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  1. Article ; Online: Notes on cutaneous manifestations of Kawasaki disease and multisystem inflammatory syndrome in children.

    Gamez-Gonzalez, Luisa Berenise / Ulloa-Gutierrez, Rolando / Yamazaki-Nakashimada, Marco Antonio

    International journal of rheumatic diseases

    2023  Volume 26, Issue 12, Page(s) 2596–2598

    MeSH term(s) Child ; Humans ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Connective Tissue Diseases
    Language English
    Publishing date 2023-07-13
    Publishing country England
    Document type Letter
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6098: Show issues Location:
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  2. Article: Role of Valganciclovir in Children with Congenital CMV Infection: A Review of the Literature.

    Pata, Davide / Buonsenso, Danilo / Turriziani-Colonna, Arianna / Salerno, Gilda / Scarlato, Lucia / Colussi, Lara / Ulloa-Gutierrez, Rolando / Valentini, Piero

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 7

    Abstract: Background: Cytomegalovirus (CMV) is the most common agent of congenital infection in humans. It is a main cause of neurodevelopmental delay and sensorineural hearing loss in infancy. Since the 2000s, a number of studies have used Valganciclovir as a ... ...

    Abstract Background: Cytomegalovirus (CMV) is the most common agent of congenital infection in humans. It is a main cause of neurodevelopmental delay and sensorineural hearing loss in infancy. Since the 2000s, a number of studies have used Valganciclovir as a therapy for children with congenital CMV infection.
    Methods: In order to evaluate the efficacy of Valganciclovir in preventing clinical sequelae and its possible side effects, we performed a review of the published literature. This search was completed via PubMed for manuscripts published from January 2007 to December 2021, combining the MeSH words "Valganciclovir", "Congenital", and "Cytomegalovirus".
    Results: A total of 27 articles were included (12 retrospective studies, 4 prospective studies, 1 randomized controlled trial, and 10 case reports). The clinical features were similar to those already described in the literature. The therapeutic protocols used were very different between the various studies included and neonatal antiviral treatments were only moderately effective. The therapy proved to be well-tolerated.
    Conclusions: The quality of the included studies and the sample size were limited due to the rarity of the disease. The use of different therapeutic protocols in terms of starting dates, doses, and durations made it impossible to compare and correctly evaluate the efficacy of the treatments. Randomized controlled trials are needed to establish the correct effective dose with the fewest side effects and the most efficient duration of therapy.
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10071246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Thoracic and Renal Actinomycosis Requiring Complete Right Nephrectomy in a Costa Rican Female Child.

    Segura-Perez, Edward / Ulloa-Gutierrez, Rolando / Ávila-Aguero, María L

    Cureus

    2020  Volume 12, Issue 2, Page(s) e6879

    Abstract: Actinomycosis is a relatively uncommon bacterial disease of childhood, especially when presenting as deep-seated infections. Only 10% of affected patients are younger than 18 years of age. In children, cervical actinomycosis is the most common form of ... ...

    Abstract Actinomycosis is a relatively uncommon bacterial disease of childhood, especially when presenting as deep-seated infections. Only 10% of affected patients are younger than 18 years of age. In children, cervical actinomycosis is the most common form of clinical presentation, and among the abdominopelvic form, renal abscesses are rare. We describe an uncommon and severe case of a five-year-old Costa Rican girl with thoracic and renal actinomycosis who required a complete nephrectomy.
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.6879
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  4. Article ; Online: Multisystem inflammatory syndrome associated with COVID19 in children and adolescents: calling for diagnosis.

    Ulloa-Gutiérrez, Rolando / Ivankovich-Escoto, Gabriela / Yamazaki-Nakashimada, Marco A

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2020  Volume 37, Issue 3, Page(s) 199–201

    Title translation Síndrome inflamatorio multisistémico asociado a COVID-19 en niños y adolescentes: un llamado al diagnóstico.
    MeSH term(s) Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/complications ; Humans ; Inflammation/diagnosis ; Inflammation/etiology ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Language Spanish
    Publishing date 2020-08-27
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/s0716-10182020000300199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Epidemiologic changes and novelties on vaccination against Bordetella pertussis in Latin America.

    Gentile, Ángela / Torres-Torreti, Juan Pablo / López-López, Pío / Ulloa-Gutierrez, Rolando

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2021  Volume 38, Issue 2, Page(s) 232–242

    Abstract: Although whooping cough is a vaccine-preventable disease (VPD), its epidemiologic characteristics in Latin America shows persistence of outbreaks in the region. This persistence is due, at least in part, to the presence of antivaccine movements, the ... ...

