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  1. Article ; Online: West Nile virus vaccines - current situation and future directions.

    Ulbert, Sebastian

    Human vaccines & immunotherapeutics

    2019  Volume 15, Issue 10, Page(s) 2337–2342

    Abstract: West Nile virus (WNV) is a widely spread human pathogenic arthropod-borne virus. It can lead to severe, sometimes fatal, neurological disease. Over the last two decades, several vaccine candidates for the protection of humans from WNV have been developed. ...

    Abstract West Nile virus (WNV) is a widely spread human pathogenic arthropod-borne virus. It can lead to severe, sometimes fatal, neurological disease. Over the last two decades, several vaccine candidates for the protection of humans from WNV have been developed. Some technologies were transferred into clinical testing, but these approaches have not yet led to a licensed product. This review summarizes the current status of a human WNV vaccine and discusses reasons for the lack of clinically advanced product candidates. It also discusses the problem of immunological cross-reactivity between flaviviruses and how it can be addressed during vaccine development.
    MeSH term(s) Animals ; Antibodies, Viral/immunology ; Clinical Trials as Topic ; Cross Reactions/immunology ; Humans ; Viral Envelope Proteins/immunology ; West Nile Fever/prevention & control ; West Nile Virus Vaccines/immunology ; West Nile virus/immunology
    Chemical Substances Antibodies, Viral ; Viral Envelope Proteins ; West Nile Virus Vaccines
    Language English
    Publishing date 2019-07-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2019.1621149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6967: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Editorial: Irradiation technologies for vaccine development.

    Wijewardana, Viskam / Ulbert, Sebastian / Cattoli, Giovanni

    Frontiers in immunology

    2023  Volume 13, Page(s) 1075335

    MeSH term(s) Gamma Rays ; Vaccine Development
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1075335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immunization with different recombinant West Nile virus envelope proteins induces varying levels of serological cross-reactivity and protection from infection.

    Weiß, Rebecca / Issmail, Leila / Rockstroh, Alexandra / Grunwald, Thomas / Fertey, Jasmin / Ulbert, Sebastian

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1279147

    Abstract: Introduction: West Nile Virus (WNV) is a zoonotic flavivirus transmitted by mosquitoes. Especially in the elderly or in immunocompromised individuals an infection with WNV can lead to severe neurological symptoms. To date, no human vaccine against WNV ... ...

    Abstract Introduction: West Nile Virus (WNV) is a zoonotic flavivirus transmitted by mosquitoes. Especially in the elderly or in immunocompromised individuals an infection with WNV can lead to severe neurological symptoms. To date, no human vaccine against WNV is available. The Envelope (E) protein, located at the surface of flaviviruses, is involved in the invasion into host cells and is the major target for neutralizing antibodies and therefore central to vaccine development. Due to their close genetic and structural relationship, flaviviruses share highly conserved epitopes, such as the fusion loop domain (FL) in the E protein, that are recognized by cross-reactive antibodies. These antibodies can lead to enhancement of infection with heterologous flaviviruses, which is a major concern for potential vaccines in areas with co-circulation of different flaviviruses, e.g. Dengue or Zika viruses.
    Material: To reduce the potential of inducing cross-reactive antibodies, we performed an immunization study in mice using WNV E proteins with either wild type sequence or a mutated FL, and WNV E domain III which does not contain the FL at all.
    Results and discussion: Our data show that all antigens induce high levels of WNV-binding antibodies. However, the level of protection against WNV varied, with the wildtype E protein inducing full, the other antigens only partial protection. On the other hand, serological cross-reactivity to heterologous flaviviruses was significantly reduced after immunization with the mutated E protein or domain III as compared to the wild type version. These results have indications for choosing antigens with the optimal specificity and efficacy in WNV vaccine development.
    MeSH term(s) Humans ; Animals ; Mice ; Aged ; West Nile virus/genetics ; Viral Envelope Proteins/genetics ; West Nile Fever ; Flavivirus ; Immunization ; Antibodies, Viral ; Recombinant Proteins/genetics ; Zika Virus ; Zika Virus Infection
    Chemical Substances Viral Envelope Proteins ; Antibodies, Viral ; Recombinant Proteins
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1279147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: West Nile virus: the complex biology of an emerging pathogen.

    Ulbert, Sebastian

    Intervirology

    2011  Volume 54, Issue 4, Page(s) 171–184

    Abstract: West Nile virus (WNV) is a zoonotic virus that circulates in birds and is transmitted by mosquitoes. Incidentally, humans, horses and other mammals can also be infected. Disease symptoms caused by WNV range from fever to neurological complications, such ... ...

