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  1. Article: Post-Coronavirus Disease 2019 Pulmonary Fibrosis: Wait or Needs Intervention.

    Yoon, Hee-Young / Uh, Soo-Taek

    Tuberculosis and respiratory diseases

    2022  Volume 85, Issue 4, Page(s) 320–331

    Abstract: Coronavirus disease 2019 (COVID-19) has become a major health burden worldwide, with over 450 million confirmed cases and 6 million deaths. Although the acute phase of COVID-19 management has been established, there is still a long way to go to evaluate ... ...

    Abstract Coronavirus disease 2019 (COVID-19) has become a major health burden worldwide, with over 450 million confirmed cases and 6 million deaths. Although the acute phase of COVID-19 management has been established, there is still a long way to go to evaluate the long-term clinical course or manage complications due to the relatively short outbreak of the virus. Pulmonary fibrosis is one of the most common respiratory complications associated with COVID-19. Scarring throughout the lungs after viral or bacterial pulmonary infection have been commonly observed, but the prevalence of post- COVID-19 pulmonary fibrosis is rapidly increasing. However, there is limited information available about post-COVID-19 pulmonary fibrosis, and there is also a lack of consensus on what condition should be defined as post-COVID-19 pulmonary fibrosis. During a relatively short follow-up period of approximately 1 year, lesions considered related to pulmonary fibrosis often showed gradual improvement; therefore, it is questionable at what time point fibrosis should be evaluated. In this review, we investigated the epidemiology, risk factors, pathogenesis, and management of post-COVID-19 pulmonary fibrosis.
    Language English
    Publishing date 2022-06-20
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2022.0053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Therapy-related myeloid leukemia during erlotinib treatment in a non-small cell lung cancer patient: A case report.

    Koo, So-My / Kim, Ki-Up / Kim, Yang-Ki / Uh, Soo-Taek

    World journal of clinical cases

    2021  Volume 9, Issue 24, Page(s) 7205–7211

    Abstract: Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are tolerable drugs used for patients with EGFR-mutant advanced non-small cell lung cancer (NSCLC). Serious adverse reactions are uncommon compared with cytotoxic drugs.! ...

    Abstract Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are tolerable drugs used for patients with EGFR-mutant advanced non-small cell lung cancer (NSCLC). Serious adverse reactions are uncommon compared with cytotoxic drugs.
    Case summary: A 52-year-old man presented with general weakness and cytopenia. He had been taking erlotinib for 11 mo to treat NSCLC. The pathological diagnosis from the right upper lobe mass was adenocarcinoma with an EGFR mutation in exon 21 (L858R). He had previously received paclitaxel/carboplatin, gemcitabin/ vinorelbine chemotherapy, stereotactic radiosurgery for brain metastasis, and whole-brain radiotherapy as treatment for NSCLC. We diagnosed the patient with acute myeloid leukemia (AML). During the induction and consolidation chemotherapy for AML, the erlotinib was discontinued. When complete remission of the AML was achieved, since the lung masses were increased, pemetrexed/ cisplatin for the NSCLC was initiated. After two cycles of chemotherapy, the cytopenia was prolonged. AML relapse occurred with the same karyotype.
    Conclusion: Therapy-related acute myeloid neoplasm (t-MN) is a rare but fatal late complication. Although a patient may be taking EGFR-TKIs, the possibility of t-MN should be considered. Further studies are needed to determine whether EGFR-TKI usage is a predisposing factor for t-MN.
    Language English
    Publishing date 2021-09-14
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i24.7205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist's point of view.

    Koo, So-My / Uh, Soo-Taek

    The Korean journal of internal medicine

    2017  Volume 32, Issue 4, Page(s) 600–610

    Abstract: Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be a significant cause of mortality in patients ... ...

