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Article ; Online: SSAVE

Talukder, Amlan / Li, Yuanyuan / Yeung, Deryck / Umbach, David M / Fan, Zheng / Li, Leping

Frontiers in sleep

2023 Volume 2

Abstract: Human sleep architecture is structured with repeated episodes of rapid-eye-movement (REM) and non-rapid-eye-movement (NREM) sleep. An overnight sleep study facilitates identification of macro and micro changes in the pattern and duration of sleep stages ... ...

Abstract	Human sleep architecture is structured with repeated episodes of rapid-eye-movement (REM) and non-rapid-eye-movement (NREM) sleep. An overnight sleep study facilitates identification of macro and micro changes in the pattern and duration of sleep stages associated with sleep disorders and other aspects of human mental and physical health. Overnight sleep studies record, in addition to electroencephalography (EEG) and other electro-physiological signals, a sequence of sleep-stage annotations.
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article
ISSN	2813-2890
ISSN (online)	2813-2890
DOI	10.3389/frsle.2023.1102391
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Article ; Online: Comparison of power spectra from overnight electroencephalography between patients with Down syndrome and matched control subjects.

Talukder, Amlan / Yeung, Deryck / Li, Yuanyuan / Anandanadarajah, Nishanth / Umbach, David M / Fan, Zheng / Li, Leping

Journal of sleep research

2024 , Page(s) e14187

Abstract: Electroencephalograms can capture brain oscillatory activities during sleep as a form of electrophysiological signals. We analysed electroencephalogram recordings from full-night in-laboratory polysomnography from 100 patients with Down syndrome, and 100 ...

Abstract	Electroencephalograms can capture brain oscillatory activities during sleep as a form of electrophysiological signals. We analysed electroencephalogram recordings from full-night in-laboratory polysomnography from 100 patients with Down syndrome, and 100 age- and sex-matched controls. The ages of patients with Down syndrome spanned 1 month to 31 years (median 4.4 years); 84 were younger than 12 years, and 54 were male. From each electroencephalogram, we extracted relative power in six frequency bands or rhythms (delta, theta, alpha, slow sigma, fast sigma, and beta) from six channels (frontal F3 and F4, central C3 and C4, and occipital O1 and O2) during five sleep stages (N3, N2, N1, R and W)-180 features in all. We examined differences in relative power between Down syndrome and control electroencephalograms for each feature separately. During wake and N1 sleep stages, alpha rhythms (8.0-10.5 Hz) had significantly lower power in patients with Down syndrome than controls. Moreover, the rate of increase in alpha power with age during rapid eye movement sleep was significantly slower in Down syndrome than control subjects. During wake and N1 sleep, delta rhythms (0.25-4.5 Hz) had higher power in patients with Down syndrome than controls. During N2 sleep, slow sigma rhythms (10.5-12.5 Hz) had lower power in patients with DS than controls. These findings extend previous research from routine electroencephalogram studies demonstrating that patients with Down syndrome had reduced circadian amplitude-the difference between wake alpha power and deep sleep delta power was smaller in Down syndrome than control subjects. We envision that these brain oscillatory activities may be used as surrogate markers for clinical trials for patients with Down syndrome.
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1122722-9
ISSN	1365-2869 ; 0962-1105
ISSN (online)	1365-2869
ISSN	0962-1105
DOI	10.1111/jsr.14187
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Article: Differences in sleep spindle wave density between patients with diabetes mellitus and matched controls: implications for sensing and regulation of peripheral blood glucose.

Yeung, Deryck / Talukder, Amlan / Shi, Min / Umbach, David M / Li, Yuanyuan / Motsinger-Reif, Alison / Fan, Zheng / Li, Leping

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Brain waves during sleep are involved in sensing and regulating peripheral glucose level. Whether brain waves in patients with diabetes differ from those of healthy subjects is unknown. We examined the hypothesis that patients with diabetes ... ...

