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  1. Article: [Medical management of esophageal motility disorders].

    Akiyama, Junichi / Yokoi, Chizu / Uemura, Naomi

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2024  Volume 121, Issue 2, Page(s) 96–103

    MeSH term(s) Humans ; Esophageal Motility Disorders/diagnosis ; Esophageal Motility Disorders/therapy ; Esophageal Achalasia ; Manometry
    Language Japanese
    Publishing date 2024-02-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.121.96
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  2. Article: [Technical evaluation of medical practice--conversion from things to skill and art. Topics: VI. Issues on fee for medical services in 20 internal medicine fields: 4. Subject regarding the fee-for-medical service in the region of the digestive organ].

    Uemura, Naomi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2015  Volume 103, Issue 12, Page(s) 3022–3024

    MeSH term(s) Digestive System ; Fees, Medical ; Humans ; Internal Medicine/economics ; Japan ; Practice Management, Medical/economics ; Reimbursement Mechanisms/economics
    Language Japanese
    Publishing date 2015-03-20
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.103.3022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Effect on medical practices after health insurance application for "H. pylori gastritis"].

    Uemura, Naomi

    Nihon rinsho. Japanese journal of clinical medicine

    2013  Volume 71, Issue 8, Page(s) 1485–1489

    Abstract: Eradication therapy for H. pylori infected gastritis became the health insurance application in Japan in 2013. It will seem that the conception of "the chronic gastritis" greatly changes from now on in Japan. "The chronic gastritis" will be classified in ...

    Abstract Eradication therapy for H. pylori infected gastritis became the health insurance application in Japan in 2013. It will seem that the conception of "the chronic gastritis" greatly changes from now on in Japan. "The chronic gastritis" will be classified in H. pylori gastritis and functional dyspepsia in the near future. On the other hand, it is expected that the process of the gastric cancer detection survey greatly changes too. It seems that the ABC checkup using the blood will be carried out in place of Barium examination. A decrease in gastric cancer mortality is expected as things mentioned above from now on.
    MeSH term(s) Gastric Mucosa/pathology ; Gastritis/diagnosis ; Gastritis/economics ; Gastritis/etiology ; Helicobacter Infections/complications ; Helicobacter Infections/diagnosis ; Helicobacter Infections/economics ; Helicobacter pylori/isolation & purification ; Humans ; Insurance, Health/economics ; Japan ; Practice Management, Medical
    Language Japanese
    Publishing date 2013-08
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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  4. Article ; Online: A case of non-esophageal eosinophilic gastrointestinal disease diagnosed by mucosal incision-assisted biopsy.

    Watanabe, Ryo / Yada, Tomoyuki / Yoshida, Ai / Odaka, Keita / Yagi, Toyokazu / Ikegami, Yurika / Sekine, Katsunori / Oide, Takashi / Uemura, Naomi

    Clinical journal of gastroenterology

    2024  Volume 17, Issue 2, Page(s) 228–233

    Abstract: A 46-year-old woman presented at our hospital with anorexia, vomiting, and diarrhea. Blood tests indicated markedly increased eosinophil counts, and esophagogastroduodenoscopy revealed slight erythema in the gastric body. Computed tomography showed ... ...

    Abstract A 46-year-old woman presented at our hospital with anorexia, vomiting, and diarrhea. Blood tests indicated markedly increased eosinophil counts, and esophagogastroduodenoscopy revealed slight erythema in the gastric body. Computed tomography showed edematous thickening of the stomach and small intestinal walls and peritonitis. Thus, eosinophilic gastrointestinal disease was suspected. Endoscopic biopsies from the esophagus, stomach, and duodenum were collected, but no significant increases in eosinophil counts were observed. Little ascites effusion was detected and puncture cytology was difficult to perform. Thus, a sample of the muscularis propria layer was obtained by mucosal incision-assisted biopsy. Histopathological examination of the biopsy revealed significant eosinophilic infiltration within the muscularis propria layer of the stomach, confirming the diagnosis of non-eosinophilic esophagitis eosinophilic gastrointestinal disease. The patient was treated with a leukotriene receptor antagonist and prednisolone, and her clinical symptoms and gastrointestinal wall thickening rapidly improved. The Japanese diagnostic guideline for non-eosinophilic esophagitis eosinophilic gastrointestinal disease requires endoscopic biopsy or eosinophilic infiltration of ascites fluid. When diagnosis is difficult using conventional methods, as in this case, mucosal incision-assisted biopsy is useful as a next step.
    MeSH term(s) Female ; Humans ; Middle Aged ; Ascites ; Enteritis/diagnosis ; Biopsy ; Esophagitis ; Eosinophilia ; Gastritis
    Language English
    Publishing date 2024-01-06
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-023-01905-8
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  5. Article: [Pathologic characteristics of gastric ulcer in the aged].

