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  1. Book: Der Darm

    Untersmayr-Elsenhuber, Eva / Ferlitsch, Monika

    warum er so wichtig ist und wie er gesund bleibt

    (Gesundheit. Wissen)

    2021  

    Author's details von Eva Untersmayr-Elsenhuber und Monika Ferlitsch
    Series title Gesundheit. Wissen
    Keywords Darm ; Darmgesundheit ; Darmerkrankung ; Lebensstil ; Darmkrebsvorsorge ; Darmkrankheit ; Coloskopie ; Ernährung
    Subject Nutrition ; Ernährungsstatus ; Ernährungszustand ; Koloskopie ; Colonoskopie ; Kolonoskopie ; Darmerkrankung ; Darmtrakt ; Intestinum
    Language German
    Size 179 Seiten, Illustrationen
    Publisher MANZ
    Publishing place Wien
    Publishing country Germany
    Document type Book
    HBZ-ID HT021128957
    ISBN 978-3-214-02196-2 ; 3-214-02196-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 1385 available for loan (reading room) Lesesaal EG

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  2. Article: Acid suppression therapy and allergic reactions.

    Untersmayr, Eva

    Allergo journal international

    2017  Volume 24, Issue 8, Page(s) 303–311

    Abstract: The development of pharmaceutical agents such as sucralfate, histamine 2 (H2) receptor blockers and proton pump inhibitors (PPIs) reducing gastric acidity has been a mile stone for treatment of dyspeptic disorders. However, due to current prescription ... ...

    Abstract The development of pharmaceutical agents such as sucralfate, histamine 2 (H2) receptor blockers and proton pump inhibitors (PPIs) reducing gastric acidity has been a mile stone for treatment of dyspeptic disorders. However, due to current prescription habits resulting in overuse of these potent drugs as well as over-the-counter (OTC) availability associated with self-medication, substantial health concern is related to the mechanisms of drug action as well as known side effects influencing gastrointestinal physiology. More than a decade ago the first study appeared reporting an association between anti-ulcer drug intake and food allergy development. Ever since this first report several experimental as well as human studies verified this correlation, demonstrating that acid suppressive drugs not only influence the sensitization capacity of orally ingested proteins, but also represent a risk factor for food allergy patients. Additionally, gastric acid suppression was reported to increase the risk for development of drug hypersensitivity reactions. These consequences of anti-ulcer drug intake might on the one hand be associated with direct influence of these drugs on immune responses. On the other hand reduction of gastric acidity leads to impaired gastrointestinal protein degradation. Nevertheless, also disruption of the gastrointestinal barrier function, changes in microbiome or lack of tolerogenic peptic digests might contribute to the connection between anti-ulcer drug intake and allergic reaction. Therefore, these drugs should only be prescribed based on a precise gastroenterological diagnosis taking into consideration allergological mechanisms to ensure patients' safety.
    Language English
    Publishing date 2017-05-26
    Publishing country Germany
    Document type Journal Article
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-015-0085-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The influence of gastric digestion on the development of food allergy.

    Untersmayr, Eva

    Revue francaise d'allergologie (2009)

    2017  Volume 55, Issue 7, Page(s) 444–447

    Abstract: Food allergy represents an increasing health concern worldwide. To identify mechanisms and risk factors associated with food allergy development major research efforts are ongoing. For a long time only food allergens that are resistant to gastric enzymes ...

    Abstract Food allergy represents an increasing health concern worldwide. To identify mechanisms and risk factors associated with food allergy development major research efforts are ongoing. For a long time only food allergens that are resistant to gastric enzymes were accepted to harbor sensitizing capacity via the oral route. However, over the past years several studies reported that even important food allergens can be readily degraded by digestive enzymes. Interestingly, a number of
    Language English
    Publishing date 2017-05-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2484013-0
    ISSN 1877-0312 ; 1877-0320
    ISSN 1877-0312 ; 1877-0320
    DOI 10.1016/j.reval.2015.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 185: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Allergen Stability in Food Allergy: A Clinician's Perspective.

