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Article ; Online: Erosion of cooperation in ageing tissue enables the emergence of the cancer phenotype.

Ujvari, Beata

BioEssays : news and reviews in molecular, cellular and developmental biology

2020 Volume 43, Issue 2, Page(s) e2000301

MeSH term(s)	Aging/genetics ; Humans ; Neoplasms/genetics ; Phenotype
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	50140-2
ISSN	1521-1878 ; 0265-9247
ISSN (online)	1521-1878
ISSN	0265-9247
DOI	10.1002/bies.202000301
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Article ; Online: Évolution de la résistance au cancer dans le monde animal.

Thomas, Frédéric / Ujvari, Beata / Dujon, Antoine M

Medecine sciences : M/S

2024 Volume 40, Issue 4, Page(s) 343–350

Abstract: Cancer is an inevitable collateral problem inherent in the evolution of multicellular organisms, which appeared at the end of the Precambrian. Faced to this constraint, a range of diverse anticancer defenses has evolved across the animal kingdom. Today, ... ...

Title translation	Evolution of cancer resistance in the animal kingdom.
Abstract	Cancer is an inevitable collateral problem inherent in the evolution of multicellular organisms, which appeared at the end of the Precambrian. Faced to this constraint, a range of diverse anticancer defenses has evolved across the animal kingdom. Today, investigating how animal organisms, especially those of large size and long lifespan, manage cancer-related issues has both fundamental and applied outcomes, as it could inspire strategies for preventing or treating human cancers. In this article, we begin by presenting the conceptual framework for understanding evolutionary theories regarding the development of anti-cancer defenses. We then present a number of examples that have been extensively studied in recent years, including naked mole rats, elephants, whales, placozoa, xenarthras (such as sloths, armadillos and anteaters) and bats. The contributions of comparative genomics to understanding evolutionary convergences are also discussed. Finally, we emphasize that natural selection has also favored anti-cancer adaptations aimed at avoiding mutagenic environments, for example by maximizing immediate reproductive efforts in the event of cancer. Exploring these adaptive solutions holds promise for identifying novel approaches to improve human health.
MeSH term(s)	Animals ; Neoplasms/genetics ; Neoplasms/pathology ; Humans ; Biological Evolution ; Disease Resistance/genetics ; Disease Resistance/physiology ; Selection, Genetic ; Mole Rats/physiology ; Mole Rats/genetics ; Elephants/genetics
Language	French
Publishing date	2024-04-23
Publishing country	France
Document type	Journal Article ; Review ; English Abstract
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2024038
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Article ; Online: Investigation of Macrolide Resistance Genotypes of

Ujvári, Barbara / Magyar, Tibor

Microbial drug resistance (Larchmont, N.Y.)

2022 Volume 28, Issue 9, Page(s) 941–947

Abstract: Macrolides are commonly used to control respiratory tract infections in ruminants, but the susceptibility ... ...

Abstract	Macrolides are commonly used to control respiratory tract infections in ruminants, but the susceptibility of
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Cattle ; Drug Resistance, Bacterial/genetics ; Erythromycin ; Genotype ; Macrolides/pharmacology ; Microbial Sensitivity Tests ; Pasteurella multocida/genetics ; RNA, Ribosomal, 23S/genetics ; Ruminants/genetics ; Tylosin/analogs & derivatives
Chemical Substances	Anti-Bacterial Agents ; Macrolides ; RNA, Ribosomal, 23S ; Erythromycin (63937KV33D) ; tilmicosin (XL4103X2E3) ; Tylosin (YEF4JXN031)
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1290490-9
ISSN	1931-8448 ; 1076-6294
ISSN (online)	1931-8448
ISSN	1076-6294
DOI	10.1089/mdr.2022.0010
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Article ; Online: Transmissible cancers, the genomes that don't melt down.

