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  1. Article ; Online: Editorial commentary: Atrial septal aneurysm as a risk factor for ischemic stroke with patent foramen ovale.

    Ueno, Yuji

    Trends in cardiovascular medicine

    2022  Volume 33, Issue 6, Page(s) 334–335

    MeSH term(s) Humans ; Foramen Ovale, Patent/diagnosis ; Foramen Ovale, Patent/diagnostic imaging ; Ischemic Stroke/complications ; Heart Septal Defects, Atrial/diagnosis ; Heart Septal Defects, Atrial/diagnostic imaging ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology ; Risk Factors ; Aneurysm/complications
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2022.05.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3419: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Parkinson' s disease complicated after 12 years from the onset of multiple sclerosis.

    Shindo, Kazumasa / Morishima, Yuto / Hata, Takanori / Nakajima, Sho / Ueno, Yuji

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Volume 45, Issue 4, Page(s) 1775–1778

    MeSH term(s) Humans ; Parkinson Disease/complications ; Multiple Sclerosis/complications
    Language English
    Publishing date 2023-11-16
    Publishing country Italy
    Document type Letter
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-07201-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Association of blood eicosapentaenoic acid levels with intracerebral hemorrhage during the COVID-19 pandemic: preliminary experience from a single-center in Japan.

    Hira, Kenichiro / Ueno, Yuji / Miyamoto, Nobukazu / Nakajima, Sho / Kijima, Chikage / Hattori, Nobutaka

    BMC neurology

    2022  Volume 22, Issue 1, Page(s) 128

    Abstract: Background: The COVID-19 pandemic has forced lockdowns and declarations of states of emergency, resulting in marked changes to daily life such as dietary habits in many countries. Though serum omega-3 polyunsaturated fatty acids levels have been shown ... ...

    Abstract Background: The COVID-19 pandemic has forced lockdowns and declarations of states of emergency, resulting in marked changes to daily life such as dietary habits in many countries. Though serum omega-3 polyunsaturated fatty acids levels have been shown to be useful markers for recurrent vascular events or worse prognosis in cardiovascular diseases and ischemic stroke, the relationship between serum omega-3 PUFA levels and the occurrence of intracerebral hemorrhage has essentially been unknown. We explored the association of serum omega-3 polyunsaturated fatty acids with intracerebral hemorrhage during the COVID-19 pandemic.
    Methods: Participants comprised patients admitted to Juntendo University Hospital (Tokyo, Japan) with intracerebral hemorrhage between January 1, 2016 and April 30, 2020. Clinical characteristics including serum omega-3 polyunsaturated fatty acid levels were compared between patients developing intracerebral hemorrhage during the period from January 1, 2016 to February 29, 2020, and the subsequent COVID-19 pandemic period (March 1 to April 30, 2020). Clinical characteristics independently related to intracerebral hemorrhage during the COVID-19 pandemic were analyzed by comparing these two cohorts of intracerebral hemorrhage patients in different periods.
    Results: A total of 103 patients (age, 67.0 ± 13.9 years; 67 males) with intracerebral hemorrhage were enrolled. Intracerebral hemorrhage developed in 91 patients before and 12 patients during the COVID-19 pandemic. Monthly averages of intracerebral hemorrhage patients admitted to our hospital during and before the COVID-19 pandemic were 6 and 1.82, respectively. Serum eicosapentaenoic acid levels were significantly lower in intracerebral hemorrhage patients during the COVID-19 pandemic than before (31.87 ± 12.93 μg/ml vs. 63.74 ± 43.29 μg/ml, p = 0.007). Multiple logistic regression analysis showed that, compared to before the COVID-19 pandemic, dyslipidemia (odds ratio 0.163, 95% confidence interval 0.031-0.852; p = 0.032) and eicosapentaenoic acid levels (odds ratio 0.947, 95% confidence interval 0.901-0.994; p = 0.029) were associated with intracerebral hemorrhage during the COVID-19 pandemic.
    Conclusions: From our preliminary results, low eicosapentaenoic acid levels were linked with intracerebral hemorrhage during the COVID-19 pandemic. Low levels of eicosapentaenoic acid might be an endogenous surrogate marker for intracerebral hemorrhage during the COVID-19 pandemic.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Cerebral Hemorrhage/epidemiology ; Communicable Disease Control ; Eicosapentaenoic Acid ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Pandemics
    Chemical Substances Eicosapentaenoic Acid (AAN7QOV9EA)
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02657-7
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  4. Article ; Online: Baseline platelet count may predict short-term functional outcome of cerebral infarction.

    Kanazawa, Kazo / Miyamoto, Nobukazu / Hira, Kenichiro / Kijima, Chikage / Ueno, Yuji / Hattori, Nobutaka

    BMC neurology

    2022  Volume 22, Issue 1, Page(s) 314

    Abstract: Background and aims: Platelets play an important role in homeostasis however, they have also been associated with increased mortality after myocardial infarction. In the present study, we investigated whether platelet count is associated with ... ...