    Koidl, Larissa / Gentile, Salvatore Alessio / Untersmayr, Eva

    Current allergy and asthma reports

    2023  Volume 23, Issue 10, Page(s) 601–612

    Abstract: Purpose of review: The globally rising food allergy prevalence is associated with the urgent need for new disease prevention methods, efficient treatment, and reliable risk assessment methods for characterization of food allergens. Due to inter- ... ...

    Abstract Purpose of review: The globally rising food allergy prevalence is associated with the urgent need for new disease prevention methods, efficient treatment, and reliable risk assessment methods for characterization of food allergens. Due to inter-individual variations in the digestive system, food allergens are degraded to a different extent in each person. Food processing also influences allergen digestion.
    Recent findings: In this review, we provide an overview of the digestive system with focus on relevance for food allergy. Main food proteins causing allergic reactions are evaluated, and the combined role of food processing and digestion for allergen stability is highlighted. Finally, clinical implications of this knowledge are discussed. Recent literature shows that allergen digestibility is dependent on food processing, digestive conditions, and food matrix. Digestion affects proteins allergenicity. It is currently not possible to predict the immunogenicity of allergens solely based on protein stability.
    MeSH term(s) Humans ; Allergens ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/prevention & control ; Food ; Food Handling ; Risk Assessment
    Chemical Substances Allergens
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-023-01107-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5548: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The clinical implications of the microbiome in the development of allergy diseases.

    Koidl, Larissa / Untersmayr, Eva

    Expert review of clinical immunology

    2021  Volume 17, Issue 2, Page(s) 115–126

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Adaptive Immunity ; Asthma/immunology ; Asthma/microbiology ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/microbiology ; Drug Hypersensitivity/immunology ; Drug Hypersensitivity/microbiology ; Food Hypersensitivity/immunology ; Food Hypersensitivity/microbiology ; Gastrointestinal Microbiome/immunology ; Gastrointestinal Microbiome/physiology ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/microbiology ; Immunity, Innate ; Microbiota/immunology ; Microbiota/physiology ; Respiratory System/immunology ; Respiratory System/microbiology ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/microbiology ; Skin/immunology ; Skin/microbiology
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2021.1874353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
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  6. Article ; Online: The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging.

    Untersmayr, Eva / Brandt, Annette / Koidl, Larissa / Bergheim, Ina

    Nutrients

    2022  Volume 14, Issue 5

    Abstract: The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical barrier consisting of epithelial cells and immune cells, the latter residing underneath and within the epithelial cells, plays a special role in health and ... ...

    Abstract The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical barrier consisting of epithelial cells and immune cells, the latter residing underneath and within the epithelial cells, plays a special role in health and disease. While there is growing knowledge on the changes to the different layers associated with disease development, the barrier function also plays an important role during aging. Besides changes in the composition and function of cellular junctions, the entire gastrointestinal physiology contributes to essential age-related changes. This is also reflected by substantial differences in the microbial composition throughout the life span. Even though it remains difficult to define physiological age-related changes and to distinguish them from early signs of pathologies, studies in centenarians provide insights into the intestinal barrier features associated with longevity. The knowledge reviewed in this narrative review article might contribute to the definition of strategies to prevent the development of diseases in the elderly. Thus, targeted interventions to improve overall barrier function will be important disease prevention strategies for healthy aging in the future.
    MeSH term(s) Aged ; Aged, 80 and over ; Aging ; Gastrointestinal Diseases ; Humans ; Intestinal Diseases ; Longevity ; Microbiota
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14050949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging

    Untersmayr, Eva / Brandt, Annette / Koidl, Larissa / Bergheim, Ina

    Nutrients. 2022 Feb. 23, v. 14, no. 5

    2022  

    Abstract: The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical barrier consisting of epithelial cells and immune cells, the latter residing underneath and within the epithelial cells, plays a special role in health and ... ...

