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  1. Article ; Online: Antiphospholipid antibody solid phase-based assays: problems and proposed solutions for the 2023 ACR/EULAR classification criteria for antiphospholipid syndrome.

    Huisman, Albert / Urbanus, Rolf T / Meijer, Piet

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 22, Issue 3, Page(s) 874–876

    MeSH term(s) Humans ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/diagnosis ; Sensitivity and Specificity
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2023-12-23
    Publishing country England
    Document type Letter
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.12.019
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  2. Article ; Online: Recent Developments in Antiphospholipid Antibodies and the Antiphospholipid Syndrome.

    Urbanus, Rolf T

    Seminars in thrombosis and hemostasis

    2018  Volume 44, Issue 5, Page(s) 417–418

    MeSH term(s) Antibodies, Antiphospholipid/immunology ; Antiphospholipid Syndrome/immunology ; Humans
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2018-06-25
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0038-1657761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rivaroxaban to treat thrombotic antiphospholipid syndrome.

    Urbanus, Rolf T

    The Lancet. Haematology

    2016  Volume 3, Issue 9, Page(s) e403–4

    MeSH term(s) Antiphospholipid Syndrome ; Humans ; Lupus Erythematosus, Systemic ; Rivaroxaban ; Thrombosis ; Warfarin
    Chemical Substances Warfarin (5Q7ZVV76EI) ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2016-08-04
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(16)30107-7
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  4. Article: Glanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm-related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency.

    Schutgens, Roger E G / Urbanus, Rolf T

    Clinical case reports

    2021  Volume 9, Issue 9, Page(s) e04757

    Abstract: A patient with Glanzmann Thrombasthenia developed recurrent venous thrombosis with ... ...

    Abstract A patient with Glanzmann Thrombasthenia developed recurrent venous thrombosis with a
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.4757
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  5. Article: Recent Developments in Antiphospholipid Antibodies and the Antiphospholipid Syndrome

    Urbanus, Rolf T.

    Seminars in Thrombosis and Hemostasis

    (Recent Developments in Antiphospholipid Antibodies and the Antiphospholipid Syndrome)

    2018  Volume 44, Issue 05, Page(s) 417–418

    Series title Recent Developments in Antiphospholipid Antibodies and the Antiphospholipid Syndrome
    Language English
    Publishing date 2018-06-25
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0038-1657761
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  6. Article ; Online: Identification of thrombosis-related conformational binding epitopes on domain I of β2-glycoprotein I.

    Kim, Seung Joong / Schneidman-Duhovny, Dina / de Groot, Philip G / Urbanus, Rolf T / Carter, Lester / de Laat-Kremers, Romy / Weiss, Thomas M / Chan, Man K / Sali, Andrej / Rand, Jacob H / de Laat, Bas

    Thrombosis research

    2024  Volume 237, Page(s) 145–147

    MeSH term(s) Humans ; Thrombosis/metabolism ; beta 2-Glycoprotein I/immunology ; beta 2-Glycoprotein I/chemistry ; beta 2-Glycoprotein I/metabolism ; Epitopes/immunology ; Protein Domains
    Chemical Substances beta 2-Glycoprotein I ; Epitopes
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.03.025
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  7. Article ; Online: Interference in point-of-care international normalized ratio monitoring in patients with lupus anticoagulant is correlated with anti-β2-glycoprotein I antibody titers.

    Noordermeer, Tessa / Urbanus, Rolf T / Wong, Chong Y / Jansma, Janna J / Wiersma, Nynke M / Zivkovic, Minka / Huisman, Albert / Limper, Maarten

    Research and practice in thrombosis and haemostasis

    2022  Volume 7, Issue 1, Page(s) 100011

    Abstract: Background: Patients with antiphospholipid syndrome (APS) receive anticoagulant therapy with vitamin K antagonists (VKAs) to prevent recurrent thrombosis. VKA treatment requires strict monitoring with an international normalized ratio (INR). It is known ...

