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  1. Article ; Online: Defective microbial sensing and clearance in perianal Crohn's disease: a role for complement factor B.

    Ghate, Arya / Uhlig, Holm H

    Gut

    2023  Volume 72, Issue 11, Page(s) 2010–2012

    MeSH term(s) Humans ; Crohn Disease ; Complement Factor B ; Rectal Fistula ; Treatment Outcome
    Chemical Substances Complement Factor B (EC 3.4.21.47)
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-329801
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  2. Article ; Online: Short-chain fatty acids: linking diet, the microbiome and immunity.

    Mann, Elizabeth R / Lam, Ying Ka / Uhlig, Holm H

    Nature reviews. Immunology

    2024  

    Abstract: The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial metabolites and their availability in the gut and other organs is determined by environmental factors, such as diet and use of antibiotics, that shape the diversity and ... ...

    Abstract The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial metabolites and their availability in the gut and other organs is determined by environmental factors, such as diet and use of antibiotics, that shape the diversity and metabolism of the microbiota. SCFAs regulate epithelial barrier function as well as mucosal and systemic immunity via evolutionary conserved processes that involve G protein-coupled receptor signalling or histone deacetylase activity. Indicatively, the anti-inflammatory role of butyrate is mediated through direct effects on the differentiation of intestinal epithelial cells, phagocytes, B cells and plasma cells, and regulatory and effector T cells. Intestinally derived SCFAs also directly and indirectly affect immunity at extra-intestinal sites, such as the liver, the lungs, the reproductive tract and the brain, and have been implicated in a range of disorders, including infections, intestinal inflammation, autoimmunity, food allergies, asthma and responses to cancer therapies. An ecological understanding of microbial communities and their interrelated metabolic states, as well as the engineering of butyrogenic bacteria may support SCFA-focused interventions for the prevention and treatment of immune-mediated diseases.
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-024-01014-8
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  3. Article ; Online: Intestinal Inflammation and Extraintestinal Disease: Understanding Dynamic Risk.

    Ashton, James J / Satsangi, Jack / Uhlig, Holm H

    Gastroenterology

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.03.040
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  4. Book ; Thesis: Intestinale Entzündung und Immunregulation durch CD4+CD25+ regulatorische T Zellen

    Uhlig, Holm H.

    2007  

    Author's details vorgelegt von Holm H. Uhlig
    Language German ; English
    Size 90 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Habil.-Schr., 2008
    Note Enth. 7 Sonderabdr. aus verschiedenen Zeitschr. - Text engl.
    HBZ-ID HT015974511
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 E 1203 order for loan Magazin

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  5. Article ; Online: Mendelian Diseases and Inflammatory Bowel Disease-Data Mining for Genetic Risk and Disease-Associated Confounders.

    Uhlig, Holm H

    Inflammatory bowel diseases

    2018  Volume 24, Issue 3, Page(s) 467–470

    MeSH term(s) Data Mining ; Genetic Predisposition to Disease ; Humans ; Inflammatory Bowel Diseases ; Risk Factors
    Language English
    Publishing date 2018-03-25
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izx090
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  6. Article ; Online: Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency.

    Azabdaftari, Aline / Uhlig, Holm H

    Science immunology

    2021  Volume 6, Issue 65, Page(s) eabm0293

    Abstract: New data suggest how epithelial dysfunction and intestinal dysbiosis contribute to inflammatory bowel disease in patients and in models of XIAP deficiency (see the related Research Articles by ... ...

    Abstract New data suggest how epithelial dysfunction and intestinal dysbiosis contribute to inflammatory bowel disease in patients and in models of XIAP deficiency (see the related Research Articles by Strigli
    MeSH term(s) Gastrointestinal Microbiome ; Genetic Diseases, X-Linked ; Lymphoproliferative Disorders ; Paneth Cells
    Language English
    Publishing date 2021-11-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abm0293
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  7. Article ; Online: Demyelination After Anti-TNF Therapy: Who is at Risk?

