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  1. Book ; Thesis: Kopplungsanalyse mit dem für die familiäre hemiplegische Migräne bekannten Locus auf Chromosom 19p13 in Familien mit Migräne mit Aura und ohne Aura

    Urban, Christine

    1999  

    Author's details vorgelegt von Christine Urban
    Language German
    Size 72 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Essen, Univ., Diss., 1999
    HBZ-ID HT011217719
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Anaplasma phagocytophilum infection associated with strong inflammatory response in 3 cats.

    Geisen, Vera / Pantchev, Nikola / Wuelfing, Katrin / Würthner, Carolin / Gierschner, Kerstin / Urban, Christine / Lambach, Yvonne / Hartmann, Katrin / Bergmann, Michèle

    Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere

    2024  Volume 52, Issue 1, Page(s) 40–47

    Abstract: Anaplasmosis is a vector-borne disease caused ... ...

    Title translation Anaplasma phagocytophilum-Infektion mit starker entzündlicher Reaktion bei 3 Katzen.
    Abstract Anaplasmosis is a vector-borne disease caused by
    MeSH term(s) Animals ; Cats ; Anaplasmosis/diagnosis ; Anaplasmosis/drug therapy ; Anaplasma phagocytophilum ; Doxycycline/therapeutic use ; Extremities ; Germany ; Ehrlichiosis/complications ; Ehrlichiosis/diagnosis ; Ehrlichiosis/drug therapy ; Ehrlichiosis/veterinary ; Cat Diseases/diagnosis ; Cat Diseases/drug therapy
    Chemical Substances Doxycycline (N12000U13O)
    Language English
    Publishing date 2024-02-27
    Publishing country Germany
    Document type Journal Article
    ISSN 2567-5842
    ISSN (online) 2567-5842
    DOI 10.1055/a-2202-4956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hap-E Search 2.0: Improving the Performance of a Probabilistic Donor-Recipient Matching Algorithm Based on Haplotype Frequencies.

    Urban, Christine / Schmidt, Alexander H / Hofmann, Jan Andreas

    Frontiers in medicine

    2020  Volume 7, Page(s) 32

    Abstract: In the setting of hematopoietic stem cell transplantation, donor-patient HLA matching is the prime donor selection criterion. Matching algorithms provide ordered lists of donors where the probability of a donor to be an HLA match is calculated in cases ... ...

    Abstract In the setting of hematopoietic stem cell transplantation, donor-patient HLA matching is the prime donor selection criterion. Matching algorithms provide ordered lists of donors where the probability of a donor to be an HLA match is calculated in cases where either donor or patient HLA typing information is ambiguous or incomplete. While providing important information for the selection of suitable donors, these algorithms are computationally demanding and often need several minutes up to hours to generate search results. Here, we present a new search kernel implementation for Hap-E Search, the haplotype frequency-based matching algorithm of DKMS. The updated search kernel uses pre-calculated information on donor genotypes to speed up the search process. The new algorithm reliably provides search results in <1 min for a large donor database (>9 Mio donors) including matching and mismatching donors, even for frequent or incomplete patient HLA data where the matching list contains several thousand donors. In these cases, the search process is accelerated by factors of 10 and more compared to the old Hap-E Search implementation. The predicted matching probabilities of the new algorithm were validated with data from verification typing requests of 67,550 donor-patient pairs.
    Language English
    Publishing date 2020-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [No title information]

    Geisen, Vera / Pantchev, Nikola / Wuelfing, Katrin / Würthner, Carolin / Gierschner, Kerstin / Urban, Christine / Lambach, Yvonne / Hartmann, Katrin / Bergmann, Michèle

    Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere

    2024  Volume 52, Issue 01, Page(s) 40–47

    Abstract: Anaplasmosis is a vector-borne disease caused by Anaplasma (A.) spp. which currently is still rarely diagnosed in cats. This article describes 3 independent cases of anaplasmosis in cats from different regions of ... ...

    Abstract Anaplasmosis is a vector-borne disease caused by Anaplasma (A.) spp. which currently is still rarely diagnosed in cats. This article describes 3 independent cases of anaplasmosis in cats from different regions of Germany presented to veterinarians in 2021. All cats showed unspecific clinical signs, such as fever, reduced general condition, and decreased appetite. One cat additionally had generalized limb pain, another showed reluctance to move as well as vomiting. On complete blood cell count, only 1 of 3 cats showed mild thrombocytopenia. A. phagocytophilum was detected in blood samples of all 3 cats by polymerase chain reaction. Additionally, in 2 cats (in which blood smears were evaluated) morulae could be detected within neutrophilic granulocytes. Initially, all 3 cats had highly elevated serum amyloid A (SAA) concentrations. Treatment with doxycycline caused a rapid improvement of clinical signs, followed by a decrease of SAA concentrations to normal levels as well as negative PCR results after a treatment duration of at least 28 days. In cats with fever, otherwise unspecific clinical signs with only mild or no hematological changes, elevated SAA concentrations, and previous exposure to ticks, attending veterinarians should consider anaplasmosis as differential diagnosis.
    Keywords Serum amyloid A ; SAA ; ticks ; vector-borne disease ; Serum-Amyloid-A ; SAA ; Zecken ; vektorübertragene Krankheiten
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2567-5842 ; 1434-1239
    ISSN (online) 2567-5842
    ISSN 1434-1239
    DOI 10.1055/a-2202-4956
    Database Thieme publisher's database

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  5. Article ; Online: World Marrow Donor Association guidelines for the reporting of novel HLA alleles.

