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Article: Adrenal Neuroblastoma Producing Catecholamines Diagnosed in Adults: Case Report.

Guzman Gómez, Guillermo Edinson / Urbano, Maria Alejandra / Martínez, Veline

2022 Volume 15, Issue 2, Page(s) 682–686

Abstract: Neuroblastoma is a solid tumor considered almost exclusively pediatric, with more than 95% of patients diagnosed before 10 years of age, with a mostly benign clinical course and with encouraging survival rates in these age ranges. It occurs rarely in ... ...

Abstract	Neuroblastoma is a solid tumor considered almost exclusively pediatric, with more than 95% of patients diagnosed before 10 years of age, with a mostly benign clinical course and with encouraging survival rates in these age ranges. It occurs rarely in adolescents, and the presentation in young adults or older people is even rarer; consequently, a more severe prognosis and higher mortality rates have been documented within this population. This is also due to a great limitation within the treatment since the chemotherapeutic regimens proposed so far are valid for pediatric patients, with low tolerance to it within the adult population. We present the case of a 24-year-old female patient with catecholamine-secreting neuroblastoma who obtained surgical management, with subsequent local tumor recurrence, with subsequent need for onco-specific and symptomatic management.
Language	English
Publishing date	2022-07-07
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000520125
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Article ; Online: Development of agricultural bio-inoculants based on mycorrhizal fungi and endophytic filamentous fungi: Co-inoculants for improve plant-physiological responses in sustainable agriculture

Díaz-Urbano, María / Goicoechea, Nieves / Velasco, Pablo / Poveda, Jorge

Biological Control. 2023 July, v. 182 p.105223-

2023

Abstract: A new more sustainable agricultural system needs to be developed to increase production without compromising human and animal health and preserving essential resources, such as soil, water and diversity. Bio-inoculants can be a tool to favor this ... ...

Abstract	A new more sustainable agricultural system needs to be developed to increase production without compromising human and animal health and preserving essential resources, such as soil, water and diversity. Bio-inoculants can be a tool to favor this transition, as they can replace or complement agrochemicals that do not meet the above premises. Bio-inoculants generated from endophytic filamentous fungi and mycorrhizal fungi, whether used individually, in combination with each other or with other microorganisms, stand out for their potential. This review provides information on how bio-inoculants based on these microorganisms have been shown to increase crop yield and quality through strategies, such as increasing nutrient uptake or levels of certain phytohormones. On how they can promote tolerance to abiotic stresses, including heavy metals, elevated temperatures, salinity or drought, through strategies, such as the accumulation of osmoregulatory substances or increasing the plant's root surface, among others. And finally, in the ability to protect the plant against pathogens and pests, either by inducing defense systems, competing for space or synthesizing metabolites with antibiotic activity. It should be noted that, although there are already commercial products using these microorganisms for agricultural purposes, such as biological control agents or biostimulants, it is expected that a deeper understanding of the mechanisms of action of the microorganisms, together with improved technical production processes, will lead to more effective, safer and cheaper products.
Keywords	animal and human health ; antibacterial properties ; biological control ; complement ; crop yield ; drought ; endophytes ; metabolites ; nutrient uptake ; plant hormones ; salinity ; soil ; sustainable agriculture ; Biostimulant ; Glomus ; Trichoderma ; Rhizophagus ; Piriformospora
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	1149971-0
ISSN	1049-9644
ISSN	1049-9644
DOI	10.1016/j.biocontrol.2023.105223
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Article ; Online: Vedolizumab is superior to infliximab in biologic naïve patients with ulcerative colitis.

Sablich, Renato / Urbano, Maria Teresa / Scarpa, Marco / Scognamiglio, Federico / Paviotti, Alberto / Savarino, Edoardo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1816

Abstract: There are no prospective, head-to-head, controlled trials comparing the efficacy and safety of Infliximab (IFX) and Vedolizumab (VDZ) for the treatment of moderate-to-severe ulcerative colitis (UC), while only a few real-life retrospective studies have ... ...