    Abstract Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be a significant cause of mortality in patients with CVD-associated ILD (CTD-ILD). There is a lack of randomized, clinical trials assessing pharmacological agents for CTD-ILD, except in cases of ILD-associated systemic sclerosis (SSc). This may be due to the lack of CTD cases available, the difficulty of histological confirmation of ILD, and the various types of CTD and ILD. As a result, evidence-based pharmacological treatment of CTD-ILD is not yet well established. CTD-ILD presents with varying degrees of histology, from inflammation to fibrosis, and a wide spectrum of clinical manifestations, from minimal symptoms to respiratory failure. This renders it difficult for clinicians to make decisions regarding treatment options, observational strategies, optimal timing for interventions, and the appropriateness of pharmacological agents for treatment. There is no specific treatment for reversing fibrosis-like idiopathic pulmonary fibrosis in a clinical setting. This review describes pharmacological interventions for SSc-ILD described in randomized control trials, and presents an overview of recent advances of CTD-ILD-dependent treatments based on the types of CTD.
    Language English
    Publishing date 2017-07
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 639023-7
    ISSN 2005-6648 ; 1226-3303
    ISSN (online) 2005-6648
    ISSN 1226-3303
    DOI 10.3904/kjim.2016.212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinical Experiences of High-Risk Pulmonary Thromboembolism Receiving Extracorporeal Membrane Oxygenation in Single Institution.

    Jang, Joonyong / Koo, So-My / Kim, Ki-Up / Kim, Yang-Ki / Uh, Soo-Taek / Jang, Gae-Eil / Chang, Wonho / Lee, Bo Young

    Tuberculosis and respiratory diseases

    2022  Volume 85, Issue 3, Page(s) 249–255

    Abstract: Background: The main cause of death in pulmonary embolism (PE) is right-heart failure due to acute pressure overload. In this sense, extracorporeal membrane oxygenation (ECMO) might be useful in maintaining hemodynamic stability and improving organ ... ...

    Abstract Background: The main cause of death in pulmonary embolism (PE) is right-heart failure due to acute pressure overload. In this sense, extracorporeal membrane oxygenation (ECMO) might be useful in maintaining hemodynamic stability and improving organ perfusion. Some previous studies have reported ECMO as a bridge to reperfusion therapy of PE. However, little is known about the patients that benefit from ECMO.
    Methods: Patients who underwent ECMO due to pulmonary thromboembolism at a single university-affiliated hospital between January 2010 and December 2018 were retrospectively reviewed.
    Results: During the study period, nine patients received ECMO in high-risk PE. The median age of the patients was 60 years (range, 22-76 years), and six (66.7%) were male. All nine patients had cardiac arrests, of which three occurred outside the hospital. All the patients received mechanical support with veno-arterial ECMO, and the median ECMO duration was 1.1 days (range, 0.2-14.0 days). ECMO with anticoagulation alone was performed in six (66.7%), and ECMO with reperfusion therapy was done in three (33.3%). The 30-day mortality rate was 77.8%. The median time taken from the first cardiac arrest to initiation of ECMO was 31 minutes (range, 30-32 minutes) in survivors (n=2) and 65 minutes (range, 33-482 minutes) in non-survivors (n=7).
    Conclusion: High-risk PE with cardiac arrest has a high mortality rate despite aggressive management with ECMO and reperfusion therapy. Early decision to start ECMO and its rapid initiation might help save those with cardiac arrest in high-risk PE.
    Language English
    Publishing date 2022-05-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2022.0004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical outcomes of dose modification during pirfenidone treatment for IPF: A nationwide post-marketing surveillance study.

    Kang, Jieun / Chung, Man Pyo / Park, Moo Suk / Oh, In Jae / Lee, Heung Bum / Kim, Young Whan / Park, Jong Sun / Uh, Soo Taek / Kim, Yun Seong / Jegal, Yangjin / Song, Jin Woo

    Frontiers in pharmacology

    2023  Volume 13, Page(s) 1025947

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1025947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effects of patient satisfaction and confidence on the success of treatment of combined rheumatic disease and interstitial lung disease in a multidisciplinary outpatient clinic.

