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  1. Article ; Online: Enhancing fluconazole reactivation against

    Di Vito, M / Rosato, R / Rizzo, S / Cacaci, M / Urbani, A / Sanguinettii, M / Bugli, F

    Microbiology spectrum

    2024  Volume 12, Issue 4, Page(s) e0017624

    MeSH term(s) Fluconazole/pharmacology ; Cinnamomum zeylanicum ; Oils, Volatile/pharmacology ; Candida auris ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Microbial Sensitivity Tests ; Acrolein/analogs & derivatives
    Chemical Substances Fluconazole (8VZV102JFY) ; Oils, Volatile ; cinnamaldehyde (SR60A3XG0F) ; Antifungal Agents ; Acrolein (7864XYD3JJ)
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Letter
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00176-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genetic Characterization of a Cohort of Italian Patients with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.

    Concolino, Paola / Perrucci, Alessia / Carrozza, Cinzia / Urbani, Andrea

    Molecular diagnosis & therapy

    2023  Volume 27, Issue 5, Page(s) 621–630

    Abstract: Introduction: Defects in the steroid 21-hydroxylase gene (CYP21A2) cause 21-hydroxylase deficiency (21OHD), the main cause of congenital adrenal hyperplasia (CAH). The disease shows a broad spectrum of clinical forms, ranging from severe or classical ( ... ...

    Abstract Introduction: Defects in the steroid 21-hydroxylase gene (CYP21A2) cause 21-hydroxylase deficiency (21OHD), the main cause of congenital adrenal hyperplasia (CAH). The disease shows a broad spectrum of clinical forms, ranging from severe or classical (salt wasting, SW, and simple virilizing, SV), to mild late onset or nonclassical (NC). 21OHD affects 1 in 15,000 in its severe classic form and 1 in 200-1000 in its mild NC form. There are many studies reporting the frequency of CYP21A2 pathogenic variants in different populations; however, few of them provide comprehensive information about Italian patients. Here, we present genetic results from a cohort of 245 unrelated Italian individuals with clinical diagnosis of CAH due to 21OHD.
    Methods: A specific polymerase chain reaction (PCR) protocol combined with Sanger sequencing was used for CYP21A2 analysis. The multiplex ligation-dependent probe amplification (MLPA) assay was employed for copy number variation (CNV) determination.
    Results: One hundred fourteen (46.5%) of the index cases had the NC form, 57 (23.3%) had the SV form, and 74 (30.2%) presented the SW form of the disease. The most prevalent variant found in NC patients was the p.Val282Leu (51.3%), while the most frequent variants in the classical form were p.Ile173Asn (8.6%) and c.293-13C>G (26.0%). In our study, the frequency of large rearrangements was 15.3%, with CAH-X alleles representing 40% of all DEL/CONV. In addition, 12 alleles carried rare variants, and 1 had a novel variant p.(Arg342Gln). We observed phenotype-genotype correlation in 94.7% of cases. A complete concordance was observed in Groups 0 (enzyme activity completely impaired) where all patients had the SW form as expected. In Group A (0-1% residual enzyme activity), 78.4% of patients had the anticipated SW form while 21.6% were diagnosed with the SV form. Within Group B (~ 2% residual enzyme activity), 93.4% of patients exhibited SV form and 6.5% SW disease. Finally, 92.6% and 7.4% of patients belonging to Group C (enzyme partially impaired to ~ 20-60% residual activity) exhibited NC and SV phenotypes, respectively.
    Conclusion: This work, representing a comprehensive genetic study, expanded the CYP21A2 variants spectrum of Italian patients with 21OHD and could be helpful in prenatal diagnosis and genetic counseling.
    MeSH term(s) Humans ; Adrenal Hyperplasia, Congenital/diagnosis ; Adrenal Hyperplasia, Congenital/genetics ; Mutation ; DNA Copy Number Variations ; Steroid 21-Hydroxylase/genetics ; Phenotype ; Multiplex Polymerase Chain Reaction ; Genotype
    Chemical Substances Steroid 21-Hydroxylase (EC 1.14.14.16) ; CYP21A2 protein, human (EC 1.14.14.16)
    Language English
    Publishing date 2023-08-07
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2232796-4
    ISSN 1179-2000 ; 1177-1062
    ISSN (online) 1179-2000
    ISSN 1177-1062
    DOI 10.1007/s40291-023-00666-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5202: Show issues Location:
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  3. Article: Mapping of Urinary Volatile Organic Compounds by a Rapid Analytical Method Using Gas Chromatography Coupled to Ion Mobility Spectrometry (GC-IMS).

    Riccio, Giulia / Baroni, Silvia / Urbani, Andrea / Greco, Viviana

    Metabolites

    2022  Volume 12, Issue 11

    Abstract: Volatile organic compounds (VOCs) are a differentiated class of molecules, continuously generated in the human body and released as products of metabolic pathways. Their concentrations vary depending on pathophysiological conditions. They are detectable ... ...

