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Article: Maladie du spectre des anticorps anti-MOG.

Lerusse, Julien / Uginet, Marjolaine / Théaudin, Marie / Bernard-Valnet, Raphaël / Pot, Caroline / Lalive, Patrice H

2024 Volume 20, Issue 871, Page(s) 828–832

Abstract: Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD) is an autoimmune disease responsible for demyelination of the central nervous system that can occur in adults or children. Overlapping phenotypes between MOGAD, multiple sclerosis ( ... ...

Title translation	Anti-MOG associated disease.
Abstract	Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD) is an autoimmune disease responsible for demyelination of the central nervous system that can occur in adults or children. Overlapping phenotypes between MOGAD, multiple sclerosis (MS) and neuromyelitis optica spectrum disease (NMOSD) have been described. The diagnostic criteria for MOGAD were proposed by a panel of international experts and published in 2023. Defining clinical, biological and imaging characteristics specific to this entity helps to improve diagnostic specificity. In this article, we present the clinical characteristics suggestive of MOGAD and discuss the importance of the antibody detection method and therapeutic management.
MeSH term(s)	Humans ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Neuromyelitis Optica/diagnosis ; Neuromyelitis Optica/immunology ; Autoantibodies/immunology ; Autoantibodies/blood ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/immunology ; Adult ; Child ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology
Chemical Substances	Myelin-Oligodendrocyte Glycoprotein ; Autoantibodies
Language	French
Publishing date	2024-04-25
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2024.20.871.828
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Article: Traitements de la sclérose en plaques : mise à jour.

Uginet, Marjolaine / Lefeuvre, Lucie / Lerusse, Julien / Pot, Caroline / Du Pasquier, Renaud / Lalive, Patrice H

Revue medicale suisse

2024 Volume 20, Issue 871, Page(s) 837–842

Abstract: The management of multiple sclerosis (MS) has undergone a veritable revolution in recent years, with the arrival of highly effective treatments. In some cases, therapeutic discussions even precede the first clinical signs of the disease. The aim of this ... ...

Title translation	Treatments for multiple sclerosis: update.
Abstract	The management of multiple sclerosis (MS) has undergone a veritable revolution in recent years, with the arrival of highly effective treatments. In some cases, therapeutic discussions even precede the first clinical signs of the disease. The aim of this review is to present the therapeutic arsenal of progression-preventing treatments available in 2024 for MS, with anti-CD20 antibodies taking pride of place, also available for certain progressive forms of MS. The use of these immunosuppressants requires in-depth knowledge of their mechanisms of action, in order to understand their risks, such as the occurrence of opportunistic infections.
MeSH term(s)	Humans ; Multiple Sclerosis/therapy ; Multiple Sclerosis/drug therapy ; Immunosuppressive Agents/therapeutic use ; Disease Progression
Chemical Substances	Immunosuppressive Agents
Language	French
Publishing date	2024-04-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; English Abstract
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2024.20.871.837
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Article: Le défi diagnostique des encéphalites auto-immunes.

Di Liberto, Giovanni / Uginet, Marjolaine / Lalive, Patrice H / Du Pasquier, Renaud

Revue medicale suisse

2024 Volume 20, Issue 871, Page(s) 822–827

Abstract: Autoimmune encephalitis encompasses a spectrum of neurological disorders characterized by an autoimmune response directed against neurons and glia. Around two-thirds of cases exhibit autoantibodies targeting neuronal or glial antigens in the ... ...

Title translation	The diagnostic challenge of autoimmune encephalitis.
Abstract	Autoimmune encephalitis encompasses a spectrum of neurological disorders characterized by an autoimmune response directed against neurons and glia. Around two-thirds of cases exhibit autoantibodies targeting neuronal or glial antigens in the cerebrospinal fluid and/or serum. The diagnosis is based on specific criteria combining a subacute clinical presentation and complementary test results. However, approximately one-quarter of patients do not present any paraclinical abnormalities, making the diagnosis complex. Testing for anti-antibodies is pivotal for diagnosis, and their interpretation should be contextual. Best practices for anti-neural antibody detection involve appropriate sample collection and confirmation of positive results in relation to the clinical picture.
MeSH term(s)	Humans ; Encephalitis/diagnosis ; Encephalitis/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Hashimoto Disease/diagnosis ; Hashimoto Disease/immunology
Chemical Substances	Autoantibodies
Language	French
Publishing date	2024-04-26
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2024.20.871.822
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Article: Prise en charge de la polyradiculoneuropathie inflammatoire démyélinisante chronique.