Abstract	There are no prospective, head-to-head, controlled trials comparing the efficacy and safety of Infliximab (IFX) and Vedolizumab (VDZ) for the treatment of moderate-to-severe ulcerative colitis (UC), while only a few real-life retrospective studies have been published so far. We assessed the efficacy of IFX vs. VDZ in two cohorts of biologic-naïve outpatients with moderate-to-severe UC or mild, but refractory, disease. Data were extracted from patients' files and reviewed. The duration of follow-up (FU) was 52 weeks. The primary endpoint was the clinical remission (CR) at the end of FU. Secondary endpoints were: drug persistency, time to obtain CR, clinical response at the end of the induction phase (IP), steroid-free CR (compared to patients who used steroids at baseline) at the end of FU, need for drug optimization, adverse events (AEs), and normalization of C-reactive protein (CRP). We also analyzed the causes of dropping out (primary non-response), or secondary loss of response (immunogenic or not), for each group. We enrolled 82 patients (50 IFX and 32 VDZ) who met the inclusion criteria. At the end of FU, CR was obtained in 32% of the patients on IFX and 75% on VDZ (p = 0.0003). Drug persistency was superior for VDZ compared to IFX (78% vs. 52%, p = 0.033). Clinical response at the end of induction was reached in 54% and in 81% in the IFX and VDZ group, respectively (p = 0.014). Steroid-free clinical remission at the end of FU was 62% and 94% in the IFX vs. VDZ group, respectively (p = 0.036). The need for drug optimization was higher for VDZ than for IFX (28% vs. 57%, p = 0.009), while the time to obtain CR, the incidence of AEs, mean duration of FU, and rate of CRP normalization at the end of IP were comparable between the two groups. There was a prevalence of patients dropping out because of primary non-response in IFX group (p = 0.027), while the incidence of secondary loss of response was similar in the two groups. At the multivariate analysis, CRP and Partial Mayo Score (PMS) at T0 did not correlate with CR at the end of FU in both groups. In this retrospective, real world data study in biologic-naïve patients, VDZ was superior to IFX in CR, clinical response rate at the end of IP, drug persistency, steroid-free remission, and need for optimization at the end of FU.
MeSH term(s)	Humans ; Biological Products/therapeutic use ; C-Reactive Protein ; Colitis, Ulcerative/drug therapy ; Gastrointestinal Agents/therapeutic use ; Infliximab/therapeutic use ; Remission Induction ; Retrospective Studies ; Steroids/therapeutic use ; Treatment Outcome ; Antibodies, Monoclonal, Humanized/therapeutic use
Chemical Substances	Biological Products ; C-Reactive Protein (9007-41-4) ; Gastrointestinal Agents ; Infliximab (B72HH48FLU) ; Steroids ; vedolizumab (9RV78Q2002) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-28907-3
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Article: Fungal endophytes of Brassicaceae: Molecular interactions and crop benefits.

Poveda, Jorge / Díaz-González, Sandra / Díaz-Urbano, María / Velasco, Pablo / Sacristán, Soledad

Frontiers in plant science

2022 Volume 13, Page(s) 932288

Abstract: Brassicaceae family includes an important group of plants of great scientific interest, e.g., the model ... ...

Abstract	Brassicaceae family includes an important group of plants of great scientific interest, e.g., the model plant
Language	English
Publishing date	2022-08-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.932288
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Article: The Impact of Depression on the Functional Outcome of the Elderly Stroke Victim from a Gender Perspective: A Systematic Review.

Franco-Urbano, María Salud / Rodríguez-Martínez, María Del Carmen / García-Pérez, Patricia

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 10

Abstract: 1) Background: The aim of this systematic review focused on analyzing the impact of depression on the functional outcome of the elderly stroke victim and how this disorder affects both the female and the male population. (2) Methods: We conducted a ... ...

Abstract	(1) Background: The aim of this systematic review focused on analyzing the impact of depression on the functional outcome of the elderly stroke victim and how this disorder affects both the female and the male population. (2) Methods: We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review was registered in PROSPERO (ID 346284). The systematic search for clinical trials was performed in the databases Pubmed, Otseeker, Scopus, Web of Science, Psycinfo, Medline Complete, ScienceDirect, SciELO, and Dialnet. Articles were selected according to the inclusion and exclusion criteria, including those dealing with post-stroke depression in adults whose psychological status had changed. Studies that only assessed the psychological state of caregivers were excluded. (3) Results: In total, 609 articles were identified, of which 11 randomized controlled trials were finally included in the review. The results indicate that post-stroke depression influences the recovery of functionality and quality of life. In addition, the need to detect the mood of the adult population after the stroke and to provide individualized treatment according to the characteristics of the person is highlighted. (4) Conclusions: This systematic review shows how early detection of post-stroke depressive symptoms can improve the degree of disability and quality of life of the person, especially in women.
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10102110
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Article: Analysis of neutropenia as a predictive factor of the efficacy of trifluridine-tipiracil treatment.

Domínguez Senín, Loreto / Rodriguez Garcés, María Yeray / Aviñó Tarazona, Victoria / Amor Urbano, María / Santos-Rubio, Maria Dolores / Bayo Calero, Juan

International journal of clinical pharmacology and therapeutics

2023 Volume 61, Issue 8, Page(s) 346–353

Abstract: Objectives: Trifluridine-tipiracil (TAS-102), an oral cytotoxic agent used in adult patients with refractory metastatic colorectal cancer (mCRC), has been associated with neutropenia (chemotherapy-induced neutropenia) (CIN)).: Materials and methods: ... ...