    Jeong, Shin Ok / Uh, Soo-Taek / Park, Suyeon / Kim, Hyun-Sook

    International journal of rheumatic diseases

    2018  Volume 21, Issue 8, Page(s) 1600–1608

    Abstract: Objectives: Multidisciplinary discussions (MDDs) have emphasized improve medical services and outcomes. We used a multidisciplinary approach to explore whether patient emotional satisfaction and confidence affected treatment outcomes in rheumatic ... ...

    Abstract Objectives: Multidisciplinary discussions (MDDs) have emphasized improve medical services and outcomes. We used a multidisciplinary approach to explore whether patient emotional satisfaction and confidence affected treatment outcomes in rheumatic disease (RD)-related interstitial lung disease (ILD).
    Methods: From December 2015 to April 2017, we evaluated 23 patients with RD and ILD and 21 with idiopathic pulmonary fibrosis (IPF). Patients with RD and ILD were managed with MDDs. Patients with IPF received standardized medical care by the same pulmonologist. All patients completed brief multiple-choice questionnaires exploring their perceptions of their illnesses and their attitudes toward medical treatment, and completed the Patient Health Questionnaire-2.
    Results: The MDD patients could more easily identify disease symptoms regardless of age stratification (under 65 age: P = 0.020, 65 years or older: P = 0.003). Among the 65 years or older group, it shows higher levels of illness perception in terms of disease timeline in the MDD group (P = 0.035). Also, the MDD group reported higher levels of satisfaction in terms of the explanations they received and their involvement in discussion, and greater satisfaction with medical staff. However, the groups did not differ significantly between treatment outcomes such as changes in forced vital capacity, the diffusion capacity of carbon monoxide, or changes in high-resolution computed tomography.
    Conclusions: MDDs afforded satisfactory management compared with standardized medical care. The MDD group felt better attention fromand satisfaction with medical staff, and had greater identification in their treatment. Further research engaging in MDDs with a comparable control group is required.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Attitude of Health Personnel ; Depression/psychology ; Emotions ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Interdisciplinary Communication ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/psychology ; Lung Diseases, Interstitial/therapy ; Male ; Middle Aged ; Outpatient Clinics, Hospital ; Patient Care Team ; Patient Compliance ; Patient Health Questionnaire ; Patient Satisfaction ; Physician-Patient Relations ; Pulmonologists/psychology ; Retrospective Studies ; Rheumatic Diseases/complications ; Rheumatic Diseases/diagnosis ; Rheumatic Diseases/psychology ; Rheumatic Diseases/therapy ; Rheumatologists/psychology ; Treatment Outcome
    Language English
    Publishing date 2018-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.13331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Perioperative Management of Antithrombotic Therapies Using Enoxaparin.

    Hwang, Hun Gyu / Koo, So My / Uh, Soo Taek / Kim, Yang Ki

    Journal of Korean medical science

    2017  Volume 32, Issue 6, Page(s) 942–947

    Abstract: Oral anticoagulant therapy is frequently and increasingly prescribed for patients at risk of arterial or venous thromboembolism (VTE). Although elective surgical or invasive procedures have necessitated temporary interruption of anticoagulants, managing ... ...

    Abstract Oral anticoagulant therapy is frequently and increasingly prescribed for patients at risk of arterial or venous thromboembolism (VTE). Although elective surgical or invasive procedures have necessitated temporary interruption of anticoagulants, managing these patients has been performed empirically and been poorly investigated. This study was designed to evaluate the adequacy of perioperative anticoagulation using enoxaparin. This was a retrospective, single-center study that evaluated the efficacy and safety of therapeutic-dose enoxaparin for bridging therapy in patients on long-term warfarin at Soonchunhyang University Hospital in Korea between August 2009 and July 2011. Warfarin was discontinued 5 days before surgery, and enoxaparin was administered twice daily by subcutaneous injection at a dose of 1 mg per kg from 3 days before the procedure to the last dose 24 hours before the procedure. Anticoagulation was restarted if proper hemostasis had been confirmed. There were 49 patients, of whom 25 (51%) were men, and the mean age was 63 years. Thirty-four (69%) received warfarin therapy for VTE, and 9 (18%) for atrial fibrillation. Twenty-nine patients (59%) underwent major surgery and 20 (41%) minor surgery. The mean postoperative duration of enoxaparin was 4 days. No patients had thromboembolic complications through 30 days after the procedure. The overall 30-day mortality rate was 0%. In conclusion, our findings demonstrate that bridging therapy with therapeutic-dose enoxaparin is feasible and associated with a low incidence of major bleeding and no thromboembolic complications. However, the optimal approach to managing patients perioperatively is uncertain and requires further evaluation.
    Language English
    Publishing date 2017-06
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2017.32.6.942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Increased antioxidant activity after exposure of ozone in murine asthma model.