    Abstract West Nile virus (WNV) is a zoonotic virus that circulates in birds and is transmitted by mosquitoes. Incidentally, humans, horses and other mammals can also be infected. Disease symptoms caused by WNV range from fever to neurological complications, such as encephalitis or meningitis. Mortality is observed mostly in older and immunocompromised individuals. In recent years, epidemics caused by WNV in humans and horses have become more frequent in several Southern European countries, such as Italy and Greece. In 1999, WNV was introduced into the USA and spread over North America within a couple of years. The increasing number of WNV outbreaks is associated with the emergence of novel viral strains, which display higher virulence and greater epidemic potential for humans. Upon infection with WNV, the mammalian immune system counteracts the virus at several different levels. On the other side, WNV has developed elaborated escape mechanisms to avoid its elimination. This review summarizes recent findings in WNV research that help to understand the complex biology associated with this emerging pathogen.
    MeSH term(s) Animals ; Birds ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/mortality ; Communicable Diseases, Emerging/pathology ; Communicable Diseases, Emerging/veterinary ; Disease Outbreaks ; Europe/epidemiology ; Genotype ; Horses ; Humans ; Immune Evasion ; Incidence ; North America/epidemiology ; Virulence ; West Nile Fever/epidemiology ; West Nile Fever/mortality ; West Nile Fever/pathology ; West Nile Fever/veterinary ; West Nile virus/immunology ; West Nile virus/pathogenicity
    Language English
    Publishing date 2011
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 184545-7
    ISSN 1423-0100 ; 0300-5526
    ISSN (online) 1423-0100
    ISSN 0300-5526
    DOI 10.1159/000328320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1040: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: Entwicklung eines diagnostischen Systems zur Entdeckung von West-Nile-Virus-Infektionen und Entwicklung eines gentechnischen Impfstoffes gegen diese Infektion

    Ulbert, Sebastian

    Schlussbericht ; Laufzeit des Vorhabens: Januar 2007 - Dezember 2009

    2010  

    Title variant Schlussberich WNV
    Institution Fraunhofer-Institut für Zelltherapie und Immunologie
    Author's details Fraunhofer IZI. Projektleiter: Sebastian Ulbert
    Language German
    Size 11 Bl.
    Publishing place Leipzig
    Document type Book
    Note Förderkennzeichen BMBF 28-1-32.003-06 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden. - Auch als elektronische Ressource vorh.
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book ; Online: Entwicklung eines diagnostischen Systems zur Entdeckung von West-Nile-Virus-Infektionen und Entwicklung eines gentechnischen Impfstoffes gegen diese Infektion

    Ulbert, Sebastian

    Schlussbericht ; Laufzeit des Vorhabens: Januar 2007 - Dezember 2009

    2010  

    Title variant Schlussberich WNV
    Institution Fraunhofer-Institut für Zelltherapie und Immunologie
    Author's details Fraunhofer IZI. Sebastian Ulbert
    Language German
    Size Online-Ressource (11 S., 122 KB)
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek
    Publishing place Hannover ; Leipzig
    Document type Book ; Online
    Note Förderkennzeichen BMBF 28-1-32.003-06 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden. - Auch als gedr. Ausg. vorhanden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: Immunization with different recombinant West Nile virus envelope proteins induces varying levels of serological cross-reactivity and protection from infection

    Weiß, Rebecca / Issmail, Leila / Rockstroh, Alexandra / Grunwald, Thomas / Fertey, Jasmin / Ulbert, Sebastian

    2023  

    Abstract: Introduction: West Nile Virus (WNV) is a zoonotic flavivirus transmitted by mosquitoes. Especially in the elderly or in immunocompromised individuals an infection with WNV can lead to severe neurological symptoms. To date, no human vaccine against WNV is ...

    Abstract Introduction: West Nile Virus (WNV) is a zoonotic flavivirus transmitted by mosquitoes. Especially in the elderly or in immunocompromised individuals an infection with WNV can lead to severe neurological symptoms. To date, no human vaccine against WNV is available. The Envelope (E) protein, located at the surface of flaviviruses, is involved in the invasion into host cells and is the major target for neutralizing antibodies and therefore central to vaccine development. Due to their close genetic and structural relationship, flaviviruses share highly conserved epitopes, such as the fusion loop domain (FL) in the E protein, that are recognized by cross-reactive antibodies. These antibodies can lead to enhancement of infection with heterologous flaviviruses, which is a major concern for potential vaccines in areas with co-circulation of different flaviviruses, e.g. Dengue or Zika viruses. Material: To reduce the potential of inducing cross-reactive antibodies, we performed an immunization study in mice using WNV E proteins with either wild type sequence or a mutated FL, and WNV E domain III which does not contain the FL at all. Results and discussion: Our data show that all antigens induce high levels of WNV-binding antibodies. However, the level of protection against WNV varied, with the wildtype E protein inducing full, the other antigens only partial protection. On the other hand, serological cross-reactivity to heterologous flaviviruses was significantly reduced after immunization with the mutated E protein or domain III as compared to the wild type version. These results have indications for choosing antigens with the optimal specificity and efficacy in WNV vaccine development.

