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  1. Article ; Online: Mpox in Children: 3 Cases.

    Frantzis, Irene / Ungar, Stephanie P / Soma, Vijaya L / Knutsen, Dorothy / Mazo, Dana / Zucker, Jason

    Pediatrics

    2024  Volume 153, Issue 2

    Abstract: Although the 2022 mpox outbreak mostly affected adults, its effect on children and adolescents was also substantial. In this report, we describe the clinical course and treatment of the first 3 known cases of mpox in children in New York City. These ... ...

    Abstract Although the 2022 mpox outbreak mostly affected adults, its effect on children and adolescents was also substantial. In this report, we describe the clinical course and treatment of the first 3 known cases of mpox in children in New York City. These cases are instructive because they illustrate various routes of transmission, clinical presentations, and diagnostic challenges that differ from previous reports of mpox in endemic countries and previous mpox outbreaks. Of note is that each of the 3 patients received treatment with tecovirimat under an US Food and Drug Administration expanded access investigational new drug application and improved without exhibiting adverse reactions.
    MeSH term(s) United States ; Adolescent ; Adult ; Child ; Humans ; Mpox (monkeypox) ; Benzamides ; Disease Outbreaks ; New York City ; United States Food and Drug Administration
    Chemical Substances Benzamides
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2022-061047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: HIV Pre-Exposure Prophylaxis: What Do Pediatricians Need to Know?

    Ungar, Stephanie P / Paret, Michal / Shust, Gail F

    Pediatric annals

    2022  Volume 51, Issue 5, Page(s) e191–e195

    Abstract: Pediatricians and adolescent providers play an important role in the health and well-being of adolescents and young adults, including their sexual health. HIV remains an ongoing concern for young people, with 21% of new HIV diagnoses occurring in this ... ...

    Abstract Pediatricians and adolescent providers play an important role in the health and well-being of adolescents and young adults, including their sexual health. HIV remains an ongoing concern for young people, with 21% of new HIV diagnoses occurring in this age group. The use of antiretroviral therapy for pre-exposure prophylaxis (PrEP) to prevent transmission of HIV to people who are not infected has been proven safe and effective. PrEP can be considered as part of a comprehensive risk mitigation strategy for adolescents and young adults, with clear guidelines for baseline evaluation and ongoing management.
    MeSH term(s) Adolescent ; Anti-HIV Agents/therapeutic use ; HIV Infections/diagnosis ; HIV Infections/prevention & control ; Humans ; Pediatricians ; Pre-Exposure Prophylaxis ; Sexual Health ; Young Adult
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2022-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20220314-07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hospital and ICU Admission Risk Associated With Comorbidities Among Children With COVID-19 Ancestral Strains.

    Ungar, Stephanie P / Solomon, Sadie / Stachel, Anna / Shust, Gail F / Clouser, Katharine N / Bhavsar, Sejal M / Lighter, Jennifer

    Clinical pediatrics

    2023  Volume 62, Issue 9, Page(s) 1048–1058

    Abstract: A large proportion of children have been affected by COVID-19; we evaluated the association between comorbidities and hospitalization/ICU (intensive care unit) admission among 4097 children under age 21 years with symptomatic COVID-19 (not just ... ...

    Abstract A large proportion of children have been affected by COVID-19; we evaluated the association between comorbidities and hospitalization/ICU (intensive care unit) admission among 4097 children under age 21 years with symptomatic COVID-19 (not just polymerase chain reaction [PCR]-positive or multisystem inflammatory syndrome in children associated with COVID-19 [MIS-C]) from 2 large health systems from March 2020 to September 2021. Significant comorbidities and demographic factors identified by univariable analysis were included in a multivariable logistic regression compared with children ages 6 to 11 without comorbidities. In all, 475 children (11.6%) were hospitalized, of whom 25.5% required ICU admission. Children under 1 year had high hospitalization risk, but low risk of ICU admission. Presence of at least 1 comorbidity was associated with hospitalization and ICU admission (odds ratio [OR] > 4). Asthma, obesity, chronic kidney disease, sickle cell disease, bone marrow transplantation, and neurologic disorders were associated with hospitalization (adjusted odds ratio [AOR] > 2). Malignancy, intellectual disability, and prematurity were associated with ICU admission (AOR > 4). Comorbidities are significantly associated with hospitalization/ICU admission among children with COVID-19.
    MeSH term(s) Humans ; Child ; Young Adult ; Adult ; COVID-19/epidemiology ; SARS-CoV-2 ; Risk Factors ; Hospitalization ; Comorbidity ; Intensive Care Units ; Hospitals ; Retrospective Studies
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228221150605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Do Not Forget About the Ticks: An Unusual Cause of Fever, GI Distress, and Cytopenias in a Child With ALL.