Bramwell, Georgina / DeGregori, James / Thomas, Frédéric / Ujvari, Beata

Evolution; international journal of organic evolution

2024

Abstract: Evolutionary theory predicts that accumulation of deleterious mutations in asexually reproducing organisms should lead to genomic decay. Clonally reproducing cell lines, i.e., transmissible cancers, when cells are transmitted as allografts/xenografts, ... ...

Abstract	Evolutionary theory predicts that accumulation of deleterious mutations in asexually reproducing organisms should lead to genomic decay. Clonally reproducing cell lines, i.e., transmissible cancers, when cells are transmitted as allografts/xenografts, break these rules, and survive for centuries and millennia. The currently known 11 transmissible cancer lineages occur in dogs (Canine Venereal Tumour Disease, CTVT), in Tasmanian devils (Devil Facial Tumour Diseases, DFT 1 and DFT2) and in bivalves (bivalve transmissible neoplasia, BTN). Despite the mutation loads of these cell lines being much higher than observed in human cancers, they have not been eliminated in space and time. Here we provide potential explanations how these fascinating cell lines may have overcome the fitness decline due to the progressive accumulation of deleterious mutations and propose that the high mutation load may carry an indirect positive fitness outcome. We offer ideas on how these host-pathogen systems could be used to answer outstanding questions in evolutionary biology. The recent studies on the evolution of these clonal pathogens reveal key mechanistic insight into transmissible cancer genomes, information that is essential for future studies investigating how these contagious cancer cell lines can repeatedly evade immune recognition, evolve, and survive in the landscape of highly diverse hosts.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036375-8
ISSN	1558-5646 ; 0014-3820
ISSN (online)	1558-5646
ISSN	0014-3820
DOI	10.1093/evolut/qpae063
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Article ; Online: Small extracellular vesicles from surviving cancer cells as multiparametric monitoring tools of measurable residual disease and therapeutic efficiency.

Valcz, Gábor / Buzás, Edit I / Gatenby, Robert A / Újvári, Beáta / Molnár, Béla

Biochimica et biophysica acta. Reviews on cancer

2024 Volume 1879, Issue 2, Page(s) 189088

Abstract: Although conventional anti-cancer therapies remove most cells of the tumor mass, small surviving populations may evolve adaptive resistance strategies, which lead to treatment failure. The size of the resistant population initially may not reach the ... ...

Abstract	Although conventional anti-cancer therapies remove most cells of the tumor mass, small surviving populations may evolve adaptive resistance strategies, which lead to treatment failure. The size of the resistant population initially may not reach the threshold of clinical detection (designated as measurable residual disease/MRD) thus, its investigation requires highly sensitive and specific methods. Here, we discuss that the specific molecular fingerprint of tumor-derived small extracellular vesicles (sEVs) is suitable for longitudinal monitoring of MRD. Furthermore, we present a concept that exploiting the multiparametric nature of sEVs may help early detection of recurrence and the design of dynamic, evolution-adjusted treatments.
MeSH term(s)	Humans ; Extracellular Vesicles/genetics ; Neoplasm, Residual/diagnosis
Language	English
Publishing date	2024-02-20
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2024.189088
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Article ; Online: Organisation and evolution of the major histocompatibility complex class I genes in cetaceans.

Day, Grace / Robb, Kate / Oxley, Andrew / Telonis-Scott, Marina / Ujvari, Beata

iScience

2024 Volume 27, Issue 4, Page(s) 109590

Abstract: A quarter of marine mammals are at risk of extinction, with disease and poor habitat quality contributing to population decline. Investigation of the Major Histocompatibility Complex (MHC) provides insight into species' capacity to respond to immune and ... ...

Abstract	A quarter of marine mammals are at risk of extinction, with disease and poor habitat quality contributing to population decline. Investigation of the Major Histocompatibility Complex (MHC) provides insight into species' capacity to respond to immune and environmental challenges. The eighteen available cetacean chromosome level genomes were used to annotate MHC Class I loci, and to reconstruct the phylogenetic relationship of the described loci. The highest number of loci was observed in the striped dolphin (
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109590
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Article ; Online: Virulence gene profiling and ompA sequence analysis of Pasteurella multocida and their correlation with host species.