Loser, Valentin / Staedler, Katia / Sukockiené, Eglé / Uginet, Marjolaine / Du Pasquier, Renaud / Lalive, Patrice H / Théaudin, Marie

Revue medicale suisse

2024 Volume 20, Issue 871, Page(s) 833–836

Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common chronic autoimmune neuropathy. Its management has considerably evolved over the last decade. In 2021, the diagnostic guidelines for CIDP were updated and the diagnostic ... ...

Title translation	Management of chronic inflammatory demyelinating polyradiculoneuropathy.
Abstract	Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common chronic autoimmune neuropathy. Its management has considerably evolved over the last decade. In 2021, the diagnostic guidelines for CIDP were updated and the diagnostic criteria simplified. They enable better characterization of the electro-clinical phenotype of the disease, and emphasize supportive criteria, in particular neuro-muscular imaging. In terms of pathophysiology, the discovery of antibodies directed against antigens in the nodal and paranodal regions has given rise to the concept of autoimmune nodopathy. Finally, the preliminary results of the ADHERE study on efgartigimod have rekindled hopes of a new, effective therapy for CIDP.
MeSH term(s)	Humans ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/therapy
Language	French
Publishing date	2024-04-25
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2024.20.871.833
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Article ; Online: Case Series of Acute Peripheral Neuropathies in Individuals Who Received COVID-19 Vaccination.

Sukockienė, Eglė / Breville, Gautier / Fayolle, Damien / Nencha, Umberto / Uginet, Marjolaine / Hübers, Annemarie

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 3

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Humans ; Middle Aged ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Pandemics ; Peripheral Nervous System Diseases/etiology ; SARS-CoV-2 ; Vaccination/adverse effects
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59030501
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Zs.A 6270: Show issues

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Article ; Online: Commentary: Prevalence of Alternative Diagnoses and Implications for Management in Idiopathic Normal Pressure Hydrocephalus Patients.

Allali, Gilles / Uginet, Marjolaine / Sveikata, Lukas

Neurosurgery

2020 Volume 87, Issue 5, Page(s) E545–E546

MeSH term(s)	Humans ; Hydrocephalus ; Hydrocephalus, Normal Pressure/diagnosis ; Hydrocephalus, Normal Pressure/epidemiology ; Hydrocephalus, Normal Pressure/surgery ; Patients ; Prevalence
Language	English
Publishing date	2020-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1093/neuros/nyaa218
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Zs.A 1424: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 539: Show issues

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Article ; Online: High-dose glucocorticoids in COVID-19 patients with acute encephalopathy: clinical and imaging findings in a retrospective cohort study.

Rhally, Alexandra / Bommarito, Giulia / Uginet, Marjolaine / Breville, Gautier / Stancu, Patrick / Accorroni, Alice / Assal, Frédéric / Lalive, Patrice H / Lövblad, Karl-Olof / Allali, Gilles

Journal of neural transmission (Vienna, Austria : 1996)

2024 Volume 131, Issue 4, Page(s) 377–384

Abstract: Objectives: Acute encephalopathy (AE) has been described as a severe complication of COVID-19. Inflammation has been suggested as a pathogenic mechanism, with high-dose glucocorticoids (GC) showing a beneficial effect. Here, we retrospectively analyzed ... ...

Abstract	Objectives: Acute encephalopathy (AE) has been described as a severe complication of COVID-19. Inflammation has been suggested as a pathogenic mechanism, with high-dose glucocorticoids (GC) showing a beneficial effect. Here, we retrospectively analyzed the clinical and radiological features in a group of COVID-19 AE patients who received GC treatment (GT) and in a non-treated (NT) group. Method: Thirty-six patients with COVID-19 AE (mean age 72.6 Results: The GT group showed signs of vulnerability, with a longer hospitalization (p = 0.009) and AE duration (p = 0.012) and a higher hypertensive arteriopathy (HTNA) score (p = 0.022), when compared to NT group. At hospital discharge, the two groups were comparable in terms of clinical outcome (modified Rankin scale; p = 0.666) or mortality (p = 0.607). In our whole group analyses, AE severity was positively correlated with periventricular white matter hyperintensities (p = 0.011), deep enlarged perivascular spaces (p = 0.039) and HTNA score (p = 0.014). Conclusion: This study suggests that, despite signs of radiological vulnerability and AE severity, patients treated by high-dose GC showed similar outcome at discharge, with respect to NT patients. Imaging features of cerebral small vessel disease correlated with AE severity, supporting the hypothesis that brain structural vulnerability can impact AE in COVID-19.
MeSH term(s)	Male ; Humans ; Aged ; Female ; Glucocorticoids/therapeutic use ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; COVID-19/complications ; Cerebral Small Vessel Diseases/pathology
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2024-02-16
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184163-4
ISSN	1435-1463 ; 0300-9564
ISSN (online)	1435-1463
ISSN	0300-9564
DOI	10.1007/s00702-024-02751-9
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Ui II Zs.150: Show issues

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Article: Encéphalopathie aiguë et Covid-19: hypothèses physiopathologiques.