    Abstract The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical barrier consisting of epithelial cells and immune cells, the latter residing underneath and within the epithelial cells, plays a special role in health and disease. While there is growing knowledge on the changes to the different layers associated with disease development, the barrier function also plays an important role during aging. Besides changes in the composition and function of cellular junctions, the entire gastrointestinal physiology contributes to essential age-related changes. This is also reflected by substantial differences in the microbial composition throughout the life span. Even though it remains difficult to define physiological age-related changes and to distinguish them from early signs of pathologies, studies in centenarians provide insights into the intestinal barrier features associated with longevity. The knowledge reviewed in this narrative review article might contribute to the definition of strategies to prevent the development of diseases in the elderly. Thus, targeted interventions to improve overall barrier function will be important disease prevention strategies for healthy aging in the future.
    Keywords disease prevention ; elderly ; epithelium ; intestines ; longevity ; microorganisms ; mucus
    Language English
    Dates of publication 2022-0223
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14050949
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Insights in Immuno-Nutrition: Vitamin D as a Potent Immunomodulator.

    Untersmayr, Eva / Kallay, Enikö

    Nutrients

    2020  Volume 12, Issue 11

    Abstract: The relationship between nutrition and the immune system is a "complicated tango", as coined earlier this year in a review ... ...

    Abstract The relationship between nutrition and the immune system is a "complicated tango", as coined earlier this year in a review in
    MeSH term(s) COVID-19/complications ; Humans ; Immunologic Factors ; Nutritional Status/immunology ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamins
    Chemical Substances Immunologic Factors ; Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2020-11-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12113554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Immunological Patient Stratification in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

    Rohrhofer, Johanna / Hauser, Lisa / Lettenmaier, Lisa / Lutz, Lena / Koidl, Larissa / Gentile, Salvatore Alessio / Ret, Davide / Stingl, Michael / Untersmayr, Eva

    Journal of clinical medicine

    2024  Volume 13, Issue 1

    Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by profound fatigue, post-exertional malaise (PEM), and neurocognitive dysfunction. Immune dysregulation and gastrointestinal symptoms are commonly observed in ...

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by profound fatigue, post-exertional malaise (PEM), and neurocognitive dysfunction. Immune dysregulation and gastrointestinal symptoms are commonly observed in ME/CFS patients. Despite affecting approximately 0.89% of the general population, the underlying pathophysiological mechanisms remain poorly understood. This study aimed to elucidate the relationship between immunological characteristics and intestinal barrier function in ME/CFS patients. ME/CFS patients were stratified into two groups based on their immune competence. After documentation of detailed medical records, serum and plasma samples were collected for the assessment of inflammatory immune mediators and biomarkers for intestinal barrier integrity by ELISA. We found reduced complement protein C4a levels in immunodeficient ME/CFS patients suggesting a subgroup-specific innate immune dysregulation. ME/CFS patients without immunodeficiencies exhibit a mucosal barrier leakage, as indicated by elevated levels of Lipopolysaccharide-binding protein (LBP). Stratifying ME/CFS patients based on immune competence enabled the distinction of two subgroups with different pathophysiological patterns. The study highlights the importance of emphasizing precise patient stratification in ME/CFS, particularly in the context of defining suitable treatment strategies. Given the substantial health and socioeconomic burden associated with ME/CFS, urgent attention and research efforts are needed to define causative treatment approaches.
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Time matters: The circadian rhythm in intestinal homeostasis and food allergy.

    Koidl, Larissa / Rohrhofer, Johanna / Untersmayr, Eva

    Allergy

    2021  Volume 76, Issue 9, Page(s) 2931–2933

    MeSH term(s) Circadian Rhythm ; Food Hypersensitivity/epidemiology ; Homeostasis ; Humans ; Intestines
    Language English
    Publishing date 2021-05-25
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
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    Zs.MO 125: Show issues

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