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  1. Article ; Online: Delivery-mediated exosomal therapeutics in ischemia-reperfusion injury: advances, mechanisms, and future directions.

    Ding, Shengzhe / Kim, Yu-Jin / Huang, Kai-Yu / Um, Daniel / Jung, Youngmee / Kong, Hyunjoon

    Nano convergence

    2024  Volume 11, Issue 1, Page(s) 18

    Abstract: Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems, including the heart, brain, and kidneys. Exosomes have shown great potentials and applications in mitigating IRI-induced cell and tissue damage through ... ...

    Abstract Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems, including the heart, brain, and kidneys. Exosomes have shown great potentials and applications in mitigating IRI-induced cell and tissue damage through modulating inflammatory responses, enhancing angiogenesis, and promoting tissue repair. Despite these advances, a more systematic understanding of exosomes from different sources and their biotransport is critical for optimizing therapeutic efficacy and accelerating the clinical adoption of exosomes for IRI therapies. Therefore, this review article overviews the administration routes of exosomes from different sources, such as mesenchymal stem cells and other somatic cells, in the context of IRI treatment. Furthermore, this article covers how the delivered exosomes modulate molecular pathways of recipient cells, aiding in the prevention of cell death and the promotions of regeneration in IRI models. In the end, this article discusses the ongoing research efforts and propose future research directions of exosome-based therapies.
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2760386-6
    ISSN 2196-5404 ; 2196-5404
    ISSN (online) 2196-5404
    ISSN 2196-5404
    DOI 10.1186/s40580-024-00423-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Myasthenia gravis and numb chin syndrome with lung carcinoma.

    Gupta, Rajesh Kumar / Gupta, Ashutosh / Um, Daniel S / Neda, Zarrin Khameh

    Journal of neurosciences in rural practice

    2023  Volume 15, Issue 1, Page(s) 159–161

    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.25259/JNRP_387_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Idiopathic Hypertrophic Spinal Pachymeningitis.

    Gupta, Ashutosh / Um, Daniel / Samant, Rohan / Hasbun, Rodrigo / Samudralwar, Rohini D / Sriwastava, Shitiz / Gupta, Rajesh K

    Journal of medical cases

    2023  Volume 14, Issue 12, Page(s) 405–412

    Abstract: Hypertrophic pachymeningitis (HP) is a rare presentation with duramater thickening and fibrosis which can result in cranial or spinal compressive disease. Most cases of spinal HP require surgical management. We present an uncommon case of idiopathic ... ...

    Abstract Hypertrophic pachymeningitis (HP) is a rare presentation with duramater thickening and fibrosis which can result in cranial or spinal compressive disease. Most cases of spinal HP require surgical management. We present an uncommon case of idiopathic hypertrophic spinal pachymeningitis (IHSP) in a 40-year-old male who showed complete improvement to steroids without any further relapses. The patient presented with bilateral upper limb weakness with magnetic resonance imaging (MRI) spine showing diffuse dural thickening of the entire spine with cervical cord compression. He had an extensive workup for underlying etiology and worsening symptoms until he was diagnosed with IHSP. Later, he was started on high-dose steroids with good response and no relapse after 2 years. A descriptive analysis of IHSP cases since 2009 including ours showed that it usually occurs after 50s with female preponderance. Weakness and sensory loss are the most common complaints with 50% patients showing clinical signs of myelopathy like hyperreflexia, clonus, Babinski sign and sensory level. Cerebrospinal fluid (CSF) and inflammatory markers like erythrocytic sedimentation rate (ESR) and C-reactive protein (CRP) can be used to assess disease progression and prognosis. Surgical removal of HP followed by steroids is the best line of management while steroids alone can be tried in cases where clinical signs of myelopathy are absent.
    Language English
    Publishing date 2023-12-29
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2586383-6
    ISSN 1923-4163 ; 1923-4163
    ISSN (online) 1923-4163
    ISSN 1923-4163
    DOI 10.14740/jmc4149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Solvent-Free Polycaprolactone Dissolving Microneedles Generated via the Thermal Melting Method for the Sustained Release of Capsaicin.

    Eum, Jaehong / Kim, Youseong / Um, Daniel Junmin / Shin, Jiwoo / Yang, Huisuk / Jung, Hyungil

    Micromachines

    2021  Volume 12, Issue 2

    Abstract: 1) Background: Dissolving microneedles (DMNs), a transdermal drug delivery system, have been developed to treat various diseases in a minimally invasive, painless manner. However, the currently available DMNs are based on burst release systems due to ... ...

    Abstract (1) Background: Dissolving microneedles (DMNs), a transdermal drug delivery system, have been developed to treat various diseases in a minimally invasive, painless manner. However, the currently available DMNs are based on burst release systems due to their hydrophilic backbone polymer. Although hydrophobic biodegradable polymers have been employed on DMNs for sustained release, dissolution in an organic solvent is required for fabrication of such DMNs. (2) Method: To overcome the aforementioned limitation, novel separable polycaprolactone (PCL) DMNs (SPCL-DMNs) were developed to implant a PCL-encapsulated drug into the skin. PCL is highly hydrophobic, degrades over a long time, and has a low melting point. Under thermal melting, PCL encapsulated capsaicin and could be fabricated into a DMN without the risk of toxicity from an organic solvent. (3) Results: Optimized SPCL-DMNs, containing PCL (height 498.3 ± 5.8 µm) encapsulating 86.66 ± 1.13 µg capsaicin with a 10% (
    Language English
    Publishing date 2021-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi12020167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Scalp Micro-Pigmentation via Transcutaneous Implantation of Flexible Tissue Interlocking Biodegradable Microneedles.

