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  1. Article: Extending heart preservation to 24 h with normothermic perfusion.

    Spencer, Brianna L / Wilhelm, Spencer K / Stephan, Christopher / Urrea, Kristopher A / Palacio, Daniela Pelaez / Bartlett, Robert H / Drake, Daniel H / Rojas-Pena, Alvaro

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1325169

    Abstract: Cold static storage (CSS) for up to 6 h is the gold standard in heart preservation. Although some hearts stored over 6 h have been transplanted, longer CSS times have increased posttransplant morbimortality. Transmedics® Organ Care System (OCS™) is the ... ...

    Abstract Cold static storage (CSS) for up to 6 h is the gold standard in heart preservation. Although some hearts stored over 6 h have been transplanted, longer CSS times have increased posttransplant morbimortality. Transmedics® Organ Care System (OCS™) is the only FDA-approved commercial system that provides an alternative to CSS using normothermic
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1325169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Artificial Intelligence-Assisted Strain Echocardiography in an Ex Vivo Heart.

    Johnson, Matthew D / Zimmerman, Karen G / Nakashima, Takahiro / Urrea, Kristopher A / Rojas-Pena, Alvaro / Bartlett, Robert H / Drake, Daniel H

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2023  Volume 69, Issue 12, Page(s) e523–e525

    MeSH term(s) Artificial Intelligence ; Heart ; Echocardiography
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.199: Show issues Location:
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  3. Article ; Online: Twenty-four-hour Normothermic Ex Vivo Heart Perfusion With Low Flow Functional Assessment in an Adult Porcine Model.

    Spencer, Brianna L / Wilhelm, Spencer K / Urrea, Kristopher A / Chakrabortty, Vikramjit / Sewera, Sebastian / Mazur, Daniel E / Niman, Joseph B / Bartlett, Robert H / Rojas-Peña, Alvaro / Drake, Daniel H

    Transplantation

    2024  

    Abstract: Background: Cold static storage and normothermic ex vivo heart perfusion are routinely limited to 6 h. This report describes intermittent left atrial (LA) perfusion that allows cardiac functional assessment in a working heart mode.: Methods: Using ... ...

    Abstract Background: Cold static storage and normothermic ex vivo heart perfusion are routinely limited to 6 h. This report describes intermittent left atrial (LA) perfusion that allows cardiac functional assessment in a working heart mode.
    Methods: Using our adult porcine model, general anesthesia was induced and a complete cardiectomy was performed following cardioplegic arrest. Back-table instrumentation was completed and normothermic ex vivo heart perfusion (NEHP) was initiated in a nonworking heart mode (Langendorff). After 1 h of resuscitation and recovery, LA perfusion was initiated and the heart was transitioned to a coronary flow-only working heart mode for 30 min. Baseline working heart parameters were documented and the heart was returned to nonworking mode. Working heart assessments were performed for 30 min every 6 h for 24 h.
    Results: Twenty-four-hour NEHP on 9 consecutive hearts (280 ± 42.1 g) was successful and no significant differences were found between working heart parameters at baseline and after 24 h of perfusion. There was no difference between initial and final measurements of LA mean pressures (5.0 ± 3.1 versus 9.0 ± 6.5 mm Hg, P = 0.22), left ventricular systolic pressures (44.3 ± 7.2 versus 39.1 ± 9.0 mm Hg, P = 0.13), mean aortic pressures (30.9 ± 5.8 versus 28.1 ± 8.1 mm Hg, P = 0.37), and coronary resistance (0.174 ± 0.046 versus 0.173 ± 0.066 mL/min/g, P = 0.90). There were also no significant differences between lactate (2.4 ± 0.5 versus 2.6 ± 0.4 mmol/L, P = 0.17) and glucose (173 ± 75 versus 156 ± 70 mg/dL, P = 0.37).
    Conclusions: A novel model using intermittent LA perfusion to create a coronary flow-only working heart mode for assessment of ex vivo cardiac function has been successfully developed.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 509: Show issues

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  4. Article ; Online: Twenty-Four Hour Normothermic Ex Vivo Heart Perfusion With Hemofiltration In an Adult Porcine Model.

    Spencer, Brianna L / Wilhelm, Spencer K / Urrea, Kristopher A / Chakrabortty, Vikramjit / Sewera, Sebastian J / Mazur, Daniel E / Bartlett, Robert H / Rojas-Peña, Alvaro / Drake, Daniel H

    Transplantation proceedings

    2023  Volume 55, Issue 9, Page(s) 2241–2246

    Abstract: Background: Historically, cardiac transplantation relied on cold static storage at 5 °C for ex vivo myocardial preservation. Currently, machine perfusion is the standard of care at many transplant centers. These storage methods are limited to 12 hours. ... ...

    Abstract Background: Historically, cardiac transplantation relied on cold static storage at 5 °C for ex vivo myocardial preservation. Currently, machine perfusion is the standard of care at many transplant centers. These storage methods are limited to 12 hours. We sought to evaluate the efficacy of hemofiltration and filtrate replacement in adult porcine hearts using normothermic heart perfusion (NEVHP) for 24 hours.
    Methods: We performed 24-hour NEVHP on 5 consecutive hearts. After anesthetic induction, sternotomy, cardioplegia administration, explantation, and back-table instrumentation, NEVHP was initiated in beating, unloaded mode. After 1 hour, plasma exchange was performed, and hemofiltration was initiated. Heart function parameters and arterial blood gasses were obtained hourly.
    Results: All hearts (n = 5) were viable at the 24-hour mark. The average left ventricular systolic pressure at the beginning of the prep was 36.6 ± 7.9 mm Hg compared with 27 ± 5.5 mm Hg at the end. Coronary resistance at the beginning of prep was 0.79 ± 0.10 mm Hg/L/min and 0.93 ± 0.28 mm Hg/L/min at the end. Glucose levels averaged 223 ± 13.9 mg/dL, and the lactate average at the termination of prep was 2.6 ± 0.3 mmol/L.
    Conclusions: We successfully perfused adult porcine hearts at normothermic temperatures for 24 hours with results comparable to our pediatric porcine heart model. The next step in our research is NEVHP evaluation in a working mode using left atrial perfusion.
    MeSH term(s) Humans ; Adult ; Child ; Swine ; Animals ; Hemofiltration ; Heart ; Heart Transplantation/methods ; Perfusion/methods ; Lactic Acid ; Organ Preservation/methods
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.08.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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