    Abstract Volatile organic compounds (VOCs) are a differentiated class of molecules, continuously generated in the human body and released as products of metabolic pathways. Their concentrations vary depending on pathophysiological conditions. They are detectable in a wide variety of biological samples, such as exhaled breath, faeces, and urine. In particular, urine represents an easily accessible specimen widely used in clinics. The most used techniques for VOCs detections are expensive and time-consuming, thus not allowing for rapid clinical analysis. In this perspective, the aim of this study is a comprehensive characterisation of the urine volatilome by the development of an alternative rapid analytical method. Briefly, 115 urine samples are collected; sample treatment is not needed. VOCs are detected in the urine headspace using gas chromatography coupled to ion mobility spectrometry (GC-IMS) by an extremely fast analysis (10 min). The method is analytically validated; the analysis is sensitive and robust with results comparable to those reported with other techniques. Twenty-three molecules are identified, including ketones, aldehydes, alcohols, and sulphur compounds, whose concentration is altered in several pathological states such as cancer and metabolic disorders. Therefore, it opens new perspectives for fast diagnosis and screening, showing great potential for clinical applications.
    Language English
    Publishing date 2022-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12111072
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  4. Article ; Online: Urokinase-type plasminogen activator soluble receptor (suPAR) assay in clinical routine: evaluation one year after its introduction in the high automation corelab of the A. Gemelli hospital.

    Sarlo, Francesca / Urbani, Andrea / Baroni, Silvia

    Clinical chemistry and laboratory medicine

    2022  Volume 61, Issue 2, Page(s) e33–e35

    MeSH term(s) Humans ; Receptors, Urokinase Plasminogen Activator ; Urokinase-Type Plasminogen Activator ; Signal Transduction ; Automation ; Hospitals ; Biomarkers
    Chemical Substances Receptors, Urokinase Plasminogen Activator ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73) ; Biomarkers
    Language English
    Publishing date 2022-10-27
    Publishing country Germany
    Document type Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2022-0686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Extracorporeal veno-venous ultrafiltration in congestive heart failure: What's the state of the art? A mini-review.

    Urbani, Andrea / Pensotti, Filippo / Provera, Andrea / Galassi, Andrea / Guazzi, Marco / Castini, Diego

    World journal of cardiology

    2023  Volume 15, Issue 5, Page(s) 205–216

    Abstract: Hospitalizations for heart failure exceed 1 million per year in both the United States and Europe and more than 90% are due to symptoms and signs of fluid overload. Rates of rehospitalizations or emergency department visit at 60 days are remarkable ... ...

    Abstract Hospitalizations for heart failure exceed 1 million per year in both the United States and Europe and more than 90% are due to symptoms and signs of fluid overload. Rates of rehospitalizations or emergency department visit at 60 days are remarkable regardless of whether loop diuretics were administered at low
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573665-6
    ISSN 1949-8462
    ISSN 1949-8462
    DOI 10.4330/wjc.v15.i5.205
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  6. Article: Analytical Performance Evaluation of a New Calcitonin Assay.

    Moretti, Giacomo / Troiani, Eliana / Sarlo, Francesca / Baroni, Silvia / Urbani, Andrea

    The journal of applied laboratory medicine

    2022  Volume 7, Issue 2, Page(s) 568–574

    Abstract: Background: The use of efficient laboratory calcitonin (CT) testing is required for optimal management of medullary thyroid carcinoma. Several pitfalls are related to the calcitonin laboratory assays and a careful evaluation is needed. We report the ... ...

    Abstract Background: The use of efficient laboratory calcitonin (CT) testing is required for optimal management of medullary thyroid carcinoma. Several pitfalls are related to the calcitonin laboratory assays and a careful evaluation is needed. We report the analytical performances of the new Siemens ADVIA-Centaur-CALCT (CT-XPT) assay and its comparison with our standard method DiaSorin-Calcitonin-II-Gen (CT-LIA) assay.
    Methods: Analytical performance of the CT-XPT-assay, limit of blank (LOB), limit of detection (LOD), and limit of quantification (LOQ), were determined. We also evaluated the in vitro stability of the sample, together with the linearity and percentage recovery.
    Results: The CT-XPT-assay showed a better detection limit than the CT-LIA assay, with lower values of LOB (0.86 pg/mL vs 1.00 pg/mL) and LOQ (1.65 pg/mL vs 3.00 pg/mL). Both values were in agreement with those reported by the manufacturer. Within- and between-run precision demonstrated a good concordance of results. Regarding the in vitro stability of CT, the low CT concentration sera showed a much greater decrease in CT levels compared to the high concentration sera. Correlation studies showed a good correlation between the two methods (Kappa Cohen coefficent, KC: 0.68, agreement % for male: 89.58%; KC: 0.63; agreement % for female: 88.33%).
    Conclusions: Our findings showed a good correlation between the CT-LIA and CT-XPT methods. Moreover, we demonstrated that the analytical performance of the CT-XPT assay, together with its technical specifications, could represent major features of the CT-XPT method. Collectively, the technical evaluation and the analytical results described in the presented paper highlight that the novel CT-XPT is a valid method for CT testing in a clinical diagnostic setting.
    MeSH term(s) Biological Assay ; Calcitonin ; Carcinoma, Neuroendocrine ; Female ; Humans ; Male ; Thyroid Neoplasms/diagnosis
    Chemical Substances Calcitonin (9007-12-9)
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfab162
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  7. Article ; Online: Inter-Regional Patients' Migration for Hospital Orthopedic Intensive Rehabilitation: The Italian Experience.