Abstract	Objectives: Trifluridine-tipiracil (TAS-102), an oral cytotoxic agent used in adult patients with refractory metastatic colorectal cancer (mCRC), has been associated with neutropenia (chemotherapy-induced neutropenia) (CIN)). Materials and methods: We evaluated the efficacy and safety of TAS-102 in a group of 45 mCRC patients (median age 66 years) in Huelva province, Spain, in a retrospective, multicenter observational study. Results: We showed that the association between TAS-102 and CIN can be used as a predictor of efficacy. 20% (9/45) of patients with an Eastern Cooperative Oncology Group (ECOG) score of 2 had received at least one previous chemotherapy treatment. Overall, 75.5% (34/45) and 28.9% (13/45) had received anti-VEGF and anti-EGFR monoclonal antibodies, respectively. Additionally, 80% (36/45) of patients had received third-line treatment. The mean treatment period, duration of overall survival (OS), and duration of progression-free survival (PFS) were 3.4, 12, and 4 months, respectively. A partial response was seen in 2 patients (4.3%), and disease stabilization was observed in 10 patients (21.3%). Neutropenia was the most frequent grade 3 - 4 toxicity (46.7%; 21/45). Other findings were anemia (77.8%; 35/45), all grades of neutropenia (73.3%; 33/45), and gastrointestinal toxicity (53.3%; 24/45). The dose of TAS-102 needed to be reduced in 68.9% (31/45) of patients, whereas treatment needed to be interrupted in 80% (36/45) of patients. Grade 3 - 4 neutropenia was a positive prognostic factor for OS (p = 0.023). Conclusion: A retrospective evaluation shows that grade 3 - 4 neutropenia is an independent predictor of treatment response and survival in patients undergoing routine treatment for mCRC, but this finding needs confirmation in a prospective study.
MeSH term(s)	Adult ; Aged ; Humans ; Antineoplastic Agents/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Colonic Neoplasms ; Colorectal Neoplasms/drug therapy ; Drug Combinations ; Neutropenia/chemically induced ; Neutropenia/drug therapy ; Prospective Studies ; Pyrrolidines/adverse effects ; Retrospective Studies ; Trifluridine/adverse effects ; Middle Aged
Chemical Substances	Antineoplastic Agents ; Drug Combinations ; Pyrrolidines ; tipiracil (NGO10K751P) ; Trifluridine (RMW9V5RW38) ; trifluridine tipiracil drug combination
Language	English
Publishing date	2023-06-08
Publishing country	Germany
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP204410
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Article ; Online: Collaborative interdisciplinary approaches for a heterogeneous group of neurodevelopmental disorders; A "Way" forward!

Deutsch, Stephen I / Burket, Jessica A / Urbano, Maria R

Progress in neuro-psychopharmacology & biological psychiatry

2019 Volume 93, Page(s) 122–123

MeSH term(s)	Autism Spectrum Disorder/etiology ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/psychology ; Humans ; Interdisciplinary Research
Language	English
Publishing date	2019-03-29
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2019.03.011
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Article ; Online: Comparison of the accuracy of four diagnostic prediction rules for pulmonary embolism in patients admitted to the emergency department.

Silva, Beatriz Valente / Jorge, Cláudia / Plácido, Rui / Menezes, Miguel Nobre / Mendonça, Carlos / Urbano, Maria Luísa / Rigueira, Joana / Almeida, Ana G / Pinto, Fausto J

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

2024

Abstract: Introduction and objectives: Ruling out pulmonary embolism (PE) through a combination of clinical assessment and D-dimer level can potentially avoid excessive use of computed tomography pulmonary angiography (CTPA). We aimed to compare the diagnostic ... ...