    Abstract Background and aims: Platelets play an important role in homeostasis however, they have also been associated with increased mortality after myocardial infarction. In the present study, we investigated whether platelet count is associated with differences in the short-term prognosis at the time of hospital discharge and early neurological deterioration in ischemic stroke patients.
    Methods: Patients with ischemic stroke were enrolled from among 661 cerebrovascular disease patients admitted between January 2018 and December 2020. Patients who received hyperacute treatment, had a pre-onset modified Rankin scale (mRS) ≥ 3, transient ischemic attack, or active malignant disease were excluded. The platelet count was divided into quartiles (Q1-4) according to the number of patients, and the relationship between platelet count and prognosis was assessed using multivariable analysis.
    Results: In total, 385 patients were included in the study. Regarding the functional outcome by platelet count, there was a significant increase in mRS ≥ 3 at discharge in the Q4 (range: 243-1327 × 10
    Conclusion: Platelet count at onset may affect the prognosis of cerebral infarction and early neurological deterioration. This study may help clarify the pathogenesis of cerebral infarction to improve prognosis.
    MeSH term(s) Brain Ischemia/therapy ; Cerebral Infarction ; Humans ; Ischemic Stroke ; Platelet Count ; Prognosis ; Retrospective Studies ; Stroke/therapy
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02845-5
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  5. Article ; Online: Correction to: Astrocytic Extracellular Vesicles Regulated by Microglial Inflammatory Responses Improve Stroke Recovery.

    Kijima, Chikage / Inaba, Toshiki / Hira, Kenichiro / Miyamoto, Nobukazu / Yamashiro, Kazuo / Urabe, Takao / Hattori, Nobutaka / Ueno, Yuji

    Molecular neurobiology

    2023  Volume 61, Issue 2, Page(s) 1022

    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03657-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Astrocytic Extracellular Vesicles Regulated by Microglial Inflammatory Responses Improve Stroke Recovery.

    Kijima, Chikage / Inaba, Toshiki / Hira, Kenichiro / Miyamoto, Nobukazu / Yamashiro, Kazuo / Urabe, Takao / Hattori, Nobutaka / Ueno, Yuji

    Molecular neurobiology

    2023  Volume 61, Issue 2, Page(s) 1002–1021

    Abstract: There are no effective treatments for post-stroke glial scar formation, which inhibits axonal outgrowth and functional recovery after stroke. We investigated whether astrocytic extracellular vesicles (AEVs) regulated by microglia modulate glial scars and ...

    Abstract There are no effective treatments for post-stroke glial scar formation, which inhibits axonal outgrowth and functional recovery after stroke. We investigated whether astrocytic extracellular vesicles (AEVs) regulated by microglia modulate glial scars and improve stroke recovery. We found that peri-infarct glial scars comprised reactive astrocytes with proliferating C3d and decreased S100A10 expression in chronic stroke. In cultured astrocytes, microglia-conditioned media and treatment with P2Y
    MeSH term(s) Rats ; Animals ; Microglia/metabolism ; NF-kappa B/metabolism ; Astrocytes/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Gliosis/pathology ; Stroke/pathology ; Extracellular Vesicles/metabolism
    Chemical Substances NF-kappa B ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03629-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Case report: Atypical case of autoimmune glial fibrillary acidic protein astrocytopathy following COVID-19 vaccination refractory to immunosuppressive treatments.

    Morishima, Yuto / Hata, Takanori / Nakajima, Sho / Shindo, Kazumasa / Tsuchiya, Mai / Watanabe, Tsubasa / Tahara, Ippei / Kondo, Tetsuo / Kimura, Akio / Shimohata, Takayoshi / Ueno, Yuji

    Frontiers in immunology

    2024  Volume 15, Page(s) 1361685

    Abstract: A 54-year-old Japanese man presented with headache and fever the day after SARS-CoV-2 vaccination. He became deeply unconscious within a week. Brain MRI showed periventricular linear enhancements and a few spotty lesions in the cerebral white matter. ... ...

