Article ; Online: Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.
PloS one
2010 Volume 5, Issue 8, Page(s) e12454
Abstract: The Arf tumor suppressor acts as a sensor of oncogenic signals, countering aberrant proliferation in large part via activation of the p53 transcriptional program, though a number of p53-independent functions have been described. Mounting evidence ... ...
| Abstract | The Arf tumor suppressor acts as a sensor of oncogenic signals, countering aberrant proliferation in large part via activation of the p53 transcriptional program, though a number of p53-independent functions have been described. Mounting evidence suggests that, in addition to promoting tumorigenesis via disruptions in the homeostatic balance between cell proliferation and apoptosis of overt cancer cells, genetic alterations leading to tumor suppressor loss of function or oncogene gain of function can also incite tumor development via effects on the tumor microenvironment. In a transgenic mouse model of multi-stage pancreatic neuroendocrine carcinogenesis (PNET) driven by inhibition of the canonical p53 and Rb tumor suppressors with SV40 large T-antigen (Tag), stochastic progression to tumors is limited in part by a requirement for initiation of an angiogenic switch. Despite inhibition of p53 by Tag in this mouse PNET model, concomitant disruption of Arf via genetic knockout resulted in a significantly accelerated pathway to tumor formation that was surprisingly not driven by alterations in tumor cell proliferation or apoptosis, but rather via earlier activation of the angiogenic switch. In the setting of a constitutional p53 gene knockout, loss of Arf also accelerated tumor development, albeit to a lesser degree. These findings demonstrate that Arf loss of function can promote tumorigenesis via facilitating angiogenesis, at least in part, through p53-independent mechanisms. |
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| MeSH term(s) | Animals ; Apoptosis/genetics ; Cell Proliferation ; Cyclin-Dependent Kinase Inhibitor p16/deficiency ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Disease Models, Animal ; Disease Progression ; Gene Knockout Techniques ; Mice ; Mice, Inbred C57BL ; Neoplasm Staging ; Neovascularization, Pathologic/genetics ; Neuroendocrine Tumors/blood supply ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/metabolism ; Neuroendocrine Tumors/pathology ; Pancreatic Neoplasms/blood supply ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Stromal Cells/metabolism ; Tumor Suppressor Protein p53/metabolism |
| Chemical Substances | Cdkn2a protein, mouse ; Cyclin-Dependent Kinase Inhibitor p16 ; Tumor Suppressor Protein p53 |
| Language | English |
| Publishing date | 2010-08-27 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ISSN | 1932-6203 |
| ISSN (online) | 1932-6203 |
| DOI | 10.1371/journal.pone.0012454 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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