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Article ; Online: Integrating neurology and pharmacy through telemedicine: A novel care model.

Li, Hanlin / Naqvi, Imama A / Tom, Sarah E / Almeida, Barbara / Baratt, Yuliya / Ulane, Christina M

2021 Volume 432, Page(s) 120085

Abstract: Teleneurology had been best studied in acute stroke care, but the Coronavirus (COVID)-19 pandemic has highlighted applicability in outpatient practice. Telepharmacy is a convenient method for pharmacists to provide medication management to enhance care. ... ...

Abstract	Teleneurology had been best studied in acute stroke care, but the Coronavirus (COVID)-19 pandemic has highlighted applicability in outpatient practice. Telepharmacy is a convenient method for pharmacists to provide medication management to enhance care. Studies in the outpatient space suggest non-inferiority of teleneurology to increase access to specialized care for patients in rural locations. The role of telemedicine based interdisciplinary collaborations in a metropolitan and under-resourced setting has not been explored. We describe our approach to a teleneurology-telepharmacy collaboration at an urban academic medical center. Since its implementation pre-COVID, the program has expanded and transformed to serve the community further.
MeSH term(s)	COVID-19 ; Humans ; Neurology ; Pharmacy ; SARS-CoV-2 ; Telemedicine
Language	English
Publishing date	2021-12-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2021.120085
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Article ; Online: Mononeuropathy Multiplex After COVID-19.

Carberry, Nathan / Badu, Helen / Ulane, Christina M / Beckley, Akinpelumi / Rosenberg, Samuel J / Brenner, Keith / Brannagan, Thomas H

Journal of clinical neuromuscular disease

2021 Volume 23, Issue 1, Page(s) 24–30

Abstract: Objectives: COVID-19 is a novel coronavirus that emerged in 2019 and is responsible for a global pandemic. Numerous neurologic manifestations have been described in the literature regarding COVID-19, but most studies are focused on the central nervous ... ...

Abstract	Objectives: COVID-19 is a novel coronavirus that emerged in 2019 and is responsible for a global pandemic. Numerous neurologic manifestations have been described in the literature regarding COVID-19, but most studies are focused on the central nervous system. The authors have noted an association between prior COVID-19 infection and the development of a systemic neuropathy that manifests with asymmetric sensorimotor loss in the peripheral nervous system. We describe 4 cases of mononeuropathy multiplex that were diagnosed after COVID-19 infection. Methods: All patients included were treated for severe COVID-19 infection at New York Presbyterian Hospital and subsequently referred to the Columbia Peripheral Neuropathy Center for persistent neuropathy. Results: Patient history, COVID-19 disease course, and mononeuropathy multiplex diagnostic evaluation of the 4 patients are recounted. Conclusions: We postulate a connection between COVID-19 and the development of mononeuropathy multiplex with implications in prognostication, rehabilitation strategies, and future treatments.
MeSH term(s)	Aged ; COVID-19/complications ; Diabetes Mellitus, Type 2/complications ; Electrodiagnosis ; Electromyography ; Female ; Humans ; Hypertension ; Male ; Middle Aged ; Mononeuropathies/diagnosis ; Mononeuropathies/etiology ; Neural Conduction ; Neurologic Examination ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Retrospective Studies
Language	English
Publishing date	2021-09-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1454947-5
ISSN	1537-1611 ; 1522-0443
ISSN (online)	1537-1611
ISSN	1522-0443
DOI	10.1097/CND.0000000000000367
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Article ; Online: Recent advances in myotonic dystrophy type 2.

Ulane, Christina M / Teed, Sarah / Sampson, Jacinda

Current neurology and neuroscience reports

2014 Volume 14, Issue 2, Page(s) 429

Abstract: Myotonic dystrophy is the commonest adult muscular dystrophy. Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are often discussed jointly, and although they share many clinical and molecular features, differences do exist. ... ...

Abstract	Myotonic dystrophy is the commonest adult muscular dystrophy. Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are often discussed jointly, and although they share many clinical and molecular features, differences do exist. Historically, more is known about DM1 than about DM2. The literature in the field of myotonic dystrophy is broad, with advances in our understanding of DM2. This article reviews recent developments in DM2 with respect to diagnosis, systemic features, and molecular mechanisms of the disease.
MeSH term(s)	Animals ; Female ; Humans ; Male ; Myotonic Disorders/diagnosis ; Myotonic Disorders/genetics ; Myotonic Disorders/physiopathology ; Myotonic Dystrophy
Language	English
Publishing date	2014-01-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057363-7
ISSN	1534-6293 ; 1528-4042
ISSN (online)	1534-6293
ISSN	1528-4042
DOI	10.1007/s11910-013-0429-1
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Article ; Online: Clinical progression in Parkinson disease and the neurobiology of axons.