    Title translation Cambios epidemiológicos y actualidades sobre vacunación contra Bordetella pertussis en Latinoamérica.
    Abstract Although whooping cough is a vaccine-preventable disease (VPD), its epidemiologic characteristics in Latin America shows persistence of outbreaks in the region. This persistence is due, at least in part, to the presence of antivaccine movements, the diversity of the surveillance systems, and the lack of a uniform case definition for the region. Given the importance of whooping cough in Latin America and the changes in vaccine recommendations, this manuscript aims to review epidemiologic data and recent changes in the vaccination calendars and their impact on the pediatric disease by Bordetella pertussis in Latin America. Recent epidemiological data reveal that between regions, countries, and administrative units within each country there is a marked heterogeneity of vaccine coverage, with different outbreak patterns. Efforts in the region have tried to improve this situation by introducing acellular pertussis vaccines (aP) in the vaccine calendars, which are less reactogenic than whole-cell pertussis vaccines (wP). Moreover, some countries have improved the case definition. Some countries have implemented a confirmed case definition by introducing polymerase chain reaction (PCR) as a diagnostic criterion. As a response to the heterogeneities observed within and between countries and the regional epidemiologic profiles, a Steering Committee from the Latin American Society for Pediatric Infectiology (SLIPE) and the Latin American Association of Pediatrics (ALAPE) propose a unified case definition and recommendations to improve vaccine coverage and reduce the outbreaks of whooping cough in Latin America.
    MeSH term(s) Bordetella pertussis ; Child ; Humans ; Latin America/epidemiology ; Pertussis Vaccine ; Vaccination ; Whooping Cough/epidemiology ; Whooping Cough/prevention & control
    Chemical Substances Pertussis Vaccine
    Language Spanish
    Publishing date 2021-06-29
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/S0716-10182021000200232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dr. Tomisaku Kawasaki (1925-2020) y su legado en América Latina.

    Soza, Guillermo / González-Mata, Antonio / Tremoulet, Adriana H / Ulloa-Gutierrez, Rolando

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2021  Volume 37, Issue 4, Page(s) 339–342

    Title translation Dr. Tomisaku Kawasaki (1925-2020) and his legacy in Latin America.
    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Japan ; Latin America ; Mucocutaneous Lymph Node Syndrome ; Pediatrics/history
    Language Spanish
    Publishing date 2021-01-05
    Publishing country Chile
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/S0716-10182020000400339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Epidemiological and clinical profile between influenza A and B virus in Costa Rican children.

    Ávila-Morales, Silvia / Ospina-Henao, Sebastián / Ulloa-Gutierrez, Rolando / Ávila-Agüero, María L

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 105, Page(s) 763–768

    Abstract: Objective: We aimed to evaluate the clinical and epidemiological behavior of influenza type A versus type B and analyze if there was any correlation or differences between the characteristics of both groups.: Methods: An observational, retrospective, ...

    Abstract Objective: We aimed to evaluate the clinical and epidemiological behavior of influenza type A versus type B and analyze if there was any correlation or differences between the characteristics of both groups.
    Methods: An observational, retrospective, descriptive, and population-based study based of children who were hospitalized at the only national pediatric hospital of Costa Rica from January 1, 2010 to December 31, 2018 and had a confirmed influenza virus infection.
    Results: 336 patients were analyzed. Mean age was 35,6 ± 36,7 months (3,0 ± 3,1 years). The only significant variables at 25% in relation to influenza type A or B virus were: sex, month of diagnosis, fever, vomiting, cough, use of antibiotics and admission to the PICU. The hospitalization rate at our hospital increased between the months of October to December, with a higher percentage of cases in November and December, which reveals that the "real peak" in our population begins between 3 to 4 months after the end of the vaccination campaign. Patients with influenza A virus had a 2.5 times greater risk of being admitted to the PICU. Mortality rate was 0.6% and 0% among influenza A and B children, respectively.
    Conclusions: Variables in which a causality was found with type A or B virus were: admission to the PICU, month of diagnosis, and cough. However, influenza B clinical behavior continues to be unpredictable.
    MeSH term(s) Child ; Child, Preschool ; Costa Rica/epidemiology ; Female ; Hospitalization/statistics & numerical data ; Hospitals, Pediatric/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Influenza A virus/isolation & purification ; Influenza B virus/isolation & purification ; Influenza Vaccines/therapeutic use ; Influenza, Human/epidemiology ; Influenza, Human/mortality ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Intensive Care Units, Pediatric/statistics & numerical data ; Male ; Retrospective Studies
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2021-03-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.03.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Multisystem Inflammatory Syndrome Temporally Related to COVID-19 in Children From Latin America and the Caribbean Region: A Systematic Review With a Meta-Analysis of Data From Regional Surveillance Systems.