Abstract	Background: Brain waves during sleep are involved in sensing and regulating peripheral glucose level. Whether brain waves in patients with diabetes differ from those of healthy subjects is unknown. We examined the hypothesis that patients with diabetes have reduced sleep spindle waves, a form of brain wave implicated in periphery glucose regulation during sleep. Methods: From a retrospective analysis of polysomnography (PSG) studies on patients who underwent sleep apnea evaluation, we identified 1,214 studies of patients with diabetes mellitus (>66% type 2) and included a sex- and age-matched control subject for each within the scope of our analysis. We similarly identified 376 patients with prediabetes and their matched controls. We extracted spindle characteristics from artifact-removed PSG electroencephalograms and other patient data from records. We used rank-based statistical methods to test hypotheses. We validated our finding on an external PSG dataset. Results: Patients with diabetes mellitus exhibited on average about half the spindle density (median=0.38 spindles/min) during sleep as their matched control subjects (median=0.70 spindles/min) ( Conclusions: Patients with diabetes have fewer spindle waves that are implicated in glucose regulation than matched controls during sleep. Besides offering a possible explanation for neurological complications from diabetes, our findings open the possibility that reversing/reducing spindle loss could improve the overall health of patients with diabetes mellitus. Funding: This research was supported by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (ZIA ES101765).
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.11.24305676
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Article ; Online: Sleep apnoea and hypoventilation in patients with five major types of muscular dystrophy.

Li, Leping / Umbach, David M / Li, Yuanyuan / Halani, Pallav / Shi, Min / Ahn, Mihye / Yeung, Deryck S C / Vaughn, Bradley / Fan, Zheng Jane

BMJ open respiratory research

2023 Volume 10, Issue 1

Abstract: Background: The characteristics of and relationship between sleep apnoea and hypoventilation in patients with muscular dystrophy (MD) remain to be fully understood.: Methods: We analysed 104 in-laboratory sleep studies of 73 patients with MD with ... ...

Abstract	Background: The characteristics of and relationship between sleep apnoea and hypoventilation in patients with muscular dystrophy (MD) remain to be fully understood. Methods: We analysed 104 in-laboratory sleep studies of 73 patients with MD with five common types (DMD-Duchenne, Becker MD, CMD-congenital, LGMD-limb-girdle and DM-myotonic dystrophy). We used generalised estimating equations to examine differences among these types for outcomes. Results: Patients in all five types had high risk of sleep apnoea with 53 of the 73 patients (73%) meeting the diagnostic criteria in at least one study. Patients with DM had higher risk of sleep apnoea compared with patients with LGMD (OR=5.15, 95% CI 1.47 to 18.0; p=0.003). Forty-three per cent of patients had hypoventilation with observed prevalence higher in CMD (67%), DMD (48%) and DM (44%). Hypoventilation and sleep apnoea were associated in those patients (unadjusted OR=2.75, 95% CI 1.15 to 6.60; p=0.03), but the association weakened after adjustment (OR=2.32, 95% CI 0.92 to 5.81; p=0.08). In-sleep average heart rate was about 10 beats/min higher in patients with CMD and DMD compared with patients with DM (p=0.0006 and p=0.02, respectively, adjusted for multiple testing). Conclusion: Sleep-disordered breathing is common in patients with MD but each type has its unique features. Hypoventilation was only weakly associated with sleep apnoea; thus, high clinical suspicion is needed for diagnosing hypoventilation. Identifying the window when respiratory muscle weakness begins to cause hypoventilation is important for patients with MD; it enables early intervention with non-invasive ventilation-a therapy that should both lengthen the expected life of these patients and improve its quality.Cite Now.
MeSH term(s)	Humans ; Hypoventilation/diagnosis ; Hypoventilation/epidemiology ; Hypoventilation/etiology ; Sleep Apnea Syndromes/diagnosis ; Sleep Apnea Syndromes/epidemiology ; Sleep Apnea Syndromes/complications ; Muscular Dystrophy, Duchenne/complications ; Sleep ; Respiration, Artificial
Language	English
Publishing date	2023-04-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2022-001506
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Article ; Online: Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines.

Li, Yuanyuan / Umbach, David M / Krahn, Juno M / Shats, Igor / Li, Xiaoling / Li, Leping

BMC genomics

2021 Volume 22, Issue 1, Page(s) 272

Abstract: Background: Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies is to translate the findings from in vitro ...

Abstract	Background: Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies is to translate the findings from in vitro studies of cancer cell lines into in vivo therapeutic relevance and, eventually, patients' care. Tremendous progress has been made. Results: In this work, we built predictive models for 453 drugs using data on gene expression and drug sensitivity (IC Conclusions: We demonstrated that our approach can predict drugs that 1) are tumor-type specific; 2) elicit higher sensitivity from tumor compared to corresponding normal tissue; 3) elicit differential sensitivity across breast cancer subtypes. If validated, our prediction could have relevance for preclinical drug testing and in phase I clinical design.
MeSH term(s)	Biomarkers ; Biomarkers, Tumor/genetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Gene Expression ; Gene Expression Profiling ; Humans ; Pharmaceutical Preparations
Chemical Substances	Biomarkers ; Biomarkers, Tumor ; Pharmaceutical Preparations
Language	English
Publishing date	2021-04-15
Publishing country	England
Document type	Journal Article
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/s12864-021-07581-7
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Article ; Online: CDSeqR: fast complete deconvolution for gene expression data from bulk tissues.