    13
    Keywords West Nile virus ; Cross-activity ; Flavivirus ; Fusion loop ; Recombinant proteins ; Vaccine
    Subject code 616
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Mucosal immunization with a low-energy electron inactivated respiratory syncytial virus vaccine protects mice without Th2 immune bias.

    Eberlein, Valentina / Rosencrantz, Sophia / Finkensieper, Julia / Besecke, Joana Kira / Mansuroglu, Yaser / Kamp, Jan-Christopher / Lange, Franziska / Dressman, Jennifer / Schopf, Simone / Hesse, Christina / Thoma, Martin / Fertey, Jasmin / Ulbert, Sebastian / Grunwald, Thomas

    Frontiers in immunology

    2024  Volume 15, Page(s) 1382318

    Abstract: The respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections associated with numerous hospitalizations. Recently, intramuscular (i.m.) vaccines against RSV have been approved for elderly and pregnant women. ... ...

    Abstract The respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections associated with numerous hospitalizations. Recently, intramuscular (i.m.) vaccines against RSV have been approved for elderly and pregnant women. Noninvasive mucosal vaccination, e.g., by inhalation, offers an alternative against respiratory pathogens like RSV. Effective mucosal vaccines induce local immune responses, potentially resulting in the efficient and fast elimination of respiratory viruses after natural infection. To investigate this immune response to an RSV challenge, low-energy electron inactivated RSV (LEEI-RSV) was formulated with phosphatidylcholine-liposomes (PC-LEEI-RSV) or 1,2-dioleoyl-3-trimethylammonium-propane and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DD-LEEI-RSV) for vaccination of mice intranasally. As controls, LEEI-RSV and formalin-inactivated-RSV (FI-RSV) were used
    MeSH term(s) Animals ; Respiratory Syncytial Virus Vaccines/immunology ; Respiratory Syncytial Virus Vaccines/administration & dosage ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Infections/immunology ; Mice ; Vaccines, Inactivated/immunology ; Vaccines, Inactivated/administration & dosage ; Female ; Th2 Cells/immunology ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; Immunity, Mucosal ; Mice, Inbred BALB C ; Immunization ; Respiratory Syncytial Virus, Human/immunology ; Vaccination/methods ; Respiratory Syncytial Viruses/immunology ; Viral Load ; Immunoglobulin A/immunology
    Chemical Substances Respiratory Syncytial Virus Vaccines ; Vaccines, Inactivated ; Antibodies, Viral ; Immunoglobulin A
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1382318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Prevalence of

    Körner, Sophia / Makert, Gustavo R / Ulbert, Sebastian / Pfeffer, Martin / Mertens-Scholz, Katja

    Frontiers in veterinary science

    2021  Volume 8, Page(s) 655715

    Abstract: The zoonosis Q fever is caused by the obligate intracellular ... ...

    Abstract The zoonosis Q fever is caused by the obligate intracellular bacterium
    Language English
    Publishing date 2021-04-26
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.655715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Low-Energy Electron Irradiation (LEEI) for the Generation of Inactivated Bacterial Vaccines.

    Fertey, Jasmin / Standfest, Bastian / Beckmann, Jana / Thoma, Martin / Grunwald, Thomas / Ulbert, Sebastian

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2414, Page(s) 97–113

    Abstract: Vaccines consisting of whole inactivated bacteria (bacterins) are generated by incubation of the pathogen with chemicals. This is a time-consuming procedure which may lead to less immunogenic material, as critical antigenic structures can be altered by ... ...

    Abstract Vaccines consisting of whole inactivated bacteria (bacterins) are generated by incubation of the pathogen with chemicals. This is a time-consuming procedure which may lead to less immunogenic material, as critical antigenic structures can be altered by chemical modification. A promising alternative approach is low-energy electron irradiation (LEEI). Like other types of ionizing radiation, it mainly acts by destroying nucleic acids but causes less damage to structural components like proteins. As the electrons have a limited penetration depth, LEEI is currently used for sterilization of surfaces. The inactivation of pathogens in liquids requires irradiation of the culture in a thin film to ensure complete penetration. Here, we describe two approaches for the irradiation of bacterial suspensions in a research scale. After confirmation of inactivation, the material can be directly used for vaccination, without any purification steps.
    MeSH term(s) Bacteria ; Bacterial Vaccines ; Electrons ; Radiation, Ionizing ; Vaccines, Inactivated
    Chemical Substances Bacterial Vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1900-1_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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