okuni, Makiko / Ueda, Naomi / Togashi, Kaori

Magnetic resonance imaging

2017 Volume 38, Page(s) 196–201

Abstract: The purpose of this study is to clarify the degree of impregnation resulting from treatment of internal waterlogged wood samples using MRI. On a 1.5T MR scanner, ... ...

Abstract	The purpose of this study is to clarify the degree of impregnation resulting from treatment of internal waterlogged wood samples using MRI. On a 1.5T MR scanner, T
MeSH term(s)	Magnetic Resonance Imaging ; Polyethylene Glycols/chemistry ; Reproducibility of Results ; Trehalose/chemistry ; Water/chemistry ; Wood/chemistry
Chemical Substances	Water (059QF0KO0R) ; Polyethylene Glycols (30IQX730WE) ; Trehalose (B8WCK70T7I)
Language	English
Publishing date	2017-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604885-7
ISSN	1873-5894 ; 0730-725X
ISSN (online)	1873-5894
ISSN	0730-725X
DOI	10.1016/j.mri.2017.01.010
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Article ; Online: Synthesis and properties of oxo-carboxylato- and dioxo-bridged diosmium complexes of tris(2-pyridylmethyl)amine.

Sugimoto, Hideki / Kitayama, Kazuhiro / Ashikari, Kenji / Matsunami, Chikako / Ueda, Naomi / Umakoshi, Keisuke / Hosokoshi, Yuko / Sasaki, Yoichi / Itoh, Shinobu

Inorganic chemistry

2011 Volume 50, Issue 18, Page(s) 9014–9023

Abstract: A series of oxo-bridged diosmium complexes with tpa ligand (tpa = tris(2-pyridylmethyl)amine) are synthesized. The hydrolytic reaction of the mononuclear osmium complex [Os(III)Cl(2)(tpa)]PF(6) in aqueous solution containing a sodium carboxylate yields a ...

Abstract	A series of oxo-bridged diosmium complexes with tpa ligand (tpa = tris(2-pyridylmethyl)amine) are synthesized. The hydrolytic reaction of the mononuclear osmium complex [Os(III)Cl(2)(tpa)]PF(6) in aqueous solution containing a sodium carboxylate yields a μ-oxo-μ-carboxylato-diosmium(III) complex, [Os(III)(2)(μ-O)(μ-RCOO)(tpa)(2)](PF(6))(3) (R = C(3)H(7) (1), CH(3) (2), or C(6)H(5) (3)). One-electron oxidation of 1 with (NH(4))(2)Ce(IV)(NO(3))(6) gives a mixed-valent [Os(III)Os(IV)(μ-O)(μ-C(3)H(7)COO)(tpa)(2)](PF(6))(4) complex (4). A mixed-valent di-μ-oxo-diosmium complex, [Os(III)Os(IV)(μ-O)(2)(tpa)(2)](PF(6))(3) (5), is also synthesized from 1 in an aerobic alkaline solution (pH 13.5). All the complexes exhibit strong absorption bands in a visible-near-infrared region based on interactions of the osmium dπ and oxygen pπ orbitals of the Os-O-Os moiety. The X-ray crystallographic analysis of 1, 3, and 4 shows that the osmium centers take a pseudo-octahedral geometry in the μ-oxo-μ-carboxylato-diosmium core. The mixed-valent osmium(III)osmium(IV) complex 4 has a shorter osmium-oxo bond and a larger osmium-oxo-osmium angle as compared with those of the diosmium(III) complex 1 having the same bridging carboxylate. Crystal structure of 5 reveals that the two osmium ions are bridged by two oxo groups to give an Os(2)(μ-O)(2) core with the significantly short osmium-osmium distance (2.51784(7) Å), which is indicative of a direct osmium-osmium bond formation with the bond order of 1.5 (σ(2)π(2)δ(2)δ(2)π(1) configuration). In the electrochemical studies, the μ-oxo-μ-carboxylato-diosmium(III) complexes exhibit two reversible Os(III)Os(III)/Os(III)Os(IV) and Os(III)Os(IV)/Os(IV)Os(IV) oxidation couples and one irreversible redox wave for the Os(III)Os(III)/Os(II)Os(III) couple in CH(3)CN. The irreversible reductive process becomes reversible in CH(3)CN/H(2)O (1:1 Britton-Robinson buffer; pH 5-11), where the {1H(+)/2e(-)} transfer process is indicated by the plot of the redox potentials against the pH values of the solution of 1. Thus, the μ-oxo-μ-butyrato-diosmium(III) center undergoes proton-coupled electron transfer to yield a μ-hydroxo-μ-butyrato-diosmisum(II) species. The di(μ-oxo) complex 5 exhibits one reversible Os(III)Os(IV)/Os(IV)Os(IV) oxidation process and one reversible Os(III)Os(IV)/Os(III)Os(III) reduction process in CH(3)CN. The comproportionation constants K(com) of the Os(III)Os(IV) states for the present diosmium complexes are on the order of 10(19). The values are significantly larger when compared with those of similar oxo-bridged dimetal complexes of ruthenium and rhenium.
Language	English
Publishing date	2011-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic201230k
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Article: A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis.

