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  1. Article: Spontaneous abortion as differential diagnosis of intermittent glomerular proteinuria in inactive systemic lupus erythematosus.

    Ullrich, Fabian T H / Skapenko, Alla / Schulze-Koops, Hendrik

    Clinical case reports

    2023  Volume 11, Issue 7, Page(s) e7686

    Abstract: In women of childbearing age, severe proteinuria in systemic lupus erythematosus raises concern for renal involvement and pregnancy complications. While persisting renal loss of protein is known to culminate in extensive interventions, intermittent ... ...

    Abstract In women of childbearing age, severe proteinuria in systemic lupus erythematosus raises concern for renal involvement and pregnancy complications. While persisting renal loss of protein is known to culminate in extensive interventions, intermittent proteinuria in inactive disease requires an adjusted approach. Contextual awareness of this urinary finding is thus essential.
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Conference proceedings: Spontaneous abortion as differential diagnosis of intermittent glomerular proteinuria in clinically and serologically inactive SLE

    Ullrich, Fabian / Schulze-Koops, Hendrik / Skapenko, Alla

    2023  , Page(s) FA.53

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh119
    Database German Medical Science

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  3. Article ; Online: E-64c-Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1'-S2' Area.

    Tromsdorf, Nora / Ullrich, Fabian T H / Rethmeier, Markus / Sommerhoff, Christian P / Schaschke, Norbert

    ChemMedChem

    2023  Volume 18, Issue 18, Page(s) e202300218

    Abstract: The zymogens of the neutrophil serine proteases elastase, proteinase 3, and cathepsin G are converted proteolytically into their pro-inflammatory active forms by the action of cathepsin C. The inhibition of this cysteine protease therefore is an ... ...

    Abstract The zymogens of the neutrophil serine proteases elastase, proteinase 3, and cathepsin G are converted proteolytically into their pro-inflammatory active forms by the action of cathepsin C. The inhibition of this cysteine protease therefore is an interesting therapeutic approach for the treatment of inflammatory disorders with a high neutrophil burden such as COPD. Based on E-64c-hydrazide as lead structure, we have recently developed a covalently acting cathepsin C inhibitor using a n-butyl residue attached at the amine nitrogen of the hydrazide moiety to efficiently address the deep hydrophobic S2 pocket. To further optimize the affinity and selectivity profile of this inhibitor, the S1'-S2' area was now investigated by a combinatorial approach, showing that Nle-tryptamide is a ligand superior to the initially used Leu-isoamylamide. Using the neutrophil precursor line U937 as a cell culture model, this optimized inhibitor blocks the intracellular cathepsin C activity and thereby suppresses the activation of neutrophil elastase.
    MeSH term(s) Cathepsin C/metabolism ; Hydrazines/pharmacology ; Leukocyte Elastase/metabolism ; Serine Proteases ; Leucine
    Chemical Substances Cathepsin C (EC 3.4.14.1) ; N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine (76684-89-4) ; Hydrazines ; Leukocyte Elastase (EC 3.4.21.37) ; Serine Proteases (EC 3.4.-) ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2023-07-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202300218
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6280: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Meralgia paraesthetica bei einer 14-jährigen Jugendlichen

    Ullrich, Fabian / Conz, Franziska / Arbogast, Martin / Hügle, Boris

    Arthritis und Rheuma

    2022  Volume 42, Issue 02, Page(s) 120–122

    Language German
    Publishing date 2022-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223481-0
    ISSN 2567-5753 ; 0176-5167
    ISSN (online) 2567-5753
    ISSN 0176-5167
    DOI 10.1055/a-1666-8116
    Database Thieme publisher's database

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  5. Article: Meralgia paraesthetica bei einer 14-jährigen Jugendlichen

    Ullrich, Fabian / Conz, Franziska / Arbogast, Martin / Hügle, Boris

    Arthritis + Rheuma

    2022  Volume 42, Issue 2, Page(s) 120

    Language German
    Document type Article
    ZDB-ID 605764-0
    ISSN 0176-5167
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Conference proceedings: Psoriasis und entzündlicher Rückenschmerz – selten ist es doch das Zebra

    Ullrich, Fabian / Hesse, Nina / Schulze-Koops, Hendrik / Lichtnekert, Julia / Poddubnyy, Denis / Skapenko, Alla

    2023  , Page(s) FA.55

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh120
    Database German Medical Science

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  7. Article ; Online: Cellular therapies in older adults with hematological malignancies: A case-based, state-of-the-art review.

    Neuendorff, Nina Rosa / Khan, Abdullah / Ullrich, Fabian / Yates, Samuel / Devarakonda, Srinivas / Lin, Richard J / von Tresckow, Bastian / Cordoba, Raul / Artz, Andrew / Rosko, Ashley E

    Journal of geriatric oncology

    2024  Volume 15, Issue 3, Page(s) 101734

    Abstract: Cellular therapies, including autologous stem cell transplant (ASCT), allogeneic hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor- (CAR-) T cell therapies are essential treatment modalities for many hematological malignancies. ... ...