    Abstract Background: Patients with antiphospholipid syndrome (APS) receive anticoagulant therapy with vitamin K antagonists (VKAs) to prevent recurrent thrombosis. VKA treatment requires strict monitoring with an international normalized ratio (INR). It is known that lupus anticoagulants (LAs) can lead to elevated INR results with point-of-care-testing (POCT) devices, which could result in inadequate adaptation of anticoagulant therapy.
    Objective: To determine discrepancies between POCT-INR and laboratory-INR in patients who are LA-positive on VKA therapy.
    Methods: Paired INR testing was performed with 1 POCT device (CoaguChek XS) and 2 laboratory assays (Owren and Quick method) in 33 patients with LA-positive APS on VKA in a single-center cross-sectional study. Patients were tested for anti-β2-glycoprotein I, anticardiolipin, and antiphosphatidylserine/prothrombin immunoglobulin (Ig) G and IgM antibodies. Agreement between assays was evaluated with Spearman's correlation, Lin's correlation coefficient, and Bland-Altman plots. Agreement limits were considered satisfactory if differences were ≤20% as determined by the Clinical and Laboratory Standards Institute.
    Results: We found poor agreement between POCT-INR and laboratory-INR based on Lin's concordance correlation coefficient (ρ
    Conclusion: There is a disagreement between INR values measured with the CoaguChek XS and laboratory-INR in a proportion of patients with LA. Consequently, laboratory-INR monitoring should be preferred over POCT-INR monitoring in patients with LA-positive APS, especially in patients with high anti-β2-glycoprotein IgG antibody titers.
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2022.100011
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  8. Article ; Online: Platelet Activation via Glycoprotein VI Initiates Thrombin Generation: A Potential Role for Platelet-Derived Factor IX?

    Li, Li / Roest, Mark / Meijers, Joost C M / de Laat, Bas / Urbanus, Rolf T / de Groot, Philip G / Huskens, Dana

    Thrombosis and haemostasis

    2022  Volume 122, Issue 9, Page(s) 1502–1512

    Abstract: Collagen triggers coagulation via activation of factor (F) XII. In a platelet-rich environment, collagen can also trigger coagulation independently of FXII. We studied a novel mechanism of coagulation initiation via collagen-dependent platelet activation ...

    Abstract Collagen triggers coagulation via activation of factor (F) XII. In a platelet-rich environment, collagen can also trigger coagulation independently of FXII. We studied a novel mechanism of coagulation initiation via collagen-dependent platelet activation using thrombin generation (TG) in platelet-rich plasma. Collagen-induced coagulation is minimally affected by active-site inactivated FVIIa, anti-FVII antibodies, or FXIIa inhibition (corn trypsin inhibitor). Activation of platelets via specific glycoprotein (GP) VI agonists initiates TG, FX activation, and fibrin formation. To determine the platelet-derived trigger of coagulation, we systematically reconstituted factor-deficient plasmas with washed platelets. TG triggered by GPVI-activated platelets was significantly affected in FIX- and FVIII-deficient plasma but not in FVII- and FXII-deficient plasma. In a purified system composed of FX and FVIII, we observed that absence of FIX was compensated by GPVI-activated platelets, which could be inhibited by an anti-FIX antibody, suggesting FIXa activity from activated platelets. Furthermore, with the addition of FVIII in FIX-deficient plasma, TG induced by GPVI-activated platelets was restored, and was inhibited by the anti-FIX antibody. In conclusion, GPVI-activated platelets initiate TG, probably via platelet-derived FIXa activity.
    MeSH term(s) Blood Coagulation Factors ; Blood Platelets ; Collagen ; Factor IX ; Glycoproteins ; Humans ; Platelet Activation ; Platelet Membrane Glycoproteins ; Thrombin
    Chemical Substances Blood Coagulation Factors ; Glycoproteins ; Platelet Membrane Glycoproteins ; platelet membrane glycoprotein VI ; Factor IX (9001-28-9) ; Collagen (9007-34-5) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2022-05-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0042-1744379
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  9. Article ; Online: Nanobodies against factor XI apple 3 domain inhibit binding of factor IX and reveal a novel binding site for high molecular weight kininogen.