Kang, Kai / Huang, Caizhi / Li, Yuanyuan / Umbach, David M / Li, Leping

BMC bioinformatics

2021 Volume 22, Issue 1, Page(s) 262

Abstract: Background: Biological tissues consist of heterogenous populations of cells. Because gene expression patterns from bulk tissue samples reflect the contributions from all cells in the tissue, understanding the contribution of individual cell types to the ...

Abstract	Background: Biological tissues consist of heterogenous populations of cells. Because gene expression patterns from bulk tissue samples reflect the contributions from all cells in the tissue, understanding the contribution of individual cell types to the overall gene expression in the tissue is fundamentally important. We recently developed a computational method, CDSeq, that can simultaneously estimate both sample-specific cell-type proportions and cell-type-specific gene expression profiles using only bulk RNA-Seq counts from multiple samples. Here we present an R implementation of CDSeq (CDSeqR) with significant performance improvement over the original implementation in MATLAB and an added new function to aid cell type annotation. The R package would be of interest for the broader R community. Result: We developed a novel strategy to substantially improve computational efficiency in both speed and memory usage. In addition, we designed and implemented a new function for annotating the CDSeq estimated cell types using single-cell RNA sequencing (scRNA-seq) data. This function allows users to readily interpret and visualize the CDSeq estimated cell types. In addition, this new function further allows the users to annotate CDSeq-estimated cell types using marker genes. We carried out additional validations of the CDSeqR software using synthetic, real cell mixtures, and real bulk RNA-seq data from the Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) project. Conclusions: The existing bulk RNA-seq repositories, such as TCGA and GTEx, provide enormous resources for better understanding changes in transcriptomics and human diseases. They are also potentially useful for studying cell-cell interactions in the tissue microenvironment. Bulk level analyses neglect tissue heterogeneity, however, and hinder investigation of a cell-type-specific expression. The CDSeqR package may aid in silico dissection of bulk expression data, enabling researchers to recover cell-type-specific information.
MeSH term(s)	Computational Biology ; Gene Expression ; Gene Expression Profiling ; Humans ; Sequence Analysis, RNA ; Single-Cell Analysis ; Software
Language	English
Publishing date	2021-05-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-021-04186-5
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Article ; Online: Depot Medroxyprogesterone Acetate Use and the Development and Progression of Uterine Leiomyoma.

Harmon, Quaker E / Patchel, Stacy A / Zhao, Shanshan / Umbach, David M / Cooper, Tracy E / Baird, Donna D

Obstetrics and gynecology

2022 Volume 139, Issue 5, Page(s) 797–807

Abstract: Objective: Investigate the association between use of depot medroxyprogesterone acetate (DMPA) (an injectable progestin-only contraceptive) and leiomyoma development.: Methods: We conducted a cohort study in the Detroit, Michigan, area that involved ... ...

