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  1. Article: Acute Disseminated Encephalomyelitis: Psychiatric Presentation of a Rare Diagnosis.

    Baral, Ashok / Gyawali, Rajan / Upreti, Dikshya / Mishra, Atindra / Gupta, Anoop Krishna

    Innovations in clinical neuroscience

    2021  Volume 18, Issue 7-9, Page(s) 44–46

    Abstract: Acute disseminated encephalomyelitis (ADEM) is an autoimmune inflammatory disease of the central nervous system that is characterized by widespread demyelination, predominantly involving the white matter of the brain and spinal cord. Often caused by a ... ...

    Abstract Acute disseminated encephalomyelitis (ADEM) is an autoimmune inflammatory disease of the central nervous system that is characterized by widespread demyelination, predominantly involving the white matter of the brain and spinal cord. Often caused by a viral infection or vaccination, its clinical features include an acute encephalopathy with multifocal neurologic signs and deficits in children. It can present with psychosis, depression, or abnormal behavior, and it might mimic a dissociative disorder. This report involves a similar rare case of a 14-year-old female patient who presented with fluctuating weakness of body, slurring of speech, tremor, loss of responsiveness, and abnormal behavior after her fever waned. Diagnosis of dissociative disorder was considered in the absence of neurological findings and ongoing significant stressor. Eventually, it turned out to be ADEM, which was confirmed by late neurological manifestations and radiological evaluation. Neuroimaging also revealed its differences from multiple sclerosis.
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2675366-2
    ISSN 2158-8341 ; 2158-8333
    ISSN (online) 2158-8341
    ISSN 2158-8333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Novel report on congenital talipes equinovarus (CTEV) following olanzapine exposure during pregnancy: case report and short review.

    Gyawali, Rajan / Baral, Ashok / Upreti, Dikshya / Yadav, Chandra Bhushan / Gupta, Anoop Krishna / Chandradasa, Miyuru / Shoib, Sheikh

    Archives of women's mental health

    2022  Volume 25, Issue 3, Page(s) 671–674

    Abstract: Olanzapine is widely used during pregnancy to manage mood and psychotic disorders with overall beneficial effects. There have been past reports of olanzapine exposure during early pregnancy and clubfoot in two newborns from India and Israel. We report a ... ...

    Abstract Olanzapine is widely used during pregnancy to manage mood and psychotic disorders with overall beneficial effects. There have been past reports of olanzapine exposure during early pregnancy and clubfoot in two newborns from India and Israel. We report a woman in Nepal diagnosed with schizophrenia and treated with olanzapine throughout the pregnancy delivering a baby boy with congenital talipes equinovarus deformity. Like in many other low-income settings, pregnancy was unplanned, and pre-conception counselling was not done. Research in mice has revealed the negative effects of olanzapine on bone development. Further reports would strengthen this potential association between exposure to olanzapine in the first trimester and the occurrence of clubfoot in the baby.
    MeSH term(s) Animals ; Clubfoot/chemically induced ; Clubfoot/epidemiology ; Female ; Humans ; India ; Infant, Newborn ; Israel ; Mice ; Olanzapine/adverse effects ; Pregnancy
    Chemical Substances Olanzapine (N7U69T4SZR)
    Language English
    Publishing date 2022-03-14
    Publishing country Austria
    Document type Case Reports ; Journal Article
    ZDB-ID 1463529-X
    ISSN 1435-1102 ; 1434-1816
    ISSN (online) 1435-1102
    ISSN 1434-1816
    DOI 10.1007/s00737-022-01221-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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