    Kim, Yang Ki / Koo, So My / Kim, Kiup / Uh, Soo-Taek / Jang, Ahnsoo / Park, Choon-Sik

    Asia Pacific allergy

    2017  Volume 7, Issue 3, Page(s) 163–170

    Abstract: Background: Ozone is well known as an important component of ambient air pollutants. Ozone can aggravate respiratory symptoms in patients with bronchial asthma, but, not in healthy person. We hypothesized asthma itself may show different response to ... ...

    Abstract Background: Ozone is well known as an important component of ambient air pollutants. Ozone can aggravate respiratory symptoms in patients with bronchial asthma, but, not in healthy person. We hypothesized asthma itself may show different response to ozone compared to nonasthma.
    Objective: This study was performed to evaluate the differences of response to ozone between normal and asthmatic mice model in terms of status of oxidant injury and antioxidant activity.
    Methods: Three parts per million of ozone was exposed to ovalbumin (OVA)-induced murine asthma model for 3 hours at 3, 7, 14, 21 days after completion of asthma model. Airway responsiveness to methacholine was measured after completion of asthma model. Bronchoalveolar lavage (BAL), protein extraction from lung for Western blot and immunohistochemistry of 4-hydroxy-2-nonenal (4-HNE), proliferating cell nuclear antigen (PCNA), NF-E2 related factor 2 (Nrf-2), and activity of glutathione were performed at before and each ozone exposure day.
    Results: Airway hyper-responsiveness and increased eosinophils in BAL fluid were observed in asthma model. In asthma model, the expression of 4-HNE already more increased at baseline (without ozone) compared to those in sham model. This increased expression is more enhanced at 3 days after ozone exposure. The expression of PCNA was significantly increased in OVA-model compared to those in sham model. The expression of Nrf-2 was observed at baseline, and 3 and 7 days after exposure ozone in asthma model, but not in sham model. The activity of glutathione increased significantly after exposure of ozone, but not in sham model.
    Conclusion: Murine asthma model has enhanced oxygen toxicity and antioxidant activity response to ozone.
    Language English
    Publishing date 2017-07-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2614800-6
    ISSN 2233-8268 ; 2233-8276
    ISSN (online) 2233-8268
    ISSN 2233-8276
    DOI 10.5415/apallergy.2017.7.3.163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Safety and Efficacy of Pirfenidone in Advanced Idiopathic Pulmonary Fibrosis: A Nationwide Post-Marketing Surveillance Study in Korean Patients.

    Chung, Man Pyo / Park, Moo Suk / Oh, In Jae / Lee, Heung Bum / Kim, Young Whan / Park, Jong Sun / Uh, Soo Taek / Kim, Yun Seong / Jegal, Yangjin / Song, Jin Woo

    Advances in therapy

    2020  Volume 37, Issue 5, Page(s) 2303–2316

    Abstract: Aim: The efficacy and safety of pirfenidone have been previously demonstrated in patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF). However, the effect of pirfenidone in patients with advanced IPF remains unclear. Here, we investigated ... ...