    Guarducci, Giovanni / Messina, Gabriele / Carbone, Simona / Urbani, Andrea / Nante, Nicola

    International journal of environmental research and public health

    2022  Volume 19, Issue 21

    Abstract: Background: Following the introduction of administrative federalism in the Italian National Health Service, inter-regional patients' mobility has become increasingly relevant because, in addition to being an indirect index of the quality of care, it has ...

    Abstract Background: Following the introduction of administrative federalism in the Italian National Health Service, inter-regional patients' mobility has become increasingly relevant because, in addition to being an indirect index of the quality of care, it has important economic and financial implications. This study aimed to evaluate the fulfillment of the need for hospital orthopedic intensive rehabilitation on site and care-seeking patients' migration to other regions.
    Methods: From 2011 to 2019, the data of intensive orthopedic rehabilitation extracts from the Hospital Discharge Cards provided by Italian Ministry of Health were analyzed. We studied the hospital networks of every Italian region (catchment areas). The epidemiological flows of inter-regional mobility were analyzed with Gandy's Nomogram, while the financial flows were analyzed through Attraction Absorption and Escape Production Indexes.
    Results: Gandy's Nomogram showed that only Piedmont, Lombardy, A.P. of Trento, E. Romagna, Umbria and Abruzzo had good public hospital planning for intensive orthopedic rehabilitation, with a positive balance for all studied periods. Lombardy, E. Romagna, Piedmont, Veneto and Latium have absorbed approximately 70% of all financial flows (about EUR 60.5 million).
    Conclusions: Only six regions appear to be able to satisfy the care needs of their residents, with a positive epidemiological and financial balance for all studied periods.
    MeSH term(s) Humans ; Hospitals ; Italy ; Orthopedics ; State Medicine ; Rehabilitation
    Language English
    Publishing date 2022-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192113726
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  8. Article: Commentary: Case Report: Hyperbilirubinemia in Gilbert Syndrome Attenuates Covid-19-Induced Metabolic Disturbances.

    Minucci, Angelo / Onori, Maria Elisabetta / Urbani, Andrea

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 685835

    Language English
    Publishing date 2021-07-22
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.685835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Artemisia

    Polito, Flavio / Di Mercurio, Mattia / Rizzo, Silvia / Di Vito, Maura / Sanguinetti, Maurizio / Urbani, Andrea / Bugli, Francesca / De Feo, Vincenzo

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 7

    Abstract: Background: The 2015 Nobel Prize in Medicine, awarded for the discovery of artemisinin in : Materials and methods: A broth microdilution test, growth curve test and : Results: These essential oils, when used in minimal concentrations (lower than 0. ...

    Abstract Background: The 2015 Nobel Prize in Medicine, awarded for the discovery of artemisinin in
    Materials and methods: A broth microdilution test, growth curve test and
    Results: These essential oils, when used in minimal concentrations (lower than 0.06%
    Conclusion: This research opens avenues for potential applications in the food industry, emphasizing the need for further exploration into the prebiotic properties of
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13070967
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  10. Article ; Online: A New Potential Resource in the Fight against Candida auris: the

    Di Vito, M / Garzoli, S / Rosato, R / Mariotti, M / Gervasoni, J / Santucci, L / Ovidi, E / Cacaci, M / Lombarini, G / Torelli, R / Urbani, A / Sanguinetti, M / Bugli, F

    Microbiology spectrum

    2023  , Page(s) e0438522

    Abstract: Candida auris is a multidrug-resistant fungus known to be a global public health problem. The skin-based transmission, together with the marked resistance to drugs, resulted in its rapid spread to all continents. The aim of this study was to identify an ... ...

    Abstract Candida auris is a multidrug-resistant fungus known to be a global public health problem. The skin-based transmission, together with the marked resistance to drugs, resulted in its rapid spread to all continents. The aim of this study was to identify an essential oil (EO) active in the fight against C. auris. A total of 15 EOs were tested against 10 clinical strains of C. auris.
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04385-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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