Abstract	Introduction and objectives: Ruling out pulmonary embolism (PE) through a combination of clinical assessment and D-dimer level can potentially avoid excessive use of computed tomography pulmonary angiography (CTPA). We aimed to compare the diagnostic accuracy of the standard approach based on the Wells and Geneva scores combined with a standard D-dimer cut-off (500 ng/ml), with three alternative strategies (age-adjusted and the YEARS and PEGeD algorithms) in patients admitted to the emergency department (ED) with suspected PE. Methods: Consecutive outpatients admitted to the ED who underwent CTPA due to suspected PE were retrospectively assessed. Sensitivity, specificity, positive and negative predictive values, likelihood ratios and diagnostic odds ratios were calculated and compared between the different diagnostic prediction rules. Results: We included 1402 patients (mean age 69±18 years, 54% female), and PE was confirmed in 25%. Compared to the standard approach (p<0.001), an age-adjusted strategy increased specificity with a non-significant decrease in sensitivity only in patients older than 70 years. Compared to the standard and age-adjusted approaches, the YEARS and PEGeD algorithms had the highest specificity across all ages, but were associated with a significant decrease in sensitivity (p<0.001), particularly in patients aged under 60 years (sensitivity of 81% in patients aged between 51 and 60 years). Conclusion: Compared to the standard approach, all algorithms were associated with increased specificity. The age-adjusted strategy was the only one not associated with a significant decrease in sensitivity compared to the standard approach, enabling CTPA requests to be reduced safely.
Language	Portuguese
Publishing date	2024-04-23
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	632718-7
ISSN	2174-2030 ; 0870-2551 ; 0304-4750
ISSN (online)	2174-2030
ISSN	0870-2551 ; 0304-4750
DOI	10.1016/j.repc.2024.02.006
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Article ; Online: Analysis of Blood Biochemistry and Pituitary-Gonadal Histology after Chronic Exposure to Bisphenol-A of Mice.

Molina-López, Ana M / Bujalance-Reyes, Francisca / Urbano, María Teresa / Lora-Benítez, Antonio / Ayala-Soldado, Nahúm / Moyano-Salvago, Rosario

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: Bisphenol-A is an emerging pollutant that is widespread in the environment, and to which live beings are continuously and inadvertently exposed. It is a substance with an endocrine-disrupting capacity, causing alterations in the reproductive, ... ...

Abstract	Bisphenol-A is an emerging pollutant that is widespread in the environment, and to which live beings are continuously and inadvertently exposed. It is a substance with an endocrine-disrupting capacity, causing alterations in the reproductive, immunological, and neurological systems, among others, as well as metabolic alterations. Our study aimed to assess its clinical signs, and effects on the most relevant blood biochemical parameters, and to evaluate pituitary and gonadal histology after a chronic exposure of adult mice to different BPA doses (0.5, 2, 4, 50 and 100 µg/kg BW/day) through their drinking water. The biochemical results showed that a marked significant reduction (
MeSH term(s)	Mice ; Animals ; Creatinine ; Dose-Response Relationship, Drug ; Gonads ; Glucose ; Urea ; Albumins ; Endocrine Disruptors/toxicity
Chemical Substances	Creatinine (AYI8EX34EU) ; bisphenol A (MLT3645I99) ; Glucose (IY9XDZ35W2) ; Urea (8W8T17847W) ; Albumins ; Endocrine Disruptors
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192113894
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Article: Comparison of 5 acute pulmonary embolism mortality risk scores in patients with COVID-19.

Rodrigues, Tiago / Silva, Beatriz Valente / Plácido, Rui / Mendonça, Carlos / Urbano, Maria Luísa / Rigueira, Joana / Almeida, Ana G / Pinto, Fausto J

International journal of cardiology. Heart & vasculature

2022 Volume 39, Page(s) 100984

Abstract: Objective: Pulmonary embolism (PE) is a common complication of SARS-CoV-2 infection. We aimed to explore the short-term outcomes among patients with acute PE and COVID-19 and to further determine and compare the performance of the different prognostic ... ...

Abstract	Objective: Pulmonary embolism (PE) is a common complication of SARS-CoV-2 infection. We aimed to explore the short-term outcomes among patients with acute PE and COVID-19 and to further determine and compare the performance of the different prognostic scores (PESI, sPESI, BOVA, FAST and ESC scores) for risk-stratification in this scenario. Methods: Retrospective single-centre study of 85 patients with SARS-CoV-2 infection and PE admitted to the Emergency Department (ED). The diagnostic accuracy of each above-mentioned prognostic score was calculated post hoc, and their discriminative power was evaluated through an AUC curve. Results: Among the 85 patients, all-cause death occurred within 7 days for 6 patients (7.1%) and within 30 days for 14 patients (16.5%). Despite being older and having a higher percentage of altered mental status on presentation, non-survivors patients did not differ from survivors regarding comorbidities, traditional risk factors for venous thromboembolism and signs and symptoms at the ED presentation.Each risk stratification tool had modest discriminative power for 7-day mortality (AUC range, 0.601-0.730) with slightly lower discrimination for 30-day mortality (AUC range, 0.543-0.638). The pair-wise comparison of ROC curves showed that PESI had better predictive value for short-term mortality than ESC score (z test = 3.92, p = 0.001) and sPESI (z test = 2.43, p = 0.015); there is no significant difference between PESI and BOVA score (z test = 1.05, p = 0.295) and FAST score (z test = 0.986, p = 0.324). Conclusion: The most common risk-stratification tools for PE had modest discriminative power to predict short-term mortality in patients with acute PE and COVID-19.
Language	English
Publishing date	2022-02-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2022.100984
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