Kohno, Hiroyuki / Maeda, Masayo / Tanino, Mikio / Tsukio, Yoshiaki / Ueda, Naomi / Wada, Keiji / Sugie, Shigeyuki / Mori, Hideki / Tanaka, Takuji

Cancer letters

2002 Volume 183, Issue 2, Page(s) 131–139

Abstract: The modifying effect of dietary administration of a diterpenoid furanolactone columbin isolated from the crude drug Calumbae Radix (the root of Jateorhiza columba MIERS, Menispermacea) on azoxymethane (AOM)-induced was investigated in male F344 rats. ... ...

Abstract	The modifying effect of dietary administration of a diterpenoid furanolactone columbin isolated from the crude drug Calumbae Radix (the root of Jateorhiza columba MIERS, Menispermacea) on azoxymethane (AOM)-induced was investigated in male F344 rats. Animals were initiated with AOM (three weekly subcutaneous injections of 15 mg/kg body weight) to induce colonic neoplasms. They were fed the experimental diets mixed with columbin (4, 20, and 100 ppm) for 4 weeks, starting 1 week before the first dosing of AOM and thereafter maintained on the basal diet without columbin. Additional experimental groups included the AOM alone group, the columbin alone group (100 ppm in diet for 4 weeks), and the untreated control group. Dietary feeding of columbin (4, 20, and 100 ppm) during the initiation phase of AOM-induced colon carcinogenesis reduced the incidence and multiplicity of colonic adenocarcinoma and the inhibition by feeding of 20 ppm (incidence: 20%, P=0.0242 and multiplicity: 0.20+/-0.40, P<0.02) and 100 ppm (incidence: 10%, P=0.0029 and multiplicity: 0.10+/-0.30, P<0.002) columbin was significant when compared with the AOM alone group (incidence: 55% and multiplicity: 0.55+/-0.50). Also, columbin administration in diet lowered the number of argyrophilic nucleolar organizer regions protein per nucleus in non-lesional colonic crypts and the blood polyamine content, which are reflected in cell proliferation activity. These results indicate chemopreventive ability of dietary columbin against chemically induced colon tumorigenesis when fed during the initiation phase, providing a scientific basis for chemopreventive ability of columbin against human colon cancer.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Azoxymethane ; Carcinogens ; Cell Nucleus/metabolism ; Colon/pathology ; Colonic Neoplasms/chemically induced ; Colonic Neoplasms/drug therapy ; Diterpenes/chemistry ; Diterpenes/pharmacology ; Dose-Response Relationship, Drug ; Lactones/chemistry ; Lactones/pharmacology ; Lactones/therapeutic use ; Male ; Mucous Membrane/pathology ; Organ Size ; Polyamines/blood ; Rats ; Rats, Inbred F344 ; Terpenes/therapeutic use ; Time Factors
Chemical Substances	Antineoplastic Agents ; Carcinogens ; Diterpenes ; Lactones ; Polyamines ; Terpenes ; columbin (KKI91P85GE) ; Azoxymethane (MO0N1J0SEN)
Language	English
Publishing date	2002-09-26
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/s0304-3835(02)00159-3
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Article: Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver.

Sasaki, Keiko / Hatta, Shinichi / Wada, Keiji / Ueda, Naomi / Yoshimura, Teruki / Endo, Tetsuya / Sakata, Masakatsu / Tanaka, Takuji / Haga, Masanobu

Life sciences

2002 Volume 70, Issue 14, Page(s) 1657–1667

Abstract: The effects of a standardized extract of Ginkgo biloba L. leaves (EGb) and its terpene constituents, bilobalide and ginkgolides, on the activities of detoxification enzymes, i.e., glutathione S-transferases (GSTs) and DT-diaphorase, and glutathione ... ...

Abstract	The effects of a standardized extract of Ginkgo biloba L. leaves (EGb) and its terpene constituents, bilobalide and ginkgolides, on the activities of detoxification enzymes, i.e., glutathione S-transferases (GSTs) and DT-diaphorase, and glutathione contents, were investigated in the mouse liver. Oral treatment with EGb (100-1,000 mg/kg) and bilobalide (10-30 mg/kg) once a day for 4 days caused a dose-dependent elevation in GST activity. Ginkgolide A (30 mg/kg, for 4 days) also significantly elevated GST activity, whereas ginkgolide B and ginkgolide C at the same dose had no effects. EGb significantly increased the protein level of GST pi, and bilobalide significantly increased those of GST alpha and GST mu Moreover, EGb-treatment and bilobalide-treatment caused significant elevations in DT-diaphorase activity and in hepatic glutathione contents.
MeSH term(s)	Animals ; Blotting, Western ; Carcinogens/metabolism ; Cyclopentanes/pharmacology ; Diterpenes ; Furans/pharmacology ; Ginkgo biloba/chemistry ; Ginkgolides ; Glutathione/metabolism ; Glutathione Transferase/metabolism ; Isoenzymes/metabolism ; Lactones/pharmacology ; Liver/drug effects ; Liver/enzymology ; Liver/metabolism ; Mice ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Plant Extracts/pharmacology ; Plant Leaves/chemistry
Chemical Substances	Carcinogens ; Cyclopentanes ; Diterpenes ; Furans ; Ginkgolides ; Isoenzymes ; Lactones ; Plant Extracts ; ginkgolide B (DF149B9460) ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; Glutathione Transferase (EC 2.5.1.18) ; Glutathione (GAN16C9B8O) ; bilobalide (M81D2O8H7U)
Language	English
Publishing date	2002-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/s0024-3205(01)01557-0
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