    Hofmann, Jan A / Bochtler, Werner / Robinson, James / Sauter, Jürgen / Askar, Medhat / Houdova, Lucie / Melchers, Mark / Schmidt, Alexander H / Spierings, Eric / Urban, Christine / Venter, Alicia / Maiers, Martin / Marsh, Steven G E / Eberhard, Hans-Peter

    HLA

    2023  Volume 102, Issue 1, Page(s) 62–64

    Abstract: The guidelines for the implementation and reporting of HLA nomenclature for the World Marrow Donor Association have served as a reliable standard for communication of HLA data in the hematopoietic cell transplantation process. Wider use of next- ... ...

    Abstract The guidelines for the implementation and reporting of HLA nomenclature for the World Marrow Donor Association have served as a reliable standard for communication of HLA data in the hematopoietic cell transplantation process. Wider use of next-generation sequencing made a special provision of the guidelines increasingly pertinent: how to communicate novel HLA alleles. Novel alleles need to be recognized by the WHO Nomenclature Committee for Factors of the HLA system to obtain official allele designations. Until then they have to be handled according to the specific rules. Leaving the actual rules basically unchanged we give some advice on how to communicate novel alleles to best facilitate the search process for cases where novel alleles are identified on donor or patient side.
    MeSH term(s) Humans ; Bone Marrow ; Alleles ; HLA Antigens/genetics ; Histocompatibility Testing ; Hematopoietic Stem Cell Transplantation ; High-Throughput Nucleotide Sequencing
    Chemical Substances HLA Antigens
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Behandlung der Mediastinaltumoren in den Jahren 1968 - 1977

    Urban-Sievert, Christine

    1980  

    Author's details vorgelegt von Christine Urban-Sievert
    Language German
    Size 67 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1980
    HBZ-ID HT000413523
    Database Catalogue ZB MED Medicine, Health

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  7. Book: Das Vorschlagswesen und seine Weiterentwicklung zum europäischen KAIZEN

    Urban, Christine

    das Vorgesetztenmodell ; Hintergründe zu aktuellen Veränderungen im betrieblichen Vorschlagswesen

    1994  

    Author's details Christine Urban
    Keywords Qualitätsmanagement ; Vorschlagswesen
    Language German
    Size 146 S., graph. Darst., 21 cm
    Edition 2. Aufl.
    Publisher Hartung-Gorre
    Publishing place Konstanz
    Document type Book
    Note Literaturverz. S. 138 - 146
    ISBN 3891916574 ; 9783891916575
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book: Das Vorschlagswesen und seine Weiterentwicklung zum europäischen KAIZEN

    Urban, Christine

    das Vorgesetztenmodell ; Hintergründe zu aktuellen Veränderungen im betrieblichen Vorschlagswesen

    1993  

    Author's details Christine Urban
    Language German
    Size 146 S, graph. Darst
    Edition 1. Aufl
    Publisher Hartung-Gorre
    Publishing place Konstanz
    Document type Book
    Note Literaturverz
    ISBN 3891916574 ; 9783891916575
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book: Das Vorschlagswesen und seine Weiterentwicklung zum europäischen KAIZEN

    Urban, Christine

    das Vorgesetztenmodell ; Hintergründe zu aktuellen Veränderungen im betrieblichen Vorschlagswesen

    1993  

    Author's details Christine Urban
    Keywords Vorschlagswesen ; Arbeitsgruppe ; Deutschland ; 13*23*14*24*41*42
    Language German
    Size 146 S. : graph. Darst
    Edition 1. Aufl
    Document type Book
    ISBN 3891916574 ; 9783891916575
    Database ECONomics Information System

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  10. Book: Jedes Kind hat seine Stärken

    Kaniak-Urban, Christine

    typgerecht erziehen, seelische Nöte erkennen, Kompetenzen fördern

    1999  

    Author's details Christine Kaniak-Urban
    Keywords Persönlichkeitstyp ; Kind ; Bewältigung ; Lebenskrise ; Erziehung
    Language German
    Size 199 S, Ill, 21 cm
    Publisher Kösel
    Publishing place München
    Document type Book
    ISBN 3466304830 ; 9783466304837
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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