Ujvári, B / Makrai, L / Magyar, T

Veterinary microbiology

2019 Volume 233, Page(s) 190–195

Abstract: This study describes the prevalence of capsule biosynthesis genes, LPS genotypes, virulence associated genes and the analysis of the outer membrane protein (ompA) sequence of Pasteurella multocida isolates (n = 180) from different locations in Hungary, ... ...

Abstract	This study describes the prevalence of capsule biosynthesis genes, LPS genotypes, virulence associated genes and the analysis of the outer membrane protein (ompA) sequence of Pasteurella multocida isolates (n = 180) from different locations in Hungary, from various host species, including humans. When combining capsular types with LPS genotypes, eight capsule - LPS genotype combinations were detected. A: L3 was the most dominant in bovine and porcine isolates, A: L1 in feline and human isolates, while D: L3 was the most common among strains from small ruminants. The P. multocida toxin encoding gene toxA was highly prevalent among small ruminant and porcine strains, while in human, feline and bovine isolates it could not be detected. Combination of the tested virulence associated genes (hgbA, nanH, hgbB, tbpA, pfhA, hsf1, hsf2, tadD, ptfA) classified our P. multocida isolates into 13 different virulence gene profiles (VGPs). These VGPs showed an association with host species. Analysis of the ompA sequence data confirmed this distribution by host species, which may indicate that host adaptation is taking place. The typing scheme used in this study may be useful in epidemiological investigations.
MeSH term(s)	Animals ; Bacterial Outer Membrane Proteins/genetics ; Cats ; Cattle ; Gene Expression Profiling ; Genes, Bacterial ; Genetic Variation ; Host Specificity ; Humans ; Hungary/epidemiology ; Molecular Typing ; Pasteurella Infections/epidemiology ; Pasteurella Infections/veterinary ; Pasteurella multocida/genetics ; Pasteurella multocida/pathogenicity ; Polymerase Chain Reaction ; Ruminants/microbiology ; Swine ; Virulence/genetics ; Virulence Factors/genetics
Chemical Substances	Bacterial Outer Membrane Proteins ; Virulence Factors ; OMPA outer membrane proteins (149024-69-1)
Language	English
Publishing date	2019-05-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2019.05.005
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Article: Development of a multiplex PCR assay for the detection of key genes associated with Pasteurella multocida subspecies

Ujvári, Barbara / Gantelet, Hubert / Magyar, Tibor

Journal of veterinary diagnostic investigation. 2022 Mar., v. 34, no. 2

2022

Abstract: The ability to distinguish among the subspecies of Pasteurella multocida isolates is important epidemiologically; however, classification at the subspecies level based on the results of conventional biochemical tests (fermentation of sorbitol and ... ...

Abstract	The ability to distinguish among the subspecies of Pasteurella multocida isolates is important epidemiologically; however, classification at the subspecies level based on the results of conventional biochemical tests (fermentation of sorbitol and dulcitol) is reportedly not accurate in all cases. Therefore, we developed a rapid, multiplex PCR assay to differentiate among the 3 subspecies of P. multocida. The PCR assay includes the P. multocida species–specific primers KMT1SP6 and KMT1T7 as an internal amplification control, with a newly designed gatD (galactitol-1-phosphate-5-dehydrogenase)-specific primer pair (unique for subsp. gallicida), and primers targeting a 16S rRNA gene region specific for subsp. septica. The subspecies specificity of the PCR was demonstrated by applying the test to a collection of 70 P. multocida isolates, including the Heddleston serovar reference strains; all isolates and strains were assigned correctly. The PCR assay is a sensitive, specific, and highly effective method for the identification of P. multocida subspecies, and an alternative to biochemical test–based differentiation. A possible relationship was noticed between P. multocida subspecies and lipopolysaccharide (LPS) genotype; all but one of the subsp. gallicida strains were isolated only from avian hosts and represented L1 LPS genotype. Subsp. multocida and subsp. septica isolates were classified into 5 and 4 different LPS genotypes, respectively, of which L3 was the only LPS genotype shared between these 2 subspecies.
Keywords	Pasteurella multocida ; birds ; fermentation ; galactitol ; genes ; genotype ; lipopolysaccharides ; oligodeoxyribonucleotides ; polymerase chain reaction ; serotypes ; sorbitol
Language	English
Dates of publication	2022-03
Size	p. 319-322.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387211063438
Database	NAL-Catalogue (AGRICOLA)