Uginet, Marjolaine / Stancu, Patrick / Bridel, Claire / Serratrice, Jacques / Lalive, Patrice H / Coen, Matteo

Revue medicale suisse

2021 Volume 17, Issue 736, Page(s) 810–815

Abstract: Acute encephalopathy is one of the most frequent neurological complication in patients hospitalized for COVID-19. Electrolyte imbalance, drugs, and hypoxemia can all affect brain homeostasis, leading to acute cognitive dysfunction and direct implications ...

Title translation	COVID-19-related acute encephalopathy: physiopathological hypothesis.
Abstract	Acute encephalopathy is one of the most frequent neurological complication in patients hospitalized for COVID-19. Electrolyte imbalance, drugs, and hypoxemia can all affect brain homeostasis, leading to acute cognitive dysfunction and direct implications of the SARS-CoV-2 are not completely understood. Neurological complications of SARS-CoV-2 infection are poorly understood: an inflammatory insult to the endothelium affecting the blood-brain barrier may explain the clinical presentation, but other hypotheses including direct viral damage or an immune-mediated reaction are also suggested. Among these various potential mechanisms, often combined, the controversy remains.
MeSH term(s)	Blood-Brain Barrier ; Brain Diseases/chemically induced ; COVID-19 ; Humans ; Nervous System Diseases ; SARS-CoV-2
Language	French
Publishing date	2021-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article: COVID-19 associated stroke and cerebral endotheliitis.

Stancu, Patrick / Uginet, Marjolaine / Assal, Frederic / Allali, Gilles / Lovblad, Karl-Olof

Journal of neuroradiology = Journal de neuroradiologie

2021 Volume 48, Issue 4, Page(s) 291–292

MeSH term(s)	Aged, 80 and over ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Encephalitis/diagnosis ; Encephalitis/therapy ; Encephalitis/virology ; Humans ; Male ; Stroke/diagnosis ; Stroke/therapy ; Stroke/virology
Language	English
Publishing date	2021-02-04
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	131763-5
ISSN	1773-0406 ; 0150-9861
ISSN (online)	1773-0406
ISSN	0150-9861
DOI	10.1016/j.neurad.2021.01.012
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Article ; Online: Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy?

Breville, Gautier / Herrmann, François / Adler, Dan / Deffert, Christine / Bommarito, Giulia / Stancu, Patrick / Accorroni, Alice / Uginet, Marjolaine / Assal, Frederic / Tamisier, Renaud / Lalive, Patrice H / Pepin, Jean-Louis / Lövblad, Karl-Olof / Allali, Gilles

BMC neurology

2023 Volume 23, Issue 1, Page(s) 340

Abstract: Background: This study evaluates the impact of high risk of obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE).: Methods: Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at the Geneva ...

Abstract	Background: This study evaluates the impact of high risk of obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE). Methods: Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at the Geneva University Hospitals with a neurological diagnosis of COVID-19 AE. They were divided in two groups depending on the presence or absence of high risk for OSA based on the modified NOSAS score (mNOSAS, respectively ≥ 8 and < 8). We compared patients' characteristics (clinical, biological, brain MRI, EEG, pulmonary CT). The severity of COVID-19 AE relied on the RASS and CAM scores. Results: Most COVID-19 AE patients presented with a high mNOSAS, suggesting high risk of OSA (> 80%). Patients with a high mNOSAS had a more severe form of COVID-19 AE (84.8% versus 27.8%), longer mean duration of COVID-19 AE (27.9 versus 16.9 days), higher mRS at discharge (≥ 3 in 58.2% versus 16.7%), and increased prevalence of brain vessels enhancement (98.1% versus 20.0%). High risk of OSA was associated with a 14 fold increased risk of developing a severe COVID-19 AE (OR = 14.52). Discussion: These observations suggest an association between high risk of OSA and COVID-19 AE severity. High risk of OSA could be a predisposing factor leading to severe COVID-19 AE and consecutive long-term sequalae.
MeSH term(s)	Humans ; COVID-19/complications ; COVID-19/epidemiology ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Brain Diseases/diagnostic imaging ; Brain Diseases/epidemiology ; Brain Diseases/complications ; Risk Factors ; Polysomnography
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-023-03393-2
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