Abstract	Objective: Investigate the association between use of depot medroxyprogesterone acetate (DMPA) (an injectable progestin-only contraceptive) and leiomyoma development. Methods: We conducted a cohort study in the Detroit, Michigan, area that involved four clinic visits at 20-month intervals over 5 years (2010-2018) and used a standardized ultrasonography protocol to prospectively measure leiomyomas 0.5 cm or more in diameter. Participants were 1,693 self-identified Black women aged 23-35 years with no prior leiomyoma diagnosis and no hysterectomy. For this substudy, years since last use of DMPA was ascertained from questionnaire data at every visit. Leiomyoma incidence was defined as the first visit with an observed leiomyoma among women who were leiomyoma-free at enrollment. Depot medroxyprogesterone acetate associations were examined with Cox models. Leiomyoma growth was calculated as the change in log-volume for leiomyomas matched at successive visits and was modeled using linear mixed models accounting for clustered data. Leiomyoma loss, defined as a reduction in leiomyoma number in successive visits, was modeled using Poisson regression. All models used time-varying exposure and covariates. Results: Of participants with at least one follow-up visit (N=1,610), 42.9% had ever used DMPA. Participants exposed to DMPA within the previous 2 years experienced reduced leiomyoma development during the subsequent observation interval compared with never users, including lower leiomyoma incidence (5.2% vs 10.7%), adjusted hazard ratio 0.6 (95% CI 0.4-1.0), 42.0% lower leiomyoma growth (95% CI -51.4 to -30.7) and 60% greater leiomyoma loss (adjusted risk ratio 1.6, 95% CI 1.1-2.2). Excess leiomyoma loss was also seen for those who used DMPA 2-4 years before the visit compared with never users, 2.1-fold increase (95% CI 1.4-3.1). Conclusion: Recent use of DMPA was associated with reduced leiomyoma development and increased leiomyoma loss. Such changes in early leiomyoma development in young women could delay symptom onset and reduce the need for invasive treatment.
MeSH term(s)	Cohort Studies ; Contraceptive Agents, Female/adverse effects ; Delayed-Action Preparations ; Female ; Humans ; Incidence ; Leiomyoma/chemically induced ; Leiomyoma/drug therapy ; Leiomyoma/epidemiology ; Medroxyprogesterone ; Medroxyprogesterone Acetate/adverse effects
Chemical Substances	Contraceptive Agents, Female ; Delayed-Action Preparations ; Medroxyprogesterone Acetate (C2QI4IOI2G) ; Medroxyprogesterone (HSU1C9YRES)
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, American Recovery and Reinvestment Act ; Research Support, N.I.H., Intramural
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000004745
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Article ; Online: Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study.

Shrestha, Srishti / Parks, Christine G / Umbach, David M / Hofmann, Jonathan N / Beane Freeman, Laura E / Blair, Aaron / Sandler, Dale P

Occupational and environmental medicine

2022 Volume 79, Issue 10, Page(s) 664–672

Abstract: Objectives: Pyrethroid insecticides have been linked with multiple health outcomes. One study reported an association with increased all-cause and cardiovascular mortality. Given the widespread use of pyrethroids, these findings warrant confirmation. We ...

Abstract	Objectives: Pyrethroid insecticides have been linked with multiple health outcomes. One study reported an association with increased all-cause and cardiovascular mortality. Given the widespread use of pyrethroids, these findings warrant confirmation. We explored associations of permethrin/pyrethroid use with overall and cause-specific mortality among 50 665 licensed pesticide applicators in the Agricultural Health Study. Methods: At enrolment (1993-1997), participants self-reported information on permethrin/pyrethroid use. Information on causes of death came from linkage with death registries through 2016. We used Cox proportional hazards models to estimate HRs and 95% CIs with adjustment for potential confounders. Results: Over an average 21 years of follow-up, 19.6% (9,955) of the cohort died. We found no clear evidence that ever-use of permethrin/pyrethroid was associated with elevated overall mortality or with mortality from most causes examined. There was suggestive evidence, based on a small number of deaths among those exposed, for elevated pyrethroid-associated mortality from some neurological, respiratory and genitourinary diseases in the overall sample and from lung cancer among never-smokers. Conclusion: Although based on mortality, which is also affected by survival, rather than incidence, these findings are biologically plausible, and future investigations in other populations may be warranted.
MeSH term(s)	Agriculture ; Humans ; Insecticides/adverse effects ; Occupational Exposure/adverse effects ; Permethrin/adverse effects ; Pesticides ; Pyrethrins/adverse effects
Chemical Substances	Insecticides ; Pesticides ; Pyrethrins ; Permethrin (509F88P9SZ)
Language	English
Publishing date	2022-06-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2021-108156
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Article ; Online: Estimating the Effects of Soil Remediation on Children's Blood Lead near a Former Lead Smelter in Omaha, Nebraska, USA.

Ye, Dongni / Brown, James S / Umbach, David M / Adams, John / Thayer, William / Follansbee, Mark H / Kirrane, Ellen F

Environmental health perspectives

2022 Volume 130, Issue 3, Page(s) 37008

Abstract: Background: Lead exposures from legacy sources threaten children's health. Soil in Omaha, Nebraska, was contaminated by emissions from a lead smelter and refinery. The U.S. Environmental Protection Agency excavated and replaced contaminated soil at the ... ...