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Article: Virulence gene profiling and ompA sequence analysis of Pasteurella multocida and their correlation with host species

Ujvári, B / Makrai, L / Magyar, T

Veterinary microbiology. 2019 June, v. 233

2019

Abstract	This study describes the prevalence of capsule biosynthesis genes, LPS genotypes, virulence associated genes and the analysis of the outer membrane protein (ompA) sequence of Pasteurella multocida isolates (n = 180) from different locations in Hungary, from various host species, including humans. When combining capsular types with LPS genotypes, eight capsule - LPS genotype combinations were detected. A: L3 was the most dominant in bovine and porcine isolates, A: L1 in feline and human isolates, while D: L3 was the most common among strains from small ruminants. The P. multocida toxin encoding gene toxA was highly prevalent among small ruminant and porcine strains, while in human, feline and bovine isolates it could not be detected. Combination of the tested virulence associated genes (hgbA, nanH, hgbB, tbpA, pfhA, hsf1, hsf2, tadD, ptfA) classified our P. multocida isolates into 13 different virulence gene profiles (VGPs). These VGPs showed an association with host species. Analysis of the ompA sequence data confirmed this distribution by host species, which may indicate that host adaptation is taking place. The typing scheme used in this study may be useful in epidemiological investigations.
Keywords	Pasteurella multocida ; biosynthesis ; cats ; cattle ; epidemiological studies ; genes ; genotype ; hosts ; humans ; outer membrane proteins ; sequence analysis ; small ruminants ; swine ; virulence ; Hungary
Language	English
Dates of publication	2019-06
Size	p. 190-195.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2019.05.005
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Article: A novel perspective suggesting high sustained energy expenditure may be net protective against cancer.

Biro, Peter A / Thomas, Frédéric / Ujvari, Beata / Beckmann, Christa

Evolution, medicine, and public health

2022 Volume 10, Issue 1, Page(s) 170–176

Abstract: Energy expenditure (EE) is generally viewed as tumorigenic, due to production of reactive oxygen species (ROS) that can damage cells and DNA. On this basis, individuals within a species that sustain high EE should be more likely to develop cancer. Here, ... ...

Abstract	Energy expenditure (EE) is generally viewed as tumorigenic, due to production of reactive oxygen species (ROS) that can damage cells and DNA. On this basis, individuals within a species that sustain high EE should be more likely to develop cancer. Here, we argue the opposite, that high EE may be net protective effect against cancer, despite high ROS production. This is possible because individuals that sustain high EE have a greater energetic capacity (=greater energy acquisition, expenditure and ability to up-regulate output), and can therefore allocate energy to multiple cancer-fighting mechanisms with minimal energetic trade-offs. Our review finds that individuals sustaining high EE have greater antioxidant production, lower oxidative stress, greater immune function and lower cancer incidence. Our hypothesis and literature review suggest that EE may indeed be net protective against cancer, and that individual variation in energetic capacity may be a key mechanism to understand the highly individual nature of cancer risk in contemporary human populations and laboratory animals.
Language	English
Publishing date	2022-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2684837-5
ISSN	2050-6201
ISSN	2050-6201
DOI	10.1093/emph/eoac012
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