    Abstract A 54-year-old Japanese man presented with headache and fever the day after SARS-CoV-2 vaccination. He became deeply unconscious within a week. Brain MRI showed periventricular linear enhancements and a few spotty lesions in the cerebral white matter. Cerebrospinal fluid (CSF) testing showed mild pleocytosis. He was treated with intravenous methylprednisolone and plasma exchange. However, the white matter lesions enlarged to involve the brainstem and cerebellum, and long cord spinal lesions appeared. Anti-glial fibrillary acidic protein (GFAP) antibody was positive in the CSF and serum, and he was therefore diagnosed as autoimmune GFAP-astrocytopathy (GFAP-A). In addition, high-dose immunoglobulin therapy was administered twice, but his symptoms did not improve; the white matter lesions enlarged further, and modified Rankin Scale score increased to 5. A brain biopsy specimen showed infiltration of macrophages and CD
    MeSH term(s) Humans ; Male ; Middle Aged ; Glial Fibrillary Acidic Protein/immunology ; COVID-19/immunology ; SARS-CoV-2/immunology ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Astrocytes/immunology ; Astrocytes/pathology ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Vaccination/adverse effects ; Brain/pathology ; Brain/diagnostic imaging
    Chemical Substances Glial Fibrillary Acidic Protein ; GFAP protein, human ; Immunosuppressive Agents ; COVID-19 Vaccines ; Autoantibodies
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1361685
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  8. Article: First isolation of Trichophyton bullosum from a horse with dermatophytosis in Japan

    Watanabe, Ryosuke / Furuta, Hikaru / Ueno, Yuji / Nukada, Toshio / Niwa, Hidekazu / Shinyashiki, Naoki / Kano, Rui

    Medical mycology case reports. 2021 June, v. 32

    2021  

    Abstract: Trichophyton bullosum is a zoophilic dermatophyte that has been rarely isolated from horses and humans in Africa and Europe. This is the first reported isolation of T. bullosum from a horse with dermatophytosis in Japan. The isolate from a skin lesion ... ...

    Abstract Trichophyton bullosum is a zoophilic dermatophyte that has been rarely isolated from horses and humans in Africa and Europe. This is the first reported isolation of T. bullosum from a horse with dermatophytosis in Japan. The isolate from a skin lesion formed a cream-colored and waxy colony that was slightly elevated in the center. Sequencing of the internal transcribe spacer region of the isolate revealed that it was 100% identical to that of T. bullosum.
    Keywords Japan ; Trichophyton ; color ; dermatomycoses ; horses ; mycology ; skin lesions ; Africa ; Europe
    Language English
    Dates of publication 2021-06
    Size p. 81-83.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2021.04.004
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Antifungal susceptibility of dermatophytes from racehorses in Japan

    Watanabe, Ryousuke / Huruta, Hikaru / Ueno, Yuji / Nukada, Toshio / Niwa, Hidekazu / Shinyashiki, Naoki / Kano, Rui

    Veterinary dermatology. 2021 Oct., v. 32, no. 5

    2021  

    Abstract: BACKGROUND: Luliconazole (LCZ) is an imidazole antifungal medication that exhibits excellent activity against dermatophytes. As a topical cream and lotion (approved for human use), LCZ has demonstrated a broad spectrum of activity against human ... ...

    Abstract BACKGROUND: Luliconazole (LCZ) is an imidazole antifungal medication that exhibits excellent activity against dermatophytes. As a topical cream and lotion (approved for human use), LCZ has demonstrated a broad spectrum of activity against human dermatophytoses. OBJECTIVES: This is the first study to investigate the in vitro susceptibility of clinical isolates from horse dermatophytoses to LCZ. ANIMALS: No animals were used in this study. METHODS AND MATERIALS: In the present study, the in vitro susceptibilities of clinical isolates of dermatophytes to LCZ, clotrimazole (CTZ), miconazole (MCZ) and terbinafine (TRF) were investigated using the Clinical & Laboratory Standards Institute M38‐A2 test. RESULTS: The minimum inhibitory concentrations (MICs) for all 16 clinical isolates of Trichophyton equinum, Microsporum equinum/canis and M. gypseum for LCZ were <0.03 mg/L. The MICs of all isolates were <0.03–0.5 mg/L for CTZ, 0.03–16 mg/L for MCZ and <0.03–1 mg/L for TRF. CONCLUSIONS: LCZ demonstrated a broad spectrum of activity against clinical isolates from horse dermatophytoses. We consider that LCZ will become the primary antifungal agent for treating horse dermatophytosis.
    Keywords Japan ; Trichophyton equinum ; clotrimazole ; cream ; dermatomycoses ; drug therapy ; humans ; imidazole ; keratinophilic fungi ; luliconazole ; miconazole ; veterinary medicine
    Language English
    Dates of publication 2021-10
    Size p. 474-e129.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2011122-8
    ISSN 1365-3164 ; 0959-4493
    ISSN (online) 1365-3164
    ISSN 0959-4493
    DOI 10.1111/vde.12993
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  10. Article: First isolation of

    Watanabe, Ryosuke / Furuta, Hikaru / Ueno, Yuji / Nukada, Toshio / Niwa, Hidekazu / Shinyashiki, Naoki / Kano, Rui

    Medical mycology case reports

    2021  Volume 32, Page(s) 81–83

    Abstract: Trichophyton ... ...

    Abstract Trichophyton bullosum
    Language English
    Publishing date 2021-04-29
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2211-7539
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2021.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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