    Abstract Cellular therapies, including autologous stem cell transplant (ASCT), allogeneic hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor- (CAR-) T cell therapies are essential treatment modalities for many hematological malignancies. Although their use in older adults has substantially increased within the past decades, cellular therapies represent intensive treatment approaches that exclude a large percentage of older adults due to comorbidities and frailty. Under- and overtreatment in older adults with hematologic malignancy is a challenge and many treatment decisions are influenced by chronologic age. The advent of efficient and well-tolerated newer treatment approaches for multiple myeloma has challenged the role of ASCT. In the modern era, there are no randomized clinical trials of transplant versus non-transplant strategies for patients ≥65 years. Nonetheless, ASCT is feasible for selected older patients and does not result in long-term compromise in quality of life. AlloHCT is the only curative approach for acute myeloid leukemia of intermediate and unfavourable risk but carries a significant risk for non-relapse mortality depending on comorbidities, general fitness, and transplant-specific characteristics, such as intensity of conditioning and donor choice. However, alloHCT is feasible in appropriately-selected older adults. Early referral for evaluation is strongly encouraged as this is the most obvious barrier. CAR-T cell therapies have shown unprecedented clinical efficacy and durability in relapsed and refractory diffuse large B cell lymphoma. Its use is well tolerated in older adults, although evidence comes from limited case numbers. Whether patients who are deemed unfit for ASCT qualify for CAR-T cell therapy remains elusive, but the tolerability and efficacy of CAR-T cell therapy appears promising, especially for older patients. The evidence from randomized trials is strong in favor of using a comprehensive geriatric assessment (CGA) to reduce treatment-related toxicities and guide treatment intensity in the care for solid tumors; its use for evaluation of cellular therapies is less evidence-based. However, CGA can provide useful information on patients' fitness, resilient mechanisms, and reveal potential optimization strategies for compensating for vulnerabilities. In this narrative review, we will discuss key questions on cellular therapies in older adults based on illustrative patient cases.
    MeSH term(s) Humans ; Aged ; Receptors, Chimeric Antigen/therapeutic use ; Quality of Life ; Hematologic Neoplasms/therapy ; Multiple Myeloma/drug therapy ; Hematopoietic Stem Cell Transplantation/adverse effects
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-03-01
    Publishing country Netherlands
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2024.101734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Conference proceedings: Unterschiede und Veränderungen im Auftreten von Nebenwirkungen nach repetitiver SARS-CoV-2 Impfung bei entzündlich rheumatisch Erkrankten und Gesunden

    Huppke, Liam / Gebhardt, Christina / Grümme, Lea / Lichtnekert, Julia / Singh, Delila / Ullrich, Fabian / Wolfrum, Stefan / Skapenko, Alla / Schulze-Koops, Hendrik

    2023  , Page(s) CO.01

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh001
    Database German Medical Science

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  9. Book ; Online: Lost and Found

    Weller, Mira / Classen, Jiska / Ullrich, Fabian / Waßmann, Denis / Tews, Erik

    Stopping Bluetooth Finders from Leaking Private Information

    2020  

    Abstract: A Bluetooth finder is a small battery-powered device that can be attached to important items such as bags, keychains, or bikes. The finder maintains a Bluetooth connection with the user's phone, and the user is notified immediately on connection loss. We ...

    Abstract A Bluetooth finder is a small battery-powered device that can be attached to important items such as bags, keychains, or bikes. The finder maintains a Bluetooth connection with the user's phone, and the user is notified immediately on connection loss. We provide the first comprehensive security and privacy analysis of current commercial Bluetooth finders. Our analysis reveals several significant security vulnerabilities in those products concerning mobile applications and the corresponding backend services in the cloud. We also show that all analyzed cloud-based products leak more private data than required for their respective cloud services. Overall, there is a big market for Bluetooth finders, but none of the existing products is privacy-friendly. We close this gap by designing and implementing PrivateFind, which ensures locations of the user are never leaked to third parties. It is designed to run on similar hardware as existing finders, allowing vendors to update their systems using PrivateFind.

    Comment: WiSec '20
    Keywords Computer Science - Cryptography and Security ; Computer Science - Networking and Internet Architecture
    Subject code 005
    Publishing date 2020-05-17
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Lost and Found: Stopping Bluetooth Finders from Leaking Private Information

    Weller, Mira / Classen, Jiska / Ullrich, Fabian / Wassmann, Denis / Tews, Erik

    Abstract: A Bluetooth finder is a small battery-powered device that can be attached to important items such as bags, keychains, or bikes. The finder maintains a Bluetooth connection with the user's phone, and the user is notified immediately on connection loss. We ...

    Abstract A Bluetooth finder is a small battery-powered device that can be attached to important items such as bags, keychains, or bikes. The finder maintains a Bluetooth connection with the user's phone, and the user is notified immediately on connection loss. We provide the first comprehensive security and privacy analysis of current commercial Bluetooth finders. Our analysis reveals several significant security vulnerabilities in those products concerning mobile applications and the corresponding backend services in the cloud. We also show that all analyzed cloud-based products leak more private data than required for their respective cloud services. Overall, there is a big market for Bluetooth finders, but none of the existing products is privacy-friendly. We close this gap by designing and implementing PrivateFind, which ensures locations of the user are never leaked to third parties. It is designed to run on similar hardware as existing finders, allowing vendors to update their systems using PrivateFind.
    Keywords covid19
    Publisher ArXiv
    Document type Article ; Online
    DOI 10.1145/3395351.3399422
    Database COVID19

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