    Ruvinsky, Silvina / Voto, Carla / Roel, Macarena / Fustiñana, Ana / Veliz, Natalia / Brizuela, Martin / Rodriguez, Susana / Ulloa-Gutierrez, Rolando / Bardach, Ariel

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 881765

    Abstract: Background: With the emergence of the COVID-19 pandemic, increasing numbers of cases of the multisystem inflammatory syndrome in children (MIS-C) have been reported worldwide; however, it is unclear whether this syndrome has a differential pattern in ... ...

    Abstract Background: With the emergence of the COVID-19 pandemic, increasing numbers of cases of the multisystem inflammatory syndrome in children (MIS-C) have been reported worldwide; however, it is unclear whether this syndrome has a differential pattern in children from Latin America and the Caribbean (LAC). We conducted a systematic review and meta-analysis to analyze the epidemiological, clinical, and outcome characteristics of patients with MIS-C in LAC countries.
    Methods: A systematic literature search was conducted in the main electronic databases and scientific meetings from March 1, 2020, to June 30, 2021. Available reports on epidemiological surveillance of countries in the region during the same period were analyzed.
    Results: Of the 464 relevant studies identified, 23 were included with 592 patients with MIS-C from LAC. Mean age was 6.6 years (IQR, 6-7.4 years); 60% were male. The most common clinical manifestations were fever, rash, and conjunctival injection; 59% showed Kawasaki disease. Pool proportion of shock was 52%. A total of 47% of patients were admitted to the pediatric intensive care unit (PICU), 23% required mechanical ventilation, and 74% required vasoactive drugs. Intravenous gamma globulin alone was administered in 87% of patients, and in combination with steroids in 60% of cases. Length of hospital stay was 10 days (IQR, 9-10) and PICU stay 5.75 (IQR, 5-6). Overall case fatality ratio was 4% and for those hospitalized in the PICU it was 7%.
    Conclusion: Limited information was available on the clinical outcomes. Improvements in the surveillance system are required to obtain a better epidemiologic overview in the region.
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.881765
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  9. Article ; Online: Clinical Outcomes of Pediatric COVID-19 During Two Waves of Different Variants Circulation in Latin America.

    Yock-Corrales, Adriana / Gomez-Vargas, Jessica / Ulloa-Gutierrez, Rolando / Brizuela, Martin / Del Aguila, Olguita / Kozicki, Verónica / Lenzi, Jacopo / Buonsenso, Danilo

    Indian journal of pediatrics

    2022  Volume 89, Issue 7, Page(s) 727

    MeSH term(s) COVID-19 ; Child ; Humans ; Latin America/epidemiology
    Language English
    Publishing date 2022-03-04
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-022-04113-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 826: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Children with a History of Multisystem Inflammatory Syndrome in Children: An International Survey.

    Hoste, Levi / Soriano-Arandes, Antoni / Buddingh, Emilie Pauline / Whittaker, Elizabeth / Belot, Alexandre / Ulloa-Gutierrez, Rolando / Olbrich, Peter / Haerynck, Filomeen

    The Journal of pediatrics

    2022  Volume 248, Page(s) 114–118

    Abstract: The optimal severe acute respiratory syndrome coronavirus 2 vaccine strategy for patients with a history of multisystem inflammatory syndrome in children (MIS-C) is unclear. We performed an international survey (32 countries) and found substantial ... ...

    Abstract The optimal severe acute respiratory syndrome coronavirus 2 vaccine strategy for patients with a history of multisystem inflammatory syndrome in children (MIS-C) is unclear. We performed an international survey (32 countries) and found substantial variations in vaccine policies. Respondents did not report relapses of MIS-C or other severe inflammatory side effects after severe acute respiratory syndrome coronavirus 2 vaccination in 273 patients with a history of MIS-C.
    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; COVID-19/prevention & control ; Child ; Humans ; SARS-CoV-2 ; Surveys and Questionnaires ; Systemic Inflammatory Response Syndrome ; Vaccination/adverse effects
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.05.028
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