    Uemura, Naomi

    Nihon rinsho. Japanese journal of clinical medicine

    2010  Volume 68, Issue 11, Page(s) 1995–2000

    Abstract: The use of aspirin continues to increase as a result of accumulation of evidence of benefits in treatment strategies for cardiovascular disease. These antiplatelet agents, however, have recognizable risks of gastrointestinal complications such as ... ...

    Abstract The use of aspirin continues to increase as a result of accumulation of evidence of benefits in treatment strategies for cardiovascular disease. These antiplatelet agents, however, have recognizable risks of gastrointestinal complications such as ulceration and related bleeding. Based on the published guidelines in Japan, the cause of gastric ulcer is divided roughly into Helicobacter pylori infection and nonsteroidal antiinflammatory drug (NSAID) including aspirin. With the decrease of H. pylori infection rate in a young and that of ulcer recurrence by H. pylori eradication therapy, the cases with peptic ulcer that is come from H. pylori infection have decreased in Japan. On the other hand, gastric ulcer based on the use of aspirin and NSAID have increased. The author reviewed pathologic characteristics of gastric ulcer in the aged in this report.
    MeSH term(s) Aged ; Aspirin/adverse effects ; Helicobacter Infections/complications ; Helicobacter pylori ; Humans ; Stomach Ulcer/chemically induced ; Stomach Ulcer/etiology ; Stomach Ulcer/pathology
    Chemical Substances Aspirin (R16CO5Y76E)
    Language Japanese
    Publishing date 2010-11
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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  6. Article ; Online: Randomised clinical trial: 3-year interim analysis results of the VISION trial to evaluate the long-term safety of vonoprazan as maintenance treatment in patients with erosive oesophagitis.

    Haruma, Ken / Kinoshita, Yoshikazu / Yao, Takashi / Kushima, Ryoji / Akiyama, Junichi / Aoyama, Nobuo / Kanoo, Tatsuhiro / Miyata, Kouji / Kusumoto, Naomi / Uemura, Naomi

    BMC gastroenterology

    2023  Volume 23, Issue 1, Page(s) 139

    Abstract: Background: VISION is a randomised, phase 4, open-label, parallel-group, multicentre study conducted in 33 centres in Japan. The aim of this study was to assess the long-term safety of vonoprazan for maintenance treatment of healed erosive oesophagitis ... ...

    Abstract Background: VISION is a randomised, phase 4, open-label, parallel-group, multicentre study conducted in 33 centres in Japan. The aim of this study was to assess the long-term safety of vonoprazan for maintenance treatment of healed erosive oesophagitis versus lansoprazole.
    Methods: Patients with endoscopically diagnosed erosive oesophagitis were randomised 2:1 to once-daily vonoprazan 20 mg or lansoprazole 30 mg, for a 4- to 8-week healing phase. Patients with endoscopically confirmed healing entered a 260-week maintenance phase with a once-daily starting dose of vonoprazan 10 mg or lansoprazole 15 mg. Primary endpoint was change in gastric mucosal histopathology.
    Results: Of 208 patients (vonoprazan, n = 139; lansoprazole, n = 69) entering the healing phase, 202 entered the maintenance phase (vonoprazan, n = 135; lansoprazole, n = 67). At 3 years, 109 vonoprazan-treated and 58 lansoprazole-treated patients remained on treatment. Histopathological evaluation of gastric mucosa showed that hyperplasia of parietal, foveolar and G cells was more common with vonoprazan than lansoprazole at week 156 of the maintenance phase. There was no marked increase in the occurrence of parietal, foveolar and G cell hyperplasia among patients in the vonoprazan group from week 48 to week 156. Histopathological evaluation of the gastric mucosa also showed no neoplastic changes in either group. No new safety issues were identified.
    Conclusions: In this interim analysis of VISION, no new safety concerns were identified in Japanese patients with healed erosive oesophagitis receiving vonoprazan or lansoprazole as maintenance treatment for 3 years. (CT.gov identifier: NCT02679508; JapicCTI-163153; Japan Registry of Clinical Trials: jRCTs031180040).
    MeSH term(s) Humans ; Proton Pump Inhibitors/therapeutic use ; Hyperplasia ; Esophagitis ; Lansoprazole/adverse effects ; Peptic Ulcer ; Treatment Outcome ; 2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use ; Anti-Ulcer Agents/therapeutic use ; Double-Blind Method
    Chemical Substances Proton Pump Inhibitors ; 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Lansoprazole (0K5C5T2QPG) ; 2-Pyridinylmethylsulfinylbenzimidazoles ; Anti-Ulcer Agents
    Language English
    Publishing date 2023-05-01
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-023-02772-w
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  7. Article ; Online: Identifying predictors for comorbidities related mortality versus pancreatic cancer related mortality in patients with intraductal papillary mucinous neoplasm.