Cheng, Hsiao-Chun / Ulane, Christina M / Burke, Robert E

Annals of neurology

2010 Volume 67, Issue 6, Page(s) 715–725

Abstract: Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson disease (PD) and the molecular pathways of cell injury and death, we remain without therapies that forestall disease progression. Although there are many ... ...

Abstract	Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson disease (PD) and the molecular pathways of cell injury and death, we remain without therapies that forestall disease progression. Although there are many possible explanations for this lack of success, one is that experimental therapeutics to date have not adequately focused on an important component of the disease process, that of axon degeneration. It remains unknown what neuronal compartment, either the soma or the axon, is involved at disease onset, although some have proposed that it is the axons and their terminals that take the initial brunt of injury. Nevertheless, this concept has not been formally incorporated into many of the current theories of disease pathogenesis, and it has not achieved a wide consensus. More importantly, in view of growing evidence that the molecular mechanisms of axon degeneration are separate and distinct from the canonical pathways of programmed cell death that mediate soma destruction, the possibility of early involvement of axons in PD has not been adequately emphasized as a rationale to explore the neurobiology of axons for novel therapeutic targets. We propose that ongoing degeneration of axons, not cell bodies, is the primary determinant of clinically apparent progression of disease, and that future experimental therapeutics intended to forestall disease progression will benefit from a new focus on the distinct mechanisms of axon degeneration.
MeSH term(s)	Axons/pathology ; Disease Progression ; Humans ; Neurobiology ; Neurons/pathology ; Parkinson Disease/pathology
Language	English
Publishing date	2010-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.21995
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Article ; Online: Pearls & Oy-sters: Large vessel ischemic stroke secondary to glioblastoma multiforme.

Obeid, Makram / Ulane, Christina / Rosenfeld, Steven

Neurology

2010 Volume 74, Issue 13, Page(s) e50–1

MeSH term(s)	Adult ; Brain/blood supply ; Brain/pathology ; Brain Ischemia/complications ; Brain Ischemia/pathology ; Brain Ischemia/therapy ; Brain Neoplasms/complications ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Cerebral Angiography ; Glioblastoma/complications ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Male ; Stroke/complications ; Stroke/pathology ; Stroke/therapy
Language	English
Publishing date	2010-03-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0b013e3181d7d66a
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Article ; Online: Preparing a neurology department for SARS-CoV-2 (COVID-19): Early experiences at Columbia University Irving Medical Center and the New York Presbyterian Hospital in New York City.

Waldman, Genna / Mayeux, Richard / Claassen, Jan / Agarwal, Sachin / Willey, Joshua / Anderson, Emily / Punzalan, Patricia / Lichtcsien, Ryan / Bell, Michelle / Przedborski, Serge / Ulane, Christina / Roberts, Kirk / Williams, Olajide / Lassman, Andrew B / Lennihan, Laura / Thakur, Kiran T

Neurology

2020 Volume 94, Issue 20, Page(s) 886–891

MeSH term(s)	Academic Medical Centers/organization & administration ; Academic Medical Centers/standards ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Hospital Departments/methods ; Hospital Departments/organization & administration ; Hospital Departments/standards ; Humans ; Neurology/methods ; Neurology/organization & administration ; Neurology/standards ; New York City ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000009519
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Article: Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components.

Ulane, Christina M / Horvath, Curt M

Virology

2002 Volume 304, Issue 2, Page(s) 160–166

Abstract: Signal transducer and activator of transcription (STAT) proteins are normally long-lived, but infection with certain Paramyxoviruses results in efficient loss of IFN-responsive STAT1 or STAT2. Expression of a virus-encoded protein called "V" is ... ...