    Lahiji, Shayan Fakhraei / Um, Daniel Junmin / Kim, Youseong / Jang, Jeesu / Yang, Huisuk / Jung, Hyungil

    Pharmaceutics

    2019  Volume 11, Issue 11

    Abstract: Alopecia, characterized by hair follicle blockage and hair loss, disrupts the normal cycle of hair growth. Although not a life-threatening condition, a growing body of evidence suggests that the psychological state of individuals experiencing alopecia ... ...

    Abstract Alopecia, characterized by hair follicle blockage and hair loss, disrupts the normal cycle of hair growth. Although not a life-threatening condition, a growing body of evidence suggests that the psychological state of individuals experiencing alopecia can be highly influenced. Despite considerable research on hair loss treatment, interest in micro-pigmentation has increased in recent decades. Micropigmentation is an effective method to camouflage the visual contrast between the scalp and hair strands. However, the localization, intensity and dimension of microdots depend highly upon the physician performing the implantation. Incorrectly localized microdots within the skin may lead to patchy or faded micropigmentation. To overcome the limitations of conventional micro-pigmentation, we aimed to develop micro-pigment-encapsulated biodegradable microneedles (PBMs), capable of accurately implanting pigments below the epithelial-dermal junction of the scalp in a minimally invasive manner. A tissue interlocking microneedle technique was utilized to fabricate double-layered PBMs over a biodegradable flexible sheet, which could be washed off post-implantation. We confirmed that the intensity, dimension and insertion depth of 1,000 μm-long PBMs was maintained on pig cadaver skin over time. This study suggested that the developed PBMs would serve as an attractive platform for scalp micro-pigmentation in the future.
    Language English
    Publishing date 2019-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics11110549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid).

    Lee, Chisong / Kim, Jinkyung / Um, Daniel Junmin / Kim, Youseong / Min, Hye Su / Shin, Jiwoo / Nam, Jee Hye / Kang, Geonwoo / Jang, Mingyu / Yang, Huisuk / Jung, Hyungil

    Pharmaceutics

    2021  Volume 13, Issue 7

    Abstract: Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly( ... ...

    Abstract Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without the use of potentially harmful organic solvents. The drug-loaded PLGA mixture, which consisted of a middle layer of the DMN, was optimized and successfully implanted into ex vivo porcine skin. Implanted HMP-DMNs separated from the patch within 10 min, enhancing user compliance, and the encapsulated molecules were released for nearly 4 weeks thereafter. In conclusion, the geometry of HMP-DMNs was successfully optimized for safe and effective transdermal sustained drug delivery without the use of organic solvents. This study provides a strategy for the innovative utilization of PLGA as a material for transdermal drug delivery systems.
    Language English
    Publishing date 2021-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13071058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Development of Lidocaine-Loaded Dissolving Microneedle for Rapid and Efficient Local Anesthesia.

    Yang, Huisuk / Kang, Geonwoo / Jang, Mingyu / Um, Daniel Junmin / Shin, Jiwoo / Kim, Hyeonjun / Hong, Jintae / Jung, Hyunji / Ahn, Hyemyoung / Gong, Seongdae / Lee, Chisong / Jung, Ui-Won / Jung, Hyungil

    Pharmaceutics

    2020  Volume 12, Issue 11

    Abstract: Lidocaine is a local anesthetic agent used in the form of injection and topical cream. However, these formulation types have limitations of being either painful or slow-acting, thereby hindering effective and complete clinical performance of lidocaine. ... ...

    Abstract Lidocaine is a local anesthetic agent used in the form of injection and topical cream. However, these formulation types have limitations of being either painful or slow-acting, thereby hindering effective and complete clinical performance of lidocaine. Dissolving microneedles (DMNs) are used to overcome these limitations owing to their fast onset time and minimally invasive administration methods. Using hyaluronic acid and lidocaine to produce the drug solution, a lidocaine HCl encapsulated DMN (Li-DMN) was fabricated by centrifugal lithography. The drug delivery rate and local anesthetic quality of Li-DMNs were evaluated using the pig cadaver insertion test and Von Frey behavior test. Results showed that Li-DMNs could deliver sufficient lidocaine for anesthesia that is required to be utilized for clinical level. Results from the von Frey test showed that the anesthetic effect of Li-DMNs was observed within 10 min after administration, thus confirming fast onset time. A toxicity test for appropriate clinical application standard was conducted with a microbial limit test and an animal skin irritation test, showing absence of skin irritation and irritation-related microorganisms. Overall, Li-DMN is a possible alternative drug delivery method for local anesthesia, meeting the requirements for clinical conditions and overcoming the drawbacks of other conventional lidocaine administration methods.
    Language English
    Publishing date 2020-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics12111067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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