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  1. Article ; Online: Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis.

    Zhang, Xiaojun / Jiang, Wen / Richter, Jeremy M / Bates, J Alex / Reznik, Samuel K / Stachura, Sylwia / Rampulla, Richard / Doddalingappa, Dyamanna / Ulaganathan, Sankar / Hua, Ji / Bostwick, Jeffrey S / Sum, Chi / Posy, Shana / Malmstrom, Sarah / Dickey, Joyce / Harden, David / Lawrence, R Michael / Guarino, Victor R / Schumacher, William A /
    Wong, Pancras / Yang, Jing / Gordon, David A / Wexler, Ruth R / Priestley, E Scott

    Journal of medicinal chemistry

    2024  Volume 67, Issue 5, Page(s) 3571–3589

    Abstract: PAR4 is a promising antithrombotic target with potential for separation of efficacy from bleeding risk relative to current antiplatelet therapies. In an effort to discover a novel PAR4 antagonist chemotype, a quinoxaline-based HTS ... ...

    Abstract PAR4 is a promising antithrombotic target with potential for separation of efficacy from bleeding risk relative to current antiplatelet therapies. In an effort to discover a novel PAR4 antagonist chemotype, a quinoxaline-based HTS hit
    MeSH term(s) Animals ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Macaca fascicularis ; Quinoxalines/pharmacology ; Quinoxalines/therapeutic use ; Receptors, Thrombin ; Thrombin ; Hemorrhage ; Thrombosis/drug therapy ; Thrombosis/prevention & control ; Receptor, PAR-1 ; Blood Platelets ; Platelet Aggregation
    Chemical Substances protease-activated receptor 4 (JWE1M73YZN) ; Fibrinolytic Agents ; Quinoxalines ; Receptors, Thrombin ; Thrombin (EC 3.4.21.5) ; Receptor, PAR-1
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ethyl (2E,4E)-5-(3-bromophenylsulfonyl)penta-2,4-dienoate

    V. Sabari / Ulaganathan Sankar / Ramakrishnan Uma / S. Aravindhan

    Acta Crystallographica Section E, Vol 69, Iss 4, Pp o488-o

    2013  Volume 488

    Abstract: In the title compound, C13H13BrO4S, both C=C double bonds adopt an E conformation. The S atom has a distorted tetrahedral geometry with bond angles ranging from 102.17 (13) to 119.77 (14)°. The ethyl acrylate substituent adopts an extented conformation ... ...

    Abstract In the title compound, C13H13BrO4S, both C=C double bonds adopt an E conformation. The S atom has a distorted tetrahedral geometry with bond angles ranging from 102.17 (13) to 119.77 (14)°. The ethyl acrylate substituent adopts an extented conformation with all torsion angles close to 180°. In the crystal, molecules are linked into centrosymmetric R22(14) dimers via pairs of C—H.O hydrogen bonds.
    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2013-04-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Ethyl (E)-3-[1′-ethyl-2-oxo-4′-(phenylsulfonyl)-2H-spiro[acenaphthylene-1,2′-pyrrolidine]-3′-yl]acrylate

    S. Sundaramoorthy / R. Uma / Ulaganathan Sankar / D. Velmurugan

    Acta Crystallographica Section E, Vol 68, Iss 5, Pp o1401-o

    2012  Volume 1401

    Abstract: In the title compound, C28H27NO5S, the five-membered pyrrolidine ring, which exhibits an envelope conformation (the C atom at the spiral junction being the flap atom), makes dihedral angles of 57.37 (10) and 86.84 (8)°, respectively, with the phenyl ring ...

    Abstract In the title compound, C28H27NO5S, the five-membered pyrrolidine ring, which exhibits an envelope conformation (the C atom at the spiral junction being the flap atom), makes dihedral angles of 57.37 (10) and 86.84 (8)°, respectively, with the phenyl ring and the acenaphthylene ring system. In the crystal, molecules associate via two C—H.O hydrogen bonds, forming R22(20) and R22(10) graph-set motifs.
    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2012-05-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cesium carbonate mediated exclusive dialkylation of active methylene compounds

    Ulaganathan Sankar / Chandran Raju / Ramakrishnan Uma

    Current Chemistry Letters, Vol 1, Iss 3, Pp 123-

    2012  Volume 132

    Abstract: Active methylene compounds are regioselectively dialkylated by variety of alkyl halides using cesium carbonate in quantitative yield. The reaction yielded exclusively dialkylated products with no intermediate monoalkyaltion or mixture of products. ...

    Abstract Active methylene compounds are regioselectively dialkylated by variety of alkyl halides using cesium carbonate in quantitative yield. The reaction yielded exclusively dialkylated products with no intermediate monoalkyaltion or mixture of products.
    Keywords Balanced base ; Aprotic solvent ; Active methylene compounds ; Reactive halides ; Complete conversion ; Chemistry ; QD1-999
    Language English
    Publishing date 2012-07-01T00:00:00Z
    Publisher Growing Science
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: (2E,4E)-Ethyl 5-(phenylsulfonyl)penta-2,4-dienoate

    Ulaganathan Sankar / V. Sabari / G. Suresh / Ramakrishnan Uma / S. Aravindhan

    Acta Crystallographica Section E, Vol 68, Iss 4, Pp o1093-o

    2012  Volume 1093

    Abstract: In the title compound, C13H14O4S, both C=C double bonds adopt an E conformation. In the crystal, molecules are linked into centrosymmetric R22(14) dimers via pairs of C—H.O hydrogen bonds. ...

    Abstract In the title compound, C13H14O4S, both C=C double bonds adopt an E conformation. In the crystal, molecules are linked into centrosymmetric R22(14) dimers via pairs of C—H.O hydrogen bonds.
    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2012-04-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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