Abstract	Signal transducer and activator of transcription (STAT) proteins are normally long-lived, but infection with certain Paramyxoviruses results in efficient loss of IFN-responsive STAT1 or STAT2. Expression of a virus-encoded protein called "V" is sufficient to mediate the destruction of STAT proteins. STAT degradation is blocked by proteasome inhibitors, strongly implicating the ubiquitin (Ub)-proteasome targeting system. We demonstrate that cellular expression of V proteins from simian virus 5 (SV5) and type II human parainfluenza virus (HPIV2) induces polyubiquitylation of STAT1 and STAT2 targets. In vitro, the V proteins catalyze Ub transfer in an ATP-dependent process that requires both Ub-activating (E1) and Ub-conjugating (E2) activities. Furthermore, SV5 and HPIV2 V-interacting protein partners were isolated by affinity purification from human cells and reveal a complex of associated cellular proteins. This complex includes both STAT1 and STAT2, and the damaged DNA binding protein, DDB1. In addition, a protein related to a family of cellular Ub ligase complex subunits, cullin 4A (Cul4A), associated with the V proteins. The roles of both DDB1 and Cul4A in STAT1 degradation by SV5 infection were analyzed using small interfering RNAs. These findings demonstrate the assembly of a V-dependent degradation complex that includes STAT1, STAT2, DDB1, and Cul4A. In agreement with prior nomenclature on SCF-type cellular E3 enzymes, we refer to this complex as VDC.
MeSH term(s)	Antigen-Antibody Complex/metabolism ; Cells, Cultured ; Cullin Proteins ; DNA-Binding Proteins/metabolism ; Humans ; Ligases/metabolism ; Neoplasm Proteins/metabolism ; RNA, Small Interfering/physiology ; Respirovirus/physiology ; STAT1 Transcription Factor ; STAT2 Transcription Factor ; Trans-Activators/metabolism ; Ubiquitin-Protein Ligases ; Viral Proteins/physiology ; Viral Structural Proteins/physiology
Chemical Substances	Antigen-Antibody Complex ; CUL4A protein, human ; Cullin Proteins ; DDB1 protein, human ; DNA-Binding Proteins ; Neoplasm Proteins ; RNA, Small Interfering ; STAT1 Transcription Factor ; STAT1 protein, human ; STAT2 Transcription Factor ; STAT2 protein, human ; Trans-Activators ; V protein, Simian parainfluenza virus 5 ; V protein, human parainfluenza virus type 1 ; Viral Proteins ; Viral Structural Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ligases (EC 6.-)
Language	English
Publishing date	2002-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1006/viro.2002.1773
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Article ; Online: Control of canalization and evolvability by Hsp90.

Milton, Claire C / Ulane, Christina M / Rutherford, Suzannah

PloS one

2006 Volume 1, Page(s) e75

Abstract: Partial reduction of Hsp90 increases expression of morphological novelty in qualitative traits of Drosophila and Arabidopsis, but the extent to which the Hsp90 chaperone also controls smaller and more likely adaptive changes in natural quantitative ... ...

Abstract	Partial reduction of Hsp90 increases expression of morphological novelty in qualitative traits of Drosophila and Arabidopsis, but the extent to which the Hsp90 chaperone also controls smaller and more likely adaptive changes in natural quantitative traits has been unclear. To determine the effect of Hsp90 on quantitative trait variability we deconstructed genetic, stochastic and environmental components of variation in Drosophila wing and bristle traits of genetically matched flies, differing only by Hsp90 loss-of-function or wild-type alleles. Unexpectedly, Hsp90 buffering was remarkably specific to certain normally invariant and highly discrete quantitative traits. Like the qualitative trait phenotypes controlled by Hsp90, highly discrete quantitative traits such as scutellor and thoracic bristle number are threshold traits. When tested across genotypes sampled from a wild population or in laboratory strains, the sensitivity of these traits to many types of variation was coordinately controlled, while continuously variable bristle types and wing size, and critically invariant left-right wing asymmetry, remained relatively unaffected. Although increased environmental variation and developmental noise would impede many types of selection response, in replicate populations in which Hsp90 was specifically impaired, heritability and 'extrinsic evolvability', the expected response to selection, were also markedly increased. However, despite the overall buffering effect of Hsp90 on variation in populations, for any particular individual or genotype in which Hsp90 was impaired, the size and direction of its effects were unpredictable. The trait and genetic-background dependence of Hsp90 effects and its remarkable bias toward invariant or canalized traits support the idea that traits evolve independent and trait-specific mechanisms of canalization and evolvability through their evolution of non-linearity and thresholds. Highly non-linear responses would buffer variation in Hsp90-dependent signaling over a wide range, while over a narrow range of signaling near trait thresholds become more variable with increasing probability of triggering all-or-none developmental responses.
MeSH term(s)	Animal Structures/anatomy & histology ; Animals ; Drosophila/anatomy & histology ; Drosophila/genetics ; Drosophila Proteins/genetics ; Evolution, Molecular ; Female ; Genes, Insect ; Genetic Variation ; HSP90 Heat-Shock Proteins/genetics ; Male ; Models, Genetic ; Mutation ; Phenotype ; Quantitative Trait, Heritable ; Wings, Animal/anatomy & histology
Chemical Substances	Drosophila Proteins ; HSP90 Heat-Shock Proteins
Language	English
Publishing date	2006-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0000075
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Article: Preparing a neurology department for SARS-CoV-2 (COVID-19): Early experiences at Columbia University Irving Medical Center and the New York Presbyterian Hospital in New York City

Neurology

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #38330
Database	COVID19

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Article ; Online: Preparing a neurology department for SARS-CoV-2 (COVID-19) ; Early experiences at Columbia University Irving Medical Center and the New York Presbyterian Hospital in New York City

Neurology

2020 Volume 94, Issue 20, Page(s) 886–891

Keywords	Clinical Neurology ; covid19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publishing country	us
Document type	Article ; Online
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/wnl.0000000000009519
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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