    Sekine, Katsunori / Nagata, Naoyoshi / Hisada, Yuya / Yamamoto, Kenjiro / Mukai, Shuntaro / Tsuchiya, Takayoshi / Machitori, Akihiro / Kojima, Yasushi / Yada, Tomoyuki / Yamamoto, Natsuyo / Uemura, Naomi / Itoi, Takao / Kawai, Takashi

    United European gastroenterology journal

    2024  

    Abstract: Backgrounds: Few data are available for surveillance decisions focusing on factors related to mortality, as the primary outcome, in intraductal papillary mucinous neoplasm (IPMN) patients.: Aims: We aimed to identify imaging features and patient ... ...

    Abstract Backgrounds: Few data are available for surveillance decisions focusing on factors related to mortality, as the primary outcome, in intraductal papillary mucinous neoplasm (IPMN) patients.
    Aims: We aimed to identify imaging features and patient backgrounds associated with mortality risks by comparing pancreatic cancer (PC) and comorbidities.
    Methods: We retrospectively conducted a multicenter long-term follow-up of 1864 IPMN patients. Competing risk analysis was performed for PC- and comorbidity-related mortality.
    Results: During the median follow-up period of 5.5 years, 14.0% (261/1864) of patients died. Main pancreatic duct ≥5 mm and mural nodules were significantly related to all-cause and PC-related mortality, whereas cyst ≥30 mm did not relate. In 1730 patients without high-risk imaging features, 48 and 180 patients died of PC and comorbidity. In the derivation cohort, a prediction model for comorbidity-related mortality was created, comprising age, cancer history, diabetes mellitus complications, chronic heart failure, stroke, paralysis, peripheral artery disease, liver cirrhosis, and collagen disease in multivariate analysis. If a patient had a 5 score, 5- and 10-year comorbidity-related mortality is estimated at 18.9% and 50.2%, respectively, more than 7 times higher than PC-related mortality. The model score was also significantly associated with comorbidity-related mortality in a validation cohort.
    Conclusions: This study demonstrates main pancreatic duct dilation and mural nodules indicate risk of PC-related mortality, identifying patients who need periodic examination. A comorbidity-related mortality prediction model based on the patient's age and comorbidities can stratify patients who do not require regular tests, especially beyond 5 years, among IPMN patients without high-risk features.
    Clinical trial registration: T2022-0046.
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12540
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  8. Article: [Gastric cancer].

    Uemura, Naomi

    Nihon rinsho. Japanese journal of clinical medicine

    2009  Volume 67, Issue 12, Page(s) 2332–2337

    Abstract: From many findings, it has been established that persistent infection of Helicobacter pylori (H. pylori) causes chronic active gastritis and subsequently causes the gastric mucosa of the high risk for gastric cancer development. On the other hand, recent ...

    Abstract From many findings, it has been established that persistent infection of Helicobacter pylori (H. pylori) causes chronic active gastritis and subsequently causes the gastric mucosa of the high risk for gastric cancer development. On the other hand, recent Japanese-study results have shown the possibility of gastric cancer prevention by H. pylor eradication. Moreover the development of gastric cancer in uninfected subjects is very rare; therefore, prevention of gastric cancer by H. pylori eradication becomes a topic in Japan. To get rid of gastric cancer from Japan, the risk of gastric cancer should be determined by presence of H. pylori infection in a young fellow, on the other hand, the risk by the examination that combined serum PG method with serum antibody method in subjects after middle aged. It is now expected that eradication treatment should be performed for these high-risk subjects.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Stomach Neoplasms/etiology
    Language Japanese
    Publishing date 2009-12
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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  9. Article: [The road to the insurance coverage of balloon-occluded retrograde transvenous obliteration for gastric varices].

    Kobayakawa, Masao / Kokubu, Shigehiro / Uemura, Naomi

    Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

    2017  Volume 115, Issue 5, Page(s) 460–466

    MeSH term(s) Balloon Occlusion/economics ; Esophageal and Gastric Varices/therapy ; Gastrointestinal Hemorrhage ; Humans ; Insurance Coverage ; Sclerosing Solutions ; Sclerotherapy ; Treatment Outcome
    Chemical Substances Sclerosing Solutions
    Language Japanese
    Publishing date 2017-03-20
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.115.460
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  10. Article: [Gastric adenoma, hyperlastic polyp and fundic gland polyp].

    Uemura, Naomi

    Nihon rinsho. Japanese journal of clinical medicine

    2005  Volume 63 Suppl 11, Page(s) 560–564

    MeSH term(s) Adenoma/diagnosis ; Adenoma/pathology ; Adenoma/therapy ; Diagnosis, Differential ; Diagnostic Imaging ; Gastroscopy ; Humans ; Polyps/diagnosis ; Polyps/pathology ; Polyps/therapy ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy
    Language Japanese
    Publishing date 2005-11
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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