Abstract	Background: Lead exposures from legacy sources threaten children's health. Soil in Omaha, Nebraska, was contaminated by emissions from a lead smelter and refinery. The U.S. Environmental Protection Agency excavated and replaced contaminated soil at the Omaha Lead Superfund Site between 1999 and 2016. Objectives: The goal of this study was to assess the association of soil lead level (SLL) and soil remediation status with blood lead levels (BLLs) in children living near or on the site. Methods: We linked information on SLL at residential properties with children's BLLs and assigned remediation status to children's BLL measurements based on whether their measurements occurred during residence at remediated or unremediated properties. We examined the association of SLL and remediation status with elevated BLL (EBLL). We distinguished the roles of temporal trend and the intervention with time-by-intervention-status interaction contrasts. All analyses estimated odds ratios (ORs) with a generalized estimating equations approach to ensure robustness under the complex correlations among BLL measurements. All analyses controlled for relevant covariates including children's characteristics. Results: EBLL ( Discussion: Residential and neighborhood SLLs were important predictors of EBLLs in children residing near or on this Superfund site. Neighborhood SLL remained a strong predictor following remediation. Our data analyses showed the benefit of soil remediation. Results from the interaction analyses should be interpreted cautiously due to imperfect correspondence of remediation times between remediation and comparison groups. https://doi.org/10.1289/EHP8657.
MeSH term(s)	Child ; Environmental Exposure/analysis ; Humans ; Lead ; Lead Poisoning ; Nebraska ; Soil ; United States
Chemical Substances	Soil ; Lead (2P299V784P)
Language	English
Publishing date	2022-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Intramural
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP8657
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Article ; Online: Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's disease.

Liu, Rui / Umbach, David M / Tröster, Alexander I / Huang, Xuemei / Chen, Honglei

Parkinsonism & related disorders

2020 Volume 72, Page(s) 23–30

Abstract: Background: Non-motor symptoms (NMS) are common in Parkinson's disease (PD), but their relationships to nigrostriatal degeneration remain largely unexplored.: Methods: We evaluated 18 NMS scores covering 5 major domains in relation to concurrent and ... ...

Abstract	Background: Non-motor symptoms (NMS) are common in Parkinson's disease (PD), but their relationships to nigrostriatal degeneration remain largely unexplored. Methods: We evaluated 18 NMS scores covering 5 major domains in relation to concurrent and future dopamine transporter (DAT) imaging in 344 PD patients from the Parkinson's Progression and Markers Initiative (PPMI). We standardized NMS assessments into z-scores for side-by-side comparisons. Patients underwent sequential DaTSCAN imaging at enrollment and at months 12, 24, and 48. Specific binding ratios (SBR) were calculated using the occipital lobe reference region. We evaluated the association of striatal DAT binding at the four time points with each baseline NMS using mixed-effects regression models. Results: Multiple baseline NMS were significantly associated with DAT binding at baseline and at follow-up scans. REM sleep behavior disorder (RBD) symptoms showed the strongest association - mean striatal SBR declined with increasing RBD symptom z-score (average of time-point-specific slopes per unit change in z-score: β Conclusions: Multiple NMS, RBD symptoms in particular, are associated with nigrostriatal dopaminergic changes in early PD.
MeSH term(s)	Aged ; Anxiety/diagnostic imaging ; Anxiety/metabolism ; Anxiety/physiopathology ; Autonomic Nervous System Diseases/diagnostic imaging ; Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/metabolism ; Autonomic Nervous System Diseases/physiopathology ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/physiopathology ; Depression/diagnostic imaging ; Depression/etiology ; Depression/metabolism ; Depression/physiopathology ; Disruptive, Impulse Control, and Conduct Disorders/diagnostic imaging ; Disruptive, Impulse Control, and Conduct Disorders/etiology ; Disruptive, Impulse Control, and Conduct Disorders/metabolism ; Disruptive, Impulse Control, and Conduct Disorders/physiopathology ; Dopamine Plasma Membrane Transport Proteins/pharmacokinetics ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Neostriatum/diagnostic imaging ; Neostriatum/metabolism ; Olfaction Disorders/diagnostic imaging ; Olfaction Disorders/etiology ; Olfaction Disorders/metabolism ; Olfaction Disorders/physiopathology ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Parkinson Disease/physiopathology ; REM Sleep Behavior Disorder/diagnostic imaging ; REM Sleep Behavior Disorder/etiology ; REM Sleep Behavior Disorder/metabolism ; REM Sleep Behavior Disorder/physiopathology ; Substantia Nigra/diagnostic imaging ; Substantia Nigra/metabolism ; Tomography, Emission-Computed, Single-Photon
Chemical Substances	Dopamine Plasma Membrane Transport Proteins
Language	English
Publishing date	2020-02-11
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2020.02.001
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