    Abstract Aim: The efficacy and safety of pirfenidone have been previously demonstrated in patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF). However, the effect of pirfenidone in patients with advanced IPF remains unclear. Here, we investigated the effects of pirfenidone against advanced IPF in a real-world setting.
    Methods: A prospective nationwide post-marketing study was conducted on 258 patients from 10 Korean institutions. Patients with a predicted forced vital capacity (FVC) less than 50% or a diffusing capacity of the lung for carbon monoxide (DLco) less than 35% at baseline were classified as the advanced IPF group.
    Results: Of 219 patients included in the analysis, the majority were male (76.3%); the mean age was 67.3 years, and the advanced group accounted for 17.8% of the patients. The median treatment duration was 298 days. Among the subjects, 86.3% experienced adverse events (AEs), of which a decreased appetite (32.4%) and a photosensitivity reaction (13.7%) were the most frequent. The incidence of AEs was similar between the advanced and non-advanced groups (92.3% vs. 85.0%, respectively; p = 0.229). Although the overall discontinuation rate was higher in the advanced group than in the non-advanced group (74.4% vs. 50.0%, respectively; p = 0.006), the percentages of the patients who discontinued treatment as a result of AEs were similar in both groups (20.5% vs. 23.3%, respectively; p = 0.704). In all patients, the rates of decline in the predicted FVC and DLco over 48 weeks were - 4.3 ± 1.3% and - 4.4 ± 1.7%, respectively. There was no between-group difference in the rate of lung function decline.
    Conclusions: Pirfenidone used for the treatment of patients with IPF in a real-world setting was well tolerated, with an acceptable safety profile and a consistent therapeutic effect, regardless of the disease severity.
    Trial registration: ClinicalTrials.gov NCT03761082; the trial was retrospectively registered on December 3, 2018.
    MeSH term(s) Aged ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Female ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/epidemiology ; Lung/diagnostic imaging ; Lung/physiopathology ; Male ; Middle Aged ; Product Surveillance, Postmarketing ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Republic of Korea/epidemiology ; Respiratory Function Tests/methods ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Pyridones ; pirfenidone (D7NLD2JX7U)
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-020-01328-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Incidence and Risk Factors of Pneumonia in Hospitalized Patients with Seasonal Influenza A or B.

    Chu, Seongjun / Park, Sang Joon / Koo, So My / Kim, Yang Ki / Kim, Ki Up / Uh, Soo Taek / Kim, Tae Hyung / Park, Suyeon

    Tuberculosis and respiratory diseases

    2017  Volume 80, Issue 4, Page(s) 392–400

    Abstract: Background: Most patients with influenza recover spontaneously or following treatment with an anti-viral agent, but some patients experience pneumonia requiring hospitalization. We conducted a retrospective review to determine the incidence and risk ... ...

    Abstract Background: Most patients with influenza recover spontaneously or following treatment with an anti-viral agent, but some patients experience pneumonia requiring hospitalization. We conducted a retrospective review to determine the incidence and risk factors of pneumonia in hospitalized patients with influenza A or B.
    Methods: A total of 213 patients aged 18 years or older and hospitalized with influenza between January 2012 and January 2015 were included in this study. A reverse-transcriptase polymerase chain reaction assay was used to detect the influenza A or B virus in the patients' sputum samples. We collected demographic and laboratory data, combined coexisting diseases, and radiologic findings.
    Results: The incidence of pneumonia was higher in patients in the influenza A group compared to those in the influenza B group (68.6% vs. 56.9%), but this difference was not statistically significant. The presence of underlying respiratory disease was significantly associated with pneumonia in the influenza A group (adjusted odds ratio [OR], 3.975; 95% confidence interval [CI], 1.312-12.043; p=0.015). In the influenza B group, the white blood cell count (adjusted OR, 1.413; 95% CI, 1.053-1.896; p=0.021), platelet count (adjusted OR, 0.988; 95% CI, 0.978-0.999; p=0.027), and existence of an underlying medical disease (adjusted OR, 15.858; 95% CI, 1.757-143.088; p=0.014) were all significantly associated with pneumonia in multivariate analyses.
    Conclusion: The incidence of pneumonia was 65.7% in hospitalized patients with influenza A or B. The risk factors of pneumonia differed in hospitalized patients with influenza A or B.
    Language English
    Publishing date 2017-09-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2016.0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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