    Ungar, Stephanie P / Varkey, Joyce / Pierro, Joanna / Raetz, Elizabeth / Ratner, Adam J

    Journal of pediatric hematology/oncology

    2021  Volume 44, Issue 5, Page(s) e901–e904

    Abstract: We report the case of a 5-year-old male with B-cell acute lymphoblastic leukemia in remission, receiving maintenance chemotherapy, who presented with fever, emesis, diarrhea, headache, and lethargy. He developed rapidly progressive cytopenias and was ... ...

    Abstract We report the case of a 5-year-old male with B-cell acute lymphoblastic leukemia in remission, receiving maintenance chemotherapy, who presented with fever, emesis, diarrhea, headache, and lethargy. He developed rapidly progressive cytopenias and was found to have acute human granulocytic anaplasmosis as well as evidence of past infection with Babesia microti. The case highlights the need to maintain a broad differential for infection in children undergoing chemotherapy or other immunosuppressive therapies with possible or known tick exposure.
    MeSH term(s) Anaplasmosis/diagnosis ; Animals ; Child, Preschool ; Diagnosis, Differential ; Fever/etiology ; Humans ; Male ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Ticks
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of Prenatal SARS-CoV-2 Infection on Infant Emergency Department Visits and Hospitalization.

    Ungar, Stephanie P / Solomon, Sadie / Stachel, Anna / Demarco, Kathleen / Roman, Ashley S / Lighter, Jennifer

    Clinical pediatrics

    2021  Volume 61, Issue 2, Page(s) 206–211

    Abstract: To better understand the impact of prenatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on infants, this study sought to compare the risk of hospital visits and of postnatal SARS-CoV-2 infection between infants born to mothers ... ...

    Abstract To better understand the impact of prenatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on infants, this study sought to compare the risk of hospital visits and of postnatal SARS-CoV-2 infection between infants born to mothers with and without prenatal SARS-CoV-2 infection. In this retrospective observational cohort study of 6871 mothers and their infants, overall rates of emergency department (ED) visits and hospital admissions in the first 90 days of life were similar for infants born to mothers with and without prenatal SARS-CoV-2 infection. Infants born to negative mothers were more likely than infants of positive mothers to be hospitalized after ED visit (relative risk: 3.76; 95% confidence interval: 1.27-11.13,
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/epidemiology ; Cohort Studies ; Emergency Service, Hospital/organization & administration ; Emergency Service, Hospital/statistics & numerical data ; Female ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Male ; New York City/epidemiology ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Retrospective Studies
    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228211065898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cefiderocol Red Wine Urine Syndrome in Pediatric Patients: A Multicenter Case Series.

    Shapiro, Kate / Ungar, Stephanie P / Krugman, Jessica / McGarrity, Orlagh / Cross, Shane J / Indrakumar, Bairavi / Hatcher, James / Ratner, Adam J / Wolf, Joshua

    The Pediatric infectious disease journal

    2023  

    Abstract: Cefiderocol is a novel cephalosporin antibiotic with activity against multidrug-resistant gram-negative bacteria and limited pediatric experience. This case series describes 3 immunocompromised children receiving blood transfusion who developed benign ... ...

    Abstract Cefiderocol is a novel cephalosporin antibiotic with activity against multidrug-resistant gram-negative bacteria and limited pediatric experience. This case series describes 3 immunocompromised children receiving blood transfusion who developed benign red or purple urine with administration of cefiderocol. Interaction with iron from blood products is a possible mechanism. It is important to recognize this phenomenon and distinguish it from hematuria to avoid unnecessary diagnostic testing.
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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