    Bar Barroeta, Awital / Marquart, J Arnoud / Bakhtiari, Kamran / Meijer, Alexander B / Urbanus, Rolf T / Meijers, Joost C M

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 20, Issue 11, Page(s) 2538–2549

    Abstract: Background: Factor XI (FXI) is a promising target for novel anticoagulants because it shows a strong relation to thromboembolic diseases, while fulfilling a mostly supportive role in hemostasis. Anticoagulants targeting FXI could therefore reduce the ... ...

    Abstract Background: Factor XI (FXI) is a promising target for novel anticoagulants because it shows a strong relation to thromboembolic diseases, while fulfilling a mostly supportive role in hemostasis. Anticoagulants targeting FXI could therefore reduce the risk for thrombosis, without increasing the chance of bleeding side effects.
    Objectives: To generate nanobodies that can interfere with FXIa mediated activation of factor IX (FIX).
    Methods: Nanobodies were selected for binding to the apple 3 domain of FXI and their effects on FXI and coagulation were measured in purified protein systems as well as in plasma-based coagulation assays. Additionally, the binding epitope of selected nanobodies was assessed by hydrogen-deuterium exchange mass spectrometry.
    Results: We have identified five nanobodies that inhibit FIX activation by FXI by competing with the FIX binding site on FXI. Interestingly, a sixth nanobody was found to target a different binding epitope in the apple 3 domain, resulting in competition with the FXI-high molecular weight kininogen (HK) interaction.
    Conclusions: We have characterized a nanobody targeting the FXI apple 3 domain that elucidates the binding orientation of HK on FXI. Moreover, we have produced five nanobodies that can inhibit the FXI-FIX interaction.
    MeSH term(s) Humans ; Anticoagulants ; Binding Sites ; Deuterium ; Epitopes ; Factor IX/metabolism ; Factor XI/metabolism ; Kininogen, High-Molecular-Weight/metabolism ; Single-Domain Antibodies
    Chemical Substances Anticoagulants ; Deuterium (AR09D82C7G) ; Epitopes ; Factor IX (9001-28-9) ; Factor XI (9013-55-2) ; Kininogen, High-Molecular-Weight ; Single-Domain Antibodies
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15815
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  10. Article ; Online: Diagnostiek bij een vermeende stollingsstoornis.

    van Vulpen, Lize F D / Wichers, Iris M / Urbanus, Rolf T / van Galen, Karin P M

    Nederlands tijdschrift voor geneeskunde

    2020  Volume 164

    Abstract: Bleeding symptoms occur frequently in the general population, but the possibility of an underlying bleeding disorder is not always recognised. Women with a bleeding disorder are disproportionally affected due to blood loss during menstruation and giving ... ...

    Title translation Diagnostics on suspicion of a bleeding disorder.
    Abstract Bleeding symptoms occur frequently in the general population, but the possibility of an underlying bleeding disorder is not always recognised. Women with a bleeding disorder are disproportionally affected due to blood loss during menstruation and giving birth. Taking a thorough family history and a history of bleeding are most important in the workup to detect a potential underlying bleeding disorder. In patients with a bleeding disorder, potentially life-threatening complications due to bleeding can be prevented by compiling an individualized treatment plan and timely targeted blood coagulation treatment. If a bleeding disorder is suspected, initial diagnostic testing consists of determining the aPTT, PT, platelet count and von Willebrand factor activity; global tests for disorders of haemostasis, such as the coagulation time and platelet function are not of any added value. It cannot be excluded that a patient in whom test results are normal may still have a platelet function disorder or a rare bleeding disorder. If there is a strong suspicion of a bleeding disorder this should always be discussed with a coagulation specialist.
    MeSH term(s) Blood Coagulation ; Blood Coagulation Disorders/diagnosis ; Blood Coagulation Tests ; Female ; Hemorrhage/diagnosis ; Hemostasis ; Humans ; Medical History Taking ; Platelet Count ; Pregnancy ; von Willebrand Diseases/diagnosis
    Language Dutch
    Publishing date 2020-03-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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