Article ; Online: Diffusion MRI-guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment.
Proceedings of the National Academy of Sciences of the United States of America
2022 Volume 119, Issue 21, Page(s) e2113778119
Abstract: Mild cognitive impairment (MCI) during aging is often a harbinger of Alzheimer’s disease, and, therefore, early intervention to preserve cognitive abilities before the MCI symptoms become medically refractory is particularly critical. Functional MRI– ... ...
| Abstract | Mild cognitive impairment (MCI) during aging is often a harbinger of Alzheimer’s disease, and, therefore, early intervention to preserve cognitive abilities before the MCI symptoms become medically refractory is particularly critical. Functional MRI–guided transcranial magnetic stimulation is a promising approach for modulating hippocampal functional connectivity and enhancing memory in healthy adults. Here, we extend these previous findings to individuals with MCI and leverage theta burst stimulation (TBS) and white matter tractography derived from diffusion-weighted MRI to target the hippocampus. Our preliminary findings suggested that TBS could be used to improve associative memory performance and increase resting-state functional connectivity of the hippocampus and other brain regions, including the occipital fusiform, frontal orbital cortex, putamen, posterior parahippocampal gyrus, and temporal pole, along the inferior longitudinal fasciculus in MCI. Although the sample size is small, these results shed light on how TBS propagates from the superficial cortex around the parietal lobe to the hippocampus. |
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| MeSH term(s) | Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/therapy ; Diffusion Magnetic Resonance Imaging ; Humans ; Magnetic Resonance Imaging/methods ; Memory/physiology ; Transcranial Magnetic Stimulation/methods ; White Matter/diagnostic imaging |
| Language | English |
| Publishing date | 2022-05-20 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 209104-5 |
| ISSN | 1091-6490 ; 0027-8424 |
| ISSN (online) | 1091-6490 |
| ISSN | 0027-8424 |
| DOI | 10.1073/pnas.2113778119 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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