    Williams, Isabelle / Uhlig, Holm H

    Journal of Crohn's & colitis

    2020  Volume 14, Issue 12, Page(s) 1651–1652

    MeSH term(s) Demyelinating Diseases/chemically induced ; Humans ; Immunotherapy ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjaa144
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  8. Article: Genomsequenzierung in Forschung und Klinik

    Uhlig, Holm H.

    Bauchredner

    2019  Volume 139, Issue 4, Page(s) 19

    Language German
    Document type Article
    ZDB-ID 1010454-9
    ISSN 1435-1862
    Database Current Contents Medicine

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  9. Article ; Online: Monogenic inflammatory bowel disease-genetic variants, functional mechanisms and personalised medicine in clinical practice.

    Azabdaftari, Aline / Jones, Kelsey D J / Kammermeier, Jochen / Uhlig, Holm H

    Human genetics

    2022  Volume 142, Issue 5, Page(s) 599–611

    Abstract: Over 100 genes are associated with monogenic forms of inflammatory bowel disease (IBD). These genes affect the epithelial barrier function, innate and adaptive immunity in the intestine, and immune tolerance. We provide an overview of newly discovered ... ...

    Abstract Over 100 genes are associated with monogenic forms of inflammatory bowel disease (IBD). These genes affect the epithelial barrier function, innate and adaptive immunity in the intestine, and immune tolerance. We provide an overview of newly discovered monogenic IBD genes and illustrate how a recently proposed taxonomy model can integrate phenotypes and shared pathways. We discuss how functional understanding of genetic disorders and clinical genomics supports personalised medicine for patients with monogenic IBD.
    MeSH term(s) Humans ; Precision Medicine ; Genetic Predisposition to Disease ; Inflammatory Bowel Diseases/genetics ; Intestines ; Phenotype
    Language English
    Publishing date 2022-06-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 223009-4
    ISSN 1432-1203 ; 0340-6717
    ISSN (online) 1432-1203
    ISSN 0340-6717
    DOI 10.1007/s00439-022-02464-7
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  10. Article ; Online: Defining Interactions Between the Genome, Epigenome, and the Environment in Inflammatory Bowel Disease: Progress and Prospects.

    Noble, Alexandra J / Nowak, Jan K / Adams, Alex T / Uhlig, Holm H / Satsangi, Jack

    Gastroenterology

    2023  Volume 165, Issue 1, Page(s) 44–60.e2

    Abstract: Recent advances in our understanding of the pathogenesis of inflammatory bowel disease (IBD) have highlighted the complex interplay between the genome, the epigenome, and the environment. Despite the exciting advances in genomics that have enabled the ... ...

    Abstract Recent advances in our understanding of the pathogenesis of inflammatory bowel disease (IBD) have highlighted the complex interplay between the genome, the epigenome, and the environment. Despite the exciting advances in genomics that have enabled the identification of over 200 susceptibility loci, these only account for a small proportion of the disease variance and the estimated heritability in IBD. It is likely that gene-environment (GxE) interactions contribute to "missing heritability" and these may act through epigenetic mechanisms. Several environmental factors, such as the microbiome, nutrition, and tobacco smoking, induce alterations in the epigenome of children and adults, which may impact disease susceptibility. Other mechanisms for GxE interactions are also directly pertinent in early life. We discuss a model in which environmental factors imprint disease risk in a window of susceptibility during infancy that may contribute to later disease onset, whereas other elements of the exposome act later in life and contribute directly to the pathogenesis and course of the disease. Understanding the mechanisms underlying GxE interactions may provide the basis for new therapeutic targets or preventative strategies for IBD.
    MeSH term(s) Adult ; Child ; Humans ; Epigenome ; Genetic Predisposition to Disease ; Inflammatory Bowel Diseases/genetics ; Genome ; Epigenesis, Genetic
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.03.238
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